DRSC/TRiP Functional Genomics Resources

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Protein Alignment sdk and IL12RB2

DIOPT Version :9

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_001361188.1 Gene:IL12RB2 / 3595 HGNCID:5972 Length:862 Species:Homo sapiens


Alignment Length:1110 Identity:187/1110 - (16%)
Similarity:337/1110 - (30%) Gaps:417/1110 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   602 VLLGLTATLQCKVS----------SDPSVPYNIDW---YREGQSSTPISNSQRIGVQADGQLEIQ 653
            :|||.|..:.|.:.          .:..:.|..|.   :..|.|    .|||..|:.....|   
Human    41 ILLGSTVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHS----LNSQVTGLPLGTTL--- 98

  Fly   654 AVRASDVGSYACVVTSPGGNETR--AARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGFDGN 716
                     :.|.:.....:|.:  .|.:.|...|..|.|:..  :.:.:|.::..:|..|.|.:
Human    99 ---------FVCKLACINSDE
IQICGAEIFVGVAPEQPQNLSC--IQKGEQGTVACTWERGRDTH 152

  Fly   717 SPISKFIIQRREVSELGPVPDPLLNWITELSNVSAD--QRWILLENLKAATVYQFRVSAVNRVGE 779
            . .:::.:|..     ||   ..|.|..:..::..|  ...|.|......:.:..:|:|||.:|.
Human   153 L-YTEYTLQLS-----GP---KNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGS 208

  Fly   780 GSPSEPSNVVELPQEAPSGP-PVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNN 843
            .| |.||....|....|..| .:.......|:|.....|:.      .|.:|...||||  ..|:
Human   209 SS-SLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRD------EGLVLLNRLRYR--PSNS 264

  Fly   844 VPWSYQNITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVE 908
            ..|:..|:|....|:.|: :|..:.:|..||::..::..|.:::.|: ..:...||..||.:   
Human   265 RLWNMVNVTKAKGRHDLL-DLKPFTEYEFQISSKLHLYKGSWSDWSE-SLRAQTPEEEPTGM--- 324

  Fly   909 AINSTAARCRWTPPNPQQINGINQGYKIQAW-QRRLIDGEWRDIERRMKTVPPSLIDPLAEQTAI 972
                                       :..| .:|.||...:.|....|.:            ::
Human   325 ---------------------------LDVWYMKRHIDYSRQQISLFWKNL------------SV 350

  Fly   973 LGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRASN 1037
            .....|...|.:::                        .|:||                 .:|..
Human   351 SEARGKILHYQVTL------------------------QELTG-----------------GKAMT 374

  Fly  1038 GILTGYTVRYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQSG 1102
            ..:||:|                                        :||.|   ||:|      
Human   375 QNITGHT----------------------------------------SWTTV---IPRT------ 390

  Fly  1103 VEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQTARNMTWFTICEINDPDAETL 1167
                                           ||     |.|                        
Human   391 -------------------------------GN-----WAV------------------------ 395

  Fly  1168 TVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRWIPLQ 1232
                         .:||:|..|||.|:..  :...:.......|..|:..:.....:.|.|.|.:
Human   396 -------------AVSAANSKGSSLPTRI--NIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPR 445

  Fly  1233 QTEWYGNP---RGYNISYKQLVKTPGTIKYVP----RSVVIEDHTANSHVLDSLEEWTLYEVKMN 1290
            :     :|   :.|.:.:::|  .||....||    ||   ..:..::.:.::::.:..||:::.
Human   446 K-----DPSAVQEYVVEWREL--HPGGDTQVPLNWLRS---RPYNVSALISENIKSYICYEIRVY 500

  Fly  1291 AC--NDVGCSKESDTAVERTREAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFY 1353
            |.  :..|||    :.:..::...|..|| .:.|......::::.|..:|.|.:.|.:..|::::
Human   501 ALSGDQGGCS----SILGNSKHKAPLSGP-HINAITEEKGSILISWNSIPVQEQMGCLLHYRIYW 560

  Fly  1354 AAADRGQQVLHKTIPNNATFTT-TLTELKKYVVYHVQVLAYTRLGN------------------- 1398
            ...|...|.....||...:..: .:..|:..|.|.:.:.|.|..|.                   
Human   561 KERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMA 625

  Fly  1399 -------------GALSTPPIRVQTF------------EDTPGVPSN--------VSFPDVSLTM 1430
                         |..||...:.:.|            .:.|. |:|        ::.....|.:
Human   626 FVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPD-PANSTCAKKYPIAEEKTQLPL 689

  Fly  1431 ARII--WDVPVDPNGKILA---YQVTYTLNGSAMLN-------------------YSREFPPSDR 1471
            .|::  |..|.||...:::   :|||.........|                   :|...||..|
Human   690 DRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPR 754

  Fly  1472 TFRATELLPGKYYSFSCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRSQIQAHQITFSWT 1536
            ..:|........|.                 ::.:..:..:|:.|:.|               ||
Human   755 ALQAESRQLVDLYK-----------------VLESRGSDPKPENPACP---------------WT 787

  Fly  1537 -------PGRDGFAPLRYYTVEMRENEGRWQPLP---ERVDP---SLSSFTAVGLRPYMTYQFRI 1588
                   |..||:.|.....:...|     .||.   |.::|   |||.|.:..|.| :|:....
Human   788 VLPAGDLPTHDGYLPSNIDDLPSHE-----APLADSLEELEPQHISLSVFPSSSLHP-LTFSCGD 846

  Fly  1589 QATND 1593
            :.|.|
Human   847 KLTLD 851

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig 71..157 CDD:299845
I-set 72..150 CDD:254352
Ig 172..245 CDD:299845
IG_like 280..356 CDD:214653
Ig 280..343 CDD:299845
IG_like 375..450 CDD:214653
Ig 378..447 CDD:143165
Ig 506..587 CDD:299845
IG_like 506..587 CDD:214653
I-set 592..682 CDD:254352 17/94 (18%)
Ig 595..682 CDD:299845 17/94 (18%)
FN3 686..789 CDD:238020 24/104 (23%)
FN3 798..893 CDD:238020 22/95 (23%)
FN3 901..1005 CDD:238020 10/104 (10%)
fn3 1011..1094 CDD:278470 10/82 (12%)
FN3 1108..1202 CDD:238020 11/93 (12%)
FN3 1210..1308 CDD:238020 20/106 (19%)
fn3 1317..1402 CDD:278470 18/117 (15%)
FN3 1415..1507 CDD:238020 19/123 (15%)
FN3 1513..1608 CDD:238020 23/94 (24%)
fn3 1617..1708 CDD:278470
FN3 1722..1823 CDD:238020
FN3 1828..1920 CDD:238020
FN3 1927..2016 CDD:238020
IL12RB2NP_001361188.1 Lep_receptor_Ig 28..110 CDD:368845 15/84 (18%)
FN3 224..316 CDD:238020 23/101 (23%)
WSXWS motif 305..309 0/3 (0%)
FN3 423..511 CDD:238020 20/101 (20%)
FN3 521..615 CDD:238020 19/94 (20%)
Box 1 motif 662..670 1/8 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 725..755 4/29 (14%)
Required for STAT4 binding 796..801 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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