DRSC/TRiP Functional Genomics Resources

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Protein Alignment sdk and Strn-Mlck

DIOPT Version :9

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_001261019.1 Gene:Strn-Mlck / 36753 FlyBaseID:FBgn0265045 Length:8255 Species:Drosophila melanogaster


Alignment Length:2854 Identity:528/2854 - (18%)
Similarity:882/2854 - (30%) Gaps:1092/2854 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 FFCYAD--------------ANLQQQNSIVQQQQLQAPRFTTHPS----------SSGS------ 83
            |.|||:              |:|::   ::...|.:.|....|.|          ||||      
  Fly  5705 FACYAEHEDRIDSTSITIKAADLKR---LINVSQEEIPSIGDHESTPWSRSQSHLSSGSQVNGNG 5766

  Fly    84 ---------------------------IVSEGSTKILQCHALGYPQPTYRWLKDGVPV------- 114
                                       .||||:...|.|...|.......|||:..|:       
  Fly  5767 ELHRAGDRVLRNVGKGKPLFHTLLHDRTVSEGANLRLVCSVSGDENTHIEWLKNHKPLPRSDNRY 5831

  Fly   115 ------GDFSSSQFYRFHSTRREDAGSYQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVI 173
                  |:.|...|    :...:|:|:|.|.|.||.|...:.      |.:.:::|..|..|   
  Fly  5832 QTVYLNGEASLEIF----AAVADDSGNYTCCATNDFGESLTH------AQLRVYKNFKEAPL--- 5883

  Fly   174 SGHPAIFDMP----------------PIESIPVPSVMWQSEDGPLNYDIKY-----AFTHANQLI 217
               |:.|..|                .:...|.|.:.|.....|:....|:     |..:| :|:
  Fly  5884 ---PSTFTQPIRDTYSLNENELVLDCRVRGQPRPEIQWIKGTEPIEASEKFKPSDQADGYA-KLV 5944

  Fly   218 ILSADENDRKGYRAKAIN----------------TQLGKEESSAFVHLNVSGDPYIEVAPEIIVR 266
            |::..|.|...|...|.|                .....|::..|.|    .||.   .|..::.
  Fly  5945 IVNPTEKDSGIYWCVARNEGAENKISHQVDFKGRQHYSLEKTHGFFH----RDPN---KPHFLLP 6002

  Fly   267 PQDVKV-KVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANSSH 330
            ..:..| ..||..:..:.:..:.|   :|..||:|...|:...|: .|.|....||.::.|....
  Fly  6003 LGNQTVCNGGTVAISAEFMETSTP---IEVKWLRDRRVVDGPNVK-ALADRGVYTLTIMNAGPEV 6063

  Fly   331 SGEYTCQVRLRSGGYPAVSASARLQIL-------EPPLFFTPMRAETFGEFGGQVQLTCDVVGEP 388
            .|.|||:.   |..:..:.::..:.:.       .||||.:....|.....|....|:..:.|:|
  Fly  6064 EGTYTCRA---SNAFGRIESNVNVDVAVGAEKDERPPLFLSRPDTEMKIAVGDPFSLSFRIAGDP 6125

  Fly   389 TPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMF--QCLAINEAG------ENSAS 445
            .|::.:.:..:.:   .:|.|          :.|.:.||...|  |...|:::|      .|:..
  Fly  6126 KPKLTFMKGTKDI---TQSDR----------VSKEVSDDYTRFSVQQAQISDSGTYFVVARNNFG 6177

  Fly   446 TWLRVKTKTAKNRVKRL--AQPR--------------------------ILRVRASHAGLGSEK- 481
            |.....|.|...|.:..  .|||                          ::....:|..|...| 
  Fly  6178 TDRIFVTVTVNPRARSATPTQPRWGLPLDSYSDTSYFRDPPGCISTEPLVVDSGPTHISLSWGKP 6242

  Fly   482 ------------------GSESGSSDR-----------------RKEFRF--------------- 496
                              |.|.|:..|                 ..|:.|               
  Fly  6243 VSANSAPVMAYKVEAWVVGHEGGAYWRELGLTPINSFDAFNLKPNVEYHFRVTPKNRYGWGPTVQ 6307

  Fly   497 ASAPI-----------MELPPQNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQIL 550
            .|:|:           :::.|....||.|...|:.|...|:|.|.:||..:..||...|.||:|.
  Fly  6308 TSSPLQVGGVECLPEFVKILPGQAKALLGSSFTLQCNMRGAPRPQVTWFKDGIQLSSSSERVKIR 6372

  Fly   551 ESGD---LLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQP---------------- 596
            :.|.   |.|:.:..:|:|.|.|...|..|.|...|.|.|:..::|.:.                
  Fly  6373 QIGSTCALTIATVSELDSGRYTCEATNSKGRVSTFARLQVVSDSRIYEADSRLKEIAHGRNVADV 6437

  Fly   597 ----PV------DTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQ-- 649
                |:      |..|.:.....|.|::...| || .|.||::.:.   |...::..:.|:||  
  Fly  6438 GDSLPIFTMRLRDRRVQVTYPVRLTCQIVGYP-VP-EILWYKDDEL---IHTDRKHLISAEGQFF 6497

  Fly   650 -LEIQAVRASDVGSYACVVTSPGGNETRAARLSV-----------IELPFPP-----------SN 691
             |||.|....|.|:|.|:..:..|:.:....|.|           ..:|..|           .:
  Fly  6498 TLEIAATTLDDSGTYTCLARNELGSVSCHCTLVVDKGIRAYISPDFYVPLDPFYIFREGSEIRLS 6562

  Fly   692 VKVERLPEPQQRSINVSW-------------TPGFDGNS-------------------------- 717
            .|||..|     |:.|:|             |...|.|.                          
  Fly  6563 TKVEAYP-----SVGVTWHRNGMRLRPSRRLTATLDSNGYVELIIAEATVRDAGIYVCVASNVVG 6622

  Fly   718 ----------------------------------PISK---FIIQRRE-----------VSELGP 734
                                              |.||   |:::.|.           ..|:..
  Fly  6623 KVETICRVAVEEAENKAVAPQRSLEIPSIKTDDLPYSKEPLFVVKPRSSEAYEGDNVIIFCEVVG 6687

  Fly   735 VPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSGP 799
            .|.|.:.|:.:..|.         |..|.|.  .||     |:|:|    |...:|:|     ..
  Fly  6688 DPKPEVVWLRDFLNP---------EYYKDAP--HFR-----RIGDG----PEYRLEIP-----SA 6727

  Fly   800 PVGFVGS-----------ARSM-------SEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPW 846
            .:.|.|:           |:::       .:|:.:.:......|:|.|            ..:|.
  Fly  6728 KLDFTGTYSVIASNCHGEAKAVISLQIFAKDILNKSRMDKVHTRHGNI------------ETLPR 6780

  Fly   847 SYQNITN---------------EAQ-RNFLIQE-----LITWKDYIVQI---------------- 874
            ..:|:.|               ||. ..|:|.|     :.:.:||::..                
  Fly  6781 FVRNLRNLRCCDGDAISLECHVEADPEPFIIWEKDGHVMPSDRDYVMSFDGTKATLSIPRVYPED 6845

  Fly   875 ------AAYNNMG---------VGVYTEGSKIKTKEGVPEAPPTNVKVEAINSTAARCRWTPPNP 924
                  .|.|::|         |.|..|...:.:::   .|.|:.: :.|.::..:..|.||  .
  Fly  6846 EGEYTCVAKNSVGRSLSSACIIVDVPEEKENMLSRQ---LARPSGL-LSAHSTPRSTPRSTP--A 6904

  Fly   925 QQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLI----------DPLAEQTAILGGLEKF 979
            :..:.:...|:..:.....:....|...|...|.|..|.          |.:..|.||.|....:
  Fly  6905 RSFSPLRLSYRTSSIDLSGVAERRRSDARNAITAPKFLAIPYNRVVEEGDSVRFQCAISGHPTPW 6969

  Fly   980 TEYNISVLCFTDPGDGVASSQVAVMTMDDVP----DEVTGLHFDDV------------------- 1021
            ..::...|..|      .:.::||..:||:.    ||||   |||.                   
  Fly  6970 ATWDKDGLIVT------PTPRIAVKEIDDLRIIEIDEVT---FDDAGLYRVTLENDFGRIEATAR 7025

  Fly  1022 -------------SDRSVKV------------LWAPPRASNG---ILTGYTVRYQVKDRPDTLKS 1058
                         |.|||:.            :..|..|..|   :.:||        |..::.|
  Fly  7026 LDVIRSSRYSKSPSVRSVRASSSRRNAHLYRRIMGPSTAIGGRMALASGY--------RGSSVPS 7082

  Fly  1059 FNLTADDTELTVNQLQATTHYWFE-------IVAWTRVGSGIPKTATIQSGVEPVLPHAPTALAL 1116
            .....:|.||..::   ..|...:       :...||...| ..|..|....:|::.........
  Fly  7083 VRFYHNDVELEASE---RVHILLQDSMALLIVDNVTREDEG-QYTCIISGDHDPLITSTTVTFHD 7143

  Fly  1117 SNIE---AFSVVLQFTPGFDGNSSITKWKVEGQT-----------ARNMTWFTICEINDPDAETL 1167
            ||.|   ..:|:.:..|      .||| .:||:.           ..:..|....||. ||::..
  Fly  7144 SNTEIRRRRAVITERLP------EITK-SLEGEVIDLCCSIECDEPYSYVWLRNGEIL-PDSDEF 7200

  Fly  1168 TV-------------------TGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFN 1213
            ..                   :|:     |..::..|::..|:  |::|.|..:|.:.......:
  Fly  7201 NYIDHGNGRLCLRINDAFDIDSGI-----YSCQVFTSDINDST--SDSTFDSHSICSLINSGCSD 7258

  Fly  1214 VTVRAMSAQQLRVRWIPLQQTEWYGNPRGYNISYKQLVKTPGTIKYVPRSVVIEDHT---ANSHV 1275
            .:    |:.:|.|    |::     :.||.:....||:|||     :|......|..   |....
  Fly  7259 CS----SSGELCV----LER-----DLRGQDEECVQLLKTP-----LPVVCASGDEALFYARVFP 7305

  Fly  1276 LDSLEEWTLYEVKMNACNDVGCSKESDTAVERTREAVPSYG-----PLDVQANATSSTTVVVQWG 1335
            .|:..:|.|....:         .::|.::..|.|:.|..|     ..||.|:.:         |
  Fly  7306 CDAEADWYLNGQLL---------AQADDSLNMTLESYPENGIRLLRMRDVTASRS---------G 7352

  Fly  1336 EVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGA 1400
            |:..|.::.|.:                .:.||...|:|:.|            ||...| ||.:
  Fly  7353 EICLQVKHPQAE----------------FRRIPTTRTYTSLL------------VLPAIR-GNSS 7388

  Fly  1401 LS---------TPP----------IRVQT-FEDTPGV-------------PSNVSFPDVSLTMAR 1432
            .|         |.|          :|:.. :|..||.             .|||:....|.....
  Fly  7389 SSSLAARSCILTRPEDCTALIGGHVRLSVRYEPFPGTKVIWYKACHPIVESSNVTIRTTSQQSTL 7453

  Fly  1433 IIWDVPVDPNGKILAYQVTYTLNGSAMLNYSREFPPSDRTFRATELLPGKYYSFSCTAQTRLGWG 1497
            .|.|:..|.:||       ||:  ..|.:|..|                                
  Fly  7454 YITDISADDSGK-------YTV--EVMNDYGVE-------------------------------- 7477

  Fly  1498 KIATALVYTTNNRERPQA-PSVPQISRSQIQAHQITFSWT-PGRDGFAPLRYYTVEMR----EN- 1555
             .|.|.|......|.|.. |||      .:...::..:|. |..||...:..:.:||:    || 
  Fly  7478 -AAAASVAVEGPPEPPSGQPSV------SLGPDRVAVAWCGPPYDGGCMITGFIIEMQTIGDENC 7535

  Fly  1556 -EGRWQPLPERVDPSLSSFTAVGLRPYMTYQFRIQATNDLGPSAFSRESVIVRTLPAAPAVGVGG 1619
             |..||.:...|| || ::|...|:|...|:||::|.|..|.||..:.|                
  Fly  7536 DEDSWQQVTRVVD-SL-AYTVKNLQPERQYRFRVRAENIHGRSAPGQAS---------------- 7582

  Fly  1620 LKVVPITTTSVRVQWSALETALWNGDAST--GGYRILYQQLSDFPTALQSTPKTDVHGINENSVV 1682
             ::|.||.|..|..         :.|||.  |...:..|...||.:..:               :
  Fly  7583 -ELVQITNTPQRST---------SSDASDRFGQATVSVQSGGDFKSRFE---------------I 7622

  Fly  1683 LSDLQQDRNYEIVVLPFNSQGPGPATPPAAVYVGEAVPTGEPRAVDAAPISSTEVRLLWKPPKQS 1747
            :.:|.:.| :.||   :..|..|......|..|.:.:.:.:.:.|      ..|:.::     ::
  Fly  7623 IEELGKGR-FGIV---YKVQERGQPEQLLAAKVIKCIKSQDRQKV------LEEISIM-----RA 7672

  Fly  1748 MQNGDILGY--------KIYYLVTYSPQALEPGRKWEEEI----------------EVVSATATS 1788
            :|:..:|..        :|..::.|    :..|..:|..:                :|....|..
  Fly  7673 LQHPKLLQLAASFESPREIVMVMEY----ITGGELFERVVADDFTLTEMDCILFLRQVCDGVAYM 7733

  Fly  1789 H--SLVFLD---------KFTEYRIQLLAFNPAGDGPRSAPITVKTLPGVPSAPLHLRFSDITMQ 1842
            |  |:|.||         ..|.::|:::.|..|......||  |:.|.|.|.             
  Fly  7734 HGQSVVHLDLKPENIMCHTRTSHQIKIIDFGLAQRLDTKAP--VRVLFGTPE------------- 7783

  Fly  1843 SLEVTWDPPKFLNGEILGY--------LVTYETTEENEKFSKQVK-QKVSNTTLRVQNLEEEVTY 1898
                 :.||:.::.|.:|:        ::.|........|..... :..||.|....:.::|   
  Fly  7784 -----FIPPEIISYEPIGFQSDMWSVGVICYVLLSGLSPFMGDTDVETFSNITRADYDYDDE--- 7840

  Fly  1899 TFTVRAQTSVDYGPGISENVTTGPQDGSPVAPRDLILTKTLSSVEMHWINGPSGRGPILGYLIEA 1963
            .|...:|.:.|:   ||:.:....:|       .|...:.|:|   .|:               :
  Fly  7841 AFDCVSQEAKDF---ISQLLVHRKED-------RLTAQQCLAS---KWL---------------S 7877

  Fly  1964 KKRDDS------------------RWTKIEQTRK--GMMQDFTVSYHILMPSTAYTFRVIAYNRY 2008
            ::.|||                  :|.|.....:  |.|.:.:||..    ::|....|::..| 
  Fly  7878 QRPDDSLSNNKICTDKLKKFIIRRKWQKTGNAIRALGRMANLSVSRR----NSAIAMGVLSSPR- 7937

  Fly  2009 GISFPVYSKDSILTPS-----------KLHLEYGYL--QHKPFYRQTWFMVSLAATSIVIIVMVI 2060
                |..|...:||.|           .||.|....  :..|..::|                  
  Fly  7938 ----PSISGLGMLTTSAIGSGTSSQMTSLHEEEDDFSGEMPPVEKRT------------------ 7980

  Fly  2061 AVLCVKSKSYKYKQE------------AQKTLEESMAMS---------------IDERQELALEL 2098
             ||.::.||...::.            ||:||..|:|.|               .|..|.::|||
  Fly  7981 -VLKLRDKSQCSERSDSGYSECSNCSGAQETLLLSLAKSKLEAIAKASTLPTVVHDTEQPVSLEL 8044

  Fly  2099 YRSRHGVGTGTLNSVGTLRSGTLGTLGRKSTSRPPPGVH--LGKS-------------PPRPSPA 2148
            ......:......:...:|..:|.....:...|..|.|.  |.:|             .|.|:.|
  Fly  8045 PTKGEAIMRSDFTNTIKMRKKSLEDSAAREKPRSKPQVKPLLCESKLKVSQLKDRFQVSPAPASA 8109

  Fly  2149 SVAYHSDEESLKCYD-------ENPDDSSVTEKPSEVSSSEASQHSESENESVRSDPHS 2200
            |.:..:..:....|.       .:....|.||:|........|...:.::..|||.|.|
  Fly  8110 SASASAANKPPLAYGPFKIAKVASVGRISRTEEPGRSGRGAPSVSGKGKSPQVRSMPSS 8168

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig 71..157 CDD:299845 29/141 (21%)
I-set 72..150 CDD:254352 29/133 (22%)
Ig 172..245 CDD:299845 18/109 (17%)
IG_like 280..356 CDD:214653 17/75 (23%)
Ig 280..343 CDD:299845 16/62 (26%)
IG_like 375..450 CDD:214653 16/82 (20%)
Ig 378..447 CDD:143165 14/76 (18%)
Ig 506..587 CDD:299845 29/83 (35%)
IG_like 506..587 CDD:214653 29/83 (35%)
I-set 592..682 CDD:254352 26/118 (22%)
Ig 595..682 CDD:299845 25/115 (22%)
FN3 686..789 CDD:238020 31/200 (16%)
FN3 798..893 CDD:238020 23/164 (14%)
FN3 901..1005 CDD:238020 20/113 (18%)
fn3 1011..1094 CDD:278470 25/136 (18%)
FN3 1108..1202 CDD:238020 22/126 (17%)
FN3 1210..1308 CDD:238020 18/100 (18%)
fn3 1317..1402 CDD:278470 17/84 (20%)
FN3 1415..1507 CDD:238020 19/104 (18%)
FN3 1513..1608 CDD:238020 31/102 (30%)
fn3 1617..1708 CDD:278470 18/92 (20%)
FN3 1722..1823 CDD:238020 22/135 (16%)
FN3 1828..1920 CDD:238020 16/100 (16%)
FN3 1927..2016 CDD:238020 17/108 (16%)
Strn-MlckNP_001261019.1 IG_like 51..127 CDD:214653
Ig <69..>112 CDD:299845
I-set 137..226 CDD:254352
I-set 235..314 CDD:254352
Ig_2 244..314 CDD:290606
I-set 438..513 CDD:254352
Ig 454..510 CDD:143165
I-set 537..626 CDD:254352
Ig 555..618 CDD:299845
I-set 636..713 CDD:254352
Ig 652..712 CDD:143165
SMC_N <2190..2854 CDD:280601
I-set 5300..5388 CDD:254352
IGc2 5313..5378 CDD:197706
IG 5412..5482 CDD:214652
IGc2 5413..5481 CDD:197706
I-set 5542..5627 CDD:254352
Ig 5556..5621 CDD:143165
Ig 5654..5721 CDD:143165 4/15 (27%)
I-set 5784..5874 CDD:254352 23/99 (23%)
IGc2 5797..5864 CDD:197706 19/70 (27%)
I-set 5887..5970 CDD:254352 16/83 (19%)
Ig 5902..5966 CDD:143165 14/64 (22%)
I-set 5997..6086 CDD:254352 21/95 (22%)
Ig 6026..6083 CDD:143165 17/63 (27%)
I-set 6097..6187 CDD:254352 21/102 (21%)
Ig 6114..6187 CDD:299845 16/85 (19%)
FN3 6216..6310 CDD:238020 9/93 (10%)
I-set 6321..6412 CDD:254352 29/90 (32%)
Ig 6328..6412 CDD:299845 29/83 (35%)
I-set 6442..6531 CDD:254352 25/93 (27%)
Ig 6459..6528 CDD:143165 21/73 (29%)
I-set 6541..6632 CDD:254352 12/95 (13%)
IGc2 6555..6622 CDD:197706 10/71 (14%)
I-set 6662..6754 CDD:254352 21/116 (18%)
Ig 6679..6751 CDD:143165 19/96 (20%)
I-set 6779..6868 CDD:254352 13/88 (15%)
IGc2 6793..6858 CDD:197706 9/64 (14%)
Ig 6938..7022 CDD:299845 20/92 (22%)
I-set 6939..7028 CDD:254352 20/97 (21%)
IG 7075..7140 CDD:214652 13/76 (17%)
Ig 7075..7140 CDD:143165 13/76 (17%)
IG 7167..7239 CDD:214652 11/79 (14%)
Ig 7173..7239 CDD:143165 9/73 (12%)
Ig 7392..7475 CDD:299845 18/91 (20%)
IG 7406..7475 CDD:214652 16/77 (21%)
FN3 7489..7588 CDD:238020 33/123 (27%)
S_TKc 7620..7876 CDD:214567 52/325 (16%)
STKc_MLCK 7626..7876 CDD:271005 52/304 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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