DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and ihog

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	173/745 - (23%)
Similarity:	261/745 - (35%)	Gaps:	175/745 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 APEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLW--------------LKDGLAVETAGVR 310
            |||.:|.|      :|..|| |:|..:.:| ...|  |              ||.|.|.......
  Fly    58 APESLVAP------LGDEVV-LECETSLQP-ERFE--WSHRSSRSPGAGFKYLKTGTAKANVSQE 112

  Fly   311 HTLNDPWNRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLF-----FTPMRAET 370
            ..:    :|...|::.::  .|||.|....  |.....|..|||::....|.     .:|::...
  Fly   113 AAI----SRLRVLVRPDT--LGEYRCVGWF--GPLVVTSTIARLELASTSLVDAQESESPLQWRV 169

  Fly   371 FGEFGGQVQLTCDVVGEPTPQVKW--FRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQC 433
              ..|..|..:|....:..|...|  :||...:....      :.|:..|.:..:..:.:..:.|
  Fly   170 --SAGNSVLWSCGQQVQSNPSASWSYYRNGVEIKPEF------IGTNGNLFLSNVSSESSGSYSC 226

  Fly   434 LAINEA-GENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFA 497
            .|.|.| ||                   |:..|..|:::.:     .|:.|||           .
  Fly   227 QATNPASGE-------------------RIQLPGSLQLQVT-----PEQRSES-----------K 256

  Fly   498 SAPIMELPP--QNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQILES---GDLL- 556
            |..::...|  |.:|..:|....:.|..||||.|.:.|     ...|:...|:...|   |..|
  Fly   257 SPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPTVVW-----SSPDVVGAVKNKRSKVFGHALE 316

  Fly   557 ISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVR--TQIIQPPVDTTVLLGLTATLQCKVSSDPS 619
            |||.|..|||.|||.:.|...... |.|:.|.|.  .||::||.......|....|:||.:..|:
  Fly   317 ISNTRVNDAGTYICFQDNGVRPAL-EHYIKVHVEQPPQIVRPPWADLTNEGDRLKLECKATGVPT 380

  Fly   620 VPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSV-- 682
            .  .|.|...|.||...|.::    .::..|.:.:|.....|...|...:..|..:....|.|
  Fly   381 P--EIYWLLNGHSSIDDSEAE----LSNNFLILHSVLKRHAGYVQCFARNRLGEHSAGTLLQVNP 439

  Fly   683 --IELP--------------------FPPSNVKVERLPEPQQRSINVSW-TPGFDGNSPISKFII 724
              |:.|                    :||:...|.||.:   .|:.:.| .|..|| .||..|.:
  Fly   440 KQIQEPRESGGTHRPKPNQGSRQKQMYPPTPPNVTRLSD---ESVMLRWMVPRNDG-LPIVIFKV 500

  Fly   725 QRREVSELGPVPDPLLNWITELSNVS-ADQRW---------ILLENLKAATVYQFRVSAVNRVGE 779
            |.|.|.:       ..||.|...|:. ...:|         ..:.:||....|:||:.||....:
  Fly   501 QYRMVGK-------RKNWQTTNDNIPYGKPKWNSELGKSFTASVTDLKPQHTYRFRILAVYSNND 558

  Fly   780 GSPSEPSNVVELPQEAPSGP-PVGFVGSARSMSE--IITQWQ--PPLEEHRNGQILGYILRYRLF 839
            ...|..|....|...|...| ||..:......||  ::..|.  ...:||   .|.||...||
  Fly   559 NKESNTSAKFYLQPGAALDPMPVPELLEIEEYSETAVVLHWSLASDADEH---LITGYYAYYR-- 618

  Fly   840 GYNNVPWS----YQNITNEA--QRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVP 898
                 |.|    |...|.|.  .|:|.|..|.|...|..::.:::......::     ..|:|..
  Fly   619 -----PSSSAGEYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAASASEFS-----ALKQGRT 673

  Fly   899 EAPPTNVKVEAINSTAARCRWTPPNPQQIN 928
            :.|.|:...|.......|...||.:.:..|
  Fly   674 QRPKTSTTEEPTLQMGDRDTTTPSHNETFN 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	20/89 (22%)
		Ig	280..343	CDD:299845	15/76 (20%)
		IG_like	375..450	CDD:214653	15/77 (19%)
		Ig	378..447	CDD:143165	14/71 (20%)
		Ig	506..587	CDD:299845	29/86 (34%)
		IG_like	506..587	CDD:214653	29/86 (34%)
		I-set	592..682	CDD:254352	21/89 (24%)
		Ig	595..682	CDD:299845	19/86 (22%)
		FN3	686..789	CDD:238020	31/133 (23%)
		FN3	798..893	CDD:238020	24/105 (23%)
		FN3	901..1005	CDD:238020	7/28 (25%)
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
ihog	NP_609085.1	IG_like	59..145	CDD:214653	24/103 (23%)
		ig	265..330	CDD:278476	24/69 (35%)
		IG_like	267..348	CDD:214653	29/86 (34%)
		Ig	314..>377	CDD:299845	24/63 (38%)
		IG_like	364..437	CDD:214653	17/78 (22%)
		IGc2	365..427	CDD:197706	15/67 (22%)
		FN3	467..565	CDD:238020	29/108 (27%)
		fn3	580..655	CDD:278470	23/84 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010