DRSC/TRiP Functional Genomics Resources

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Protein Alignment sdk and ush2a

DIOPT Version :9

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:XP_009291422.1 Gene:ush2a / 568982 ZFINID:ZDB-GENE-060503-794 Length:5243 Species:Danio rerio


Alignment Length:1744 Identity:407/1744 - (23%)
Similarity:653/1744 - (37%) Gaps:411/1744 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   647 DGQLEIQAVRASDVG--SYACVVTSP------------GGNETRAARLSVIELPFPPSNVKVERL 697
            ||:|    |..:|.|  ||......|            ||..:|:.|. ||:.|..    ..||:
Zfish  3745 DGEL----VFTADGGKMSYTDAGLQPNTRYVYELEATTGGGSSRSDRY-VIQTPIS----SPERI 3800

  Fly   698 PEPQQ------RSINVSWTPG--FDGNSPISKFIIQRREVSELGPVPDPLLNWITE--LSNVSAD 752
            |.|..      ||:.|:|:|.  ::.:.|:...|               |||..||  |...:..
Zfish  3801 PPPYNVSLHGPRSVFVAWSPPGVYNLSFPLEYNI---------------LLNAGTERPLIRSAGL 3850

  Fly   753 QRWILLENLKAATVYQFRVSAVN----RVGEGSPSEPSNVVELPQEAP--SGPPVGFVGSARSMS 811
            ::::||:.|...|:|..:|.|..    .||:|.      .|..|:.||  ..||   |.:|...:
Zfish  3851 EQFLLLQGLDPYTIYHVQVQACQPDGCGVGQGV------TVRTPEAAPIAQDPP---VTTATGAA 3906

  Fly   812 EIITQWQPPLEEHR-NGQILGYILRYRLFGYNNVPWSYQNITNEAQRNFL--IQELITWKDYIVQ 873
            .|..:|.||   |: ||.|..|.:..|..|.......:  |..|....|:  ...|..:.:|..:
Zfish  3907 VIEVRWSPP---HKPNGIITNYFIYRRPAGTQEELLVF--IWTEGPLEFIDASDSLHPFTEYEYR 3966

  Fly   874 IAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVEAINSTAA---RCRWTPPNPQQINGINQGYK 935
            :||.|:.| ...:..|.|:|.    ||.|..:...:.:.|:|   ...||.||..  ||:...||
Zfish  3967 VAAVNSKG-SASSSWSSIRTL----EAEPQGMNAPSAHPTSAYSLLLSWTQPNAP--NGVILVYK 4024

  Fly   936 IQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQT-----AILG--------GLEKFTEYNISVL 987
            : .:|:                 |||  ||....|     .:||        |||.:|.|||.|.
Zfish  4025 V-VYQK-----------------PPS--DPTFNSTTVTALTVLGNVFQAYVFGLEPYTTYNIRVE 4069

  Fly   988 CFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVS----DRSVKVLWAPPRASNGILTGYTVRYQ 1048
            .....|. |:|....:.|::..|   :||....|.    .|::.:.||.|.:.||::..|.:..:
Zfish  4070 AVNGAGQ-VSSPWTTIRTLEASP---SGLANFSVERREHGRALLLQWAEPASPNGVIKMYNIFNE 4130

  Fly  1049 VKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQSGVEPVLPHAPTA 1113
                 |.|:...|.   .:....:|:..|.|...:.|.|.  :|..::|..:...|..:|.:..|
Zfish  4131 -----DNLEFSGLA---RQFLFRRLEPYTVYTLILEACTE--AGCTRSAPQRVTTEEAIPSSQPA 4185

  Fly  1114 LALSNIEAFSVVLQFTPGFDGNSSITKWKV-------------EGQTARNMTWFTICEINDPDAE 1165
            ..:..:.:.||.|.::|....|..|.::::             |..:.|....|.   .|:..|.
Zfish  4186 PTVYQVHSRSVELFWSPPAQPNGRILQYQLLAVRLEDGRVRSDEDDSLRAKIVFI---QNNTQAN 4247

  Fly  1166 TLT--VTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPK--HPPFNVTVRAMSAQQLRV 1226
            :.:  ::||:|:::|:.|:..||..|.:.....|  .||.||.|:  .|| :|:.......::.|
Zfish  4248 SFSYNMSGLLPWSRYKFRVRVSNAAGFTDSPWLT--VQTKQAPPRGLAPP-SVSHIEGKPNEVFV 4309

  Fly  1227 RWIPLQQTEWYGNPRGYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLD----SLEEWTLYEV 1287
            .|.|..:      |.|..::|:           :.|..:....:.:|.|.:    .|..:|||..
Zfish  4310 AWTPPLE------PNGVLLTYR-----------IQRDNIGFHFSFDSSVFNYTDVDLNAYTLYSY 4357

  Fly  1288 KMNACNDVGCSKESDTAVERTREAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGY--K 1350
            .:.||...||.....|.: ||.|..|:.....:.::.| |.::.|.| .|| ..:||:|..|  |
Zfish  4358 AIIACTVAGCVTSGPTQI-RTLEGAPATVDSPILSDIT-SYSLNVSW-TVP-SFQNGEIVVYILK 4418

  Fly  1351 VFYAAADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTP 1415
            |......||:::           :..:.:|:.:|.|.:.:.|.|  ..|..|:.||.:||.|..|
Zfish  4419 VNNDEVYRGKRL-----------SVQVLDLQPHVSYSIILTACT--NGGCTSSSPILIQTREAPP 4470

  Fly  1416 -GVPSNVSFPDVSLT---MARIIWDVPVDPNGKILAYQVTYTLNGSAMLNYSREFPPSDRTFRAT 1476
             |:|:    |.:.:|   ...:.|..||.|||.|:.|::  ..|||.:      :..:|..:...
Zfish  4471 SGMPA----PTLKVTGPESVEVTWREPVHPNGVIMGYEL--RRNGSLI------YTGTDTRYHDF 4523

  Fly  1477 ELLPGKYYSFSCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRSQIQA---HQITFSWTPG 1538
            .|||...||::.||....|......|:.     |.:|.|||  .::..::||   ..:...|.|.
Zfish  4524 TLLPSVEYSYTITANNSEGATTSPPAVA-----RTQPSAPS--GVAPPRLQALGPFSVMVKWDPP 4581

  Fly  1539 RDGFAPLRYYTVEMRE----NEGRWQPLPERVDPSLSSFTAVGLRPYMTYQFRIQATNDLGPSAF 1599
            ......:..|::..|:    |..|:............||:...|:||..|:.|::|.:.||.:|.
Zfish  4582 ARPNGVIISYSLYKRDPAENNVKRFVFASHHSAFQSRSFSLNTLKPYYRYEVRVEACSLLGCAAS 4646

  Fly  1600 SRESVIVRTLPAAPAVGVGGLKVVPITTTSVRVQWSALETAL---WNGDASTGG----YRILYQQ 1657
            ...|  ::||.:.||       ..|.....::.....|:|..   |:......|    |.:..:.
Zfish  4647 DWSS--IQTLESPPA-------GQPAPLLELQTNPKGLQTVFLLSWSPPTEPNGKLLHYELYRKH 4702

  Fly  1658 LSDF-----PTALQSTPKTDVHGINENSVVLSDLQQDRNYEIVVLPFNSQGPGPATPPAAVYVGE 1717
            |||.     .|.:.|...|..|.        ..||....||..|...||.|.. .:|.|..:.|.
Zfish  4703 LSDMESRSVTTLVYSDSSTSCHD--------DKLQPYTAYEYQVWAVNSAGRA-GSPWAQGHTGP 4758

  Fly  1718 AVPTG--EPRAVDAAPISSTEVRLLWKPPKQSMQNGDILGYKIYYLVTYSPQALEPGRKWEEEIE 1780
            |.|.|  .|:.:   .|.||...:...||  :..||.|..|:::.....|.|.|..|        
Zfish  4759 APPEGISSPKFL---YIYSTSAVVDISPP--TKPNGIISLYRVFAQNKDSYQLLSEG-------- 4810

  Fly  1781 VVSATATSH--SLVFLDKFTEYRIQL---LAFNPAGDGPRSAPITVKTLPG--VPSAPLHLRFSD 1838
                  |||  :|..|..||.|.:.:   ..|.....||.|...|..:.|.  .|..|:.|    
Zfish  4811 ------TSHQQTLHGLRPFTVYSVGVEVCTCFLCCSRGPLSELRTQASAPAQQPPPRPIAL---- 4865

  Fly  1839 ITMQSLEVTWDPPKFLNGEILGYLVTYETTEENEKFS----------------KQVKQKVSNTTL 1887
             |.:|..|.||.|...||.|       |:.|...:.|                .:||......:.
Zfish  4866 -TSRSALVEWDMPLQPNGII-------ESCELQVRLSCPQPPQPVPVPCAIGPVEVKFFGMGQSF 4922

  Fly  1888 RVQNLEEEVTYTFTVRAQTSVDYGPGISENVTTGPQDGSPVAPRDLILTKTLSSVEMHWINGPSG 1952
            .:..|.....|...|.:..::  |...|:.|:.......|......::...|:||.:.|....|.
Zfish  4923 NISGLLPYANYELCVVSYNNM--GSTASDWVSITTLKEPPQYMEAFVVHSNLTSVFVDWSGSFSL 4985

  Fly  1953 RGPILGY-LIEAKKRDDSRWTKIEQTRKGMMQDFTVSYHILMPSTAYTFRVIAYN-RYGISFPVY 2015
            .||:..| |.|:..|..|.:.......:...:.|.........|.:.:..||.|| ..||     
Zfish  4986 NGPLTEYSLTESSLRVYSGFHSFLHIPRTSDKTFAFQVTCTTDSGSASSPVIKYNTATGI----- 5045

  Fly  2016 SKDSILTPS--KLHLEYGYLQHKPFYRQTWFMVSLAATSIVIIVMVIAVLCVKSKSYKYKQEAQK 2078
              |::.:.|  |..| || .::| ||.:.||::.:|...::::.:::.::..::.          
Zfish  5046 --DAVESSSGGKTGL-YG-SEYK-FYTELWFIILMALVGLLLLALLMGLVLKRAL---------- 5095

  Fly  2079 TLEESMAMSIDERQELALELYRSRHGVGTGTLNSVGTLRSGTLGTLGRKSTSRPP---------- 2133
                |....|.||..:.                           .|.|:||..||          
Zfish  5096 ----SKPPFIRERPPIM---------------------------PLQRRSTKYPPKDSYLRASSE 5129

  Fly  2134 ------------PGVHLGKSPPRPSPASVAYHSDEESLKCYDENPDDSSVTEKPSEVSSSEASQH 2186
                        |...:|.:..:......:.||.:.|:          ||...||:...|    |
Zfish  5130 LCSNHASTALLQPDTPMGLTDTKIGGTCTSNHSYQASM----------SVLRVPSQSQLS----H 5180

  Fly  2187 SESENESVRSDPHSFVNHYANVNDSLRQSWKKTKPVRNYSSYTDSEPEGSAVMS 2240
            :.|:|...||     |:...:..|  ::||.......:...|...|..|..:.|
Zfish  5181 AYSQNSLHRS-----VSQLIDTQD--KKSWDADLHATDSGMYVGDEDFGETIKS 5227

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig 71..157 CDD:299845
I-set 72..150 CDD:254352
Ig 172..245 CDD:299845
IG_like 280..356 CDD:214653
Ig 280..343 CDD:299845
IG_like 375..450 CDD:214653
Ig 378..447 CDD:143165
Ig 506..587 CDD:299845
IG_like 506..587 CDD:214653
I-set 592..682 CDD:254352 13/48 (27%)
Ig 595..682 CDD:299845 13/48 (27%)
FN3 686..789 CDD:238020 28/116 (24%)
FN3 798..893 CDD:238020 26/97 (27%)
FN3 901..1005 CDD:238020 31/119 (26%)
fn3 1011..1094 CDD:278470 19/86 (22%)
FN3 1108..1202 CDD:238020 22/108 (20%)
FN3 1210..1308 CDD:238020 21/101 (21%)
fn3 1317..1402 CDD:278470 20/86 (23%)
FN3 1415..1507 CDD:238020 26/95 (27%)
FN3 1513..1608 CDD:238020 24/101 (24%)
fn3 1617..1708 CDD:278470 21/102 (21%)
FN3 1722..1823 CDD:238020 28/107 (26%)
FN3 1828..1920 CDD:238020 23/107 (21%)
FN3 1927..2016 CDD:238020 21/90 (23%)
ush2aXP_009291422.1 Laminin_G_3 160..297 CDD:290121
Laminin_N 307..528 CDD:295486
EGF_Lam 529..577 CDD:238012
EGF_Lam 586..638 CDD:238012
Laminin_EGF 653..703 CDD:278482
Laminin_EGF 706..756 CDD:278482
EGF_Lam 759..797 CDD:214543
Laminin_EGF 808..857 CDD:278482
EGF_Lam 859..912 CDD:238012
EGF_Lam 913..963 CDD:238012
EGF_Lam 965..1014 CDD:238012
EGF_Lam 1015..1064 CDD:238012
FN3 1177..1253 CDD:238020
FN3 1264..1375 CDD:238020
FN3 1386..1469 CDD:214495
LamG 1537..1699 CDD:238058
LamG 1737..1890 CDD:238058
FN3 1981..2071 CDD:238020
FN3 2163..2253 CDD:238020
FN3 2258..2341 CDD:238020
FN3 2352..2443 CDD:238020
FN3 2447..2544 CDD:238020
FN3 2547..2633 CDD:238020
FN3 2635..2733 CDD:238020
FN3 2743..2807 CDD:238020
FN3 2830..2932 CDD:238020
fn3 2939..3014 CDD:278470
FN3 3032..>3099 CDD:238020
FN3 3542..3611 CDD:238020
FN3 3615..3701 CDD:238020
fn3 3718..3784 CDD:278470 11/42 (26%)
FN3 3801..3887 CDD:238020 26/106 (25%)
FN3 3908..3971 CDD:238020 18/67 (27%)
FN3 3996..4086 CDD:238020 30/112 (27%)
FN3 4186..4284 CDD:238020 20/102 (20%)
fn3 4288..4366 CDD:278470 19/95 (20%)
FN3 4382..4465 CDD:238020 24/98 (24%)
FN3 4470..4553 CDD:238020 26/99 (26%)
FN3 4555..4653 CDD:238020 24/101 (24%)
FN3 4679..4753 CDD:238020 19/82 (23%)
fn3 4760..4830 CDD:278470 24/88 (27%)
FN3 4864..4955 CDD:238020 21/104 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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