DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and NCAM2

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	1021	Identity:	225/1021 - (22%)
Similarity:	361/1021 - (35%)	Gaps:	302/1021 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VSEGSTKILQCHALGYPQPTYRWLKDGVPVGDFSSSQFYRFHSTRREDAGSYQCIARNDAGSIFS 149
            :|.|.:|...|.|:|.|:..           |:.:.|..:..||:|
Human    57 LSVGESKFFTCTAIGEPESI-----------DWYNPQGEKIISTQR------------------- 91

  Fly   150 EKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDGPLNYDIKYAFTHAN 214
                |||...|:     ..|||
Human    92 ----VVVQKEGV-----RSRLT------------------------------------------- 104

  Fly   215 QLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVV 279
               |.:|:..|...||.:|.:.:...:|::..:.:      |.::....:|.||:.|......||
Human   105 ---IYNANIEDAGIYRCQATDAKGQTQEATVVLEI------YQKLTFREVVSPQEFKQGEDAEVV 160

  Fly   280 ELQCIANARP-------LHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANSSHSGEYTCQ 337
               |..::.|       .|..|...:.|......|          |..|.:|..|.|..|.|.|:
Human   161 ---CRVSSSPAPAVSWLYHNEEVTTISDNRFAMLA----------NNNLQILNINKSDEGIYRCE 212

  Fly   338 VRLRSGGYPAVSASARLQILE-PPLFFTPMRA-ETFGEFGGQVQLTCDVVGEPTPQVKWFRNAES 400
            .|:.:.|  .:.....:.|:. ||....|.:: ....|.|.::..:|...|.|.|.:.||||.:.
Human   213 GRVEARG--EIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKL 275

  Fly   401 VDAHIESGRYTLNTDNT-LVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQ 464
            ::   |:.:|.|...|| |.::.:|..|...:.|.|.|:|||:....:|:|           ..|
Human   276 IE---ENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQV-----------FVQ 326

  Fly   465 PRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNP 529
            |.|::::                                    |.|..:....|:.|.|.|.|.|
Human   327 PHIIQLK------------------------------------NETTYENGQVTLVCDAEGEPIP 355

  Fly   530 NITWIYNETQLVD----------ISSRVQIL---ESGDLLISNIRSVDAGLYICVRANEAGSVKG 581
            .|||    .:.||          :..|:::.   .|..|.|.:::..|:|.|.|..|:..|..:.
Human   356 EITW----KRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQK 416

  Fly   582 EAYLSVLVRTQIIQPPVDTTVLL---GLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIG 643
            ..||.:....:.|.   :.|:..   |....:.|.|.|:|  |.:|.|.|: :...|..|:..:.
Human   417 SMYLDIEYAPKFIS---NQTIYYSWEGNPINISCDVKSNP--PASIHWRRD-KLVLPAKNTTNLK 475

  Fly   644 VQADGQ---LEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSI 705
            ..:.|:   |||.....:|.|.|.|..|:..|...:...|::.::|..|..||:..|   .|.:.
Human   476 TYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIEL---SQTTA 537

  Fly   706 NVSWT-PGFDGNSPISKFIIQRREV-SELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQ 768
            .||:. |...|..||..:.:..:|| ||:         |  ::......|..::|.||:..|.|:
Human   538 KVSFNKPDSHGGVPIHHYQVDVKEVASEI---------W--KIVRSHGVQTMVVLNNLEPNTTYE 591

  Fly   769 FRVSAVNRVGEGSPSEPSNVVELPQEAPSGPPV-GFVGSARSMSEIITQWQPPLEEHRNGQILGY 832
            .||:|||..|:|..|:......||...||.|.: |...|.:|....||:     ::.....||.|
Human   592 IRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITK-----QDDGGAPILEY 651

  Fly   833 ILRYRLFGYNNVPWSYQNITNEAQRNFLIQELITW-KDYIVQIAAYNNMGVGVYTEGSKIKTKEG 896
            |::||.....: .|..:.:  :..::.:|.|.:.| ..|.|||.|.|.:|   |:|
Human   652 IVKYRSKDKED-QWLEKKV--QGNKDHIILEHLQWTMGYEVQITAANRLG---YSE--------- 701

  Fly   897 VPEAPPTNVKVEAINSTAARCRWTPPNPQQI-----NGINQGYKIQAWQRRLI------------ 944
                 ||..:..           .||.|..|     ||:..|..|......|:
Human   702 -----PTVYEFS-----------MPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTDVSCFF 750

  Fly   945 ---DGEWRDIERRMKTVPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTM 1006
               .|....|.|||          ..:::...|..::..|...:.|     .||.....|.:.|.
Human   751 IRQCGLLMCITRRM----------CGKKSGSSGKSKELEEGKAAYL-----KDGSKEPIVEMRTE 800

  Fly  1007 DD------------VPDEVTGLHFDDVSDRSVKVLWAPPRASNGIL 1040
            |:            .|:|.|.|...:.      |.|:....|||.|
Human   801 DERVTNHEDGSPVNEPNETTPLTEPEY------VAWSAHLCSNGKL 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	14/71 (20%)
		I-set	72..150	CDD:254352	12/64 (19%)
		Ig	172..245	CDD:299845	7/72 (10%)
		IG_like	280..356	CDD:214653	16/82 (20%)
		Ig	280..343	CDD:299845	15/69 (22%)
		IG_like	375..450	CDD:214653	24/75 (32%)
		Ig	378..447	CDD:143165	22/69 (32%)
		Ig	506..587	CDD:299845	25/93 (27%)
		IG_like	506..587	CDD:214653	25/93 (27%)
		I-set	592..682	CDD:254352	24/95 (25%)
		Ig	595..682	CDD:299845	23/92 (25%)
		FN3	686..789	CDD:238020	31/104 (30%)
		FN3	798..893	CDD:238020	25/96 (26%)
		FN3	901..1005	CDD:238020	22/123 (18%)
		fn3	1011..1094	CDD:278470	9/30 (30%)
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274	26/170 (15%)
		I-set	47..136	CDD:254352	26/163 (16%)
		I-set	142..218	CDD:254352	21/88 (24%)
		IGc2	153..214	CDD:197706	16/73 (22%)
		Ig	233..326	CDD:299845	29/106 (27%)
		I-set	240..323	CDD:254352	25/85 (29%)
		Ig5_NCAM-2	325..422	CDD:143278	28/136 (21%)
		IG_like	333..420	CDD:214653	23/126 (18%)
		IG_like	438..515	CDD:214653	21/79 (27%)
		IGc2	439..507	CDD:197706	20/70 (29%)
		FN3	521..613	CDD:238020	31/105 (30%)
		fn3	619..703	CDD:278470	27/108 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900