DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and Sdk1

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_808547.3	Gene:	Sdk1 / 330222	MGIID:	2444413	Length:	2193	Species:	Mus musculus

Alignment Length:	2250	Identity:	808/2250 - (35%)
Similarity:	1161/2250 - (51%)	Gaps:	196/2250 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 APRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDGVPVGDFSSSQFYRFHSTRREDAGS 135
            ||.|.|.|... .|..||:..:|.|.|.|.....::|:::...:..:||...|...|.::.|||.
Mouse    85 APYFKTEPGLP-QIHLEGNRLVLTCLAEGSWPLEFKWIRNDSELTTYSSEYKYIIPSLQKLDAGF 148

  Fly   136 YQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDG 200
            |:|:.||..|::...||::.|||||.|.:|.: |.||..||.|:.::.||.|.|.|.|.|..|..
Mouse   149 YRCVVRNRMGALLQRKSEIQVAYMGNFMDTDQ-RKTVSQGHAALLNLLPIVSCPQPQVTWFREGH 212

  Fly   201 PLNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVSGD--PYIEVAPEI 263
            .:....:.|.|..|||:||:...:|...|..:|:|.:.|:.::|.|:||:|:.|  .:..:||.|
Mouse   213 KIIPSSRIAITLENQLVILATTASDAGAYYVQAVNEKNGENKTSPFIHLSVARDTGTHEAMAPII 277

  Fly   264 IVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANS 328
            :|.|.:..|..|:....|:|||||||:.||...|.::|:.: |:|: |:    :.|.|.:....|
Mouse   278 VVAPGNRSVVAGSSETTLECIANARPVEELSVHWKRNGVRL-TSGL-HS----YGRRLTITNPTS 336

  Fly   329 SHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVK 393
            :.:|.|.|:..||...:....|.|.|.|:|||.|.....:...||....:.:.|..:|.|.|.::
Mouse   337 ADTGMYVCEATLRGSTFEPARARAFLSIIEPPYFTAEPESRILGEVEETMDIPCRAMGVPLPTLQ 401

  Fly   394 WFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNR 458
            |:::|..: :.:::.||.:.....|.|:||..:|:.:|||.|.||.||....|:|.|..
Mouse   402 WYKDAVPL-SKLQNPRYKVLPSGGLHIQKLSPEDSGIFQCFASNEGGEVQTHTYLDVTN------ 459

  Fly   459 VKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRA 523
                                                   .||.....|.:.|..||..|.:.|..
Mouse   460 ---------------------------------------IAPAFTQRPVDTTVTDGMTAVLRCEV 485

  Fly   524 VGSPNPNITWIYNETQLVDISSRV---QILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYL 585
            .|:|.|.|||......|...|.|:   .:||||.|.|:.:...|||.|.|..||...||...|.|
Mouse   486 SGAPKPAITWKRGNHILASGSVRIPRFMLLESGGLRIAPVFIQDAGNYTCYAANTEASVNASAML 550

  Fly   586 SVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQL 650
            :|..||.|:.||.|..|:.|.||||.|..:.||.......|.::....| .|:|.||.|:.||.|
Mouse   551 TVWNRTSIVHPPEDRVVIKGTTATLCCGATHDPRTSLRYVWKKDNVVIT-ASSSSRIVVEKDGSL 614

  Fly   651 EIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGFDG 715
            .|....:.|:|.|.|.:.|.||:::|.|||.|||||.||.|: :..|...:..|:.:||...|||
Mouse   615 VISQTWSGDIGDYTCEIISEGGSDSRTARLEVIELPHPPQNL-LASLSPARSHSVTLSWVRPFDG 678

  Fly   716 NSPISKFIIQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEG 780
            |||:..:|:|   |||..   .|   |...||||..:...:.:..|..|..|||||.|||:||:|
Mouse   679 NSPVLYYIVQ---VSENN---SP---WKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNQVGKG 734

  Fly   781 SPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVP 845
            ..|..::.:.||:|.||.||...|.|.|:...|:.|||||.|...||.:.||||||||.|   :|
Mouse   735 QYSTETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAG---LP 796

  Fly   846 WSYQ--NITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVE 908
            ..:|  ||::......|:.:||.|..|.:|:||||..|:||::......|.:|||.|||.||:.|
Mouse   797 GEHQQRNISSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQAE 861

  Fly   909 AINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMK--TVPPSLIDPLAEQTA 971
            |:|||.....|.||..|.|||||||||:.||.        .|....:.  |:.|   |.......
Mouse   862 AVNSTTVHFLWNPPPQQFINGINQGYKLLAWP--------ADAPETVTVVTIAP---DFHGIHHG 915

  Fly   972 ILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRAS 1036
            .:..|:|||.|..||||||.||||..||...|.|.:|.|..|..|.|.::.|.|:||.|..|...
Mouse   916 YITNLKKFTAYFTSVLCFTTPGDGPPSSPQLVWTHEDKPGAVGHLSFTEILDTSLKVSWQEPLER 980

  Fly  1037 NGILTGYTVRYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQS 1101
            |||:.||.:.::|..|.|:..:..|.:...|..:..|.:.|.|..::.|.|..|.|:..::||.|
Mouse   981 NGIIMGYQISWEVYGRNDSRLTHTLNSTMHEYKIQGLSSLTTYTIDVAALTAAGVGVTTSSTISS 1045

  Fly  1102 GVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQTAR---NMTWFTIC-EINDP 1162
            ||.|.||.||:.|.:|||...|..|||.||:||.::|.:|.||||...   ...|.|:. |.|:|
Mouse  1046 GVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTAICRWIVEGQVGAIGDEEEWVTLYEEENEP 1110

  Fly  1163 DAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVR 1227
            ||:.|.:..|.|:|.||.|:...|:||.|..|::::..||:||.|...|.::|||..|...||:|
Mouse  1111 DAQMLEIPNLTPYTHYRFRMRQVNIVGPSPFSQSSRVIQTLQAPPDVAPTSLTVRTASETSLRLR 1175

  Fly  1228 WIPLQQTEWYGNPR--GYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKMN 1290
            |:||..:::.|||.  ||.:.|.:..:....:     :.|:.|.......::.|||||.||::|.
Mouse  1176 WVPLPDSQYNGNPESVGYRVKYWRSDQPSSAL-----AQVVSDRLERELTIEELEEWTEYELRMQ 1235

  Fly  1291 ACNDVGCSKESDTAVERTREAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAA 1355
            |.|.:|....|:....||||:|||..|.:|.|.|.|||.:::.|..||.|.:||.|.||||.|.|
Mouse  1236 AFNAIGAGPWSELVRGRTRESVPSAAPENVSAEAVSSTQILLTWASVPEQDQNGLILGYKVLYCA 1300

  Fly  1356 ADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVPSN 1420
            .|...:.....:..|.|.:..|..|:|:|||.:||||:||:|||..|:|.|..:|.:||||.|..
Mouse  1301 KDLDPEPRSHVVRGNHTQSALLAGLRKFVVYELQVLAFTRIGNGVPSSPLILERTKDDTPGPPVR 1365

  Fly  1421 VSFPDVSLTMARIIWDVPVDPNGKILAYQVTYTL-NGSAMLNYSREFPPSDRTFRATELLPGKYY 1484
            :.||:|.||..||:|..|.:|||.||.||:.|.| :||.....:.|...:.|.|.||||.|...|
Mouse  1366 LVFPEVRLTAVRIVWQPPEEPNGVILGYQIAYRLASGSPHTFTTVEVGATVRQFTATELAPESAY 1430

  Fly  1485 SFSCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRSQIQAHQITFSWTPGRDGFAPLRYYT 1549
            .|..:|:||.|||:...|.|.||..||||..|....:.::::.|..:...|.||.||.:|:||:|
Mouse  1431 IFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFT 1495

  Fly  1550 VEMRE-NEGRWQPLPERVDPSLSSFTAVGLRPYMTYQFRIQATNDLGPSAFSRESVIVRTLPAAP 1613
            |::|| ..|.||.....:....::.....|||:.:|:.|::||||:|.|.||.|:..|.||...|
Mouse  1496 VQVRELPGGEWQTYSSSISHEATACAVERLRPFTSYKLRLKATNDIGDSDFSAETEAVTTLQDVP 1560

  Fly  1614 AVGVGGLKVVPITTTSVRVQWSALETALWNGDASTGGYRILYQQLSD------------FPTALQ 1666
            ....|.:...|.||:||.:||........||  ...||||.|::|..            .|:||:
Mouse  1561 GEPPGSVSATPHTTSSVLIQWQPPRDESLNG--LLQGYRIYYRELESETGMSPEPKTLKSPSALR 1623

  Fly  1667 S--TPKTDVHGINENSVV----LSDLQQDRNYEIVVLPFNSQGPGPATPPAAVYVGEAVPTGEPR 1725
            :  |.::....:|.:|.:    |:.|::.|.||:::..:|..|..||:.|..|:||||.|...|:
Mouse  1624 AELTAQSSFKTVNSSSSLTTYELTHLKKYRRYEVIMTAYNIIGESPASVPVEVFVGEAAPAMAPQ 1688

  Fly  1726 AVDAAPISSTEVRLLWKPPKQSMQNGDILGYKIYYLVTYSPQALEPGRKWE-------EEIEVVS 1783
            .|...|::::::.:.|.||....|||:|.|||:||              ||       |:::|:.
Mouse  1689 NVQVTPLTASQLEVTWDPPPPESQNGNIQGYKVYY--------------WEADSRNETEKMKVLF 1739

  Fly  1784 ATATSHSLVFLDKFTEYRIQLLAFNPAGDGPRSAPITVKTLPGVPSAPLHLRFSDITMQSLEVTW 1848
            .......:..|...|:|.|.:.|||.|||||:|.|...:|....|..|..|.||:||..:|.|:|
Mouse  1740 LPEPVVKIKDLTSHTKYLISISAFNAAGDGPKSDPCQGRTHQAAPGPPSFLAFSEITSTTLNVSW 1804

  Fly  1849 DPPKFLNGEILGYLVTYETTEENEKFSKQVKQKVSNT---TLRVQNLEEEVTYTFTVRAQTSVDY 1910
            ..|...||.:.||.|.||.....:..||.|...|...   .|:|::|.:.|||.|.|:|:| :.|
Mouse  1805 GEPSAANGILQGYRVVYEPLAPVQGVSKVVTVDVKGNWQRWLKVRDLTKGVTYFFRVQART-IAY 1868

  Fly  1911 GPGISENVTTGPQDGSPVAPRDLILTKTLSSVEMHWINGPSGRGPILGYLIEAKKRDDSRWTKIE 1975
            ||.:..|||.||.:|||.:||::::||:.|.:.:.|..|.:|..|..||:|||:..|:..|....
Mouse  1869 GPELQANVTAGPAEGSPGSPRNVLVTKSASELTLQWTEGNAGTTPTTGYVIEARPSDEGLWDMFA 1933

  Fly  1976 QTRKGMMQDFTVSYHILMPSTAYTFRVIAYNRYGISFPVYSKDSILTPSKLHLEYGYLQHKPFYR 2040
            :........:||....|.....|.|||:|.|:.|...|  |:.||...::        ...|||.
Mouse  1934 KDIPRSATSYTVDLDKLRQGVTYEFRVVAVNKAGFGEP--SRPSIAVSAQ--------AEAPFYE 1988

  Fly  2041 QTWFMVSLAATSIVIIVMVIAVLCVKSKSYKYKQ----EAQKTLEESMAMSIDERQELALELYRS 2101
            :.||::.:|.:|:::|::|:.||.:..:|.|||.    :....:||:  :::|.....|||| .|
Mouse  1989 EWWFLLVMALSSLLLILLVVFVLVLHGQSKKYKSCSTGKGISNMEET--VTLDNGGFAALEL-NS 2050

  Fly  2102 RHGVGTGTLNSVGTLRSGTLGTLGRKSTSRPPPGVHLGKSPPRPSPASVAYHSDEESLKCYDENP 2166
            ||                    |..|||.....|.   :|||||||..:.| |||:....|:...
Mouse  2051 RH--------------------LNVKSTFSKKNGT---RSPPRPSPGGLHY-SDEDICNKYNGAV 2091

  Fly  2167 DDSSVTEKPSEVSSSEASQHSESENESVRSDPHSFVNHYANVNDSLRQSWKKTKPV---RNYSSY 2228
            ...||..|...|..|| |:.|:|:.|.. ...|||||||.: :.:...|||:..|.   ..|.:.
Mouse  2092 LTESVNLKEKSVDGSE-SEASDSDYEEA-LPKHSFVNHYMS-DPTYYNSWKRRPPAAAPHRYEAV 2153

  Fly  2229 TDSE--PE-GSAVMSLNGGQIIVNNMARSRAPLPGFSSFV 2265
            ..:|  |. .:.:.:.:.|.:.......:||||.||||||
Mouse  2154 AGAEAGPHLHTVITTQSAGGVYTPAGPGARAPLTGFSSFV 2193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	27/85 (32%)
		I-set	72..150	CDD:254352	24/77 (31%)
		Ig	172..245	CDD:299845	24/72 (33%)
		IG_like	280..356	CDD:214653	26/75 (35%)
		Ig	280..343	CDD:299845	23/62 (37%)
		IG_like	375..450	CDD:214653	23/74 (31%)
		Ig	378..447	CDD:143165	21/68 (31%)
		Ig	506..587	CDD:299845	32/83 (39%)
		IG_like	506..587	CDD:214653	32/83 (39%)
		I-set	592..682	CDD:254352	35/89 (39%)
		Ig	595..682	CDD:299845	34/86 (40%)
		FN3	686..789	CDD:238020	39/102 (38%)
		FN3	798..893	CDD:238020	40/96 (42%)
		FN3	901..1005	CDD:238020	46/105 (44%)
		fn3	1011..1094	CDD:278470	26/82 (32%)
		FN3	1108..1202	CDD:238020	40/97 (41%)
		FN3	1210..1308	CDD:238020	31/99 (31%)
		fn3	1317..1402	CDD:278470	38/84 (45%)
		FN3	1415..1507	CDD:238020	41/92 (45%)
		FN3	1513..1608	CDD:238020	33/95 (35%)
		fn3	1617..1708	CDD:278470	30/108 (28%)
		FN3	1722..1823	CDD:238020	33/107 (31%)
		FN3	1828..1920	CDD:238020	37/94 (39%)
		FN3	1927..2016	CDD:238020	28/88 (32%)
Sdk1	NP_808547.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		Ig_2	94..169	CDD:290606	22/75 (29%)
		IG_like	100..169	CDD:214653	21/68 (31%)
		IG_like	183..263	CDD:214653	29/79 (37%)
		Ig	197..247	CDD:299845	17/49 (35%)
		IG_like	281..357	CDD:214653	26/81 (32%)
		IGc2	294..347	CDD:197706	21/58 (36%)
		I-set	368..457	CDD:254352	27/89 (30%)
		Ig	388..454	CDD:143165	21/66 (32%)
		I-set	462..552	CDD:254352	33/89 (37%)
		Ig	476..552	CDD:299845	29/75 (39%)
		I-set	557..646	CDD:254352	35/89 (39%)
		Ig	562..646	CDD:299845	33/84 (39%)
		FN3	650..741	CDD:238020	39/100 (39%)
		fn3	753..839	CDD:278470	40/88 (45%)
		FN3	854..949	CDD:238020	46/105 (44%)
		FN3	954..1036	CDD:238020	26/81 (32%)
		FN3	1052..1148	CDD:238020	40/95 (42%)
		FN3	1158..1253	CDD:238020	31/99 (31%)
		FN3	1261..1349	CDD:238020	39/87 (45%)
		FN3	1360..1453	CDD:238020	41/92 (45%)
		FN3	1459..1554	CDD:238020	32/94 (34%)
		FN3	1562..1676	CDD:238020	32/115 (28%)
		FN3	1686..1779	CDD:238020	33/106 (31%)
		FN3	1784..1865	CDD:238020	31/80 (39%)
		FN3	1885..1978	CDD:238020	31/94 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2057..2080		11/26 (42%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2187..2193		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7587
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1346	1.000	Inparanoid score	I144
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46050
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002891
OrthoInspector	1	1.000	-	-		otm43888
orthoMCL	1	0.900	-	-		OOG6_104033
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4749
SonicParanoid	1	1.000	-	-		X1909
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760