DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and cntn1a

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_851300.2	Gene:	cntn1a / 353150	ZFINID:	ZDB-GENE-030427-1	Length:	1032	Species:	Danio rerio

Alignment Length:	1138	Identity:	266/1138 - (23%)
Similarity:	421/1138 - (36%)	Gaps:	255/1138 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 QAPRFTTHPSSSGSIVSEGSTKI-LQCHALGYPQPTYRW--------LKDGVPVGD--FSSSQFY 123
            :.|..|.:|..|      ...|| |.|.....|..:|||        |.:|   ||  :|.|:..
Zfish    50 EQPLDTIYPEES------PEEKITLTCRTRANPPASYRWRLNNAELVLAEG---GDPHYSVSEGN 105

  Fly   124 RFHST--RREDAGSYQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIE 186
            ...|:  :.:.||:|.|:|.|..||:.|.::.|...|:.:|.......:.|..|..|:....|..
Zfish   106 LLISSPDKSKHAGNYTCVASNQYGSVTSRRARVQFGYLDMFSTDEREAVYVKEGQGAVLLCAPPP 170

  Fly   187 SIPVP-SVMWQSEDGPLNYDI---KYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFV 247
            ..|.. |..|...:.|....:   ::.......|.|.:....|...|.....:..:.|...|.|:
Zfish   171 HFPEDLSFRWMLNEFPEFIPLDQRRFVSQSTGNLYISTVRSTDSGNYSCFVSSPAIAKSVFSKFI 235

  Fly   248 HLNVSGDPYIEVAPEIIVR-PQDVKVK-------VGTGVVELQCIANARPLHELETLWLK-DGLA 303
                   |.:.:|...:.: |.|:|||       :|..:. |:|.|...|:.::.  |.| ||:
Zfish   236 -------PLVPIAERSLRKYPADIKVKSPDSWALLGQNIT-LECFALGNPIPQIR--WRKLDGV- 289

  Fly   304 VETAGVRHTLNDPWNRTLALLQANS---SHSGEYTCQVRLRSG-----------GYP----AVSA 350
              ...:||.:    :.:.|||...|   ...|.|.|:.....|           |.|    .:|:
Zfish   290 --LPPLRHDV----SMSGALLHLYSLQYEDEGLYECEADNSKGKDWHKTHLYVEGAPDWLEQISS 348

  Fly   351 SARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTD 415
            |.                   .:.||...::|...|:|.|.|.:.:|     .|:....:.:.
Zfish   349 SE-------------------VDIGGDYIMSCQASGKPKPHVHFLKN-----GHMYMKGHEVR-- 387

  Fly   416 NTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSE 480
                ..:|..:|:.|:||:|.|..|...|:..|||
Zfish   388 ----FSRLGFEDSGMYQCVAENRHGVIHANAELRV------------------------------ 418

  Fly   481 KGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATI--SCRAVGSPNPNITWIYNETQLVDI 543
                           |||||..:..|.....|..::..:  .||...:|.||||| ...|:|:..
Zfish   419 ---------------FASAPSFQYNPVKPKLLGARNGRVVFECRPRAAPRPNITW-SKGTELLHN 467

  Fly   544 SSRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTA 608
            |||:.|...|.|.:.||...|.|.|.|...|:.|.......||:...|:|...|.:..|.:|..|
Zfish   468 SSRISIWLDGSLELLNISKSDEGKYTCFAENDRGRANSTGSLSITDATKITLAPSNADVSVGEDA 532

  Fly   609 TLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQ----------------LEIQAVRA 657
            .::|..|.||.:.....|..:|.:         |.:|.|.|                |.|...:.
Zfish   533 RMECVASHDPGLDLTFIWSLDGHT---------IDLQRDAQHYQRKMDSASGTSSSELLITHTQL 588

  Fly   658 SDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKF 722
            ...|.|:|...:|..|.|.:|.|.|...|.||..|:|:   |....|:.|.|:.|.|..||||::
Zfish   589 RHAGRYSCTAQTPVDNTTASAELVVRGPPGPPGGVRVD---EVTSDSVRVLWSHGTDNLSPISRY 650

  Fly   723 IIQRREVSELGPVPDPLLNW---ITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSE 784
            .:|.||.:       ...:|   .|...||..:.....:.||...|.|:|||.|.|.:|.|.|||
Zfish   651 TVQLRESA-------AQQDWRDAATSPVNVEGNAEMATVVNLLPWTEYEFRVIATNTLGTGPPSE 708

  Fly   785 PSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQ 849
            ||......:..|...|....|...:..|:...|.|...::..|...|||:.::  .:|:..|...
Zfish   709 PSPKTTTREARPIVAPSDIGGGGGTSRELTITWTPVQSQYYYGSNFGYIIAFK--PHNDPEWLRV 771

  Fly   850 NITNEAQRNFLIQELITWKD--------YIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVK 906
            .:|:...:.::      .||        :.|::.|:|:.|.|.::..:.|.:.:.||...|...:
Zfish   772 TVTDPEVQKYV------HKDPKIPPSTRFEVKMKAFNSQGEGPFSNSAFIYSAQDVPAEAPIITE 830

  Fly   907 VEAINSTAARCRWTPPNPQQINGINQGYKIQAW----------QRRLIDGEWRDIERRMKTVPPS 961
            ..|:::|.|...|.|.....:    :.|:::.|          ||.|:..  |:...|:..:.|.
Zfish   831 ARALSATEAIVIWVPVQLPTV----ERYQVRYWRESVENEASAQRVLVSS--RENHTRLDNMKPD 889

  Fly   962 LIDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDE-----VTGLHFDDV 1021
                              :.|.:.|......|.|.||.:..:.|....|..     .|.:|:
Zfish   890 ------------------SHYLVEVRACNGAGYGPASQRNRIYTKKSPPSRPPKIISTKMHY--- 933

  Fly  1022 SDRSVKVLWAPPRASN--GILTGYTVRYQVKDRPD-TLKSFNLTADDTELTVNQLQATTHYWFEI 1083
            |..|:.:.|....:.|  ..:.||.|.|:...:|. ||.:....:.|..:...:      |..|:
Zfish   934 SGSSINIAWEKVESLNNESTVAGYKVLYRQHGQPSGTLYTTEKQSIDLPMRRGE------YLVEV 992

  Fly  1084 VAWTRVGSGIPKTATIQSGVEPVLPHAPTALAL 1116
            .|.:..|.|......| :|..|. |...:||.|
Zfish   993 RAHSEGGDGAVAQVRI-TGSAPA-PALASALLL 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	29/98 (30%)
		I-set	72..150	CDD:254352	27/90 (30%)
		Ig	172..245	CDD:299845	13/76 (17%)
		IG_like	280..356	CDD:214653	22/94 (23%)
		Ig	280..343	CDD:299845	17/66 (26%)
		IG_like	375..450	CDD:214653	19/74 (26%)
		Ig	378..447	CDD:143165	16/68 (24%)
		Ig	506..587	CDD:299845	27/82 (33%)
		IG_like	506..587	CDD:214653	27/82 (33%)
		I-set	592..682	CDD:254352	25/105 (24%)
		Ig	595..682	CDD:299845	24/102 (24%)
		FN3	686..789	CDD:238020	38/105 (36%)
		FN3	798..893	CDD:238020	20/102 (20%)
		FN3	901..1005	CDD:238020	20/113 (18%)
		fn3	1011..1094	CDD:278470	19/90 (21%)
		FN3	1108..1202	CDD:238020	4/9 (44%)
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
cntn1a	NP_851300.2	Ig	45..136	CDD:299845	28/94 (30%)
		I-set	46..134	CDD:254352	27/92 (29%)
		Ig	142..237	CDD:299845	17/101 (17%)
		IG_like	154..229	CDD:214653	12/74 (16%)
		Ig	249..337	CDD:299845	24/97 (25%)
		IG_like	256..336	CDD:214653	19/89 (21%)
		Ig	341..418	CDD:299845	21/106 (20%)
		IG_like	347..418	CDD:214653	21/100 (21%)
		I-set	423..511	CDD:254352	28/88 (32%)
		Ig5_Contactin_like	440..511	CDD:143170	25/71 (35%)
		I-set	516..611	CDD:254352	24/103 (23%)
		Ig	530..611	CDD:299845	20/89 (22%)
		FN3	627..714	CDD:238020	33/93 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..729		10/29 (34%)
		FN3	723..816	CDD:238020	19/100 (19%)
		FN3	825..905	CDD:214495	17/103 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	907..926		4/18 (22%)
		FN3	920..1001	CDD:214495	19/89 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910