DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and lrit1a

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_001018174.2	Gene:	lrit1a / 553943	ZFINID:	ZDB-GENE-040924-5	Length:	643	Species:	Danio rerio

Alignment Length:	600	Identity:	117/600 - (19%)
Similarity:	198/600 - (33%)	Gaps:	188/600 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 ESSAFVHLNVS----------GDPYIEVAPEIIVRPQDV-KVKV-GTGVVELQCIANARPLHELE 294
            :.|.|.| |:|          .||.|.:.|...  |.|. |::: .|.:..:...|.:. |..||
Zfish    26 QCSCFYH-NLSDGSRARSVICNDPEISLVPASF--PGDTSKLRIEKTAIKRIPSEAFSY-LSNLE 86

  Fly   295 TLWLKDGLAVETAGVRHTLNDPWNRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILEP 359
            .||:       :..|..:||            :.|..|.|:.: .||..|....|......:..|
Zfish    87 FLWM-------SFNVLSSLN------------SDSFRGLYSLE-ELRLDGNSLSSFPWESLMDMP 131

  Fly   360 PLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLI 424
            .|....:........             |:....:.:|...:|         |:::|.|.:...:
Zfish   132 SLRLLDIHNNQLSSL-------------PSEAALYMKNITYLD---------LSSNNLLTVPAEV 174

  Fly   425 LDDAAMFQCLAINEAGENSASTWLRVK-TKTAKN----------------RVKRLAQ----PRI- 467
            |                   :|||.:| |..|::                |:..|.|    |.:
Zfish   175 L-------------------NTWLTIKPTLGAESSKLILGLHDNPWLCDCRLYDLVQFQKSPSLS 220

  Fly   468 -----LRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSP 527
                 .|:|.      ::..|.||......|.|....|.:......|.:..|.:..:.|..||.|
Zfish   221 VAFIDTRLRC------ADPESLSGVLFSDAELRRCQGPRVHTAVARVRSAVGNNVLLRCGTVGVP 279

  Fly   528 NPNITWIYNETQLVDISSRVQILESGDLLISNIRSV------DAGLYICVRANEAGSVKGEAYLS 586
            .|.:.|  .......::..|.:..|.:.::.:|.||      |.|.|||...|.|||  .||.:|
Zfish   280 IPELAW--RRADGKPLNGTVLLENSKEGIVWSILSVPAVSYRDTGKYICKATNYAGS--AEAVIS 340

  Fly   587 VLVR--TQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQ 649
            :::.  .::..|.:|....|         .|..|:...... |:|...:|.:|.:.:.|:...|.
Zfish   341 LIINDAPKMENPTLDPKPKL---------KSKKPNTMVKAA-YQEKHIATYVSPTPKNGLPLSGT 395

  Fly   650 LEIQAVRASDVGSYACV-------------VTSPGG-NETRAARLSVIELPFPPSNVKVERLPEP 700
            :       |..|.|..:             ..||.| .||..:.|:.       :...:::.|:.
Zfish   396 V-------SYTGPYPGMESDNAANSRMNTQTASPDGFLETNLSNLAA-------NTSSLQQDPDR 446

  Fly   701 QQRSINV----SWTPGFDGNSPISK---------FIIQRREVSELGPVPDPLLNWITELSNVSAD 752
            ..||:.|    .:|...:..:|.:|         .:...|::..:               |||..
Zfish   447 VVRSVKVIGDTDYTVCLNWRAPTAKNTTAFSVLYAVFGERDMRRI---------------NVSPG 496

  Fly   753 QRWILLENLKAATVY 767
            ...|::|.|...|.|
Zfish   497 NNRIVIEGLVPKTKY 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845	0/2 (0%)
		IG_like	280..356	CDD:214653	16/75 (21%)
		Ig	280..343	CDD:299845	14/62 (23%)
		IG_like	375..450	CDD:214653	10/74 (14%)
		Ig	378..447	CDD:143165	7/68 (10%)
		Ig	506..587	CDD:299845	24/86 (28%)
		IG_like	506..587	CDD:214653	24/86 (28%)
		I-set	592..682	CDD:254352	20/103 (19%)
		Ig	595..682	CDD:299845	20/100 (20%)
		FN3	686..789	CDD:238020	15/94 (16%)
		FN3	798..893	CDD:238020
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
lrit1a	NP_001018174.2	leucine-rich repeat	61..84	CDD:275378	4/23 (17%)
		LRR_8	63..119	CDD:290566	17/76 (22%)
		LRR_RI	<77..175	CDD:238064	24/140 (17%)
		leucine-rich repeat	85..108	CDD:275378	9/41 (22%)
		LRR_8	108..167	CDD:290566	10/81 (12%)
		leucine-rich repeat	109..132	CDD:275378	4/23 (17%)
		leucine-rich repeat	133..156	CDD:275378	2/35 (6%)
		leucine-rich repeat	157..170	CDD:275378	4/21 (19%)
		LRRCT	199..243	CDD:214507	9/49 (18%)
		I-set	252..343	CDD:254352	26/94 (28%)
		Ig	259..333	CDD:299845	19/75 (25%)
		fn3	448..515	CDD:278470	14/78 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900