DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and LRIT3

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_940908.3	Gene:	LRIT3 / 345193	HGNCID:	24783	Length:	679	Species:	Homo sapiens

Alignment Length:	432	Identity:	90/432 - (20%)
Similarity:	139/432 - (32%)	Gaps:	139/432 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 NARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANSSHSGEYTCQVR-----LRSGGY 345
            |.:.||||..    ||.::........|:.|..|||.|      |:.:.|....     |::..|
Human   103 NLKQLHELRL----DGNSLAAFPWASLLDMPLLRTLDL------HNNKITSVPNEALRYLKNLAY 157

  Fly   346 PAVSASARLQILEPP-------LFFTPMRAETFGEFGGQVQLTCD--VVG-EPTPQVKWFRNAES 400
            ..:| |.||..|.|.       |..||         .|.:.|:..  ::| :..|   ||
Human   158 LDLS-SNRLTTLPPDFLESWTHLVSTP---------SGVLDLSPSRIILGLQDNP---WF----- 204

  Fly   401 VDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQP 465
            .|.|               |.|:|                                 .:.::..|
Human   205 CDCH---------------ISKMI---------------------------------ELSKVVDP 221

  Fly   466 RILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPN 530
            .|  |........||....:|...:|.|......|.:......:.:..|.:..:.|.|.|.|.|.
Human   222 AI--VLLDPLMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQ 284

  Fly   531 ITWIYNETQLVDISSRVQILESG----DLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRT 591
            |||..:::..|:.:...:..|.|    .:.::.|.|.|||.|.|...|.||  ..||.::|.|
Human   285 ITWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAG--MSEAVVTVTV-- 345

  Fly   592 QIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVR 656
                        ||:|.|                       ..|...|:|.|...:..::..:.|
Human   346 ------------LGITTT-----------------------PIPPDTSERTGDHPEWDVQPGSGR 375

  Fly   657 ASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLP 698
            ::.|.|.:..:.|...:.|.:...|.:.   |||.......|
Human   376 STSVSSASSYLWSSSFSPTSSFSASTLS---PPSTASFSLSP 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	21/74 (28%)
		Ig	280..343	CDD:299845	16/61 (26%)
		IG_like	375..450	CDD:214653	11/77 (14%)
		Ig	378..447	CDD:143165	10/71 (14%)
		Ig	506..587	CDD:299845	24/84 (29%)
		IG_like	506..587	CDD:214653	24/84 (29%)
		I-set	592..682	CDD:254352	13/89 (15%)
		Ig	595..682	CDD:299845	13/86 (15%)
		FN3	686..789	CDD:238020	4/13 (31%)
		FN3	798..893	CDD:238020
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
LRIT3	NP_940908.3	LRR 1	56..79
		leucine-rich repeat	59..82	CDD:275378
		LRR_8	61..117	CDD:290566	7/17 (41%)
		LRR 2	80..103		90/432 (21%)
		leucine-rich repeat	83..106	CDD:275378	1/2 (50%)
		LRR 3	104..128		7/27 (26%)
		LRR_8	105..165	CDD:290566	18/70 (26%)
		LRR_4	105..146	CDD:289563	14/50 (28%)
		leucine-rich repeat	107..130	CDD:275378	7/26 (27%)
		LRR 4	129..151		7/27 (26%)
		LRR_4	131..170	CDD:289563	13/45 (29%)
		leucine-rich repeat	131..154	CDD:275378	7/28 (25%)
		LRR 5	152..175		8/23 (35%)
		leucine-rich repeat	155..168	CDD:275378	5/13 (38%)
		Ig	267..345	CDD:299845	25/79 (32%)
		IG_like	267..345	CDD:214653	25/79 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..375		5/46 (11%)
		FN3	486..550	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900