DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and Dscam3

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster

Alignment Length:	1930	Identity:	413/1930 - (21%)
Similarity:	666/1930 - (34%)	Gaps:	568/1930 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 FFCYADANL--QQQNS---IVQQQQLQ---APRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTY 105
            |.|.....|  ::|.|   ::|.::|.   |||.|..|... ..|..|:...|.|:..|.|.|.:
  Fly   215 FSCLVTNTLNGERQRSDAVMLQVKELSKNLAPRTTQKPVME-IHVERGNDVHLPCNIQGNPFPIF 278

  Fly   106 RWLKDGVPVGDFSSSQFYRFHSTRR---------------EDAGSYQCIARNDAGSIFSEKSDVV 155
            .|.:    |.|  |:..|...|::|               .|||.:.|.|.|..|
  Fly   279 TWYR----VSD--SAALYPIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFG---------- 327

  Fly   156 VAYMGIFENTTEGRLTVISGHPAIFDMPPIESI---------------PVPSVMWQSEDGPLNYD 205
                   |...|.||:| :.:.::..:|.::.:               .:.::.|.....||..:
  Fly   328 -------EQRIEIRLSV-NSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQAN 384

  Fly   206 -------IKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVSGDPYIEVAPEI 263
                   ....|...:.|::.:....||..|:....|.   :..:.|...|.: ||    ..||:
  Fly   385 NALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQ---RASAQAMAELKL-GD----TVPEL 441

  Fly   264 IVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTL---------NDPWNR 319
            |....:..|:.|. ::.|:|.|:..|..:.  .||.|...:....:.|..         .|
  Fly   442 IYTFIEQNVRPGP-LISLKCSASGSPPPQF--AWLLDSQPIMDVSLHHRFAIGQFVDMSGD---- 499

  Fly   320 TLALLQANSSH-----SGEYTCQVRLRSGGYPAVSASARLQILEPPLF--FTPMRAETFGEFGGQ 377
              .:...|.||     .|.|.|   :.|....:|..||||.:..||..  ..|::|..    |..
  Fly   500 --VISHLNISHVRPDDGGLYKC---VASNSMGSVQHSARLNVYGPPYVRAIGPIKAVA----GED 555

  Fly   378 VQLTCDVVGEPTPQVKWFRNAESVDAHIE---SGRYTLNT---DNTLVIKKLILD-DAAMFQCLA 435
            :.:.|...|.|..|::|.:      ||.|   |..|.|.:   ...||||.:... |..::.|:.
  Fly   556 IIVHCPFAGYPVEQIRWEK------AHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIV 614

  Fly   436 INEAGENS-ASTWLRVKT-------KTAKN------------------------RVKRLAQPRIL 468
            .:.|||.: ....|.|.:       |..||                        :....:.|..|
  Fly   615 RSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSL 679

  Fly   469 R----------------VRASHAGLGSEKGSESGSS-DRRKEFRFASAPIMELPPQNVTALDGKD 516
            :                :.|.|:|..:...|.:.:. :...|.:...||.....|.:...:.|..
  Fly   680 QITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNT 744

  Fly   517 ATISCRAVGSPNPNITWIYNE----TQLVDISSRVQILESGDLLISNIRSVDAGLYICVRANEAG 577
            .:|:|.|.|.|.|.|||...:    .....:|.|     :..||::.....|.|.|:|...||.|
  Fly   745 ISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMR-----NHSLLLNLATDNDEGYYMCQATNEIG 804

  Fly   578 SVKGEAYLSVLVRTQIIQP----------------PVDTTVLLGLTATLQCKVSSDPSVPYNIDW 626
                 |.|...:|..:.:|                ||          ||.|....|.  |..|.|
  Fly   805 -----AGLKKTIRINVNEPARFEQSARNISSRRNDPV----------TLDCHAKGDE--PITIGW 852

  Fly   627 YREGQSSTPISNSQRIGVQ--------------ADGQLEIQAVRASDVGSYACVVTSPGGNETRA 677
                     ..|:.||.:.              .|.||.|......|.|.|.|:..:|.|...:.
  Fly   853 ---------TQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQI 908

  Fly   678 ARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVSEL---GPVPDPL 739
            ..|:|.|.|..||::::.   |...|::.:||...||||||:..:::|.:.:..|   |.:....
  Fly   909 IFLAVQERPDTPSHLEIF---EVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAG 970

  Fly   740 LNWITELSNVSADQRWI------------LLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELP 792
            .:|...:.|||.....|            ::..|..||.:..|:.|:|.: |.|....:.|::..
  Fly   971 GDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEI-ERSAYTEAIVLKTQ 1034

  Fly   793 QEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQNI-----T 852
            :|||:..|..........||:|..||.|..|..||:::||.:        |.....|||     .
  Fly  1035 EEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGELIGYTV--------NCSEEKQNINFISVV 1091

  Fly   853 NEAQRNFLIQELITWK----------DYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKV 907
            |.:.::.::....|.|          .|.|.|.|.|:.|.|.::......|.||||||.|.||..
  Fly  1092 NSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNC 1156

  Fly   908 EAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQTAI 972
            .|::|.:.:..|..|..|...||.|||||.          :|.|..::.......|...:.....
  Fly  1157 TALSSQSLKISWLEPPLQFHGGIIQGYKIL----------YRPIVHQIDFPAKLEIKRTSNLETY 1211

  Fly   973 LGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRASN 1037
            |..|.|.:.|:|.||.:|..|||:||..:...|.|||||....:....::..|:.:.|..|:..|
  Fly  1212 LHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADSILISWLTPKNRN 1276

  Fly  1038 GILTGYTVRYQVKDRPDTLKS---------FNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGI 1093
            ||::.|||..:...|....|:         :.:|.:...|..||:     |.|.:.|.|.||.|.
  Fly  1277 GIISHYTVYSREAGRKGQAKTHMVRVDENGYPVTFESRSLAENQM-----YEFWVSASTSVGEGE 1336

  Fly  1094 PKTATIQSGVEPVLPHAPTALALSNIEAFSVVLQ------------------------------- 1127
            |.:         |:..|....|.:.|.:|..|::
  Fly  1337 PTS---------VIAQATNTRAPARIASFGQVVRKAVGTGLVLECLAVGNPTPRARWLTRDRPVT 1392

  Fly  1128 FTPGF----DGNSSITKWKVEGQTARNMTWFTICEINDPDAETLTVTGLVPFTQYRLRLSASNVV 1188
            |:|.:    :||..|  .:|||..:.|.|    |                         :|:|:.
  Fly  1393 FSPFYEVTNEGNLKI--HRVEGSLSGNYT----C-------------------------TANNLF 1426

  Fly  1189 GSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRW-------IPLQQTEWYGNPRGYNIS 1246
            ||.:     ..:|.|..:|...| .:.|:..||..:||.|       .|||         ||.||
  Fly  1427 GSDE-----IQYQVIAMKPPSAP-QIIVQYASADSIRVSWDAPDDGGAPLQ---------GYTIS 1476

  Fly  1247 YKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKMNACNDVG---CSKESDTAVERT 1308
            |....::....:.:|.:        |:..:..|:....|.:||:|.|.||   .|:|.:...:..
  Fly  1477 YHTAGESWSITELLPEN--------NAFTISGLKCGNQYIIKMSAHNMVGSGVASEEINVWTKGK 1533

  Fly  1309 REAVPSYGPLDVQANATSSTTVVVQW--------------------------GEVPRQHRNGQ-- 1345
            ....|:...| :..|||.....:..|                          .::.....|.:
  Fly  1534 ASQAPNANEL-IATNATCVNLKLSSWQNGGCSIHHFSIEHRPLGDIRWTVVTSDISNAEENRENL 1597

  Fly  1346 ----------------------------------IDGY-----KVFYAAADRGQQVLHKTIPNNA 1371
                                              |||.     .||.:..|....:::.|.|.:.
  Fly  1598 IFCDFLPAKWYQLRISATNDAGKTTEHYHFSTTNIDGITIPPPSVFPSENDLMNNLINSTNPTSG 1662

  Fly  1372 TFTTTLTELKKYVVYHVQV--LAYTRLGNGALSTPPIRVQTFEDTPGVPSNVSFPDVSLTMARII 1434
            .:..||..:   |:..|.:  :|.|......|..|   :....::..:|.:......:....::.
  Fly  1663 DWFATLIVV---VIITVSIITIALTIKHRRTLCGP---IAEGYESRTLPGDYKEDHENRRNQQVY 1721

  Fly  1435 WDVP---VDPNGKILAYQV----TYTLNG----------------SAMLNYSREFP----PSDRT 1472
            ...|   ||...:...|::    |:::||                ...|:|:.:|.    |....
  Fly  1722 SASPVKTVDKGNESEMYEISPYATFSVNGGRTGAPAKTPTRAVAAQTPLDYTMQFKTFGHPEGEN 1786

  Fly  1473 FRAT--ELLPGKYYSFSCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRSQ---------- 1525
            ..||  .|||...:..   .:::..|.|   ...|.|.: |...:.|:..::.||
  Fly  1787 LNATAYPLLPSSGFGH---VKSKSSWHK---QRYYNTED-ESTLSKSMTIVAGSQAGHSKKSNGG 1844

  Fly  1526 ------------IQAHQITFSWTPGRDGFAPLRYYTV---EMRENEGRWQPLPERVDPSLSSFTA 1575
                        :...:...|.:|..: |:.:..|.|   ..|.::||  .:.:...|..|:
  Fly  1845 RSAKSSAACSGVVAGSESDTSISPSTE-FSNMPTYRVPCKSSRSSDGR--AVVDMFRPDSST--- 1903

  Fly  1576 VGLRPYMTYQFRIQATNDLG-PSAFSRESVIVRTLPAAPAVGVGG 1619
                         ::.||.| |:...|.:.....|....|:|:||
  Fly  1904 -------------ESNNDQGSPAPERRHNTPRHVLGMGMAMGLGG 1935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	26/100 (26%)
		I-set	72..150	CDD:254352	25/92 (27%)
		Ig	172..245	CDD:299845	11/94 (12%)
		IG_like	280..356	CDD:214653	21/89 (24%)
		Ig	280..343	CDD:299845	15/76 (20%)
		IG_like	375..450	CDD:214653	22/82 (27%)
		Ig	378..447	CDD:143165	20/76 (26%)
		Ig	506..587	CDD:299845	24/84 (29%)
		IG_like	506..587	CDD:214653	24/84 (29%)
		I-set	592..682	CDD:254352	24/119 (20%)
		Ig	595..682	CDD:299845	24/116 (21%)
		FN3	686..789	CDD:238020	29/117 (25%)
		FN3	798..893	CDD:238020	26/109 (24%)
		FN3	901..1005	CDD:238020	31/103 (30%)
		fn3	1011..1094	CDD:278470	23/91 (25%)
		FN3	1108..1202	CDD:238020	20/128 (16%)
		FN3	1210..1308	CDD:238020	27/107 (25%)
		fn3	1317..1402	CDD:278470	20/153 (13%)
		FN3	1415..1507	CDD:238020	20/120 (17%)
		FN3	1513..1608	CDD:238020	18/120 (15%)
		fn3	1617..1708	CDD:278470	2/3 (67%)
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	29/114 (25%)
		Ig	264..334	CDD:143165	21/92 (23%)
		I-set	345..433	CDD:254352	11/90 (12%)
		Ig	358..431	CDD:143165	10/75 (13%)
		Ig	456..533	CDD:143165	18/87 (21%)
		IGc2	553..619	CDD:197706	18/71 (25%)
		I-set	634..724	CDD:254352	10/89 (11%)
		ig	645..712	CDD:278476	6/66 (9%)
		IG_like	734..815	CDD:214653	25/90 (28%)
		Ig	745..815	CDD:299845	23/79 (29%)
		I-set	820..913	CDD:254352	23/113 (20%)
		Ig	838..920	CDD:299845	23/92 (25%)
		FN3	917..1033	CDD:238020	30/119 (25%)
		FN3	1040..1142	CDD:238020	26/109 (24%)
		fn3	1150..1237	CDD:278470	29/96 (30%)
		FN3	1263..1345	CDD:238020	24/95 (25%)
		Ig	1350..1436	CDD:299845	19/121 (16%)
		IG_like	1358..1436	CDD:214653	17/113 (15%)
		FN3	1441..1530	CDD:238020	27/106 (25%)
		FN3	1542..1620	CDD:238020	6/78 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I8189
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.810