DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and SDK2

DIOPT Version :10

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens


Alignment Length:2289 Identity:857/2289 - (37%)
Similarity:1193/2289 - (52%) Gaps:235/2289 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 APRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDGVPVGDFSSSQFYRFHSTRREDAGS 135
            :|.|.|.|..: .:..||:..:|.|.|.|.....::||.:...:..||....|...|..|..||.
Human    25 SPYFKTEPVRT-QVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITSLDRTHAGF 88

  Fly   136 YQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDG 200
            |:||.||..|::...:::|.|||||.||. .|...:|..|..|:...|.|.|.|.|.|.|..:..
Human    89 YRCIVRNRMGALLQRQTEVQVAYMGSFEE-GEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGR 152

  Fly   201 PLNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVS--GDPYIEVAPEI 263
            .:....:.|.|..|.|:|||....|...|..:|:|.:.|..::|..:.|.|.  |.|...:||.|
Human   153 KIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTI 217

  Fly   264 IVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANS 328
            |:.|::..|..||..|.|:|:||||||.:|..:|.|||:.:......|      ||.|.:.....
Human   218 IIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDH------NRRLTIPNPTG 276

  Fly   329 SHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVK 393
            |.:|.|.|:..|||...|:|...|.|.:||||.|..........|....|.:.|...|.|.|.:.
Human   277 SDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSIT 341

  Fly   394 WFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNR 458
            |:::|..|:.. :..|:....|..|.|..|:.||..||||.|.|.|||...||:|.|.       
Human   342 WYKDAAVVEVE-KLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT------- 398

  Fly   459 VKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRA 523
                                                  :.||.:...|.:.|.:||....::|..
Human   399 --------------------------------------SIAPNITRGPLDSTVIDGMSVVLACET 425

  Fly   524 VGSPNPNITWIYNETQLVDISSRVQI-----LESGDLLISNIRSVDAGLYICVRANEAGSVKGEA 583
            .|:|.|.|||...|..|.  |..||:     ||||.||||.....|||.|.|:..|..|..:..|
Human   426 SGAPRPAITWQKGERILA--SGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 488

  Fly   584 YLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADG 648
            .|.|..||:|.:||.|.:|:.|..|::.|.|:.||.|.....|.::| ::....:..||.:..:|
Human   489 DLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDG-ATLGTESHPRIRLDRNG 552

  Fly   649 QLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGF 713
            .|.|....:.|:|:|.|.|.|.|||::|:|.|.|.:||..|.: .|..|...::|:||::||..|
Human   553 SLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEH-PVATLSTVERRAINLTWTKPF 616

  Fly   714 DGNSPISKFIIQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVG 778
            |||||:.::|:   |:|| ...|     |...|::|......:.::.|..|..||||:.|||.||
Human   617 DGNSPLIRYIL---EMSE-NNAP-----WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVG 672

  Fly   779 EGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNN 843
            :|..|:.:..|.||:|.|:.||...:.|.|:...|:.|||||.|.|:||.:.|||:||.|.|   
Human   673 KGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAG--- 734

  Fly   844 VPWSYQ--NITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIK--TKEGVPEAPPTN 904
            :|..||  |||:....|.|:::||.|.:|.:::||||:.|:|||:  ||:.  |.:|||..||.|
Human   735 LPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYS--SKVTEWTLQGVPTVPPGN 797

  Fly   905 VKVEAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQ 969
            |..||.|||..|..|..|:||.|||||||||:.||:..      ::.|..|.|..|:..|.:  .
Human   798 VHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPE------QEEEVTMVTARPNFQDSI--H 854

  Fly   970 TAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPR 1034
            ...:.||:|||||..||||||.||||..|:...|.|.:|||..|..|.|.::.|.|:||.|..|.
Human   855 VGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPG 919

  Fly  1035 ASNGILTGYTVRYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATI 1099
            ..|||||||.:.::..:|.:|..:..|.....|..|..|.|.|.|..|:.|.|..|.|....:||
Human   920 EKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTI 984

  Fly  1100 QSGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQ---TARNMTWFTICEI-N 1160
            .|||.|.||..||.|.:|||...||.|||.||:||.:||::|.||.|   ......|..|.:: |
Human   985 SSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSN 1049

  Fly  1161 DPDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLR 1225
            :|||.::.|..|.|||.|..|:...|:||:|.||:.::..||:||.|...|.||::|..|...|.
Human  1050 EPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLW 1114

  Fly  1226 VRWIPLQQTEWYGNPR--GYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVK 1288
            :||:||.:.|:.|||.  ||.|.|.   ::.|..|.:  |.|::|.....:.::.|||||.|.|:
Human  1115 LRWMPLPEMEYNGNPESVGYKIKYS---RSDGHGKTL--SHVVQDRVERDYTIEDLEEWTEYRVQ 1174

  Fly  1289 MNACNDVGCSKESDTAVERTREAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFY 1353
            :.|.|.:|....|.|.|.||||:|||.||.:|.|.||:|::::|:|.|||...|||.:.||||.|
Human  1175 VQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMY 1239

  Fly  1354 AAADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVP 1418
            ...|...|.....:..|::.:..||.|.|||:|.|||||:||:|:|:.|.|||..:|.:|.||.|
Human  1240 KEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPP 1304

  Fly  1419 SNVSFPDVSLTMARIIWDVPVDPNGKILAYQVTYTLNGSAMLNYSRE-FPPSDRTFRATELLPGK 1482
            ..:.||:|..|..|:||..|..|||.|||||:|:.||.:.....:.| ..||.|.:.||.|.|..
Human  1305 MGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPES 1369

  Fly  1483 YYSFSCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRSQIQAHQITFSWTPGRDGFAPLRY 1547
            .|.|..|||||.|||:.|.|||.||..|:|||.||.|.:.:..::|..:..||.||.||.:|:||
Human  1370 VYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRY 1434

  Fly  1548 YTVEMRE-NEGRWQPLPERVDPSLSSFTAVGLRPYMTYQFRIQATNDLGPSAFSRESVIVRTLPA 1611
            ||::.|| ..|||......|..:.|||....|:|:.:|:||::||||:|.|.||.||..:.||.|
Human  1435 YTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQA 1499

  Fly  1612 APAVGVGGLKVVPITTTSVRVQWSALETALWNGDASTGGYRI-----LYQQLSDF---------P 1662
            ||......|.|.|.|||||.::|........||...  |:||     ||:.|..|         .
Human  1500 APDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILL--GFRIRYRELLYEGLRGFTLRGINNPGA 1562

  Fly  1663 TALQSTPKTDVHGINENSVV---LSDLQQDRNYEIVVLPFNSQGPGPATPPAAVYVGEAVPTGEP 1724
            |..:.|....:..::..|:.   |.:|.:.|.|||.:..:|:.|.||::||..|:|||||||..|
Human  1563 TWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAP 1627

  Fly  1725 RAVDAAPISSTEVRLLWKPPKQSMQNGDILGYKIYYLVTYSPQALEPGRKWE-------EEIEVV 1782
            |.|.....::|::.:.|:||....|||||.|||||:              ||       |.::.:
Human  1628 RNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYF--------------WEAQRGNLTERVKTL 1678

  Fly  1783 SATATSHSLVFLDKFTEYRIQLLAFNPAGDGPRSAPITVKTLPGVPSAPLHLRFSDITMQSLEVT 1847
            .....|..|..|..:|.|.:.:.|||.|||||||.|...:|....||||..::||::|..|:.|:
Human  1679 FLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVS 1743

  Fly  1848 WDPPKFLNGEILGYLVTYETTEENEKFSKQVKQKVSNTT---LRVQNLEEEVTYTFTVRAQTSVD 1909
            |:.|:|.||.:.||.:.||.....:..||.|...|...:   |:|::|.|.|||.|.:||:| ..
Human  1744 WEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKT-FT 1807

  Fly  1910 YGPGISENVTTGPQDGSPVAPRDLILTKTLSSVEMHWINGPSGRGPILGYLIEAKKRDDSRWTKI 1974
            |||.|..||||||.:|:|..|...|:.:..|::.:||.:|..|:|||..|:|||:..|:..|..:
Human  1808 YGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDIL 1872

  Fly  1975 EQTRKGMMQDFTVSYHILMPSTAYTFRVIAYNRYGISFPVYSKDSILTPSKLHLEYGYLQHKPFY 2039
            .:.....:..:|.|..||.|..:|.|||||.|.||...|  |..|...|::        :..|||
Human  1873 IKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTP--SSPSQSVPAQ--------KANPFY 1927

  Fly  2040 RQTWFMVSLAATSIVIIVMVIAVLCVKSKSYKYKQEAQKT----------LEESMAMSIDERQEL 2094
            .:.||:|.:|...::.|::::.||.::.:|.||   |:||          |..|..||:||....
Human  1928 EEWWFLVVIALVGLIFILLLVFVLIIRGQSKKY---AKKTDSGNSAKSGALGHSEMMSLDESSFP 1989

  Fly  2095 ALELYRSRHGVGTGTLNSVGTLRSGTLGTLGRKSTSRPPPGVHLGKSPPRPSPASVAYHSDEESL 2159
            ||||...|..|               ..:..||:      |::. :|||||||.|:.| |||:..
Human  1990 ALELNNRRLSV---------------KNSFCRKN------GLYT-RSPPRPSPGSLHY-SDEDVT 2031

  Fly  2160 KCYDENP-DDSSVTEKPSEVSSSEASQHSESENESVRSDPHSFVNHYANVNDSLRQSWKKTKP-- 2221
            |..|..| :.||:||||||:|.|:.|. ||.|.:|.....|||||||.: :.:...||::.:.  
Human  2032 KYNDLIPAESSSLTEKPSEISDSQGSD-SEYEVDSNHQKAHSFVNHYIS-DPTYYNSWRRQQKGI 2094

  Fly  2222 --VRNYSSYTDS---EPEGSAV---MSLNGGQIIVNNMAR------------------------- 2253
              .:.| |||:|   ||:.:.|   .|...|.:.....:|                         
Human  2095 SRAQAY-SYTESDSGEPDHTTVTNSTSTQQGSLFRPKASRTPTPQNPPNPPSQQSTLYRPPSSLA 2158

  Fly  2254 --SRAPLPGFSSFV 2265
              ||||:.||||||
Human  2159 PGSRAPIAGFSSFV 2172

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig_3 72..142 CDD:464046 22/69 (32%)
Ig 280..344 CDD:409353 24/63 (38%)
Ig strand B 280..283 CDD:409353 1/2 (50%)
Ig strand C 292..298 CDD:409353 1/5 (20%)
Ig strand E 319..323 CDD:409353 2/3 (67%)
Ig strand F 333..338 CDD:409353 2/4 (50%)
Ig 360..451 CDD:472250 30/90 (33%)
Ig strand B 378..382 CDD:409353 1/3 (33%)
Ig strand C 391..395 CDD:409353 0/3 (0%)
Ig strand E 416..420 CDD:409353 1/3 (33%)
Ig strand F 430..435 CDD:409353 4/4 (100%)
Ig strand G 443..446 CDD:409353 0/2 (0%)
Ig 502..587 CDD:472250 33/89 (37%)
Ig strand B 517..521 CDD:409353 0/3 (0%)
Ig strand C 530..534 CDD:409353 2/3 (67%)
Ig strand E 554..557 CDD:409353 1/2 (50%)
Ig strand F 567..572 CDD:409353 2/4 (50%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 31/89 (35%)
Ig strand B 608..612 CDD:409353 1/3 (33%)
Ig strand C 623..627 CDD:409353 0/3 (0%)
Ig strand E 648..652 CDD:409353 2/3 (67%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 1/2 (50%)
FN3 686..789 CDD:238020 36/102 (35%)
FN3 798..893 CDD:238020 43/98 (44%)
FN3 901..1005 CDD:238020 49/103 (48%)
FN3 <960..>1261 CDD:442628 128/306 (42%)
fn3 1317..1402 CDD:394996 38/84 (45%)
FN3 1415..1507 CDD:238020 44/92 (48%)
FN3 1513..1608 CDD:238020 41/95 (43%)
FN3 1583..>2011 CDD:442628 171/454 (38%)
SDK2NP_001138424.1 Ig_3 26..95 CDD:464046 22/69 (32%)
Ig 121..197 CDD:472250 22/75 (29%)
Ig strand B 130..134 CDD:409353 1/3 (33%)
Ig strand C 144..148 CDD:409353 1/3 (33%)
Ig strand E 166..170 CDD:409353 2/3 (67%)
Ig strand F 180..185 CDD:409353 1/4 (25%)
Ig strand G 193..196 CDD:409353 0/2 (0%)
Ig 233..286 CDD:409353 22/58 (38%)
Ig strand B 233..237 CDD:409353 2/3 (67%)
Ig strand C 248..252 CDD:409353 0/3 (0%)
Ig strand E 267..271 CDD:409353 2/3 (67%)
Ig strand F 281..286 CDD:409353 2/4 (50%)
Ig 308..397 CDD:472250 30/89 (34%)
Ig strand B 326..330 CDD:409353 1/3 (33%)
Ig strand C 339..343 CDD:409353 0/3 (0%)
Ig strand E 363..367 CDD:409353 1/3 (33%)
Ig strand F 377..382 CDD:409353 4/4 (100%)
Ig strand G 390..393 CDD:409353 0/2 (0%)
Ig 404..492 CDD:472250 33/89 (37%)
Ig strand B 419..423 CDD:409353 0/3 (0%)
Ig strand C 432..436 CDD:409353 2/3 (67%)
Ig strand E 458..462 CDD:409353 2/3 (67%)
Ig strand F 472..477 CDD:409353 2/4 (50%)
Ig strand G 485..488 CDD:409353 0/2 (0%)
Ig_3 497..571 CDD:464046 23/74 (31%)
FN3 <596..1028 CDD:442628 195/453 (43%)
FN3 960..>1337 CDD:442628 168/381 (44%)
FN3 1188..>1522 CDD:442628 156/333 (47%)
FN3 1504..1608 CDD:214495 29/105 (28%)
FN3 <1577..1932 CDD:442628 140/379 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729 12/21 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067 15/28 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172 19/74 (26%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172 4/5 (80%)

Return to query results.
Submit another query.