DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and itgb4

DIOPT Version :9

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:XP_005166847.1 Gene:itgb4 / 335269 ZFINID:ZDB-GENE-030131-7209 Length:1931 Species:Danio rerio


Alignment Length:2262 Identity:445/2262 - (19%)
Similarity:734/2262 - (32%) Gaps:707/2262 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 YCDSCFF----CYADANLQ----------------QQNSIVQQQQLQAPRFTTHPSSSGSIVSEG 88
            ||....|    |....||:                |:|..:.:|..|:   ...|......:..|
Zfish    50 YCPDEVFEHERCDLKENLEAQKCSKIVNFESSRQIQENVKINEQLKQS---QVSPQLMSMTLLPG 111

  Fly    89 STKILQCHALGYPQPTYRWLKDGVPVGDFSSSQFYRFHSTRREDAGSYQCIARNDAGSIFSEKSD 153
            ..|.::....   :|| |...|...:.|||:|.        .:|..:.:.:....|..:.....|
Zfish   112 EEKEVEMEVF---EPT-RGPLDLYILMDFSNSM--------SDDLDNLKRMGEKLARLVGDLSDD 164

  Fly   154 VVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDGPLNYDIKYAFTHANQLII 218
            ..:.:....:..||.:.          ||.|.: :..|   |.:.|.|        |:..|.:.:
Zfish   165 YTIGFGKFVDKVTEPQT----------DMRPAK-LAEP---WSNSDPP--------FSFRNVIKL 207

  Fly   219 LSADENDRKGYRAKAINTQLGKEES--SAFVHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVEL 281
            .|...:.|:..:.:.|:..|...|.  .|.:...|..|                  ::|      
Zfish   208 TSNITSFRQKLQKERISGNLDAPEGGFDAILQTAVCQD------------------QIG------ 248

  Fly   282 QCIANARPLHELETLWLKDG---LAVETAGVRHTLNDPWNRTLALLQANSSH-----SGEYTCQV 338
                           |.||.   |...|....|...|..|....:|..|...     .|.||..|
Zfish   249 ---------------WRKDSTHLLVFSTESAFHYEADGANVLAGILDRNDEQCHLNVDGNYTHDV 298

  Fly   339 RLRSGGYPAVSASARLQILEP--PLFFTPMRAETFGE-----FG----GQVQLTCDVVGEPTPQV 392
            |   ..||::....||.:...  |:|.....:.::.|     |.    ||:|       |.:..:
Zfish   299 R---QDYPSIPTLVRLLVKHNIIPIFAVTNHSYSYYEKLHEYFPIAELGQLQ-------EDSSNI 353

  Fly   393 -----KWFRNAES------------VDAHI--------ESGRYTLNTDNTLVIKKLILDDAAMFQ 432
                 |.|.|..|            |:..|        |.|.:.:....|...|         .:
Zfish   354 LSILEKAFENIRSKISIRAEDRPKAVETKIFSQSGTFSEYGNFKITPGQTGKFK---------VR 409

  Fly   433 CLAINEAGE---------NSASTWLRVKTKTAKNRVKRLAQ-----------PRILRVRAS---- 473
            ..|:|:.||         :.|.| ||||..|..:..|..|:           |....||.:    
Zfish   410 MKALNQVGEEPVCKVNQADRAGT-LRVKPTTFSSAFKINAEVLCPTCDCEKTPVKNAVRCTGHGD 473

  Fly   474 --------HAG-LGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALD-GKDATISCRAVGSPN 528
                    :|| ||......:|:|                 ..:|..:: ||  |..|...|...
Zfish   474 LVCGKCQCYAGWLGPLCNCSAGAS-----------------TDSVMCIERGK--TEPCSGRGDCM 519

  Fly   529 PNITWIYNETQL------VDISSRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYLSV 587
            ......||..|.      .|.|   |....|..|.:...|...|..:|     :....|||    
Zfish   520 CGTCVCYNPNQFEGPYCQFDKS---QCQRFGGFLCNERGSCSMGRCVC-----SPGWSGEA---- 572

  Fly   588 LVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLE- 651
                                  .:|..|:|..        |:.:..  |.|.:  ||...|:.| 
Zfish   573 ----------------------CECPTSNDSC--------RDSKGG--ICNDR--GVCKCGRCEC 603

  Fly   652 ----------IQAVRASDVG----SYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQ 702
                      .:|.....||    ..:||.........|..| ...|.||  ..|:|:.|.|.: 
Zfish   604 EHSGLPLSPTCEANFQQQVGMCEAKRSCVQCQAWSTGERKGR-KCDECPF--KIVRVDELEEDK- 664

  Fly   703 RSINVSWTPGFDGNSPISKFIIQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVY 767
               ||..|..|            |.|..:                                 ..|
Zfish   665 ---NVIETCSF------------RDEDDD---------------------------------CTY 681

  Fly   768 QFRVSAVNRVGEGSPSEPSNVVE-----LPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNG 827
            .:.|           :.|||:.:     |.::....||.||:            |..||..... 
Zfish   682 HYNV-----------NYPSNITDKEHRVLVKKKKDCPPAGFL------------WLIPLIMFLM- 722

  Fly   828 QILGYIL---------------------RYRLFGYNNVPWSYQNITNEAQRNFLIQELITWKDY- 870
            .:||.:|                     |.|:.|:.             :..:|:::.....|| 
Zfish   723 LLLGLLLLCCWKYCACCQSCLALLPCCARGRMVGFK-------------ENQYLLRQSFLQNDYL 774

  Fly   871 --------------IVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKV-----EAINSTAAR 916
                          :|:....:|:..|.....::|:.........|.::::     |.:::..||
Zfish   775 DTPMVRSGPLKSTDVVRWKVADNVHRGTNHPQNQIRPNPKETIQYPVSLRLNRQFSEVLSNPDAR 839

  Fly   917 -----CRWTPPNPQ----QINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLID-PLAEQTA 971
                 .|....|..    ||.|      .|..|:.|...:....:|:..|:..:::. |.:....
Zfish   840 DTDMLRREVEDNLNDVFLQIPG------AQPVQKTLFRTQRNSGKRQNNTIVDTVLSAPRSSYPD 898

  Fly   972 ILGGLEKFTEYNISVLCFTD----PGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAP 1032
            |:    |.|:..:....|.|    ||....:|........:.|:.|          .||.|    
Zfish   899 IV----KLTDKQVQSGNFRDLKVIPGYYTVASDKEAAGAVEFPENV----------ESVDV---- 945

  Fly  1033 PRASNGILTGYTVRYQVKDRPDTLKSFNLTA------------DDTELTVNQLQATTHYWFEIVA 1085
                       .|...:||..|..|...:.|            |...:||.:.||::.:.|...:
Zfish   946 -----------RVPLFIKDEDDEKKELLVQAVDVPVGIAKIGKDHVNITVLKEQASSVFTFLEPS 999

  Fly  1086 WT---RVG-SGIP-KTATIQSGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEG 1145
            :|   :.| :.|| |...|:.|...|........|....:..||        ||:.|..    .|
Zfish  1000 YTYSRQDGVANIPIKRQIIEDGRAQVTYSTADLTAKDKKDYISV--------DGDLSYG----AG 1052

  Fly  1146 QTARNMTWFTICEINDPDAETLTVTGLVPFTQYR-LRLSASNVVGSSKPSEATKDFQTIQARPKH 1209
            :|.: :....:.|:.:.|       ||:...|.: ..:..:|...|:|.....:...||..:|:.
Zfish  1053 ETEK-IVPVKLLELGEQD-------GLLEDKQVKQFVMDLTNPRQSAKLGRYPRTVITIADKPES 1109

  Fly  1210 P--PFNVTVRAMSAQQLRVRWIPLQQTEWYGNPRGYNISYKQLVKTPGTI--------------- 1257
            .  .|..:.:..|... .:..||:::|   ||.           :||.|:               
Zfish  1110 SVMAFKKSTQTFSTTD-SLYTIPVERT---GNR-----------ETPATVHWRTNKASRFDISSP 1159

  Fly  1258 -KYVP----RSVVIEDHTANSHVLDSLEEWTLYEVKMNACNDVGCSKESDTAV------------ 1305
             |:.|    ::::|...|..|.::.......|.:...||.  :|..|.::..|            
Zfish  1160 LKFAPGEAEKNILINPRTHPSPIIPEKFNLELLDPSNNAI--IGKRKTTEVIVTDGRGDGKNQDF 1222

  Fly  1306 ---ERTREAVPS-----YGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQQV 1362
               |...:...|     |.|.:::|.||....:.:.|  .|.|:.||....|.::....|:.:.:
Zfish  1223 QKMEYVTQTATSPGGRLYSPANIKAVATGPKNIRLNW--KPSQNANGYKVKYWIYGDPEDKAKFM 1285

  Fly  1363 LHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVPSNVSFPDVS 1427
            ..|| |.     ..||.|..|..|.::|..|..||:|..| ..|:.||.||.||.|..::|..:|
Zfish  1286 DVKT-PQ-----AELTNLDPYCDYEMRVCGYNALGDGNYS-DIIQCQTLEDIPGEPGRLAFNVIS 1343

  Fly  1428 LTMARIIWDVPVDPNGKILAYQVTYTLNGSAMLNYSREFP-----------PSDRTFRATELLPG 1481
            .|:.::.|..|.:.||.|..|:|.|     ..:|..:: |           |..|......|.|.
Zfish  1344 PTVTQVSWAEPAEANGIITGYEVIY-----MPINEDKK-PTGPPKKVMIDNPKKRMLLIENLQPS 1402

  Fly  1482 KYYSFSCTAQTRLGWGKIATALVYTTNNRERPQA-PSVPQISRSQIQAHQ-----ITFSWTPGRD 1540
            :.|.:...|..::|||....|.:...:...||.: |.:|.|.....:|.:     :.:|....|.
Zfish  1403 QTYCYKVRASNKVGWGPYREATINLASQPTRPMSIPIIPDIPIVDAEAGEEYDSYLMYSNEVLRS 1467

  Fly  1541 GFAPLRYYTVEMRENE---GRWQP---LPERVDPSLSSFTAVGLRPYMTYQFRIQATN------- 1592
            ..:.||....::.:::   |:|:.   .|.....|||...:.....|.....|...||       
Zfish  1468 PTSSLRPSVTDLSDDQFVNGKWEQNFLFPGGGGGSLSRNISSSSTTYSHSTPRTNVTNNSSTTTY 1532

  Fly  1593 ------------DLGPSAFSRESVIVRTLPAAPAVGVGGLKVVPITTTSVRVQWSALETALWNGD 1645
                        |:......:|.||:|..                :......:...:..::..|:
Zfish  1533 ISGKGGSTTHRYDVRDGGLLKEDVILRKR----------------SENRHYTEGDGVRDSIVMGN 1581

  Fly  1646 ASTGGYRIL----YQQLSDFPTALQSTPKTDVHGINENSVVLSDLQQDRNYEIVVLPFNSQGPG- 1705
            .|.|....|    :.|.:....:|.|..:|....||:..:.|..:.|:..:.          || 
Zfish  1582 LSGGLLDNLGVSSFSQTTSTSYSLSSRARTQSEDINDALLNLDSVLQESRFT----------PGV 1636

  Fly  1706 PATPPAAVYVGEAVPTGEPRAVDAAPISSTEVRLLWKPPKQSMQNGDILGYKIYYLVTYSPQALE 1770
            ||||...|:               :.:..|.:::.|:.|.   ...|:|||.:.|      |.:.
Zfish  1637 PATPSRLVF---------------SALGHTALKVSWQEPH---CESDVLGYCVLY------QLIN 1677

  Fly  1771 PGRKWEEEIEVVSATATSHSLVFLDKFTEYRIQLLAFNPAGDGP-RSAPITVKT----------L 1824
            .|.  .:.|||.:....|..:..|.....|..::.|.:..|.|| |...||:::          :
Zfish  1678 GGD--VKRIEVNNPAQNSVLVQDLLPNQSYIFKVKAQSREGWGPEREGVITIESNVDPKSPLSPV 1740

  Fly  1825 PG------VPSAPLHLRFSDITMQSLEVTWDPPKFLNGEILGYLVTYETTE-ENEKFSKQVKQKV 1882
            ||      .||||..|.|:.:...:|:::|:.|:..||:||||:||.|... ..:..|.||....
Zfish  1741 PGSPFTLSTPSAPGPLIFTALRPDTLQLSWEKPRKPNGDILGYVVTCEQLHGGGDLRSFQVNGNA 1805

  Fly  1883 SNTTLRVQNLEEEVTYTFTVRAQTSVDYGPGISENVTTGPQDG--------SPVAPRDLI-LTKT 1938
            : |:|.|.:|:|.:.|.|.|:|||:..:||.....:|...|||        ..|..|::. |...
Zfish  1806 A-TSLTVSDLKENMPYKFKVQAQTTQGFGPEREGIITIESQDGGSMSQYSSQSVTKREVFNLPTE 1869

  Fly  1939 LSSVEMHWINGP--SGRGPILGYLIEAKKRDDSRWTKIEQTRKGMMQDFTVS 1988
            ::.......:.|  |..|.::....:..:...|...::|..::|:|...||:
Zfish  1870 ITHTSHTMFSEPFVSSDGMMMMSSRQITESGGSMTRQVEMVQRGVMSSSTVT 1921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig 71..157 CDD:299845 14/85 (16%)
I-set 72..150 CDD:254352 13/77 (17%)
Ig 172..245 CDD:299845 14/74 (19%)
IG_like 280..356 CDD:214653 19/83 (23%)
Ig 280..343 CDD:299845 15/70 (21%)
IG_like 375..450 CDD:214653 21/112 (19%)
Ig 378..447 CDD:143165 17/102 (17%)
Ig 506..587 CDD:299845 20/87 (23%)
IG_like 506..587 CDD:214653 20/87 (23%)
I-set 592..682 CDD:254352 17/104 (16%)
Ig 595..682 CDD:299845 17/101 (17%)
FN3 686..789 CDD:238020 17/102 (17%)
FN3 798..893 CDD:238020 20/130 (15%)
FN3 901..1005 CDD:238020 23/122 (19%)
fn3 1011..1094 CDD:278470 18/98 (18%)
FN3 1108..1202 CDD:238020 16/94 (17%)
FN3 1210..1308 CDD:238020 22/134 (16%)
fn3 1317..1402 CDD:278470 24/84 (29%)
FN3 1415..1507 CDD:238020 26/102 (25%)
FN3 1513..1608 CDD:238020 23/125 (18%)
fn3 1617..1708 CDD:278470 15/95 (16%)
FN3 1722..1823 CDD:238020 23/101 (23%)
FN3 1828..1920 CDD:238020 34/92 (37%)
FN3 1927..2016 CDD:238020 12/65 (18%)
itgb4XP_005166847.1 Integrin_beta 37..457 CDD:278776 94/502 (19%)
EGF_2 <468..490 CDD:285248 4/21 (19%)
EGF_2 545..573 CDD:285248 8/58 (14%)
Integrin_B_tail 625..709 CDD:285239 24/146 (16%)
Calx-beta 991..1064 CDD:295344 17/85 (20%)
FN3 1242..1326 CDD:238020 26/92 (28%)
FN3 1331..1420 CDD:238020 25/94 (27%)
fn3 1640..1720 CDD:278470 21/105 (20%)
fn3 1751..1835 CDD:278470 32/84 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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