DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and DIP-beta

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	376	Identity:	75/376 - (19%)
Similarity:	126/376 - (33%)	Gaps:	110/376 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 PEIIVRPQDVKVKVGTGVVELQCIANARPLHEL---------ETLWLK-DGLAV----------- 304
            |:.::..::|.:..|.... ..|:.|....|.:         :..|:| |..|:
  Fly    98 PDFVIPLENVTIAQGRDAT-FTCVVNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIHEHVITNN 161

  Fly   305 ETAGVRHTLNDPWNRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAE 369
            :...|:|...:.|  ||.:.......:|:|.|||...    |....:|.|:::.||   ..:..|
  Fly   162 DRLSVQHNDYNTW--TLNIRGVKMEDAGKYMCQVNTD----PMKMQTATLEVVIPP---DIINEE 217

  Fly   370 TFGEF----GGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNT------------- 417
            |.|:.    ||..:|.|...|.|.|::.|.|         |.||..:..:.:
  Fly   218 TSGDMMVPEGGSAKLVCRARGHPKPKITWRR---------EDGREIIARNGSHQKTKAQSVEGEM 273

  Fly   418 LVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKG 482
            |.:.|:...:...:.|:|.|..            ..|...|:|       |:|...
  Fly   274 LTLSKITRSEMGAYMCIASNGV------------PPTVSKRMK-------LQVHFH--------- 310

  Fly   483 SESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRV 547
                             |::::|.|.|.|....|.|:.|....||.....|.....:::....|.
  Fly   311 -----------------PLVQVPNQLVGAPVLTDVTLICNVEASPKAINYWQRENGEMIIAGDRY 358

  Fly   548 QILESGD--------LLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVR 590
            .:.|..:        |.|..::|.|.|.|.|:..|..|..:|...|..:.|
  Fly   359 ALTEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSIGDTEGTIRLYEMER 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	20/96 (21%)
		Ig	280..343	CDD:299845	17/83 (20%)
		IG_like	375..450	CDD:214653	17/87 (20%)
		Ig	378..447	CDD:143165	15/81 (19%)
		Ig	506..587	CDD:299845	22/88 (25%)
		IG_like	506..587	CDD:214653	22/88 (25%)
		I-set	592..682	CDD:254352
		Ig	595..682	CDD:299845
		FN3	686..789	CDD:238020
		FN3	798..893	CDD:238020
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	23/117 (20%)
		ig	102..195	CDD:278476	19/95 (20%)
		IG_like	219..307	CDD:214653	22/115 (19%)
		Ig	221..307	CDD:299845	21/113 (19%)
		Ig	311..404	CDD:299845	23/92 (25%)
		IG_like	327..405	CDD:214653	18/77 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810