DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and Sdk1

DIOPT Version :10

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_808547.3 Gene:Sdk1 / 330222 MGIID:2444413 Length:2193 Species:Mus musculus


Alignment Length:2250 Identity:808/2250 - (35%)
Similarity:1161/2250 - (51%) Gaps:196/2250 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 APRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDGVPVGDFSSSQFYRFHSTRREDAGS 135
            ||.|.|.|... .|..||:..:|.|.|.|.....::|:::...:..:||...|...|.::.|||.
Mouse    85 APYFKTEPGLP-QIHLEGNRLVLTCLAEGSWPLEFKWIRNDSELTTYSSEYKYIIPSLQKLDAGF 148

  Fly   136 YQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDG 200
            |:|:.||..|::...||::.|||||.|.:|.: |.||..||.|:.::.||.|.|.|.|.|..|..
Mouse   149 YRCVVRNRMGALLQRKSEIQVAYMGNFMDTDQ-RKTVSQGHAALLNLLPIVSCPQPQVTWFREGH 212

  Fly   201 PLNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVSGD--PYIEVAPEI 263
            .:....:.|.|..|||:||:...:|...|..:|:|.:.|:.::|.|:||:|:.|  .:..:||.|
Mouse   213 KIIPSSRIAITLENQLVILATTASDAGAYYVQAVNEKNGENKTSPFIHLSVARDTGTHEAMAPII 277

  Fly   264 IVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANS 328
            :|.|.:..|..|:....|:|||||||:.||...|.::|:.: |:|: |:    :.|.|.:....|
Mouse   278 VVAPGNRSVVAGSSETTLECIANARPVEELSVHWKRNGVRL-TSGL-HS----YGRRLTITNPTS 336

  Fly   329 SHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVK 393
            :.:|.|.|:..||...:....|.|.|.|:|||.|.....:...||....:.:.|..:|.|.|.::
Mouse   337 ADTGMYVCEATLRGSTFEPARARAFLSIIEPPYFTAEPESRILGEVEETMDIPCRAMGVPLPTLQ 401

  Fly   394 WFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNR 458
            |:::|..: :.:::.||.:.....|.|:||..:|:.:|||.|.||.||....|:|.|..      
Mouse   402 WYKDAVPL-SKLQNPRYKVLPSGGLHIQKLSPEDSGIFQCFASNEGGEVQTHTYLDVTN------ 459

  Fly   459 VKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRA 523
                                                   .||.....|.:.|..||..|.:.|..
Mouse   460 ---------------------------------------IAPAFTQRPVDTTVTDGMTAVLRCEV 485

  Fly   524 VGSPNPNITWIYNETQLVDISSRV---QILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYL 585
            .|:|.|.|||......|...|.|:   .:||||.|.|:.:...|||.|.|..||...||...|.|
Mouse   486 SGAPKPAITWKRGNHILASGSVRIPRFMLLESGGLRIAPVFIQDAGNYTCYAANTEASVNASAML 550

  Fly   586 SVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQL 650
            :|..||.|:.||.|..|:.|.||||.|..:.||.......|.::....| .|:|.||.|:.||.|
Mouse   551 TVWNRTSIVHPPEDRVVIKGTTATLCCGATHDPRTSLRYVWKKDNVVIT-ASSSSRIVVEKDGSL 614

  Fly   651 EIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGFDG 715
            .|....:.|:|.|.|.:.|.||:::|.|||.|||||.||.|: :..|...:..|:.:||...|||
Mouse   615 VISQTWSGDIGDYTCEIISEGGSDSRTARLEVIELPHPPQNL-LASLSPARSHSVTLSWVRPFDG 678

  Fly   716 NSPISKFIIQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEG 780
            |||:..:|:|   |||..   .|   |...||||..:...:.:..|..|..|||||.|||:||:|
Mouse   679 NSPVLYYIVQ---VSENN---SP---WKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNQVGKG 734

  Fly   781 SPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVP 845
            ..|..::.:.||:|.||.||...|.|.|:...|:.|||||.|...||.:.||||||||.|   :|
Mouse   735 QYSTETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAG---LP 796

  Fly   846 WSYQ--NITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVE 908
            ..:|  ||::......|:.:||.|..|.:|:||||..|:||::......|.:|||.|||.||:.|
Mouse   797 GEHQQRNISSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQAE 861

  Fly   909 AINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMK--TVPPSLIDPLAEQTA 971
            |:|||.....|.||..|.|||||||||:.||.        .|....:.  |:.|   |.......
Mouse   862 AVNSTTVHFLWNPPPQQFINGINQGYKLLAWP--------ADAPETVTVVTIAP---DFHGIHHG 915

  Fly   972 ILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRAS 1036
            .:..|:|||.|..||||||.||||..||...|.|.:|.|..|..|.|.::.|.|:||.|..|...
Mouse   916 YITNLKKFTAYFTSVLCFTTPGDGPPSSPQLVWTHEDKPGAVGHLSFTEILDTSLKVSWQEPLER 980

  Fly  1037 NGILTGYTVRYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQS 1101
            |||:.||.:.::|..|.|:..:..|.:...|..:..|.:.|.|..::.|.|..|.|:..::||.|
Mouse   981 NGIIMGYQISWEVYGRNDSRLTHTLNSTMHEYKIQGLSSLTTYTIDVAALTAAGVGVTTSSTISS 1045

  Fly  1102 GVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQTAR---NMTWFTIC-EINDP 1162
            ||.|.||.||:.|.:|||...|..|||.||:||.::|.:|.||||...   ...|.|:. |.|:|
Mouse  1046 GVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTAICRWIVEGQVGAIGDEEEWVTLYEEENEP 1110

  Fly  1163 DAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVR 1227
            ||:.|.:..|.|:|.||.|:...|:||.|..|::::..||:||.|...|.::|||..|...||:|
Mouse  1111 DAQMLEIPNLTPYTHYRFRMRQVNIVGPSPFSQSSRVIQTLQAPPDVAPTSLTVRTASETSLRLR 1175

  Fly  1228 WIPLQQTEWYGNPR--GYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKMN 1290
            |:||..:::.|||.  ||.:.|.:..:....:     :.|:.|.......::.|||||.||::|.
Mouse  1176 WVPLPDSQYNGNPESVGYRVKYWRSDQPSSAL-----AQVVSDRLERELTIEELEEWTEYELRMQ 1235

  Fly  1291 ACNDVGCSKESDTAVERTREAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAA 1355
            |.|.:|....|:....||||:|||..|.:|.|.|.|||.:::.|..||.|.:||.|.||||.|.|
Mouse  1236 AFNAIGAGPWSELVRGRTRESVPSAAPENVSAEAVSSTQILLTWASVPEQDQNGLILGYKVLYCA 1300

  Fly  1356 ADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVPSN 1420
            .|...:.....:..|.|.:..|..|:|:|||.:||||:||:|||..|:|.|..:|.:||||.|..
Mouse  1301 KDLDPEPRSHVVRGNHTQSALLAGLRKFVVYELQVLAFTRIGNGVPSSPLILERTKDDTPGPPVR 1365

  Fly  1421 VSFPDVSLTMARIIWDVPVDPNGKILAYQVTYTL-NGSAMLNYSREFPPSDRTFRATELLPGKYY 1484
            :.||:|.||..||:|..|.:|||.||.||:.|.| :||.....:.|...:.|.|.||||.|...|
Mouse  1366 LVFPEVRLTAVRIVWQPPEEPNGVILGYQIAYRLASGSPHTFTTVEVGATVRQFTATELAPESAY 1430

  Fly  1485 SFSCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRSQIQAHQITFSWTPGRDGFAPLRYYT 1549
            .|..:|:||.|||:...|.|.||..||||..|....:.::::.|..:...|.||.||.:|:||:|
Mouse  1431 IFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFT 1495

  Fly  1550 VEMRE-NEGRWQPLPERVDPSLSSFTAVGLRPYMTYQFRIQATNDLGPSAFSRESVIVRTLPAAP 1613
            |::|| ..|.||.....:....::.....|||:.:|:.|::||||:|.|.||.|:..|.||...|
Mouse  1496 VQVRELPGGEWQTYSSSISHEATACAVERLRPFTSYKLRLKATNDIGDSDFSAETEAVTTLQDVP 1560

  Fly  1614 AVGVGGLKVVPITTTSVRVQWSALETALWNGDASTGGYRILYQQLSD------------FPTALQ 1666
            ....|.:...|.||:||.:||........||  ...||||.|::|..            .|:||:
Mouse  1561 GEPPGSVSATPHTTSSVLIQWQPPRDESLNG--LLQGYRIYYRELESETGMSPEPKTLKSPSALR 1623

  Fly  1667 S--TPKTDVHGINENSVV----LSDLQQDRNYEIVVLPFNSQGPGPATPPAAVYVGEAVPTGEPR 1725
            :  |.::....:|.:|.:    |:.|::.|.||:::..:|..|..||:.|..|:||||.|...|:
Mouse  1624 AELTAQSSFKTVNSSSSLTTYELTHLKKYRRYEVIMTAYNIIGESPASVPVEVFVGEAAPAMAPQ 1688

  Fly  1726 AVDAAPISSTEVRLLWKPPKQSMQNGDILGYKIYYLVTYSPQALEPGRKWE-------EEIEVVS 1783
            .|...|::::::.:.|.||....|||:|.|||:||              ||       |:::|:.
Mouse  1689 NVQVTPLTASQLEVTWDPPPPESQNGNIQGYKVYY--------------WEADSRNETEKMKVLF 1739

  Fly  1784 ATATSHSLVFLDKFTEYRIQLLAFNPAGDGPRSAPITVKTLPGVPSAPLHLRFSDITMQSLEVTW 1848
            .......:..|...|:|.|.:.|||.|||||:|.|...:|....|..|..|.||:||..:|.|:|
Mouse  1740 LPEPVVKIKDLTSHTKYLISISAFNAAGDGPKSDPCQGRTHQAAPGPPSFLAFSEITSTTLNVSW 1804

  Fly  1849 DPPKFLNGEILGYLVTYETTEENEKFSKQVKQKVSNT---TLRVQNLEEEVTYTFTVRAQTSVDY 1910
            ..|...||.:.||.|.||.....:..||.|...|...   .|:|::|.:.|||.|.|:|:| :.|
Mouse  1805 GEPSAANGILQGYRVVYEPLAPVQGVSKVVTVDVKGNWQRWLKVRDLTKGVTYFFRVQART-IAY 1868

  Fly  1911 GPGISENVTTGPQDGSPVAPRDLILTKTLSSVEMHWINGPSGRGPILGYLIEAKKRDDSRWTKIE 1975
            ||.:..|||.||.:|||.:||::::||:.|.:.:.|..|.:|..|..||:|||:..|:..|....
Mouse  1869 GPELQANVTAGPAEGSPGSPRNVLVTKSASELTLQWTEGNAGTTPTTGYVIEARPSDEGLWDMFA 1933

  Fly  1976 QTRKGMMQDFTVSYHILMPSTAYTFRVIAYNRYGISFPVYSKDSILTPSKLHLEYGYLQHKPFYR 2040
            :........:||....|.....|.|||:|.|:.|...|  |:.||...::        ...|||.
Mouse  1934 KDIPRSATSYTVDLDKLRQGVTYEFRVVAVNKAGFGEP--SRPSIAVSAQ--------AEAPFYE 1988

  Fly  2041 QTWFMVSLAATSIVIIVMVIAVLCVKSKSYKYKQ----EAQKTLEESMAMSIDERQELALELYRS 2101
            :.||::.:|.:|:::|::|:.||.:..:|.|||.    :....:||:  :::|.....|||| .|
Mouse  1989 EWWFLLVMALSSLLLILLVVFVLVLHGQSKKYKSCSTGKGISNMEET--VTLDNGGFAALEL-NS 2050

  Fly  2102 RHGVGTGTLNSVGTLRSGTLGTLGRKSTSRPPPGVHLGKSPPRPSPASVAYHSDEESLKCYDENP 2166
            ||                    |..|||.....|.   :|||||||..:.| |||:....|:...
Mouse  2051 RH--------------------LNVKSTFSKKNGT---RSPPRPSPGGLHY-SDEDICNKYNGAV 2091

  Fly  2167 DDSSVTEKPSEVSSSEASQHSESENESVRSDPHSFVNHYANVNDSLRQSWKKTKPV---RNYSSY 2228
            ...||..|...|..|| |:.|:|:.|.. ...|||||||.: :.:...|||:..|.   ..|.:.
Mouse  2092 LTESVNLKEKSVDGSE-SEASDSDYEEA-LPKHSFVNHYMS-DPTYYNSWKRRPPAAAPHRYEAV 2153

  Fly  2229 TDSE--PE-GSAVMSLNGGQIIVNNMARSRAPLPGFSSFV 2265
            ..:|  |. .:.:.:.:.|.:.......:||||.||||||
Mouse  2154 AGAEAGPHLHTVITTQSAGGVYTPAGPGARAPLTGFSSFV 2193

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig_3 72..142 CDD:464046 21/69 (30%)
Ig 280..344 CDD:409353 23/63 (37%)
Ig strand B 280..283 CDD:409353 1/2 (50%)
Ig strand C 292..298 CDD:409353 2/5 (40%)
Ig strand E 319..323 CDD:409353 2/3 (67%)
Ig strand F 333..338 CDD:409353 2/4 (50%)
Ig 360..451 CDD:472250 27/90 (30%)
Ig strand B 378..382 CDD:409353 0/3 (0%)
Ig strand C 391..395 CDD:409353 0/3 (0%)
Ig strand E 416..420 CDD:409353 1/3 (33%)
Ig strand F 430..435 CDD:409353 3/4 (75%)
Ig strand G 443..446 CDD:409353 0/2 (0%)
Ig 502..587 CDD:472250 32/87 (37%)
Ig strand B 517..521 CDD:409353 1/3 (33%)
Ig strand C 530..534 CDD:409353 2/3 (67%)
Ig strand E 554..557 CDD:409353 1/2 (50%)
Ig strand F 567..572 CDD:409353 2/4 (50%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 35/89 (39%)
Ig strand B 608..612 CDD:409353 3/3 (100%)
Ig strand C 623..627 CDD:409353 0/3 (0%)
Ig strand E 648..652 CDD:409353 2/3 (67%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 1/2 (50%)
FN3 686..789 CDD:238020 39/102 (38%)
FN3 798..893 CDD:238020 40/96 (42%)
FN3 901..1005 CDD:238020 46/105 (44%)
FN3 <960..>1261 CDD:442628 118/306 (39%)
fn3 1317..1402 CDD:394996 38/84 (45%)
FN3 1415..1507 CDD:238020 41/92 (45%)
FN3 1513..1608 CDD:238020 33/95 (35%)
FN3 1583..>2011 CDD:442628 156/455 (34%)
Sdk1NP_808547.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..56
Ig_3 86..155 CDD:464046 21/69 (30%)
Ig 180..248 CDD:472250 24/68 (35%)
Ig strand B 190..194 CDD:409353 1/3 (33%)
Ig strand C 204..208 CDD:409353 1/3 (33%)
Ig strand E 227..230 CDD:409353 2/2 (100%)
Ig strand F 240..245 CDD:409353 1/4 (25%)
Ig_3 275..347 CDD:464046 27/77 (35%)
Ig 368..457 CDD:472250 27/89 (30%)
Ig strand B 386..390 CDD:409353 0/3 (0%)
Ig strand C 399..403 CDD:409353 0/3 (0%)
Ig strand E 423..427 CDD:409353 1/3 (33%)
Ig strand F 437..442 CDD:409353 3/4 (75%)
Ig strand G 450..453 CDD:409353 0/2 (0%)
I-set 462..552 CDD:400151 33/89 (37%)
Ig strand B 479..483 CDD:409353 1/3 (33%)
Ig strand C 492..496 CDD:409353 2/3 (67%)
Ig strand E 518..522 CDD:409353 2/3 (67%)
Ig strand F 532..537 CDD:409353 2/4 (50%)
Ig strand G 545..548 CDD:409353 0/2 (0%)
FN3 <554..943 CDD:442628 173/413 (42%)
fn3 652..737 CDD:394996 37/94 (39%)
fn3 753..839 CDD:394996 40/88 (45%)
FN3 954..1036 CDD:238020 26/81 (32%)
FN3 1022..>1415 CDD:442628 163/397 (41%)
FN3 1360..1453 CDD:238020 41/92 (45%)
FN3 <1501..1923 CDD:442628 150/438 (34%)
FN3 1885..1978 CDD:238020 31/94 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2057..2080 11/26 (42%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2187..2193 4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.