DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and CDON

DIOPT Version :10

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_001230526.1 Gene:CDON / 50937 HGNCID:17104 Length:1287 Species:Homo sapiens


Alignment Length:1573 Identity:337/1573 - (21%)
Similarity:538/1573 - (34%) Gaps:483/1573 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 PSQPKLASLLAV-LVLLCYCDSCFFCYADANLQQQNSIVQQQQLQAPRFTTHPSSSGSIVSEGST 90
            |....|.:||.| |.:||                  |.|...  .||.||:.|.|  ::...|..
Human     3 PDLGPLCTLLYVTLTILC------------------SSVSSD--LAPYFTSEPLS--AVQKLGGP 45

  Fly    91 KILQCHALGYPQP-TYR--WLKDGVPVGDFSSSQFYRFH-------STRREDAGSYQCIARNDAG 145
            .:|.|.|    || |.|  ||.:|..:.  .:.:..:.|       |......|.|||:|.|..|
Human    46 VVLHCSA----QPVTTRISWLHNGKTLD--GNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIG 104

  Fly   146 SIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDGPLNYDIK-YA 209
            :|.|..:.|.||.:|.|.::|:..:|..............||.|...|.::.....|.:..: |.
Human   105 AIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYL 169

  Fly   210 FTHANQLIILSADENDRKGYRAKAIN--------TQLGKE-----ESSAFVHLNVSGDPYIEVAP 261
            ...:..|.||:....|:..|:..|.|        ..:|::     .||..||             
Human   170 ILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVH------------- 221

  Fly   262 EIIVRP---QDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLAL 323
              |:.|   |.:.| :....|.|:|:.:..|..::  .|||||..:..       ...|.|..:.
Human   222 --ILHPTHSQALAV-LSRSPVTLECVVSGVPAPQV--YWLKDGQDIAP-------GSNWRRLYSH 274

  Fly   324 LQANS---SHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVV 385
            |..:|   :.||.|:|....:||....|  :..:.:||.......:: :.....|..|..||||.
Human   275 LATDSVDPADSGNYSCMAGNKSGDVKYV--TYMVNVLEHASISKGLQ-DQIVSLGATVHFTCDVH 336

  Fly   386 GEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRV 450
            |.|.|...||.||:.:.   .|.|: |...|.|.|..:.::|..|:||:|.|..|...::..|.:
Human   337 GNPAPNCTWFHNAQPIH---PSARH-LTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEI 397

  Fly   451 KTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGK 515
            :                               ::.|       |:    |::...|.:....||.
Human   398 E-------------------------------NDGG-------FK----PVIITAPVSAKVADGD 420

  Fly   516 DATISCRAVGSPNPNITWIYNETQLVDISSRVQILES---------------------------G 553
            ..|:||.|.|.|.|.|.| |:...|: .|...|:|.|                           .
Human   421 FVTLSCNASGLPVPVIRW-YDSHGLI-TSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGAS 483

  Fly   554 DLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDP 618
            .|.|..:....||.|||..|||.|:.:.||.|.|:        |.:|.. ...|.||       |
Human   484 SLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVV--------PFETNT-KAETVTL-------P 532

  Fly   619 SVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVI 683
            ....|.|..:...|.|.:.:|..:.|..                 :.|.::|   |..|:.:||.
Human   533 DAAQNDDRSKRDGSETGLLSSFPVKVHP-----------------SAVESAP---EKNASGISVP 577

  Fly   684 ELPF---PPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVSE----LGPVPDPLLN 741
            :.|.   ||..    ..|:    :.|:.|..|.||..||:.:.::.|::.:    ||       :
Human   578 DAPIILSPPQT----HTPD----TYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLG-------S 627

  Fly   742 WITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSP------SEPSNVVELPQEAPSGPP 800
            |.|  ..|...:..:.|..|:.:::|:..:.|.:..|||.|      :.............|.||
Human   628 WHT--VRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPP 690

  Fly   801 VGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQNITNEAQRNFLIQELI 865
            ||                                         :|                    
Human   691 VG-----------------------------------------IP-------------------- 694

  Fly   866 TWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAP--PTNVKVEAINSTAARCRWTPPNPQQIN 928
              |..:|..||.||.|| |.|:.|:   ..||||||  ||   :...:.|:....|.|    :.|
Human   695 --KYPVVSEAANNNFGV-VLTDSSR---HSGVPEAPDRPT---ISTASETSVYVTWIP----RAN 746

  Fly   929 GINQGYKIQAWQRRLIDGEWRDIE-RRMKT---------VPPSLIDPLAEQTAILGGLEKFTEYN 983
            |   |..|.|::          :| :||:|         :|||.:      :..:..||..:.|.
Human   747 G---GSPITAFK----------VEYKRMRTSNWLVAAEDIPPSKL------SVEVRSLEPGSTYK 792

  Fly   984 ISVLCFTDPGDGVASSQVAVMTMDDVPDE-----VTGLHF---DDVSDRSVKVLWA--PPRASNG 1038
            ..|:.....|:...||......:...|:.     :||.|.   :.|||..:.:.|.  |...:|.
Human   793 FRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNT 857

  Fly  1039 ILTGYTVRYQVKD------------------------RPDT-----LKSFNLTADD-------TE 1067
            .:.|:.:.|:..|                        :|:|     ::.||...:.       .|
Human   858 PIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICE 922

  Fly  1068 LTVNQLQATTHYWFEIVAW--TRVGSG---IPKTATIQS------------GVEPVLPHAPTALA 1115
            ..|.::...:.|..:.::.  ..:|||   .|.|:..:|            ||..::.....|:.
Human   923 TKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPATSPARSSDMLYLIVGCVLGVMVLILMVFIAMC 987

  Fly  1116 LSNIEAFSVVLQFTP------GFDGNSSITKWKVEGQTARNMTWFTICEIN-DPDAETLTVTGL- 1172
            |......:.:.::.|      |.|.|         ||.....|.....:|| :.....||..|| 
Human   988 LWKNRQQNTIQKYDPPGYLYQGSDMN---------GQMVDYTTLSGASQINGNVHGGFLTNGGLS 1043

  Fly  1173 --VPFTQYRLRLSASNVVG--------SSKPSEATK---DFQTIQARPKHPPFNVTVRAMSAQQL 1224
              .....:::..:.:.:|.        |...:..|:   ||:       ||...|....|.....
Human  1044 SGYSHLHHKVPNAVNGIVNGSLNGGLYSGHSNSLTRTHVDFE-------HPHHLVNGGGMYTAVP 1101

  Fly  1225 RVRWIPLQQTEWYGNPRGYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKM 1289
            ::.  ||:..    |.|....:.:...||..|....|..||   .....:..|.||...|..||:
Human  1102 QID--PLECV----NCRNCRNNNRCFTKTNSTFSSSPPPVV---PVVAPYPQDGLEMKPLSHVKV 1157

  Fly  1290 NACNDVG---CSKESDTAVERTREAVPSYGPL--DVQANATSSTTVVVQWGEVPRQHRNGQIDGY 1349
            ..|....   |.:..:.:|:...|.||:....  |:..:.:|..:      |.|.:...||    
Human  1158 PVCLTSAVPDCGQLPEESVKDNVEPVPTQRTCCQDIVNDVSSDGS------EDPAEFSRGQ---- 1212

  Fly  1350 KVFYAAADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTR-----LGNGALSTPPIRVQ 1409
                      :.:::..||::       .:|.|..|:.....|::.     :...||..||:...
Human  1213 ----------EGMINLRIPDH-------LQLAKSCVWEGDSCAHSETEINIVSWNALILPPVPEG 1260

  Fly  1410 TFEDT----PGVP 1418
            ..|.|    ||:|
Human  1261 CAEKTMWSPPGIP 1273

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig_3 72..142 CDD:464046 23/79 (29%)
Ig 280..344 CDD:409353 17/66 (26%)
Ig strand B 280..283 CDD:409353 1/2 (50%)
Ig strand C 292..298 CDD:409353 0/5 (0%)
Ig strand E 319..323 CDD:409353 1/3 (33%)
Ig strand F 333..338 CDD:409353 2/4 (50%)
Ig 360..451 CDD:472250 27/90 (30%)
Ig strand B 378..382 CDD:409353 1/3 (33%)
Ig strand C 391..395 CDD:409353 0/3 (0%)
Ig strand E 416..420 CDD:409353 2/3 (67%)
Ig strand F 430..435 CDD:409353 3/4 (75%)
Ig strand G 443..446 CDD:409353 0/2 (0%)
Ig 502..587 CDD:472250 32/111 (29%)
Ig strand B 517..521 CDD:409353 1/3 (33%)
Ig strand C 530..534 CDD:409353 1/3 (33%)
Ig strand E 554..557 CDD:409353 1/2 (50%)
Ig strand F 567..572 CDD:409353 3/4 (75%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 16/89 (18%)
Ig strand B 608..612 CDD:409353 2/3 (67%)
Ig strand C 623..627 CDD:409353 2/3 (67%)
Ig strand E 648..652 CDD:409353 0/3 (0%)
Ig strand F 662..667 CDD:409353 0/4 (0%)
Ig strand G 675..678 CDD:409353 0/2 (0%)
FN3 686..789 CDD:238020 25/115 (22%)
FN3 798..893 CDD:238020 16/94 (17%)
FN3 901..1005 CDD:238020 25/115 (22%)
FN3 <960..>1261 CDD:442628 68/384 (18%)
fn3 1317..1402 CDD:394996 13/91 (14%)
FN3 1415..1507 CDD:238020 3/4 (75%)
FN3 1513..1608 CDD:238020
FN3 1583..>2011 CDD:442628
CDONNP_001230526.1 Ig 29..114 CDD:472250 27/92 (29%)
Ig strand B 46..50 CDD:409353 1/3 (33%)
Ig strand C 58..62 CDD:409353 1/3 (33%)
Ig strand E 80..84 CDD:409353 0/3 (0%)
Ig strand F 94..99 CDD:409353 3/4 (75%)
Ig strand G 107..110 CDD:409353 1/2 (50%)
Ig 141..200 CDD:409353 13/58 (22%)
Ig strand C 151..155 CDD:409353 1/3 (33%)
Ig strand E 174..178 CDD:409353 1/3 (33%)
Ig strand F 188..193 CDD:409353 1/4 (25%)
Ig 226..300 CDD:472250 21/83 (25%)
Ig strand B 239..243 CDD:409353 2/3 (67%)
Ig strand C 252..256 CDD:409353 0/5 (0%)
Ig strand E 273..277 CDD:409353 1/3 (33%)
Ig strand F 287..292 CDD:409353 2/4 (50%)
I-set 313..387 CDD:400151 25/78 (32%)
Ig strand B 329..333 CDD:409353 1/3 (33%)
Ig strand C 342..346 CDD:409353 0/3 (0%)
Ig strand E 363..367 CDD:409353 2/3 (67%)
Ig strand F 377..382 CDD:409353 3/4 (75%)
Ig strand G 390..393 CDD:409353 0/2 (0%)
Ig 405..517 CDD:472250 33/113 (29%)
Ig strand B 422..426 CDD:409353 1/3 (33%)
Ig strand C 435..447 CDD:409353 4/13 (31%)
Ig strand E 483..487 CDD:409353 1/3 (33%)
Ig strand F 497..502 CDD:409353 3/4 (75%)
Ig strand G 510..513 CDD:409353 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 531..553 6/28 (21%)
FN3 590..1078 CDD:442628 114/602 (19%)
FN3 721..811 CDD:238020 28/115 (24%)
FN3 836..923 CDD:238020 13/86 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 933..955 4/21 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1268..1287 3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

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