DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and nrcama

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_005164693.1	Gene:	nrcama / 556537	ZFINID:	ZDB-GENE-041210-235	Length:	1324	Species:	Danio rerio

Alignment Length:	1272	Identity:	309/1272 - (24%)
Similarity:	502/1272 - (39%)	Gaps:	242/1272 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LQAPRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDG-------------VP-----VG 115
            |..|...|:.|....|:.......:.|.|.|.|.|::.|.::|             :|     |.
Zfish    42 LPQPPTITNQSPKDYIIDPRENINIFCEAKGKPHPSFSWTRNGTHFDVEKDPKVVMMPGTGNLVI 106

  Fly   116 DFS--SSQFYRFHSTRREDAGSYQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPA 178
            |.|  .::.|.         |.|||||||:.||..|....:..:...::.......:||..|...
Zfish   107 DISGEKAEVYE---------GVYQCIARNEHGSAVSNNIVIRQSRSPLWSKEKNEPITVQRGTSL 162

  Fly   179 IFDMPPIESIPVPSVMWQSED-----------GPLNYDIKYAFTHANQLIILSADENDRKGYRAK 232
            |....|...:|.|.:.|...:           ..||.|:.::      .:|:....||...| |:
Zfish   163 ILQCRPPAGLPPPIIFWMDNNFQRLPQNSRVSQALNGDLYFS------NVIMEDTRNDYICY-AR 220

  Fly   233 AINTQLGKEES-----------------SAFVHLNVS---GD-PYIEVAPEIIVRP--QDVKVKV 274
            ..:||..:::.                 :||  ||.|   || |..|..|..:..|  :...:.:
Zfish   221 FPHTQTIQQKQPITVKVLDIEAMNDTVLAAF--LNGSDFWGDSPSGERVPSFLHPPGMESTTMVL 283

  Fly   275 GTGVVELQCIANARPLHELETLWLK-DGLAVETAGVRHTLNDPWNRTLALLQANSSHSGEYTCQV 338
            ....:||:|||:..|...:.  |.| :|   |....|.:... :.:||.:.:...:..|:|.|..
Zfish   284 KGDTLELECIADGLPTPNIS--WTKVNG---ELPSGRFSFYS-FQKTLKIKEVTEADGGDYRCIA 342

  Fly   339 RLRSGG----YPAVSASARLQILEPP-LFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNA 398
            :.|.|.    ...|..:|...|..|. |...|.      |.|   .|||||.|.|.|.:.|..|.
Zfish   343 KNRMGSSQHTITVVVRAAPFWISAPQNLILAPK------ETG---NLTCDVDGNPKPTITWSVNG 398

  Fly   399 ESVD-AHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRL 462
            ..:: :|.:..|..  :|..:.:..:....:|::||.|.|:.|...|:.::.|           |
Zfish   399 NPIESSHNDPSRKV--SDGVITLSDVQTGSSAVYQCNASNDYGYLLANAFVSV-----------L 450

  Fly   463 AQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSP 527
            |:|..:....:|                                 ..:.:....|.:.|.:.|||
Zfish   451 AEPPRVLTSLNH---------------------------------EYSVISNSRALLDCASFGSP 482

  Fly   528 NPNITWIYNETQLVDISSRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQ 592
            .|.||| :.::|.:..|....|.::|.|.|:..:..::|.|.|:.:|..|:.:...:|.|...|:
Zfish   483 LPKITW-FKDSQSILNSDLYHIHKNGTLEINVAQPQNSGKYTCIASNNLGNKENHVHLQVKEPTR 546

  Fly   593 IIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRA 657
            ||:.|....|.....|..:|||..||::..::.|.::   :..:.:..|..|.:| .|.|..|..
Zfish   547 IIRQPEYKEVQRNSIAVFECKVKHDPTLIPSMIWLKD---NGELPDDPRFEVGSD-SLTIHDVTE 607

  Fly   658 SDVGSYACVVTSPGGNETRAARLSVIEL----------PFPPSNVKVERLPEPQQRSINVSWTPG 712
            .|.|:|.|:..:....::.:|.|:|:|.          |.||::::   |.:.::||:.::||||
Zfish   608 DDEGTYTCIRNTTLDQDSASATLTVVEATPTPTMILEQPDPPTDLE---LTDQRERSVRLTWTPG 669

  Fly   713 FDGNSPISKFIIQRRE-VSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNR 776
            .:.||||..|:||..: :.|    |...|| :||:|..|...:   || |.....|.|||.|:|.
Zfish   670 DEHNSPIKLFLIQYEDSLHE----PGVWLN-MTEVSGTSTTAQ---LE-LSPYVYYSFRVLALNG 725

  Fly   777 VGEGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGY 841
            ||....|:||.........|...|.....|..|...:...|:.......||..|.|.:.:|:  .
Zfish   726 VGLSESSDPSRQYRTNPAKPDVNPSDVEVSGTSPDTMTISWRELSGLESNGPGLQYKVSWRM--K 788

  Fly   842 NNVPWSYQNITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVK 906
            :...|:...:.|.:|.  ::....|:..|.|.:.|.|:.|.|...|.....:.|..|...|.|||
Zfish   789 DAEQWTTVTLANVSQH--VVTGTPTFTLYEVTVQAVNDYGEGPRPEVVLGYSGENSPTVAPENVK 851

  Fly   907 VEAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQTA 971
            |...:.|.|...|.......:.|..:|||:...:.|.:..:..|.|.     |..||....|...
Zfish   852 VSVQSGTEAEVHWEAVPLSSVRGRLKGYKVTYQKMRSLHKQDYDREN-----PQVLIFSGEETVG 911

  Fly   972 ILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRAS 1036
            .|..|..::.|.:::..|...|||.:|:.....|.:.||...|.::..:::..|:.|.|.||...
Zfish   912 RLPDLHPYSHYRLNIRAFNGHGDGPSSTDQQFQTPEGVPGPPTNVNIRNLNLDSLLVEWTPPLED 976

  Fly  1037 NGILTGYTVRYQ---VKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSG--IPKT 1096
            ||.||||.::||   ..:....||...|.|::|..|:::|..:|||.|.:.|.|..|||  :.|.
Zfish   977 NGHLTGYLLKYQPINTTEEAGLLKEVLLPANETSYTLDKLTHSTHYKFFLNAMTETGSGPAVTKE 1041

  Fly  1097 ATIQ--------------SGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDG----------NSS 1137
            |..:              .|..|..|..||.....:::         |.|..          |||
Zfish  1042 AFTEVDEALIRHPAVEAGKGSAPPSPPPPTPPVTQSLQ---------PPFQAPPAGPMFGNVNSS 1097

  Fly  1138 ITK------WKVEGQTARNMTWFTICEINDP-------DAETLTVTGLVPFTQYRLRLSASNVVG 1189
            :.:      |:..|........:.:....:|       ...|..:.||.|...||:||.|.:  .
Zfish  1098 VKEDHAVISWEYLGPDGNVYVEYVVDNSKEPWKTEFVNGTRTFQIRGLKPGMSYRVRLVAKD--H 1160

  Fly  1190 SSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRV 1226
            |.....:|::..            :||.||:.:|..:
Zfish  1161 SDATIHSTQEML------------ITVPAMTNRQAEI 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	27/105 (26%)
		I-set	72..150	CDD:254352	26/97 (27%)
		Ig	172..245	CDD:299845	17/100 (17%)
		IG_like	280..356	CDD:214653	20/80 (25%)
		Ig	280..343	CDD:299845	17/63 (27%)
		IG_like	375..450	CDD:214653	21/75 (28%)
		Ig	378..447	CDD:143165	20/69 (29%)
		Ig	506..587	CDD:299845	21/80 (26%)
		IG_like	506..587	CDD:214653	21/80 (26%)
		I-set	592..682	CDD:254352	23/89 (26%)
		Ig	595..682	CDD:299845	21/86 (24%)
		FN3	686..789	CDD:238020	39/103 (38%)
		FN3	798..893	CDD:238020	20/94 (21%)
		FN3	901..1005	CDD:238020	27/103 (26%)
		fn3	1011..1094	CDD:278470	30/87 (34%)
		FN3	1108..1202	CDD:238020	22/116 (19%)
		FN3	1210..1308	CDD:238020	5/17 (29%)
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
nrcama	XP_005164693.1	IG_like	53..134	CDD:214653	23/89 (26%)
		Ig	64..139	CDD:299845	23/83 (28%)
		Ig	144..236	CDD:299845	18/98 (18%)
		IG_like	152..237	CDD:214653	18/91 (20%)
		IG_like	278..357	CDD:214653	18/84 (21%)
		Ig3_L1-CAM_like	288..358	CDD:143208	19/75 (25%)
		I-set	361..449	CDD:254352	26/98 (27%)
		Ig4_L1-NrCAM_like	376..450	CDD:143179	23/89 (26%)
		IG_like	464..541	CDD:214653	21/77 (27%)
		IGc2	468..531	CDD:197706	19/63 (30%)
		I-set	546..632	CDD:254352	23/89 (26%)
		Ig	562..632	CDD:299845	19/73 (26%)
		FN3	646..736	CDD:238020	38/101 (38%)
		FN3	748..834	CDD:238020	20/89 (22%)
		fn3	846..938	CDD:278470	26/96 (27%)
		FN3	950..1044	CDD:238020	33/93 (35%)
		fn3	1096..1157	CDD:278470	13/60 (22%)
		Bravo_FIGEY	1212..1300	CDD:290593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910