DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and igsf9a

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_005155702.1	Gene:	igsf9a / 557459	ZFINID:	ZDB-GENE-060503-288	Length:	1619	Species:	Danio rerio

Alignment Length:	1779	Identity:	348/1779 - (19%)
Similarity:	590/1779 - (33%)	Gaps:	592/1779 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 DVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDGPLNYDIKYAFTHANQLI 217
            :|:||.:.:|.:|:.....|.:...:...:|.  |:|.|    |.:.....|.|::.
Zfish    10 EVIVAVLCLFNDTSAAEEHVRAKKDSSAVLPC--SLPAP----QKDSSASQYVIEWV-------- 60

  Fly   218 ILSADENDRKGYRAKAINTQLGKEESSAFVHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQ 282
                    |:|:.. .|..|||       ||..|..|             .|.:|.: .|...||
Zfish    61 --------RQGFDT-PIFMQLG-------VHPRVHPD-------------YDGRVSL-FGGTSLQ 95

  Fly   283 CIANARPLHELETLWLKDGLAVETAGVRHTLNDPWN--RTLALLQA--NSSHSGEYTCQVRLRSG 343
                            ..||.:|..|        |.  |.|.|.|.  .:..||.:|
Zfish    96 ----------------MSGLQLEDEG--------WYECRILPLDQTTEEAGSSGSWT-------- 128

  Fly   344 GYPAVSASARLQILEPPLF--FTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIE 406
                     ||.:..||:.  .:|...|.|  .|..:.|.|...|.|.|.:.|.::.    |.|:
Zfish   129 ---------RLSVTAPPVLTETSPPEVEVF--VGRSLTLKCAAQGNPRPTITWSKDG----APIK 178

  Fly   407 SGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVR 471
            ........:.::....:..:.|..:||...|..|..:..|.|::
Zfish   179 PQHKVKMVNGSVSFHAVSREAAGQYQCYTSNSEGNATHVTRLKI--------------------- 222

  Fly   472 ASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYN 536
                                     ...|::.:||.:......:||.:.|:|...| ||:|:::
Zfish   223 -------------------------IGPPVIIIPPSDTVLNMSQDAKLKCQAEADP-PNMTYVW- 260

  Fly   537 ETQLVDI------SSRVQILESGDLLISNIRSVDAGLYICVRANEAG-SVKGEAYLSVLVRTQII 594
            :.|.|||      .||::::..|.||||.:...|:|.|.|:..|... |....|.|:|....|:|
Zfish   261 QRQGVDIYHIDSLKSRIKVIVDGTLLISRLAPEDSGNYTCMPTNGLPVSPSASAVLTVQHPAQVI 325

  Fly   595 QPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIG--VQADGQLEIQAVRA 657
            |.|..|.:..|:...:.|.|.::|.:.: |||.::|:   |:......|  :.:||.:.|..|..
Zfish   326 QMPKLTFLPTGMRGAIVCPVRAEPPLSH-IDWIKDGK---PLDLGMYPGWTLASDGSIVIATVND 386

  Fly   658 SDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKF 722
            ...|.|.|...:..|...::...:|| |..||| .||                      ||.:::
Zfish   387 DAAGVYICTPYNSFGTTGQSEPTTVI-LQDPPS-FKV----------------------SPRNEY 427

  Fly   723 IIQRREVSELGPV-------PDPLLNW----------ITELSNVSADQRWILLENLKAATVYQFR 770
               |::|..:..:       |.|.:||          .|...|.|     ::|..|......::.
Zfish   428 ---RQDVGTMLVIPCQMVGNPAPKVNWRKIGAATRSLFTLAGNGS-----LILHPLSKDHQGEWE 484

  Fly   771 VSAVNRVGE-----------GSPSEPSNVVELP--QEAPSGPPVGFVGSARSMSEIITQWQPPLE 822
            .|:.|||..           .||...|:|..:|  .:|......||.|   ..::..|.|...:.
Zfish   485 CSSSNRVATVSIKTMVLVLGTSPHAVSSVSVIPGTNQANVSWVAGFDG---GYTQTFTVWYKQVS 546

  Fly   823 EHRNGQILGYILRYRLFGYNNVPW-SYQNITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYT 886
            ..|..:              ...| |:.:::.|  .:.|:..|:...:|...:.|.|.:|.|.::
Zfish   547 AGRTEE--------------KQEWLSFSDLSTE--NSLLVTNLLPATEYQFSVMAQNKIGTGPFS 595

  Fly   887 EGSKIKTKEGVPEA----PPTNVKVEAINSTAARCRWTPPNPQQINGINQGYKIQAW--QRRLID 945
            |...:.|.:.:|..    ||||:.|.. :|......|:.|:       ::...|.::  |.||..
Zfish   596 EIITVTTLDALPVVAKLEPPTNLSVNK-SSEGFLLLWSAPH-------SKSPPIDSFVVQSRLEG 652

  Fly   946 GEWRDIERRMKTVPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPGD--GVASSQVAVMTMDD 1008
            |||.:::..        |.| ||....|.||.|..:|.:.:|  :..||  .:.|..::|.|.
Zfish   653 GEWDNLKED--------ISP-AESKIFLPGLCKDCKYELRLL--SQHGDQLSMPSPSISVSTF-- 704

  Fly  1009 VPDEVTGLHFDDVSDRSVKVLWAPPRASNGILTGYTV-----------------------RYQVK 1050
                  |::....|.|   :|..|.....|::.|..:                       |..:|
Zfish   705 ------GMNMRPASSR---LLDFPNHIMAGVMGGVGLLCLVLVLTLAIACFISYKRSRRRRQNIK 760

  Fly  1051 DRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQSGVEPVLPHAPTALA 1115
            |.|..:        |...:||                     ||.. |::..:.|..| ..|:.:
Zfish   761 DLPPAM--------DKNASVN---------------------IPDD-TLKQRLLPAHP-LSTSSS 794

  Fly  1116 LSNIEAFSVVLQFTPGFDGNSSITKWKVEGQTARNMTWFTICEINDPDAETLTVTGLVPFTQYRL 1180
            .||                :||:.|:  ......::....:.:.|.|...:|        .:..|
Zfish   795 ASN----------------HSSLDKF--SHSDFHDLRQHHLPQANPPSHHSL--------PESHL 833

  Fly  1181 RLSASNVVGSSK-------------PSEATKDFQT-IQARPKHPPFNV-----TVRAMSAQQLR- 1225
            :||:...|.|.:             |.|...:|.: |:..|.......     :.|...:|.||
Zfish   834 QLSSLAPVSSVEFIHRGPDGRFVVHPGEGDSNFSSQIKRNPNQNSHQASDGSRSFRIQKSQSLRS 898

  Fly  1226 ----------VRWIPLQQTEWYGNPRGYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLE 1280
                      |..:.|.       |.|.||....  :|...:|::         :.|.|.:..||
Zfish   899 YMDEQRRPPFVLSVDLP-------PFGSNIPSSS--RTRAVVKHL---------SLNGHYMPILE 945

  Fly  1281 EWTLYEVKMNACNDVGCSKE-SDTAVERTREAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNG 1344
            :    |: |:..:....|.: ||:.:....|:...........|.::::|:|:|     .:|...
Zfish   946 K----EI-MDVPDQTSLSSDCSDSYLYAHSESTLGQKSPKRDTNHSTASTLVLQ-----MEHERE 1000

  Fly  1345 QIDGYKVFYAAADRGQQVLHKTIPNNATFTTTLTELKKYVV-----YHVQVLAYTRLGN----GA 1400
            |.:..:....|.:|  :.|.:             ||:||.|     .|.|  .....||    ..
Zfish  1001 QGNLSRCLTLARER--EELER-------------ELRKYTVDLNSSSHEQ--TDDEYGNLWKTQE 1048

  Fly  1401 LSTPPIRVQT----------------------FEDTPGVPSNVSFP-------DV---------S 1427
            .|||.::.||                      :|:...:.|....|       |:         |
Zfish  1049 ASTPQVKYQTMRQSILSENTGMFKRRAASCIPWEERHKISSANLLPLHKSYEKDIKYRQNQGYNS 1113

  Fly  1428 LTMARI---------------IWD-----VPVDPNGKILAYQVTYTLNG-------SAMLNYSRE 1465
            :..:|.               .||     .||:.:...:..::.|.|..       .|.:..||.
Zfish  1114 VQRSRYQRSRSLDREEHRKSHTWDQRRSKTPVESSRYCVIDELIYKLENPQTCEGPRARMTSSRS 1178

  Fly  1466 --------FP-PSDRTFRAT-----ELLP-GKYYSFSCT--------AQTRLGWGKIATALVYTT 1507
                    :| |.|:.:|..     |:.| |.|...|..        |.:|   ..:.:...|.|
Zfish  1179 QHYFDPCIYPSPGDQQWRTVQRSNREIHPVGDYSEMSVDGPDFESQHANSR---STVRSEHSYET 1240

  Fly  1508 NNRERPQAPSVPQISRSQIQAHQITFSWTPGRDGFAPLRYYTVEMRENEGRWQPLPERVDPSLSS 1572
            .:.:||:.        |:::..::.   .||.                      :..|.|..|::
Zfish  1241 LDYDRPRL--------SELEMDRLV---KPGH----------------------VSSRKDKKLNN 1272

  Fly  1573 FTAVGLRPYMTYQFRIQATNDLG-------PSAFSRESVIVRTLPAAPAVGVGGLKVVPITTTSV 1630
            :::....|....:...|.||.:|       .|..|.:|.:.:.....|...:..|.:....|.|.
Zfish  1273 WSSKTESPMNVSERMPQRTNSIGSKIRDQHQSTHSLDSKLYKDQFLTPDAWIDSLTLPQDCTMSP 1337

  Fly  1631 RVQWSALETALWNGDASTGGYRILYQQLSDFPTALQS-TPK----TDVHGINENSVVLSDLQQDR 1690
            .|   :...::.|...|:..    .|..|..|:..|| .|:    ...:|...:.....:|..:|
Zfish  1338 LV---SRPNSVANKPKSSPN----LQDHSFVPSGSQSHVPQRRASKSPNGFTNDQHSQRNLMSER 1395

  Fly  1691 NYEIVVLPFNSQGPGPATPPAAVY 1714
            |.. ..||     ||.::.|.|.|
Zfish  1396 NAH-TALP-----PGGSSLPRAYY 1413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	1/3 (33%)
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845	14/72 (19%)
		IG_like	280..356	CDD:214653	16/79 (20%)
		Ig	280..343	CDD:299845	14/66 (21%)
		IG_like	375..450	CDD:214653	16/74 (22%)
		Ig	378..447	CDD:143165	13/68 (19%)
		Ig	506..587	CDD:299845	28/87 (32%)
		IG_like	506..587	CDD:214653	28/87 (32%)
		I-set	592..682	CDD:254352	23/91 (25%)
		Ig	595..682	CDD:299845	21/88 (24%)
		FN3	686..789	CDD:238020	25/130 (19%)
		FN3	798..893	CDD:238020	17/95 (18%)
		FN3	901..1005	CDD:238020	29/107 (27%)
		fn3	1011..1094	CDD:278470	14/105 (13%)
		FN3	1108..1202	CDD:238020	18/106 (17%)
		FN3	1210..1308	CDD:238020	21/114 (18%)
		fn3	1317..1402	CDD:278470	18/93 (19%)
		FN3	1415..1507	CDD:238020	26/157 (17%)
		FN3	1513..1608	CDD:238020	15/101 (15%)
		fn3	1617..1708	CDD:278470	20/95 (21%)
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
igsf9a	XP_005155702.1	IG_like	27..110	CDD:214653	28/150 (19%)
		Ig	35..111	CDD:299845	27/143 (19%)
		I-set	140..221	CDD:254352	18/86 (21%)
		IGc2	151..212	CDD:197706	13/64 (20%)
		Ig	233..318	CDD:299845	27/86 (31%)
		I-set	233..318	CDD:254352	27/86 (31%)
		Ig	<349..402	CDD:299845	14/56 (25%)
		IG_like	423..502	CDD:214653	16/86 (19%)
		Ig	435..498	CDD:143165	13/67 (19%)
		FN3	507..602	CDD:238020	22/113 (19%)
		fn3	614..696	CDD:278470	27/100 (27%)
		PHA02666	1105..>1312	CDD:222914	40/242 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900