DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and cntn3b

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_684096.6	Gene:	cntn3b / 556251	ZFINID:	ZDB-GENE-130530-645	Length:	1029	Species:	Danio rerio

Alignment Length:	1066	Identity:	270/1066 - (25%)
Similarity:	434/1066 - (40%)	Gaps:	154/1066 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 IVSEGSTKILQCHALGYPQPTYRWLKDGVPV---GD----FSSSQFYRFHSTRREDAGSYQCIAR 141
            |.|.....:|.|.|.|.|.|.|||..:|..:   ||    .|..........|.:|:|.|||.|.
Zfish    45 IYSPQQEAVLSCEASGAPSPQYRWSLNGTLIDLGGDERRRLSGGNLIITGLDRDQDSGVYQCTAF 109

  Fly   142 NDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDM-PPIESIPVPSVMWQSEDGP--LN 203
            |..|:|.|:::.:..||:..|:..|...:.|..|...:... .|:.|..: :..|...:.|  :.
Zfish   110 NTRGTILSQRATLQFAYLENFKTQTRSAVNVREGQGVVLLCGTPLHSGEL-TFTWVFNEYPHFVQ 173

  Fly   204 YDI-KYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVSGDPYI-EVAPEIIVR 266
            .|. ::.......|.|...:.:|...|.....||...:...|:...|.:..|..: |..|:|.:.
Zfish   174 QDSRRFVSQETGNLYIAKVEPSDVGNYTCVVNNTITKERVFSSPTPLVLRNDGAMGEYEPKIELH 238

  Fly   267 -PQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANS-- 328
             |..:....|: .::|:|.|...|:..:.  |.:      |:.|..........:.|:|:..|
Zfish   239 FPDTIPAAKGS-ALKLECFALGNPVPRIS--WRR------TSDVSFPNKVKLKNSNAILEIPSFQ 294

  Fly   329 -SHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQV 392
             ..:|.|.| :...|.|..|  |..|:.....|.:...| .:|.......:...|...|:|.|..
Zfish   295 QEDTGTYEC-IAENSRGKNA--ARGRVSFHATPHWLQTM-TDTAMSIEENLFWECKANGKPKPSY 355

  Fly   393 KWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKN 457
            .|.:|.||:   |..||..:. :..|.|..|.|.|..|:||:|.|:.|...:|..|.|
Zfish   356 SWLKNGESL---ISEGRVQIE-NGALSIFSLNLSDGGMYQCVAENKHGIIYSSAELMV------- 409

  Fly   458 RVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPP--QNVTALDGKDATIS 520
                                                  .||||.....|  |.:.|..|.|.::.
Zfish   410 --------------------------------------LASAPSFSQNPLSQTLKARSGSDVSLD 436

  Fly   521 CRAVGSPNPNITWIYNETQLVDISSRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYL 585
            ||...||.....| ...|:::..:.|..:..:|.|.|:||...|.|.|.||..|:.|:......|
Zfish   437 CRPHASPRAISLW-KRGTEILQRNERTFLFPNGTLKITNITKRDGGSYTCVAKNQFGTASTTGKL 500

  Fly   586 SVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPI------SNSQRIGV 644
            .:...|:|.|.|..|.:.:|.:..|.|:|::||::.....|...||   ||      .:.:|:|.
Zfish   501 IITEPTRISQSPSSTEITVGESVVLPCQVTADPALDVAFSWAFNGQ---PIDFHQDADHFERVGG 562

  Fly   645 QADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSW 709
            ...|.|.|:.::.:..|.|.|:|.:...:.:..|.|.|...|.||..|.||   |....:..:||
Zfish   563 SFSGDLMIRNIQLNHGGKYVCLVDTDVESLSADAILVVKGPPSPPDMVVVE---EVTDSTAQLSW 624

  Fly   710 TPGFDGNSPISKFIIQRREVSELG-----PVPDPLLNWITELSNVSADQRWILLENLKAATVYQF 769
            :||.|..|||:.:.||.|....:|     .||: ::|..|..:.|.....|:         .|:|
Zfish   625 SPGQDNGSPITGYAIQGRTPFTVGWQAVDTVPE-VINGNTLTATVVGLNAWV---------EYEF 679

  Fly   770 RVSAVNRVGEGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYIL 834
            ||.|.|.||.|.||.||..:......|...|....|...:.||::..|:|..||.:||:..|||:
Zfish   680 RVLASNSVGMGEPSPPSTKIRTEDSMPDAAPTDVGGGGGTKSELVITWEPVPEELQNGEGFGYII 744

  Fly   835 RYRLFGYNNVPW-----SYQNITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTK 894
            .:|..|.  |.|     |..::|....||..|.   .:..:.|::.|:||.|.|.::..:.:.:.
Zfish   745 AFRPVGM--VTWTRVVISAPSLTRYVFRNDTIP---PFSPFNVKVGAFNNRGEGPFSTIATVFSA 804

  Fly   895 EGVPEAPPTNVKVEAINSTAARCRWTP--PNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMKT 957
            |.||...|..|..:::::......|.|  ..|:::    .||::..|:    |....|...:::.
Zfish   805 EEVPSIAPEKVSAKSLSAADIEVTWEPIASIPERV----LGYEVVYWE----DDTKPDTVGKVRI 861

  Fly   958 VPPSLIDPLAEQTAI-LGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDE-VTGLHFDD 1020
            .        ...||: :.||:..|:|.::|..|...|.|..|:.|.:.|....|.: ...:.::.
Zfish   862 T--------GNYTAVNVSGLQGNTQYYLAVCAFNTAGTGPQSAPVNITTKKPPPGQPPQNVEWNL 918

  Fly  1021 VSDRSVKVLWAPPRA--SNGILTGYTVRYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEI 1083
            :..:.: :.|.|..|  :...:|||.|.|: :.|.:.:.|........|||:|   ...:|..:|
Zfish   919 IGSQLI-LQWDPVIALETESEVTGYIVLYR-RHRNNDMYSIITNKTSAELTLN---PNDNYVIQI 978

  Fly  1084 VAWTRVGSGIPKTATIQSGVEPVLPH 1109
            .:.:..|.|        .|.||:..|
Zfish   979 KSLSEGGLG--------EGSEPIHIH 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	26/79 (33%)
		I-set	72..150	CDD:254352	25/72 (35%)
		Ig	172..245	CDD:299845	13/76 (17%)
		IG_like	280..356	CDD:214653	18/78 (23%)
		Ig	280..343	CDD:299845	13/65 (20%)
		IG_like	375..450	CDD:214653	24/74 (32%)
		Ig	378..447	CDD:143165	23/68 (34%)
		Ig	506..587	CDD:299845	25/82 (30%)
		IG_like	506..587	CDD:214653	25/82 (30%)
		I-set	592..682	CDD:254352	26/95 (27%)
		Ig	595..682	CDD:299845	25/92 (27%)
		FN3	686..789	CDD:238020	38/107 (36%)
		FN3	798..893	CDD:238020	28/99 (28%)
		FN3	901..1005	CDD:238020	22/106 (21%)
		fn3	1011..1094	CDD:278470	18/85 (21%)
		FN3	1108..1202	CDD:238020	1/2 (50%)
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
cntn3b	XP_684096.6	Ig	31..121	CDD:299845	26/75 (35%)
		IG_like	50..115	CDD:214653	22/64 (34%)
		Ig	126..220	CDD:299845	17/94 (18%)
		Ig	233..321	CDD:299845	22/99 (22%)
		IG_like	240..311	CDD:214653	16/80 (20%)
		I-set	324..409	CDD:254352	27/89 (30%)
		Ig	326..409	CDD:299845	26/87 (30%)
		IG_like	422..502	CDD:214653	24/80 (30%)
		Ig	430..502	CDD:299845	22/72 (31%)
		I-set	507..600	CDD:254352	26/95 (27%)
		Ig	521..604	CDD:299845	22/85 (26%)
		FN3	604..701	CDD:238020	38/109 (35%)
		FN3	709..801	CDD:238020	28/96 (29%)
		FN3	811..902	CDD:238020	22/106 (21%)
		FN3	921..995	CDD:238020	21/86 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910