DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and DIP-kappa

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	149/783 - (19%)
Similarity:	230/783 - (29%)	Gaps:	282/783 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 KGYRAKAINTQLGKEESSAFVHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANARPLH 291
            ||...: ::||...:|.|.|              |.......:|.|.||...: :.|:  ...|.
  Fly    55 KGKHTR-LDTQQTAQEDSDF--------------PRFAEPIANVTVSVGRDAL-MACV--VENLK 101

  Fly   292 ELETLWLKDGLAVET---AGVRH-----------TLNDPWNRTLALLQANSSHSGEYTCQVRLRS 342
            ..:..|::    |:|   ..:.|           |.||..:..|.:.:...:..|.|.|||...
  Fly   102 GYKVAWVR----VDTQTILSIHHNVISQNSRISLTYNDHRSWYLHIKEVEETDRGWYMCQVNTD- 161

  Fly   343 GGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQ-VQLTCDVVGEPTPQVKWFRNAESVDAHIE 406
               |..|....||::.||:....:.:.......|| :.|.|...|.|.|.|.|.|  |..:..:.
  Fly   162 ---PMRSRKGYLQVVVPPIIVEGLTSNDMVVREGQNISLVCKARGYPEPYVMWRR--EDGEEMLI 221

  Fly   407 SGRYTLNTDNTLV-IKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRV 470
            .|.:....|..|: |.|:.....|.:.|:|.|.                        ..|.|
  Fly   222 GGEHVNVVDGELLHITKVSRLHMAAYLCVASNG------------------------VPPSI--- 259

  Fly   471 RASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIY 535
                              .:|...|....|::.:|.|...|..|:|..:.|.....|.....|
  Fly   260 ------------------SKRVHLRVQFPPMLSIPNQLEGAYLGQDVILECHTEAYPASINYW-- 304

  Fly   536 NETQLVDISSRVQILESGDLLISN------------------------IRSV---DAGLYICVRA 573
                         ..|.||::||:                        ||:|   |.|.|.||..
  Fly   305 -------------TTERGDMIISDTSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVAK 356

  Fly   574 NEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATL----------QCKVSSDPSVP-YNIDWY 627
            |..|...|...|.        :.|..||.::...:.|          :.|..|..::| |.::.:
  Fly   357 NSLGETDGNIKLD--------EMPTPTTAIISEMSLLNRSYDGKRRHRNKFDSANALPDYGVEEW 413

  Fly   628 REGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNV 692
            |:|.......|        :|......||           ..||.....|..|:
  Fly   414 RDGAQGNNAGN--------NGDNNQTPVR-----------NPPGAFHNSAGSLA----------- 448

  Fly   693 KVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVSELGPVPDPLLNWITELSNVSADQRWIL 757
                     |.::......|....|    |.|.:|..|.|.........|::.||.|||..||
  Fly   449 ---------QHNLLAKIMLGIKTQS----FGIFKRLSSSLPLAAGQSFLWLSTLSLVSAPSRW-- 498

  Fly   758 LENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEI-------IT 815
                        |:|.|    |..|:.|..||.....|..     :...:..:||.       ||
  Fly   499 ------------RMSNV----ENRPNSPETVVNNDTAAEC-----WETRSHCVSESNNNNNSRIT 542

  Fly   816 QWQPPLEEHRNGQILGYILRYRLFGYNNVP----WSYQNITNEAQRNFLIQELITWK-------- 868
            | :||:          :....|:|...:.|    ..||.:   .:|.:..|.|..|:
  Fly   543 Q-RPPM----------WARHLRIFHIAHTPCGASTQYQRL---CERQWQWQRLWQWQCQWKWQHQ 593

  Fly   869 -----------------DYIVQIAAYNNMGVGVYT----------------EGSKIKTKEGVPEA 900
                             .::..:..:....:|.::                .|:|:..|...|..
  Fly   594 WQWPMLICIVILAGCFVRWLPMLLHFIGRHIGTFSISATHRQHLMCTFWDNRGNKVVAKNTTPAR 658

  Fly   901 PPT 903
            |.|
  Fly   659 PST 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845	5/17 (29%)
		IG_like	280..356	CDD:214653	18/89 (20%)
		Ig	280..343	CDD:299845	15/76 (20%)
		IG_like	375..450	CDD:214653	20/76 (26%)
		Ig	378..447	CDD:143165	18/69 (26%)
		Ig	506..587	CDD:299845	24/107 (22%)
		IG_like	506..587	CDD:214653	24/107 (22%)
		I-set	592..682	CDD:254352	18/100 (18%)
		Ig	595..682	CDD:299845	18/97 (19%)
		FN3	686..789	CDD:238020	22/102 (22%)
		FN3	798..893	CDD:238020	19/146 (13%)
		FN3	901..1005	CDD:238020	2/3 (67%)
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	22/102 (22%)
		IG_like	82..174	CDD:214653	23/102 (23%)
		IG_like	184..267	CDD:214653	23/129 (18%)
		IGc2	191..255	CDD:197706	20/89 (22%)
		IG_like	282..368	CDD:214653	22/100 (22%)
		Ig	288..367	CDD:143165	19/93 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810