DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and LSAMP

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_001305844.1	Gene:	LSAMP / 4045	HGNCID:	6705	Length:	361	Species:	Homo sapiens

Alignment Length:	340	Identity:	80/340 - (23%)
Similarity:	133/340 - (39%)	Gaps:	63/340 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 IESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRI-- 467
            :.|..:...|||..|.:    .|.|:.:|:.   ..:||...||...........|....||:
Human    29 VRSVDFNRGTDNITVRQ----GDTAILRCVV---EDKNSKVAWLNRSGIIFAGHDKWSLDPRVEL 86

  Fly   468 ---------LRVRASHAGLGSEKGSESGSSDRRKEFRFASA-PIMELPPQ------NVTALDGKD 516
                     ||::....   .::||.:.|...:.|.:.:.. .|:::||:      :||..:|.:
Human    87 EKRHSLEYSLRIQKVDV---YDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSN 148

  Fly   517 ATISCRAVGSPNPNITWIYNETQLVDISSRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKG 581
            .|:.|.|.|.|.|.|||.:......:.....:.||     |..|....:|.|.|..|||..|...
Human   149 VTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLE-----ILGITREQSGKYECKAANEVSSADV 208

  Fly   582 EAYLSVLVRTQIIQPPVDT-----TVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQR 641
            :.     |:..:..||..|     ....|..|:|:|:.|:.|:..:  :|||:   .|.|:::..
Human   209 KQ-----VKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDF--EWYRD---DTRINSANG 263

  Fly   642 IGVQA-DGQ--LEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQR 703
            :.::: :||  |.:..|.....|:|.||..:..|....:..|....||         .:|.|.|
Human   264 LEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFKRVLP---------TIPHPIQ- 318

  Fly   704 SINVSWTPGFDGNSP 718
              .:..|..|....|
Human   319 --EIGTTVHFKQKGP 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653
		Ig	280..343	CDD:299845
		IG_like	375..450	CDD:214653	12/44 (27%)
		Ig	378..447	CDD:143165	10/41 (24%)
		Ig	506..587	CDD:299845	24/86 (28%)
		IG_like	506..587	CDD:214653	24/86 (28%)
		I-set	592..682	CDD:254352	24/97 (25%)
		Ig	595..682	CDD:299845	24/94 (26%)
		FN3	686..789	CDD:238020	7/33 (21%)
		FN3	798..893	CDD:238020
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
LSAMP	NP_001305844.1	Ig	38..128	CDD:386229	20/99 (20%)
		Ig	132..215	CDD:386229	25/92 (27%)
		Ig_3	219..294	CDD:372822	21/79 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810