DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and Sdk2

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_006247755.1	Gene:	Sdk2 / 360652	RGDID:	1310397	Length:	2175	Species:	Rattus norvegicus

Alignment Length:	2286	Identity:	849/2286 - (37%)
Similarity:	1193/2286 - (52%)	Gaps:	231/2286 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 PRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDGVPVGDFSSSQFYRFHSTRREDAGSY 136
            |.|.|.|..: .:..||:..:|.|.|.|.....::||.:...:..||....|...|..|..||.|
  Rat    29 PYFKTEPVRT-QVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTRFSLEYRYMITSLDRTHAGFY 92

  Fly   137 QCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDGP 201
            :||.||..|::...:::|.|||||.||. .|...:|..|..|:...|.|.|.|.|.|.|..:...
  Rat    93 RCIVRNRMGALLQRQTEVQVAYMGSFEE-GEKHQSVSHGEAAVIKAPRISSFPRPQVTWFRDGRK 156

  Fly   202 LNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVS--GDPYIEVAPEII 264
            :....:.|.|..|.|:|||....|...|..:|:|.:.|..::|..:.|.|.  |.|...:||.||
  Rat   157 IPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLAVENVGGPADPIAPTII 221

  Fly   265 VRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANSS 329
            :.|::..|..||..|.::|:||||||.:|..:|.||| |:.:.|:     ..:||.|.:.....|
  Rat   222 IPPKNTSVVAGTSEVTMECVANARPLIKLHIVWKKDG-ALLSNGI-----SDYNRRLTITNPMVS 280

  Fly   330 HSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKW 394
            .:|.|.|:..|||.....|:..|.|.:||||.|..........|....|.:.|...|.|.|.:.|
  Rat   281 DAGYYECEAMLRSSSVAPVTRGAYLSVLEPPQFVREPERHITAEMEKVVDIPCRAKGVPPPSITW 345

  Fly   395 FRNAESVDAHIESG---RYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAK 456
            :::|    |.:|.|   |:...:|..|.|..|:.||..|.||.|.|.|||...||:|.|.
  Rat   346 YKDA----ALVEVGKLTRFKQRSDGGLQISGLLPDDTGMVQCFAHNAAGEAQTSTYLAVT----- 401

  Fly   457 NRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISC 521
                                                    :.||.:...|.:.|.:||....::|
  Rat   402 ----------------------------------------SIAPNITRGPLDSTVIDGMSVVLAC 426

  Fly   522 RAVGSPNPNITWIYNETQLVDIS---SRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEA 583
            ...|:|.|.|||...|..|...|   .|..:||||.||||.....|||.|.|:..|..|..:..|
  Rat   427 ETSGAPRPAITWQKGERILASGSVQLPRFTLLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 491

  Fly   584 YLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADG 648
            .|.|..||:|.:||.|.:|:.|..|::.|.|:.||.|.....|.::| ::..:..:.||.:..:|
  Rat   492 DLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTVRYVWEKDG-ATLAVETNPRIRLDRNG 555

  Fly   649 QLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGF 713
            .|.|....:.|:|:|.|.|.|.|||::|.|.|.|.:||..|.: .|..|...::|:||::|...|
  Rat   556 SLHISQTWSGDIGTYTCRVLSAGGNDSRNAHLRVRQLPHAPEH-PVATLSTMERRAINLTWAKPF 619

  Fly   714 DGNSPISKFIIQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVG 778
            |||||:.::|:   |:|| ...|     |...|::|..:...::::.|..|..||||:.|||.||
  Rat   620 DGNSPLMRYIL---EMSE-NNAP-----WTILLASVDPEATSVMVKGLVPARSYQFRLCAVNDVG 675

  Fly   779 EGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNN 843
            :|..|:.:..|.||:|.|:.||...:.|.|:...|:.|||||.|.|:||.:.|||:||.|.|
  Rat   676 KGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAG--- 737

  Fly   844 VPWSYQ--NITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIK--TKEGVPEAPPTN 904
            :|..||  |||:....|.|:::||.|.:|.:::||||:.|:|||:  ||:.  |.:|||..||.|
  Rat   738 LPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYS--SKVTEWTLQGVPTVPPGN 800

  Fly   905 VKVEAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQ 969
            |..||.||||.|..|..|:||.|||||||||:.||:      ..::.|..|.|..|:..|.:  .
  Rat   801 VHAEATNSTAIRFTWNAPSPQFINGINQGYKLIAWE------PTQEEEVTMVTARPNFQDSI--H 857

  Fly   970 TAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPR 1034
            ...:.||:|||||..||||||.||||..||...|.|.:|||..|..|.|:|:.|.|:||.|..|.
  Rat   858 VGFVSGLKKFTEYFTSVLCFTTPGDGPRSSPQLVRTHEDVPGPVGHLSFNDILDTSLKVSWQEPG 922

  Fly  1035 ASNGILTGYTVRYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATI 1099
            ..|||||||.:.::..:|.:|..:..|.....|..|..|.|.|.|..|:.|.|..|.|....:||
  Rat   923 EKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTI 987

  Fly  1100 QSGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVE---GQTARNMTWFTICEI-N 1160
            .|||.|.||.|||.|.:|||...||.|||.||:||.:||::|.||   |.......|..|.:: |
  Rat   988 SSGVPPELPGAPTNLGISNIGPRSVTLQFRPGYDGKTSISRWVVEAQVGMIGEGEEWLLIYQLSN 1052

  Fly  1161 DPDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLR 1225
            :|||.::.|..|.|||.|..|:...|:||:|.||:.::..||:||.|...|.|||:|..|...|.
  Rat  1053 EPDARSMEVPDLNPFTYYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVTLRTASETSLW 1117

  Fly  1226 VRWIPLQQTEWYGNPR--GYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVK 1288
            :||:||.:.|:.|||.  ||.|.|.   ::.|..|.:  |..::|.....:.::.|||||.|.|:
  Rat  1118 LRWMPLPEMEYNGNPESVGYKIKYS---RSDGHGKTL--SHTVQDRVEREYTIEDLEEWTEYRVQ 1177

  Fly  1289 MNACNDVGCSKESDTAVERTREAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFY 1353
            :.|.|.:|....|...|.||||:|||.||.:|.|.||:|::::|:|.|:|...|||.:.||||.|
  Rat  1178 VQAFNAIGSGPWSQAVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEIPEADRNGLVLGYKVRY 1242

  Fly  1354 AAADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVP 1418
            ...|...|.....:..|::.:..||.|.|||:|.|||||:||:|:|:.|.|||..:|.:|.||.|
  Rat  1243 KEKDSDSQARFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPP 1307

  Fly  1419 SNVSFPDVSLTMARIIWDVPVDPNGKILAYQVTYTLNGSAMLNYSRE-FPPSDRTFRATELLPGK 1482
            ..:.||:|..|..|:||..|..|||.|||||:|:.||.:.....:.| ..||.|.:.||.|.|..
  Rat  1308 MGILFPEVRTTSVRLIWQPPATPNGIILAYQITHRLNATTANTATVEVLAPSARQYMATGLKPES 1372

  Fly  1483 YYSFSCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRSQIQAHQITFSWTPGRDGFAPLRY 1547
            .|.|..|||||.|||:.|.|||.||..|:|||.||.|.:.:..::|..:..||.||.||.:|:||
  Rat  1373 VYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSKPVVQQEDVKARSVLLSWEPGSDGLSPVRY 1437

  Fly  1548 YTVEMRE-NEGRWQPLPERVDPSLSSFTAVGLRPYMTYQFRIQATNDLGPSAFSRESVIVRTLPA 1611
            ||::.|| ..|||......|..:.|:||...|:|:.:|:||::||||:|.|.||.||..:.||.|
  Rat  1438 YTIQTRELPSGRWALHSASVSHNASAFTVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQA 1502

  Fly  1612 APAVGVGGLKVVPITTTSVRVQWSALETALWNGDASTGGYRI-----LYQQLSDF-------PTA 1664
            ||......|.|.|.|||||.::|........||...  |:||     ||:.|..|       |.|
  Rat  1503 APDEAPTILSVTPHTTTSVLIRWQPPSEDKINGILL--GFRIRYRELLYEGLRGFTLRGINNPGA 1565

  Fly  1665 --LQSTPKTDVHGINENSVV---LSDLQQDRNYEIVVLPFNSQGPGPATPPAAVYVGEAVPTGEP 1724
              .:.|....:..:...|:.   |.:|.:.|.|||.:..:|:.|.||.:||..|:|||||||..|
  Rat  1566 KWAELTSLYSMRNLTRPSLTQYELDNLTKHRRYEIRMSVYNAVGEGPLSPPQEVFVGEAVPTAAP 1630

  Fly  1725 RAVDAAPISSTEVRLLWKPPKQSMQNGDILGYKIYYLVTYSPQALEPGRKWE-------EEIEVV 1782
            :.|.....::|::.:.|:||....|||||.|||||:              ||       |.::.:
  Rat  1631 QNVAIHSATATQLDVTWEPPPLDNQNGDIQGYKIYF--------------WEVQRRNLTERVKTL 1681

  Fly  1783 SATATSHSLVFLDKFTEYRIQLLAFNPAGDGPRSAPITVKTLPGVPSAPLHLRFSDITMQSLEVT 1847
            .....|..|..|..:|.|.:.:.|||.|||||||.|...:|....||||..::||::|..|:.|:
  Rat  1682 FLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPGSVKFSELTTTSVNVS 1746

  Fly  1848 WDPPKFLNGEILGYLVTYETTEENEKFSKQVKQKVSNTT---LRVQNLEEEVTYTFTVRAQTSVD 1909
            ||.|:|.||.:.||.:.||.....:..||.|...|...:   |:|::|.|.:||.|.::|:| ..
  Rat  1747 WDAPQFPNGPLEGYRLVYEPCTPVDGVSKIVTVDVKGNSPLWLKVKDLAEGMTYRFRIKAKT-FT 1810

  Fly  1910 YGPGISENVTTGPQDGSPVAPRDLILTKTLSSVEMHWINGPSGRGPILGYLIEAKKRDDSRWTKI 1974
            |||.|..|:||||.:|:|..|...|:.:..|::.:||.:|..|:|||..|:|||:..|:..|..:
  Rat  1811 YGPEIEANITTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDIL 1875

  Fly  1975 EQTRKGMMQDFTVSYHILMPSTAYTFRVIAYNRYGISFPVYSKDSILTPSKLHLEYGYLQHKPFY 2039
            .:.....:..:|.|..||.|..:|.|||||.|.||...|  |..|...|::        :..|||
  Rat  1876 IKDIPKEVTSYTFSMDILKPGVSYDFRVIAVNDYGFGTP--SSPSQSVPAQ--------KASPFY 1930

  Fly  2040 RQTWFMVSLAATSIVIIVMVIAVLCVKSKSYKYKQEAQK-------TLEESMAMSIDERQELALE 2097
            .:.||:|.:|...::.|::::.||.::.:|.||.::...       .|.....:|:||....|||
  Rat  1931 EEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYSKKTDAGGNTKSGALGHGEMLSLDESSFPALE 1995

  Fly  2098 LYRSRHGVGTGTLNSVGTLRSGTLGTLGRKSTSRPPPGVHLGKSPPRPSPASVAYHSDEESLKCY 2162
            |...|..|               ..:..||:      |::. :|||||||.|:.| |||:..|..
  Rat  1996 LNNRRLSV---------------KNSFCRKN------GLYT-RSPPRPSPGSLHY-SDEDVTKYN 2037

  Fly  2163 DENP-DDSSVTEKPSEVSSSEASQHSESENESVRSDPHSFVNHYANVNDSLRQSWKKTKP----V 2222
            |..| :.||:||||||:|.|:.|. ||.|.::.....|||||||.: :.:...||::.:.    .
  Rat  2038 DLIPAESSSLTEKPSEISDSQGSD-SEYEVDTNTQKAHSFVNHYIS-DPTYYNSWRRQQKGISRA 2100

  Fly  2223 RNYSSYTDS---EPEGSAVMSLNG---GQIIVNNMAR---------------------------S 2254
            :.| |||:|   ||:...|.:.|.   |.:.....:|                           |
  Rat  2101 QAY-SYTESDSGEPDHVTVPNSNSTQQGSLFRPKASRTPTPQNPPNPPSQQSTLYRPPSSLAPGS 2164

  Fly  2255 RAPLPGFSSFV 2265
            |||:.||||||
  Rat  2165 RAPIAGFSSFV 2175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	26/84 (31%)
		I-set	72..150	CDD:254352	25/77 (32%)
		Ig	172..245	CDD:299845	22/72 (31%)
		IG_like	280..356	CDD:214653	27/75 (36%)
		Ig	280..343	CDD:299845	23/62 (37%)
		IG_like	375..450	CDD:214653	28/77 (36%)
		Ig	378..447	CDD:143165	26/71 (37%)
		Ig	506..587	CDD:299845	32/83 (39%)
		IG_like	506..587	CDD:214653	32/83 (39%)
		I-set	592..682	CDD:254352	31/89 (35%)
		Ig	595..682	CDD:299845	30/86 (35%)
		FN3	686..789	CDD:238020	35/102 (34%)
		FN3	798..893	CDD:238020	43/98 (44%)
		FN3	901..1005	CDD:238020	51/103 (50%)
		fn3	1011..1094	CDD:278470	31/82 (38%)
		FN3	1108..1202	CDD:238020	42/97 (43%)
		FN3	1210..1308	CDD:238020	35/99 (35%)
		fn3	1317..1402	CDD:278470	37/84 (44%)
		FN3	1415..1507	CDD:238020	44/92 (48%)
		FN3	1513..1608	CDD:238020	41/95 (43%)
		fn3	1617..1708	CDD:278470	32/107 (30%)
		FN3	1722..1823	CDD:238020	35/107 (33%)
		FN3	1828..1920	CDD:238020	37/94 (39%)
		FN3	1927..2016	CDD:238020	32/88 (36%)
Sdk2	XP_006247755.1	IG_like	43..112	CDD:214653	22/68 (32%)
		IGc2	43..101	CDD:197706	20/57 (35%)
		IG_like	123..206	CDD:214653	24/82 (29%)
		Ig	135..191	CDD:299845	17/55 (31%)
		IG_like	225..307	CDD:214653	31/87 (36%)
		IGc2	236..289	CDD:197706	22/58 (38%)
		I-set	311..400	CDD:254352	31/92 (34%)
		Ig	329..397	CDD:143165	26/71 (37%)
		I-set	405..495	CDD:254352	33/89 (37%)
		Ig	419..495	CDD:299845	29/75 (39%)
		Ig	505..589	CDD:299845	29/84 (35%)
		IG_like	505..589	CDD:214653	29/84 (35%)
		FN3	593..684	CDD:238020	35/100 (35%)
		FN3	696..789	CDD:238020	43/97 (44%)
		FN3	797..893	CDD:238020	51/103 (50%)
		FN3	898..986	CDD:238020	32/87 (37%)
		FN3	996..1090	CDD:238020	42/93 (45%)
		FN3	1102..1197	CDD:238020	35/99 (35%)
		FN3	1204..1293	CDD:238020	39/88 (44%)
		FN3	1304..1397	CDD:238020	44/92 (48%)
		FN3	1403..1487	CDD:238020	35/83 (42%)
		FN3	1506..1619	CDD:238020	34/114 (30%)
		FN3	1629..1722	CDD:238020	35/106 (33%)
		FN3	1727..1808	CDD:238020	31/80 (39%)
		FN3	1840..1919	CDD:238020	30/80 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7472
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10406
Inparanoid	1	1.050	1344	1.000	Inparanoid score	I130
OMA	1	1.010	-	-		QHG46050
OrthoDB	1	1.010	-	-		D134749at2759
OrthoFinder	1	1.000	-	-		FOG0002891
OrthoInspector	1	1.000	-	-		oto98033
orthoMCL	1	0.900	-	-		OOG6_104033
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1909
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.780