DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and Negr1

DIOPT Version :9

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:XP_036019026.1 Gene:Negr1 / 320840 MGIID:2444846 Length:362 Species:Mus musculus


Alignment Length:376 Identity:79/376 - (21%)
Similarity:127/376 - (33%) Gaps:113/376 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   263 IIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLA----VETAGVRHTLNDPW------ 317
            ::||..|..|        |:|             :|:||.:    :..:.:.....|.|      
Mouse    42 MLVRKGDTAV--------LRC-------------YLEDGASKGAWLNRSSIIFAGGDKWSVDPRV 85

  Fly   318 --------NRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEF 374
                    :.:|.:...:.:..|.|||.|:.:   :...:....|.:..||..:......|..| 
Mouse    86 SISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQ---HTPRTMQVHLTVQVPPKIYDISNDMTINE- 146

  Fly   375 GGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEA 439
            |..|.|||...|:|.|.:.| |:........|:|:|       |.|..:..|.|..::|.|.|: 
Mouse   147 GTNVTLTCLATGKPEPVISW-RHISPSAKPFENGQY-------LDIYGITRDQAGEYECSAEND- 202

  Fly   440 GENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMEL 504
                                  ::.|.:.:||..                    ..||.. |.|:
Mouse   203 ----------------------VSFPDVKKVRVI--------------------VNFAPT-IQEI 224

  Fly   505 PPQNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQILESGD---LLISNIRSVDAG 566
            ....||  .|:...|.|...|.|.|...|...|.:|.:....:.|.....   |.::|:.....|
Mouse   225 KSGTVT--PGRSGLIRCEGAGVPPPAFEWYKGEKRLFNGQQGIIIQNFSTRSILTVTNVTQEHFG 287

  Fly   567 LYICVRANEAGSVKGEAYLSVLVRTQIIQP--------PVDTTVLLGLTAT 609
            .|.||.||:.|:......|:     |||:|        |..:|...|:|.:
Mouse   288 NYTCVAANKLGTTNASLPLN-----QIIEPTTSSPVTSPAPSTAQYGITGS 333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig 71..157 CDD:299845
I-set 72..150 CDD:254352
Ig 172..245 CDD:299845
IG_like 280..356 CDD:214653 14/93 (15%)
Ig 280..343 CDD:299845 13/80 (16%)
IG_like 375..450 CDD:214653 20/74 (27%)
Ig 378..447 CDD:143165 19/68 (28%)
Ig 506..587 CDD:299845 22/83 (27%)
IG_like 506..587 CDD:214653 22/83 (27%)
I-set 592..682 CDD:254352 8/26 (31%)
Ig 595..682 CDD:299845 5/23 (22%)
FN3 686..789 CDD:238020
FN3 798..893 CDD:238020
FN3 901..1005 CDD:238020
fn3 1011..1094 CDD:278470
FN3 1108..1202 CDD:238020
FN3 1210..1308 CDD:238020
fn3 1317..1402 CDD:278470
FN3 1415..1507 CDD:238020
FN3 1513..1608 CDD:238020
fn3 1617..1708 CDD:278470
FN3 1722..1823 CDD:238020
FN3 1828..1920 CDD:238020
FN3 1927..2016 CDD:238020
Negr1XP_036019026.1 FR1 38..55 CDD:409353 6/33 (18%)
Ig strand A' 40..46 CDD:409353 1/3 (33%)
IG_like 41..129 CDD:214653 18/110 (16%)
Ig strand B 48..56 CDD:409353 4/28 (14%)
CDR1 56..60 CDD:409353 2/3 (67%)
FR2 61..68 CDD:409353 0/6 (0%)
Ig strand C 61..67 CDD:409353 0/5 (0%)
CDR2 69..79 CDD:409353 1/9 (11%)
Ig strand C' 71..74 CDD:409353 0/2 (0%)
Ig strand C' 76..79 CDD:409353 1/2 (50%)
FR3 80..115 CDD:409353 5/34 (15%)
Ig strand D 84..91 CDD:409353 0/6 (0%)
Ig strand E 94..100 CDD:409353 1/5 (20%)
Ig strand F 107..115 CDD:409353 4/7 (57%)
CDR3 116..120 CDD:409353 0/6 (0%)
Ig strand G 120..129 CDD:409353 1/8 (13%)
FR4 122..129 CDD:409353 1/6 (17%)
Ig strand A' 139..144 CDD:409353 0/4 (0%)
IGc2 146..204 CDD:197706 21/89 (24%)
Ig strand B 150..157 CDD:409353 4/6 (67%)
Ig strand C 163..168 CDD:409353 1/5 (20%)
Ig strand C' 170..172 CDD:409353 0/1 (0%)
Ig strand E 180..186 CDD:409353 3/12 (25%)
Ig strand F 193..200 CDD:409353 1/6 (17%)
Ig_3 219..295 CDD:404760 20/78 (26%)
putative Ig strand A 219..225 CDD:409353 2/6 (33%)
Ig strand B 235..239 CDD:409353 1/3 (33%)
Ig strand C 248..252 CDD:409353 0/3 (0%)
Ig strand E 274..278 CDD:409353 1/3 (33%)
Ig strand F 288..293 CDD:409353 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.