DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and NRCAM

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_011514555.1	Gene:	NRCAM / 4897	HGNCID:	7994	Length:	1311	Species:	Homo sapiens

Alignment Length:	1286	Identity:	311/1286 - (24%)
Similarity:	507/1286 - (39%)	Gaps:	244/1286 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 MPSQPKL-ASLLAVLVLLCYCDSCFFCYADANLQQQNSIVQQQQLQAPRFTTHPSSSGSIVSEGS 89
            ||.:.:| |..:.:::.||...|......|..|.:  .:||      |...|..|....|:....
Human     6 MPKKKRLSAGRVPLILFLCQMISALEVPLDPKLLE--DLVQ------PPTITQQSPKDYIIDPRE 62

  Fly    90 TKILQCHALGYPQPTYRWLKDG----------VPVGDFSSSQFYRFHSTRREDA--GSYQCIARN 142
            ..::||.|.|.|.|::.|.::|          |.:...:.:......|..:.:.  |.|||.|||
Human    63 NIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARN 127

  Fly   143 DAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMW---------QSE 198
            :.|:..|....|..:...::.......:|:.||...:....|...:|.|.:.|         |||
Human   128 ERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSE 192

  Fly   199 ------DGPLNYD-----------IKYA-FTHAN--------QLIILSADE---------NDRKG 228
                  :|.|.:.           |.|| |.|..        .:.::|.||         :|.:.
Human   193 RVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEF 257

  Fly   229 YRAKAINTQLGKEESSAFVHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANARPLHEL 293
            |.||:     .:|....|            :.||   .....|.::...|:.|:|||...|...:
Human   258 YGAKS-----SRERPPTF------------LTPE---GNASNKEELRGNVLSLECIAEGLPTPII 302

  Fly   294 ETLWLK-DGLAVETAGVRHTLNDPWNRTLALLQANSSHSGEYTC-------------QVRLRSGG 344
              .|.| ||:..:    ..|:...:.:||.::..:.:.||.|.|             .||:::..
Human   303 --YWAKEDGMLPK----NRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAP 361

  Fly   345 YPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGR 409
            | .::|...| :|.|            ||.|   .|.|...|.|.|::.|..|...::...:...
Human   362 Y-WITAPQNL-VLSP------------GEDG---TLICRANGNPKPRISWLTNGVPIEIAPDDPS 409

  Fly   410 YTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQ-PRILRVRAS 473
            ..::.| |::...:....:|::||.|.||.|...|:.::.|           ||: |||
Human   410 RKIDGD-TIIFSNVQERSSAVYQCNASNEYGYLLANAFVNV-----------LAEPPRI------ 456

  Fly   474 HAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNV--TALDGKDATISCRAVGSPNPNITWIYN 536
                                          |.|.|.  ..:..:.|.:.|...|||.|.|.| :.
Human   457 ------------------------------LTPANTLYQVIANRPALLDCAFFGSPLPTIEW-FK 490

  Fly   537 ETQLVDISSRVQIL-ESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDT 600
            ..:...:...:.:| |:|.|.|...:....|.|.||..|:.|..|.|.:|.:...|.|::.|...
Human   491 GAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYA 555

  Fly   601 TVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYAC 665
            .|..|...:.:|||..|.::...:.|.::.:.   :.:.:|..|..| .|.:..|...|.|:|.|
Human   556 VVQRGSMVSFECKVKHDHTLSLTVLWLKDNRE---LPSDERFTVDKD-HLVVADVSDDDSGTYTC 616

  Fly   666 VVTSPGGNETRAARLSVI----------ELPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPIS 720
            |..:...:.:.:|.|||:          ::|.||.:::   |.:...:|:.:|||||.|.||||:
Human   617 VANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLE---LTDQLDKSVQLSWTPGDDNNSPIT 678

  Fly   721 KFIIQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEP 785
            ||||:..:.     :..|.| |..: :.||..|....|: |.....|.|||.|||.:|:..|||.
Human   679 KFIIEYEDA-----MHKPGL-WHHQ-TEVSGTQTTAQLK-LSPYVNYSFRVMAVNSIGKSLPSEA 735

  Fly   786 SNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQN 850
            |.........|...|....|.......::..|:|......||..|.|.:.:|....:: .|:...
Human   736 SEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDD-EWTSVV 799

  Fly   851 ITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVEAINSTAA 915
            :.|.::  :::....|:..|::::.|.|:||...........:.|.:|...|.||:|..:|||.|
Human   800 VANVSK--YIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLA 862

  Fly   916 RCRWTPPNPQQINGINQGYKIQAWQRRLID-GEWRDIERRMKTVPPSLIDPLAEQTAILGGLEKF 979
            ...|.|...:.|.|..|||:|..|:.:... ...|.||:::.|...|      :...:|.|||.|
Human   863 EVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGS------KTHGMLPGLEPF 921

  Fly   980 TEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRASNGILTGYT 1044
            :.|.::|......|:|.||......|.:.||...:.|...:.:..|:.:.|.||...|||||.||
Human   922 SHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYT 986

  Fly  1045 VRYQVKDRP---DTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKT----ATIQSG 1102
            ::||..:..   ..|....:.|:.|..|:..|..:|.|.|...|.|..|||...|    .|:..|
Human   987 LKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEG 1051

  Fly  1103 --------------VEPVLPHAPTALALSNIEAFS--VVLQFTPGFDGNSSITKWKVEGQTARNM 1151
                          |:.|.|.      :||:.|.:  .....:..::|...:..:...|......
Human  1052 KMAGILPPDVGAGKVQAVNPR------ISNLTAAAAETYANISWEYEGPEHVNFYVEYGVAGSKE 1110

  Fly  1152 TWFTICEINDPDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQT 1202
            .|..  ||.:.......:.||:|.|.|::|:.|   ||.|....:...|:|
Human  1111 EWRK--EIVNGSRSFFGLKGLMPGTAYKVRVGA---VGDSGFVSSEDVFET 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	24/97 (25%)
		I-set	72..150	CDD:254352	22/89 (25%)
		Ig	172..245	CDD:299845	24/116 (21%)
		IG_like	280..356	CDD:214653	21/89 (24%)
		Ig	280..343	CDD:299845	18/76 (24%)
		IG_like	375..450	CDD:214653	18/74 (24%)
		Ig	378..447	CDD:143165	17/68 (25%)
		Ig	506..587	CDD:299845	24/83 (29%)
		IG_like	506..587	CDD:214653	24/83 (29%)
		I-set	592..682	CDD:254352	21/89 (24%)
		Ig	595..682	CDD:299845	20/86 (23%)
		FN3	686..789	CDD:238020	39/102 (38%)
		FN3	798..893	CDD:238020	17/94 (18%)
		FN3	901..1005	CDD:238020	33/104 (32%)
		fn3	1011..1094	CDD:278470	27/85 (32%)
		FN3	1108..1202	CDD:238020	20/95 (21%)
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
NRCAM	XP_011514555.1	IG_like	53..139	CDD:214653	20/85 (24%)
		Ig6_NrCAM	64..140	CDD:143282	19/75 (25%)
		Ig	145..237	CDD:299845	17/91 (19%)
		IG_like	153..238	CDD:214653	17/84 (20%)
		I-set	268..357	CDD:254352	22/109 (20%)
		Ig	288..358	CDD:299845	18/75 (24%)
		I-set	361..449	CDD:254352	25/105 (24%)
		Ig4_NrCAM	375..450	CDD:143276	21/89 (24%)
		I-set	454..542	CDD:254352	28/124 (23%)
		IGc2	469..532	CDD:197706	18/63 (29%)
		I-set	548..633	CDD:254352	21/88 (24%)
		Ig	566..636	CDD:299845	19/73 (26%)
		FN3	647..737	CDD:238020	38/100 (38%)
		fn3	750..832	CDD:278470	17/84 (20%)
		fn3	848..940	CDD:278470	31/97 (32%)
		FN3	952..1047	CDD:238020	29/94 (31%)
		fn3	1070..1147	CDD:278470	19/87 (22%)
		Bravo_FIGEY	1194..1287	CDD:290593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910