DRSC/TRiP Functional Genomics Resources

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Protein Alignment sdk and Robo3

DIOPT Version :10

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:XP_063121496.1 Gene:Robo3 / 315564 RGDID:1311018 Length:1413 Species:Rattus norvegicus


Alignment Length:1485 Identity:282/1485 - (18%)
Similarity:467/1485 - (31%) Gaps:482/1485 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 PRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDGVPVGDF------------SSSQFYR 124
            ||....|..  .:||.|....|.|.|.|.|:|...|.|:|..|...            |.:.|:.
  Rat    77 PRIVEQPPD--LLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATAREDPRAHRLLLPSGALFFP 139

  Fly   125 --FHSTR-REDAGSYQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIE 186
              .|..| |.|.|.|.|:|||..|:..|..:.:.||.:......:.|.:.|..|.||:.:..|.:
  Rat   140 RIVHGRRSRPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVMECVPPK 204

  Fly   187 SIPVPSVMWQSEDGPLNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNV 251
            ..|.|.|.|                              :||      ||:|.:||.    .:.:
  Rat   205 GHPEPLVTW------------------------------KKG------NTKLKEEEG----RITI 229

  Fly   252 SGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDP 316
            .|...:                                                   :.||.   
  Rat   230 RGGKLM---------------------------------------------------MSHTF--- 240

  Fly   317 WNRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFF-TPMRAETFGEFGGQVQL 380
                       .|.:|.|.|.....:|  ...|.:|.|.:||.|.|. .|:......:  ..|..
  Rat   241 -----------KSDAGMYMCVASNMAG--ERESGAAELVVLERPSFLRRPINQVVLAD--APVNF 290

  Fly   381 TCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSAS 445
            .|:|.|:|.|.::|.::    |..:.:|||.:.:|::|.|:::..:|...:.|:|.|..|...||
  Rat   291 LCEVQGDPQPNLRWRKD----DGELPTGRYEIRSDHSLWIEQVSAEDEGTYTCVAENSVGRAEAS 351

  Fly   446 TWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVT 510
            ..|.|..                                              .|.....|||.|
  Rat   352 GSLSVHV----------------------------------------------PPQFVTKPQNQT 370

  Fly   511 ALDGKDATISCRAVGSPNPNITWIYNETQLVDISS-------RVQILESGDLLISNIRSVDAGLY 568
            |..|::.:..|...|:|.|.|.|....:|::...|       |:.:...|.|.|:.::..|.|.|
  Rat   371 AAPGENVSFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPMGRLLVSPRGQLNITEVKIGDGGYY 435

  Fly   569 ICVRANEAGSVKGEAYLSVL------VRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWY 627
            :|...:.|||:..:|.|.:.      :...|:|.|.:.|::||.:..|.|:|..:|..  |:.| 
  Rat   436 VCQAVSVAGSILAKALLEIKGASIDGLPPIILQGPANQTLVLGSSVWLPCRVIGNPQP--NVQW- 497

  Fly   628 REGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIE-------- 684
            ::.::.....||| ..:..:|.|.|.:|:..|:|.|:||..|..|..|..:.|...|        
  Rat   498 KKDETWLQGDNSQ-FNLMDNGTLYIASVQEMDMGFYSCVAKSSIGEATWNSWLRKREHWGASPGP 561

  Fly   685 ------LPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVSELGPVPDPLLNWI 743
                  .|.|||...|   .|....||.::|.|.....:..:.::|:....:...       .|.
  Rat   562 ATEPGNPPGPPSQPIV---TEVTTNSITLTWKPNPQSGARATSYVIEAFSQAAGN-------TWR 616

  Fly   744 TELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSGPPVGFVGSAR 808
            |....|..:...:  ..|:..|:|.|.|.||...|...||..|..|:....:.|.|........:
  Rat   617 TVADGVQLETHTV--SGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVQTQDSSLSRPVEDPWKGQQ 679

  Fly   809 SMSEIITQWQPPL-----------EEHRNGQIL-GYILRYRLFGYNNVPWSYQNITNEAQRNFLI 861
            .::|:..:.|.|:           .....||:: |:.:.:|:.|.:...|:..::.:..:::.::
  Rat   680 GLAEVAVRMQEPIVLGPRTLQVSWTVEGPGQLVQGFRVSWRIAGLDQGSWTALDVQSPHKQSTVL 744

  Fly   862 QELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVE--AINSTAARCRWTPPNP 924
            :.|.......:::......|:|..:........|..|..||..|.|.  ...:::....|.||.|
  Rat   745 RGLPPGSQIQIKVQVQGQEGLGAESPSVTRSIPEEAPSGPPQGVAVALGGDRNSSITVSWEPPLP 809

  Fly   925 QQINGINQGYKI---------------QAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQTAILG 974
            .|.||:...|:|               ..|.|.::          .:.:.|.|:           
  Rat   810 SQQNGVITEYQIWCLGNESRFHLNRSAAGWARSVM----------FRGLLPGLL----------- 853

  Fly   975 GLEKFTEYNISVLCFTDPGDGVASSQVAVM-----TMDDVPDEVTGLHFDDVSDRSVKVLWAP-- 1032
                   |...|...|..|.||||:.|.|.     ..:..|:...||     ::|..:||..|  
  Rat   854 -------YRAIVAAATSAGVGVASAPVLVQLPFPPVAEPGPEVSEGL-----AERLSRVLRKPAF 906

  Fly  1033 ----PRASNGILTG-----YTVRYQVKDRPDTLKSFNLT-----------ADDTELTVNQLQATT 1077
                ..|...:|.|     |..:.|.|:......||..|           :..:......|....
  Rat   907 LAGSSAACGALLLGLCAALYRRQKQRKELSHYTASFAYTPAVSFPHSEGLSGSSSRPPMGLGPAA 971

  Fly  1078 HYWFE--------------------------------------IVAWTRVGSGIPKTATIQSGVE 1104
            :.|..                                      .:|.|..|:..|....:.|.::
  Rat   972 YPWLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGANAPGEGPVYSTID 1036

  Fly  1105 PVLPHAPTALALSNIEAFSVVLQFTPGFDGNSS----------ITKWKVEGQTAR---------- 1149
            ||.....|               |..||..:||          ..:|......||          
  Rat  1037 PVGEELQT---------------FHGGFPQHSSGDPSTWSQYAPPEWSEGDSGARGGKGKLLGKP 1086

  Fly  1150 ----NMTWFTI-------CEINDPDAETLTVTG----------------LV-------------- 1173
                :::|...       ||::.|:.....:.|                |:              
  Rat  1087 VQMPSLSWPEALPPPPPSCELSCPEGPEEELKGSSDLEEWCPPMPEKKHLIDSRSSGACMVAPAR 1151

  Fly  1174 -----PFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKH------PPFNVTVRAMSAQQLRVR 1227
                 |.:.|..:.:|:.......|.:...|...:...|:.      .|.:|:..|:|:..    
  Rat  1152 GETPSPTSSYGQQSTATLTPSPPDPPQPPSDIPHLHQMPRRVPLGPSSPLSVSQPALSSHD---- 1212

  Fly  1228 WIPLQQTEWYGNPRGYN----ISY--------KQLVKTPGTIKYVPRSVVIEDHTANSHV----- 1275
                      |.|.|..    :||        ......||..:.|...:....|...:.:     
  Rat  1213 ----------GRPVGLGAGPIVSYHPSPSPVPSTASSAPGRTRQVTGEMTPPLHGHRARIRKKTK 1267

  Fly  1276 -----------------LDSLEEWTLYEVKMNACNDVGCSKESDTAVERTREAVP 1313
                             |...||.|.:.:.:.|...:...:...:...|..:|||
  Rat  1268 ALPHRREHSPGDLPPPPLPPPEEETSWPLGLRAAGSMSSLEREHSGERRVAQAVP 1322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig_3 72..142 CDD:464046 26/84 (31%)
Ig 280..344 CDD:409353 6/63 (10%)
Ig strand B 280..283 CDD:409353 0/2 (0%)
Ig strand C 292..298 CDD:409353 0/5 (0%)
Ig strand E 319..323 CDD:409353 0/3 (0%)
Ig strand F 333..338 CDD:409353 2/4 (50%)
Ig 360..451 CDD:472250 25/91 (27%)
Ig strand B 378..382 CDD:409353 1/3 (33%)
Ig strand C 391..395 CDD:409353 0/3 (0%)
Ig strand E 416..420 CDD:409353 1/3 (33%)
Ig strand F 430..435 CDD:409353 1/4 (25%)
Ig strand G 443..446 CDD:409353 1/2 (50%)
Ig 502..587 CDD:472250 27/91 (30%)
Ig strand B 517..521 CDD:409353 0/3 (0%)
Ig strand C 530..534 CDD:409353 1/3 (33%)
Ig strand E 554..557 CDD:409353 1/2 (50%)
Ig strand F 567..572 CDD:409353 2/4 (50%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 28/89 (31%)
Ig strand B 608..612 CDD:409353 1/3 (33%)
Ig strand C 623..627 CDD:409353 1/3 (33%)
Ig strand E 648..652 CDD:409353 2/3 (67%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 1/2 (50%)
FN3 686..789 CDD:238020 25/102 (25%)
FN3 798..893 CDD:238020 13/106 (12%)
FN3 901..1005 CDD:238020 27/125 (22%)
FN3 <960..>1261 CDD:442628 69/449 (15%)
fn3 1317..1402 CDD:394996
FN3 1415..1507 CDD:238020
FN3 1513..1608 CDD:238020
FN3 1583..>2011 CDD:442628
Robo3XP_063121496.1 None
Blue background indicates that the domain is not in the aligned region.

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