DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and igsf9ba

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_009289969.2	Gene:	igsf9ba / 567389	ZFINID:	ZDB-GENE-060503-729	Length:	1475	Species:	Danio rerio

Alignment Length:	1619	Identity:	313/1619 - (19%)
Similarity:	515/1619 - (31%)	Gaps:	544/1619 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 PQDVKVKVGTGVVELQCIANARPLHELET----LWLKDGLAV---------------ETAGVRHT 312
            ||.|..:.|..|| |.|.. :.||:..:|    .|.|.|:.:               |.|| |.:
Zfish    30 PQFVTARAGESVV-LGCDV-SHPLNGQQTPYVVEWFKFGVPIPFFINFRFYPPHVDPEYAG-RAS 91

  Fly   313 LNDPWNRTLALLQANSSHSGEYTCQVRLRSGGYPAV--SASARLQILEPPLFF-TPMRAETFGEF 374
            |:.  ..:|.:.|..|...|.|.|:|.:....|...  .:...|.:..||.|. ||.:.....|
Zfish    92 LHG--KASLQIEQVRSEDQGWYECRVLMLEQQYDTFHNGSWVHLTVNAPPTFSDTPPQYVEARE- 153

  Fly   375 GGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEA 439
            ||.:.|||...|.|.|.|.|.|..:.:.:   :.:||: :|.:|.::.:..:|...:.|.|.::.
Zfish   154 GGSITLTCTAFGNPKPVVTWLREGDQLTS---TRKYTV-SDGSLTVQAITREDRGAYSCRAHSDQ 214

  Fly   440 GENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMEL 504
            ||...:|.|.|:                                              ..|.:..
Zfish   215 GEALHTTRLLVQ----------------------------------------------GPPYIVT 233

  Fly   505 PPQNVTALDGKDATISCRAVGSP-NPNITWIYNETQLV---DISSRVQILESGDLLISNIRSVDA 565
            ||:|:|....::|..:|:|...| |...||.:.|..:.   |:..||:|...|.|:|..::..||
Zfish   234 PPENITVNISQNAQFTCQAEAYPGNLTYTWYWEEDNVYFKNDLKLRVRIFIDGTLIIYRVKPEDA 298

  Fly   566 GLYICVRANEAG-SVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDP----------- 618
            |.|.|..:|..| |....|||:|....:::..|....|...|:..::|.|.::|
Zfish   299 GKYTCSPSNSLGISPSASAYLTVQYPARVVNMPPVIYVPRKLSGIIRCPVDANPPVTSVRWEKDG 363

  Fly   619 ---------------------------------SVPYNI-------------------------D 625
                                             .||||:                         .
Zfish   364 YPLRIEKYPGWSQMTDGSIRVAEVTEDSLGTYTCVPYNVLGTMGQSPPATLVLKDPPYFNVRPGG 428

  Fly   626 WYRE-------------GQSSTPISNSQRIG--------VQADGQLEIQAVRASDVGSYACVVTS 669
            .||:             |....|....:::|        :...|.|:..::...|.|.:.||.|:
Zfish   429 EYRQEAGRELVIPCAASGDPEIPTIQWRKVGKPSRSKHNLLPSGSLQFVSLSKEDHGEWECVATN 493

  Fly   670 PGGNETRAARLSVI-ELPFPPSNVKVERLPEPQQRSINVSWTPGFDGN---------SPISKFII 724
            ...:.|.:.||.|| ..|..|:||.|    .....|.||||.||:||.         .|:
Zfish   494 VVTSITASTRLFVIGTSPHAPTNVHV----SASTSSANVSWEPGYDGGFEQTFSVWYGPV----- 549

  Fly   725 QRREVSELG-------PVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSP 782
              :..:::|       |||              ..|.|::::.|:..|.|||.|.|.|::|.|..
Zfish   550 --KVKNDVGTHDWLSIPVP--------------GSQMWLVVQGLEPKTAYQFSVLAQNKLGTGPF 598

  Fly   783 SEPSNV------VELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGY 841
            ||...|      :..|:......|...:.:.|:...::..|.||  .:....|..|::.:||
Zfish   599 SEVVTVTTGGYPISTPEPLVLLTPPRCLTANRTQQGVLLTWLPP--ANHTSPIDRYVIEFRL--- 658

  Fly   842 NNVPWS-YQNITNEAQRNFLIQELI--TWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPT 903
             ...|. ..::....:...:.::||  :|.::.. :|..:::    .:|.|.:.........|||
Zfish   659 -GEKWEVLDDLIPATETEIIARDLIQDSWYEFRA-LAIMDDL----VSESSNVVGVSSTDPFPPT 717

  Fly   904 NVKVEAIN--------------------STAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEW 948
            .:..|.:.                    ||.|.|           .:|:.::.:..::|  |...
Zfish   718 EISDEGLAKPVVAGIVATICFLAAAILFSTLAAC-----------FVNKQHRRKLKRKR--DPPL 769

  Fly   949 RDIERRMKTVPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPG-------------------- 993
            .....|.....|..:.||.       |:|.:.|         :|.
Zfish   770 SITHTRKSIESPPPLTPLP-------GIEPYWE---------EPDRSSYRPPSTSPQLSSGKISP 818

  Fly   994 DGVASSQVAVMTMDDVPDEVT-----GLHFDDVSDRSVKVLWAPPRASNGILTGYTVRYQVKDRP 1053
            :.:|||:         |..:.     ||:        ||.|.:|.:.....|      |:...|.
Zfish   819 ESIASSR---------PPSLASVGGHGLY--------VKKLPSPRKEKELSL------YKKTKRA 860

  Fly  1054 DTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQSGVEPVLPHAPTALALSN 1118
            .|.|.::::..:.|:|..         .|:::....|..:.....|.|.::|           ..
Zfish   861 ITSKKYSVSKHEAEVTTP---------IELISRGPDGRFVMDPNDIDSSLKP-----------RR 905

  Fly  1119 IEAFSVVLQ--FTPGFDGNSSITKWKVEGQTARNMTWFTICEINDPDAETLTVTGLVPFTQYRLR 1181
            ||.|..|.:  ..|.|..:..                    |.:||        |.:|.....||
Zfish   906 IEGFPFVEESDLYPEFRQSDE--------------------ENDDP--------GPLPPVMATLR 942

  Fly  1182 LSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRWIPLQQTEWYGNPRGYNIS 1246
            ...|.|..|.:        ..:|.....|.|...:..||..:    ...||.|   |..|   :|
Zfish   943 PQISPVSSSQE--------SYMQPPAYSPRFQRPMEGMSISE----GSRLQAT---GQSR---VS 989

  Fly  1247 YKQLVKTPGTI-KYVPRSVVIEDH--------TANSHVLDSLEEWTLYEVKMNACNDVGCSKESD 1302
            :...|..||.. .|:.....:|.|        :..|..:.|...:.          ..|..:...
Zfish   990 HFHRVFPPGPFYGYIGSGAEVELHPPFYMPDVSPRSSAMSSSPSYP----------PEGPFRHPT 1044

  Fly  1303 TAVERTREAVPSYG------PLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQQ 1361
            ...||....:..||      || |.:..:|.:|.:.|..:.|...:.|.      ..|...|...
Zfish  1045 IPEEREELRIHQYGASGHALPL-VHSPPSSRSTEIWQPPDFPFLGQEGP------RLALPPRHSS 1102

  Fly  1362 VLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVPSNVSF--- 1423
            .||:.:|....:                               |...:|...|..:||:.:|
Zfish  1103 YLHRDLPEPPPY-------------------------------PSHSRTVSTTSQLPSSSAFLQL 1136

  Fly  1424 ----PDVSLTMARIIWDVPVDPNGKILAYQVTYTLN---------GSAMLNYS----REFPPS-- 1469
                ..:|.:..|.   .|..|:.|.:..|...||.         |..:|.||    |...||
Zfish  1137 EAPRTHLSRSPGRF---PPQGPSAKHITMQQAQTLGQLRHTAHGMGVPVLPYSGATTRMGSPSTL 1198

  Fly  1470 ------------------------DRTFRATELLPGKYYSFSCT-AQTRLGWGKIAT------AL 1503
                                    |...:...|.|.:....:.| ..:..|...|..      ::
Zfish  1199 HSESSDGWRSEAQPWMSPRAARKMDLGLQQVVLQPSRLSPLTQTPPSSHAGSPDILVRPPPRPSI 1263

  Fly  1504 VYTTNNRERPQA---PSVPQISRSQIQAHQITFSWTPGRDGFAPLRYYTVEMRENEGRWQPLPER 1565
            :.::.::|.|::   |:....||..:.:...| |.|.|:.|..|...|...|...........:.
Zfish  1264 LRSSRSQEMPESARHPASVSFSRRSLSSSPAT-SPTQGQSGQRPSLSYRAHMAFATAAASYPSQS 1327

  Fly  1566 VDPSLSSFTAVGLRPYMTYQFRIQATNDLGPSAFSRESVIVRTLPAAPAVG--VGGLKV 1622
            ..|...|..|.|..|                   |:.......||:.|:.|  :|.::|
Zfish  1328 PSPPAESSDAFGQMP-------------------SQRRTDEEMLPSEPSPGEHLGAVRV 1367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	22/96 (23%)
		Ig	280..343	CDD:299845	20/81 (25%)
		IG_like	375..450	CDD:214653	22/74 (30%)
		Ig	378..447	CDD:143165	18/68 (26%)
		Ig	506..587	CDD:299845	29/85 (34%)
		IG_like	506..587	CDD:214653	29/85 (34%)
		I-set	592..682	CDD:254352	25/179 (14%)
		Ig	595..682	CDD:299845	25/176 (14%)
		FN3	686..789	CDD:238020	34/124 (27%)
		FN3	798..893	CDD:238020	16/97 (16%)
		FN3	901..1005	CDD:238020	22/143 (15%)
		fn3	1011..1094	CDD:278470	15/87 (17%)
		FN3	1108..1202	CDD:238020	16/95 (17%)
		FN3	1210..1308	CDD:238020	20/106 (19%)
		fn3	1317..1402	CDD:278470	13/84 (15%)
		FN3	1415..1507	CDD:238020	24/144 (17%)
		FN3	1513..1608	CDD:238020	18/97 (19%)
		fn3	1617..1708	CDD:278470	2/6 (33%)
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
igsf9ba	XP_009289969.2	IG	30..115	CDD:214652	25/89 (28%)
		I-set	139..225	CDD:254352	27/90 (30%)
		I-set	229..321	CDD:333254	31/91 (34%)
		Ig	345..415	CDD:325142	7/69 (10%)
		Ig	438..503	CDD:319273	11/64 (17%)
		FN3	511..606	CDD:238020	34/119 (29%)
		FN3	622..706	CDD:238020	16/94 (17%)
		Atrophin-1	<924..1361	CDD:331285	97/553 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000