DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and DIP-alpha

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	344	Identity:	78/344 - (22%)
Similarity:	119/344 - (34%)	Gaps:	79/344 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 PEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLK-DGLAVET-----------AGVRHTL 313
            ||.:....:|.|.||.... ..|  :.|.|......||| |..|::.           ..|.|..
  Fly    42 PEFVESISNVSVAVGRDAT-FTC--HVRHLGGYRVGWLKADTKAIQAIHENVITHNPRVTVSHLD 103

  Fly   314 NDPWNRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFT-PMRAETFGEFGGQ 377
            .:.||  |.:...:....|.|.||:...    |..|....|.::.||.|.: ...::.....|..
  Fly   104 QNTWN--LHIKAVSEEDRGGYMCQLNTD----PMKSQIGFLDVVIPPDFISEDTSSDVIVPEGSS 162

  Fly   378 VQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLI----LDDAAMFQCLAINE 438
            |:|||...|.|.|.|.|.|         |.|       |.:|:|..:    |..:...:.|.:::
  Fly   163 VRLTCRARGYPEPIVTWRR---------EDG-------NEIVLKDNVGTKTLAPSFRGEVLKLSK 211

  Fly   439 AGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIME 503
            ...|...::|.:    |.|.|......||......|                         |:::
  Fly   212 ISRNEMGSYLCI----ASNGVPPSVSKRISLSIHFH-------------------------PVIQ 247

  Fly   504 LPPQNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQILESG--------DLLISNI 560
            :|.|.|.|..|.|..|.|....||.....||.:..:::..|.:..:.||.        .:::...
  Fly   248 VPNQLVGAPLGTDVQIECHVEASPKSINYWIKDTGEMIVTSGKYHVQESSQSMYETKMSMIVRKF 312

  Fly   561 RSVDAGLYICVRANEAGSV 579
            :..|.|.|.|:..|..|.|
  Fly   313 QKDDVGSYRCIAKNSLGEV 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	20/87 (23%)
		Ig	280..343	CDD:299845	17/74 (23%)
		IG_like	375..450	CDD:214653	20/78 (26%)
		Ig	378..447	CDD:143165	18/72 (25%)
		Ig	506..587	CDD:299845	21/82 (26%)
		IG_like	506..587	CDD:214653	21/82 (26%)
		I-set	592..682	CDD:254352
		Ig	595..682	CDD:299845
		FN3	686..789	CDD:238020
		FN3	798..893	CDD:238020
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	21/84 (25%)
		Ig	51..131	CDD:299845	21/88 (24%)
		I-set	144..240	CDD:254352	27/115 (23%)
		IGc2	159..228	CDD:197706	22/88 (25%)
		Ig	244..337	CDD:299845	23/88 (26%)
		I-set	244..337	CDD:254352	23/88 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810