DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and negr1

DIOPT Version :9

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:XP_009300786.1 Gene:negr1 / 445374 ZFINID:ZDB-GENE-040822-27 Length:360 Species:Danio rerio


Alignment Length:361 Identity:74/361 - (20%)
Similarity:122/361 - (33%) Gaps:102/361 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   297 WLKDGLA----VETAGVRHTLNDPWN----------------RTLALLQANSSHSGEYTCQVRLR 341
            :|.||::    :..:.:.:..||.|:                .:|.:.:.:.:..|.|||.::..
Zfish    60 YLLDGISKGAWLNRSSIIYAGNDKWSGDPRVSIVSNVGDKHEYSLQIQKVDVTDEGVYTCSIQSE 124

  Fly   342 SGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIE 406
            ...:|.:   .:|.:..||..:......|..| |..|.|.|...|:|.|::.| |:........|
Zfish   125 RNLHPKL---IQLIV
KVPPKIYDISSDITVNE-GSNVSLICAASGKPEPKISW-RHISPSARKYE 184

  Fly   407 SGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVR 471
            ||.|       |.|..:..|.|..::|.|.|:                       :|.|....||
Zfish   185 SGEY-------LNITGISRDQAGDYECGAEND-----------------------IASPDTKTVR 219

  Fly   472 ASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYN 536
            .:                    ..|..| |.|:....|.  .|:.|.:.|.|...|:|...| |.
Zfish   220 VT--------------------VNFPPA-IHEMKSHGVR--PGQVALLRCEAAAVPSPVFEW-YK 260

  Fly   537 ETQLVDISSRVQI--LESGDLL-ISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVR---TQIIQ 595
            ..:.:::...:.|  |.|..:| :.|:.....|.|.||..|..|:......|:.::.   |..:.
Zfish   261 GEKRINMGQGIVINNLSSRSVLTVKNMTQDRYGNYTCVAVNRLGTANASVPLNPIIEPTTTSAVS 325

  Fly   596 PPVDTTVLLGLT----ATLQCKVSSDPSVPYNIDWY 627
            .|.....:.|.|    ..|.|             ||
Zfish   326 SPASNPAMYGSTGGAEVLLAC-------------WY 348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig 71..157 CDD:299845
I-set 72..150 CDD:254352
Ig 172..245 CDD:299845
IG_like 280..356 CDD:214653 13/78 (17%)
Ig 280..343 CDD:299845 11/65 (17%)
IG_like 375..450 CDD:214653 20/74 (27%)
Ig 378..447 CDD:143165 19/68 (28%)
Ig 506..587 CDD:299845 21/83 (25%)
IG_like 506..587 CDD:214653 21/83 (25%)
I-set 592..682 CDD:254352 7/40 (18%)
Ig 595..682 CDD:299845 7/37 (19%)
FN3 686..789 CDD:238020
FN3 798..893 CDD:238020
FN3 901..1005 CDD:238020
fn3 1011..1094 CDD:278470
FN3 1108..1202 CDD:238020
FN3 1210..1308 CDD:238020
fn3 1317..1402 CDD:278470
FN3 1415..1507 CDD:238020
FN3 1513..1608 CDD:238020
fn3 1617..1708 CDD:278470
FN3 1722..1823 CDD:238020
FN3 1828..1920 CDD:238020
FN3 1927..2016 CDD:238020
negr1XP_009300786.1 Ig 42..121 CDD:299845 11/60 (18%)
IG_like 44..136 CDD:214653 13/78 (17%)
I-set 140..222 CDD:254352 27/133 (20%)
IGc2 153..208 CDD:197706 20/63 (32%)
IG_like 236..312 CDD:214653 20/78 (26%)
IGc2 238..304 CDD:197706 18/66 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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