DRSC/TRiP Functional Genomics Resources

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Protein Alignment sdk and LEPR

DIOPT Version :9

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_002294.2 Gene:LEPR / 3953 HGNCID:6554 Length:1165 Species:Homo sapiens


Alignment Length:1280 Identity:240/1280 - (18%)
Similarity:419/1280 - (32%) Gaps:468/1280 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 ILQCHALGYPQPTYRWLKDGVPVGDFSSSQFYRFHSTRREDA----GSYQCIAR---NDAGSIFS 149
            ::....|.||...:|:....:|..  |:..::...:...::.    |.|:....   |.:|:.||
Human    18 VITAFNLSYPITPWRFKLSCMPPN--STYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFS 80

  Fly   150 EKSDVVV---------AYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDGPLNY- 204
            ..|....         ....:..:..||: |.:|              .|.|:::|..|...|. 
Human    81 NLSKTTFHCCFRSEQDRNCSLCADNIEGK-TFVS--------------TVNSLVFQQIDANWNIQ 130

  Fly   205 -----DIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVSGDPYIEVAPEII 264
                 |:|....:...|.     :|..:.|..|              |||       :.|.||::
Human   131 CWLKGDLKLFICYVESLF-----KNLFRNYNYK--------------VHL-------LYVLPEVL 169

  Fly   265 VRPQDVKVKVGTGVVELQCIANARPLHE-LETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANS 328
            .....|..|....:|...|     .:|| .|.|     :.|.||    .|||    ||.:     
Human   170 EDSPLVPQKGSFQMVHCNC-----SVHECCECL-----VPVPTA----KLND----TLLM----- 211

  Fly   329 SHSGEYTCQVRLRSGGYPAVSASARLQIL-----EPPLFFTPMRAETFGEFGGQVQLTCDVVGE- 387
                   | :::.|||....|....:|.:     :|||             |..:::|.|  |. 
Human   212 -------C-LKITSGGVIFQSPLMSVQPINMVKPDPPL-------------GLHMEITDD--GNL 253

  Fly   388 ----------PTP---QVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEA 439
                      |.|   |||:..|:.:|                                  |.||
Human   254 KISWSSPPLVPFPLQYQVKYSENSTTV----------------------------------IREA 284

  Fly   440 GENSASTWLRV------KTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFAS 498
            .:..::|.|.|      .:...:.|.|||..|.|.                   ||......|.:
Human   285 DKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIW-------------------SDWSTPRVFTT 330

  Fly   499 APIMELPPQNVTALDGKDATISC------RAVGSPNPNITWIYNETQLV---------DISSRVQ 548
            ..::..||:.:|:: |.:.:..|      :.|  |:..|.|..|..:.:         |..|:|.
Human   331 QDVIYFPPKILTSV-GSNVSFHCIYKKENKIV--PSKEIVWWMNLAEKIPQSQYDVVSDHVSKVT 392

  Fly   549 ILESGDLLISNIRSVDAGLYIC--------------VRANEAGSVKGEAYLSVLV---RTQIIQP 596
            .....:.......:.|| :|.|              :..|...|.:.:.||:.:.   .|..||.
Human   393 FFNLNETKPRGKFTYDA-VYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQS 456

  Fly   597 PVDTTVLLGL-TATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLE--------- 651
            ..::|:.|.. .::|.|  |..||:             .|||..:...:|:||..|         
Human   457 LAESTLQLRYHRSSLYC--SDIPSI-------------HPISEPKDCYLQSDGFYECIFQPIFLL 506

  Fly   652 ---IQAVRAS-DVGSY----ACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSIN-- 706
               ...:|.: .:||.    .||:..           ||:: |.|||:||.|       .:||  
Human   507 SGYTMWIRINHSLGSLDSPPTCVLPD-----------SVVK-PLPPSSVKAE-------ITINIG 552

  Fly   707 ---VSW-TPGFDGNS---PISKFIIQRREVSELGPVPDPLLNW-ITELSNVSADQRWILLENLKA 763
               :|| .|.|..|:   .| ::.:..:||           .| :.|:.:..:....:.:.:|.|
Human   553 LLKISWEKPVFPENNLQFQI-RYGLSGKEV-----------QWKMYEVYDAKSKSVSLPVPDLCA 605

  Fly   764 ATVYQFRVSAVNRVGEGSP-SEPSNVVELPQEAP-SGPPVGFVGSARSMSE---IITQWQPPLEE 823
            ....|.|...::.:|..|. |.|:..|.:..:.| .||....:.:..:|.:   :...|:|.::.
Human   606 VYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKN 670

  Fly   824 HRNGQILGYILRYRLFGYNNVPWSYQNITNEAQRNFLIQELITWKD--YIVQIAAYNNMGVGVYT 886
            .....:..|::.:..  ..|..|| :::.|..:..||      |.:  :.|.:.|.|::|..|..
Human   671 DSLCSVQRYVINHHT--SCNGTWS-EDVGNHTKFTFL------WTEQAHTVTVLAINSIGASVAN 726

  Fly   887 EG-------SKIKTKEGVPEAPPTNVKVEAINSTAARCRW-TPPNPQQINGINQGYKIQAWQRRL 943
            ..       ||:...:.:...|        :||:.....| ..|:..::.     |.|..|:...
Human   727 FNLTFSWPMSKVNIVQSLSAYP--------LNSSCVIVSWILSPSDYKLM-----YFIIEWKNLN 778

  Fly   944 IDGE--WRDIERRMKT-------VPPSLIDPLAEQTAILGGLEK--FTEYNISVLCFTDPGDGVA 997
            .|||  |..|...:|.       :|                :||  |:.|.|.:       :||.
Human   779 EDGEIKWLRISSSVKKYYIHDHFIP----------------IEKYQFSLYPIFM-------EGVG 820

  Fly   998 SSQVA-VMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRASNGILTGYTVRYQVKDRPDTLKSFNL 1061
            ..::. ..|.||:...        .||..:.|: .|...|:.||...|                 
Human   821 KPKIINSFTQDDIEKH--------QSDAGLYVI-VPVIISSSILLLGT----------------- 859

  Fly  1062 TADDTELTVNQLQATTHYWFEI-----VAWTRVGSGIPK-----------TATIQSGVEPVLPHA 1110
                  |.::..:....:|.::     .:|.: |....|           ||::..|  |:|...
Human   860 ------LLISHQRMKKLFWEDVPNPKNCSWAQ-GLNFQKPETFEHLFIKHTASVTCG--PLLLEP 915

  Fly  1111 PTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQ----------TARNMTWFTIC------EI 1159
            .|.....:::                  |.||.:.:          :..::...::|      .:
Human   916 ETISEDISVD------------------TSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFNSV 962

  Fly  1160 NDPDAETLTVT-----GLVPFTQYRLRLSASNVVGSSKPSEATKD 1199
            |..:||...||     ...||.:|      :.::.:|||||..::
Human   963 NFSEAEGTEVTYEDESQRQPFVKY------ATLISNSKPSETGEE 1001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig 71..157 CDD:299845 13/80 (16%)
I-set 72..150 CDD:254352 11/64 (17%)
Ig 172..245 CDD:299845 12/78 (15%)
IG_like 280..356 CDD:214653 18/76 (24%)
Ig 280..343 CDD:299845 14/63 (22%)
IG_like 375..450 CDD:214653 16/88 (18%)
Ig 378..447 CDD:143165 13/82 (16%)
Ig 506..587 CDD:299845 20/109 (18%)
IG_like 506..587 CDD:214653 20/109 (18%)
I-set 592..682 CDD:254352 21/107 (20%)
Ig 595..682 CDD:299845 20/104 (19%)
FN3 686..789 CDD:238020 27/113 (24%)
FN3 798..893 CDD:238020 20/106 (19%)
FN3 901..1005 CDD:238020 22/116 (19%)
fn3 1011..1094 CDD:278470 12/87 (14%)
FN3 1108..1202 CDD:238020 18/113 (16%)
FN3 1210..1308 CDD:238020
fn3 1317..1402 CDD:278470
FN3 1415..1507 CDD:238020
FN3 1513..1608 CDD:238020
fn3 1617..1708 CDD:278470
FN3 1722..1823 CDD:238020
FN3 1828..1920 CDD:238020
FN3 1927..2016 CDD:238020
LEPRNP_002294.2 FN3 237..330 CDD:238020 29/160 (18%)
Lep_receptor_Ig 333..420 CDD:283889 17/90 (19%)
Leptin-binding. /evidence=ECO:0000305|PubMed:22405007 467..484 7/31 (23%)
FN3 537..627 CDD:238020 25/108 (23%)
WSXWS motif 622..626 1/3 (33%)
fn3 741..812 CDD:278470 18/99 (18%)
Box 1 motif 871..879 1/7 (14%)
Required for JAK2 activation. /evidence=ECO:0000250|UniProtKB:P48356 893..898 0/4 (0%)
Required for STAT3 phosphorylation. /evidence=ECO:0000250|UniProtKB:P48356 898..906 2/7 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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