DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and Fas2

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	879	Identity:	194/879 - (22%)
Similarity:	321/879 - (36%)	Gaps:	244/879 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 SSAFVHLNVSGDPYIEVAPEIIVRPQDVKVK-VGTGVVELQCIANARPLHELETL-----WLKDG 301
            |.:.:.|..:..|.:|:.|:     |:|:.| ||..:: |.|    ||.....:|     | ||.
  Fly    19 SCSLIELTRAQSPILEIYPK-----QEVQRKPVGKPLI-LTC----RPTVPEPSLVADLQW-KDN 72

  Fly   302 LAVETAGVRHTLNDP--WNRT-----LALLQANSS--HSGEYTCQVRLRSGGYPAVSASARLQIL 357
            .........:..|.|  :..|     |||:..:.|  ..|:|.|           .::.|..:||
  Fly    73 RNNTILPKPNGRNQPPMYTETLPGESLALMITSLSVEMGGKYYC-----------TASYANTEIL 126

  Fly   358 EP--------PLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNT 414
            |.        .:.:|......:...|....:.|:|..:|.|.:.|.||.:.:  ...:.:|.:.|
  Fly   127 EKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWLRNGDPI--RTTNDKYVVQT 189

  Fly   415 DNTLVIKKLILDDAAMFQC-LAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLG 478
             |.|:|:.:...|..::.| .|:.|.||....|          .||:...||.|:.:
  Fly   190 -NGLLIRNVQESDEGIYTCRAAVIETGELLERT----------IRVEVFIQPEIISL-------- 235

  Fly   479 SEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYNETQL-VD 542
                                       |.|:.|::||....:|.|.|.|.|.|:||.:.||| |.
  Fly   236 ---------------------------PTNLEAVEGKPFAANCTARGKPVPEISWIRDATQLNVA 273

  Fly   543 ISSRVQI-LESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGL 606
            .:.|.|: .::|.:.||::...|.|.|.|:..|.||.|..:..|:||||.||.:       |..:
  Fly   274 TADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYE-------LYNV 331

  Fly   607 TA--------TLQCKVSSDPSVPYNIDW-----YREGQSS-------TPISNSQRIGVQADGQLE 651
            |.        |.:.|....|::.:. .|     |..||..       .|..:.:|  .::.|.|.
  Fly   332 TGARTKEIAITCRAKGRPAPAITFR-RWGTQEEYTNGQQDDDPRIILEPNFDEER--GESTGTLR 393

  Fly   652 IQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEP---QQRSINVSWTPGF 713
            |.....||.|.|.|:..:.|.:..:...::|   .|.|....::.||..   :||..|:|.....
  Fly   394 ISNAERSDDGLYQCIARNKGADAYKTGHITV---EFAPDFSHMKELPPVFSWEQRKANLSCLAMG 455

  Fly   714 DGNSPISKFIIQRREVSEL----------GPVPDPLLNWITE---------LSNVSADQRWILLE 759
            ..|:.| ::....|::.:|          ||..|.:::.:|.         .:|:.......:
  Fly   456 IPNATI-EWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDM-- 517

  Fly   760 NLKAATVYQFRVSAVNRVGEGSPSE------------PSNVVELPQEAPSGPPVGFVGSARSMSE 812
            .||.|.|..|       |.|..||:            ||..:.||
  Fly   518 QLKEARVPDF-------VSEAKPSQLTATTMTFDIRGPSTELGLP-------------------- 555

  Fly   813 IITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWS-YQNITNEAQRNFLIQELITWKDYIVQIAA 876
                            ||.|.::|:  ...|..|| ..|.:......::::.|....:|..:.||
  Fly   556 ----------------ILAYSVQYK--EALNPDWSTAYNRSWSPDSPYIVEGLRPQTEYSFRFAA 602

  Fly   877 YNNMGVGVYTEGSKIKT-KEGVPEAP-PTNVKVE---------AINSTAARCRWTPP--NPQQIN 928
            .|.:|:|.:....:..| :...||.| |.:..|:         :..|.....||..|  |.:.|:
  Fly   603 RNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEPID 667

  Fly   929 GINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLA-EQTAILGGLEKFTEYNISVLCFTDP 992
                .|:|:......|.|.|.::|....||  .:::..: |.|.::|.    |.|.|.:......
  Fly   668 ----RYQIKYCPGVKISGTWTELENSCNTV--EVMETTSFEMTQLVGN----TYYRIELKAHNAI 722

  Fly   993 GDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSV 1026
            |....:|.:...|        .|:....|::|.|
  Fly   723 GYSSPASIIMKTT--------RGIDVIQVAERQV 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845	1/1 (100%)
		IG_like	280..356	CDD:214653	19/89 (21%)
		Ig	280..343	CDD:299845	18/76 (24%)
		IG_like	375..450	CDD:214653	20/75 (27%)
		Ig	378..447	CDD:143165	18/69 (26%)
		Ig	506..587	CDD:299845	31/82 (38%)
		IG_like	506..587	CDD:214653	31/82 (38%)
		I-set	592..682	CDD:254352	22/109 (20%)
		Ig	595..682	CDD:299845	20/106 (19%)
		FN3	686..789	CDD:238020	28/136 (21%)
		FN3	798..893	CDD:238020	15/95 (16%)
		FN3	901..1005	CDD:238020	25/116 (22%)
		fn3	1011..1094	CDD:278470	4/16 (25%)
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	27/110 (25%)
		IG_like	144..226	CDD:214653	22/94 (23%)
		IGc2	152..209	CDD:197706	15/59 (25%)
		I-set	230..319	CDD:254352	33/123 (27%)
		IGc2	243..309	CDD:197706	24/65 (37%)
		IG_like	330..424	CDD:214653	19/96 (20%)
		IGc2	339..412	CDD:197706	17/75 (23%)
		Ig	447..518	CDD:143165	11/73 (15%)
		fn3	534..611	CDD:278470	20/114 (18%)
		FN3	640..735	CDD:238020	22/104 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900