DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and bdl

DIOPT Version :9

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_608822.1 Gene:bdl / 33635 FlyBaseID:FBgn0028482 Length:719 Species:Drosophila melanogaster


Alignment Length:728 Identity:150/728 - (20%)
Similarity:255/728 - (35%) Gaps:197/728 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   266 RPQDVKVKVGTGVVELQCIAN---ARPLHELETLWLKDGLAV------ETA------GVRHTL-N 314
            |..:::.|||:.|| ..|..:   ..|:..| ..|.||...:      ||:      |..|.: |
  Fly    39 RQTNLEAKVGSHVV-FNCYIDFPFDAPIPYL-VHWTKDNKKIFTWYEQETSTSELFNGRLHLVEN 101

  Fly   315 DP-WNRTLALLQA-NSSHSGEYTCQVRLRSGGYPAVSASAR-------LQILEPPLFFTPMRAET 370
            .| :.|....|.| ..|..|.|.|||     .:|..|.|.|       |.:....|...|...:|
  Fly   102 HPEFGRASVNLTAIRESDQGWYHCQV-----SFPNRSPSVRNNGTAYHLAVQGGSLIRIPPVNQT 161

  Fly   371 FGEFGGQVQLTCDVVGEP-TPQVKWFRNA---ESVDAHIESGRYTLNTDNTLVIKKLILDDAAMF 431
            ..|  ||......|:..| ..|..|:::.   :.|...:.  |:.:..|.:|.|...::.|...:
  Fly   162 IRE--GQTAFFHCVMKHPENSQASWYKDGVLLQEVQDLVR--RFYMGPDGSLSIDPTMMSDLGEY 222

  Fly   432 QCLAINEAGE-NSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFR 495
            :|...|..|| .:|..:|.::.|                                          
  Fly   223 ECKVRNSDGELQTAKAFLNIQYK------------------------------------------ 245

  Fly   496 FASAPIMELPPQNVTALDGKDATISCR-AVGSPNPNITW-----IYNETQLVDISSRVQILESGD 554
               |.::..||: |....|:.|.:.|. ....|..|:.|     :::...:..:..::    :|.
  Fly   246 ---AKVIYAPPE-VFLPYGQPAVLDCHFRANPPLKNLRWEKDGLLFDSYNVPGVFYKM----NGS 302

  Fly   555 LLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTV-------LLGLTATLQC 612
            |..:.:....||.|.|...|:.|:......:||:|    ::||:.:..       .||..|.|.|
  Fly   303 LFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVIV----LRPPIFSVTPKAIYIQKLGEAAELPC 363

  Fly   613 K-VSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETR 676
            : :..|.:...:|.|.|:.....|.......|    |.|.|..:...|.|.|.|..|:.....|.
  Fly   364 EAIDRDGNNRPSIIWGRKDGQPLPADRFSLSG----GNLTITGLVEGDRGIYECSATNEAATITA 424

  Fly   677 AARLSVIEL-PFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVSELGPVPDPLL 740
            .|.|.:..: |..|.|:..    ...:..|.:.|.||:  ..|..::.:..|    |...|:   
  Fly   425 EAELMIENIAPRAPYNLTA----NSTETCITIRWQPGY--LRPNLEYTVWYR----LMEAPE--- 476

  Fly   741 NWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSG------- 798
             |.| |..:........:::|:....|:|.|.:.::.|:|..|:......||....:.       
  Fly   477 -WRT-LRVLDKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQQL 539

  Fly   799 --------PPVGFVGSARSMSEIITQ------WQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQ 849
                    .|.|.:|:..:::.|..|      |:.|::.....::  |.:|:         |   
  Fly   540 QHDLGQVTAPAGGLGAPWNLTAISNQQGWLLHWEHPVQGLEGLRL--YAVRW---------W--- 590

  Fly   850 NITNEAQRNFLIQELITWKDYI------------VQIAAYNNMGVGVYTEGSKIKTKEGVPEAP- 901
                :...:|||....|:.:|.            ||:.|     ||.       :|::.||... 
  Fly   591 ----KEPEHFLIGHAETFDNYYQLRHLKEDTLFKVQVLA-----VGT-------ETQQSVPSHEL 639

  Fly   902 ----PTNVKVEAI 910
                |:..||.|:
  Fly   640 LIDVPSQRKVRAL 652

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig 71..157 CDD:299845
I-set 72..150 CDD:254352
Ig 172..245 CDD:299845
IG_like 280..356 CDD:214653 26/100 (26%)
Ig 280..343 CDD:299845 21/80 (26%)
IG_like 375..450 CDD:214653 18/79 (23%)
Ig 378..447 CDD:143165 15/73 (21%)
Ig 506..587 CDD:299845 16/86 (19%)
IG_like 506..587 CDD:214653 16/86 (19%)
I-set 592..682 CDD:254352 24/97 (25%)
Ig 595..682 CDD:299845 24/94 (26%)
FN3 686..789 CDD:238020 21/102 (21%)
FN3 798..893 CDD:238020 20/127 (16%)
FN3 901..1005 CDD:238020 4/15 (27%)
fn3 1011..1094 CDD:278470
FN3 1108..1202 CDD:238020
FN3 1210..1308 CDD:238020
fn3 1317..1402 CDD:278470
FN3 1415..1507 CDD:238020
FN3 1513..1608 CDD:238020
fn3 1617..1708 CDD:278470
FN3 1722..1823 CDD:238020
FN3 1828..1920 CDD:238020
FN3 1927..2016 CDD:238020
bdlNP_608822.1 IG_like 42..128 CDD:214653 26/92 (28%)
Ig 43..131 CDD:299845 26/94 (28%)
I-set 153..242 CDD:254352 21/92 (23%)
Ig 157..242 CDD:299845 20/88 (23%)
Ig_2 252..337 CDD:290606 19/89 (21%)
IG_like 260..327 CDD:214653 14/70 (20%)
I-set 341..428 CDD:254352 22/90 (24%)
IGc2 356..419 CDD:197706 18/66 (27%)
FN3 435..524 CDD:238020 21/103 (20%)
FN3 554..636 CDD:238020 20/111 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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