DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and rst

DIOPT Version :9

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_001284835.1 Gene:rst / 31290 FlyBaseID:FBgn0003285 Length:764 Species:Drosophila melanogaster


Alignment Length:577 Identity:123/577 - (21%)
Similarity:207/577 - (35%) Gaps:164/577 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 HANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVSGDPYIEVAPE-IIVRPQDVKVKVG 275
            |..||::|:               |.:|...||          ||.....: ..:.|||....||
  Fly     3 HTMQLLLLA---------------TIVGMVRSS----------PYTSYQNQRFAMEPQDQTAVVG 42

  Fly   276 TGVVELQCIANARPLHELETL-WLKD----GLAVETAGV-RHTL---NDPWNRTLALLQANSSHS 331
            ..|. |.|    |.:::..|| |.||    |.:.:.:|. |:.:   ::..:.:|.:........
  Fly    43 ARVT-LPC----RVINKQGTLQWTKDDFGLGTSRDLSGFERYAMVGSDEEGDYSLDIYPVMLDDD 102

  Fly   332 GEYTCQVRLRSGGYPAV-SASARLQILEPP----------LFFTPMRAETFGEFGGQVQLTC-DV 384
            ..|.|||.....|.||: |..|.|.:|.||          ::.|..|         :|::.| .|
  Fly   103 ARYQCQVSPGPEGQPAIRSTFAGLTVLVPPEAPKITQGDVIYATEDR---------KVEIECVSV 158

  Fly   385 VGEPTPQVKWFRN-----AESVDAHI----ESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAG 440
            .|:|..::.|...     .::::..:    :..|:|..:...|..||  ......|.|.|.|.|.
  Fly   159 GGKPAAEITWIDGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKK--EHHNTNFSCQAQNTAD 221

  Fly   441 ENSASTWLRVKTKTAK-------------------------------NRVKRLAQPRI-LRVRAS 473
            ....|..:||:.|.|.                               :|:...:|.|: .|..|:
  Fly   222 RTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADAN 286

  Fly   474 HAG------------LGSEK---------------------GSESGSSDRRKEFRFASAPIMELP 505
            .:.            :|.:|                     .:..|.|:..:....:.||.....
  Fly   287 PSDVRYRWFINDEPIIGGQKTEMVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDISYAPSFRQR 351

  Fly   506 PQNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQILESGDLLISNIRSVDAGLYIC 570
            ||::.|..|...:::|....:|.|.|.||.:.:.        :::.:...|..::.:..||.|.|
  Fly   352 PQSMEADVGSVVSLTCEVDSNPQPEIVWIQHPSD--------RVVGTSTNLTFSVSNETAGRYYC 408

  Fly   571 VRANEAG--SVKGEAYL----SVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYRE 629
             :||..|  .:..:||:    |..:.:|..|     ..|:|.||.::|..||.|...: :.|...
  Fly   409 -KANVPGYAEISADAYVYLKGSPAIGSQRTQ-----YGLVGDTARIECFASSVPRARH-VSWTFN 466

  Fly   630 GQS-STPISNSQRIGVQA-----DGQLEIQAVRASDVGSYACVVTSPGGNETRAARL 680
            ||. |:...:...|.|.|     ...|.|:..:|...|.|.|.|.:..||:....:|
  Fly   467 GQEISSESGHDYSILVDAVPGGVKSTLIIRDSQAYHYGKYNCTVVNDYGNDVAEIQL 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig 71..157 CDD:299845
I-set 72..150 CDD:254352
Ig 172..245 CDD:299845 7/32 (22%)
IG_like 280..356 CDD:214653 22/85 (26%)
Ig 280..343 CDD:299845 16/71 (23%)
IG_like 375..450 CDD:214653 17/84 (20%)
Ig 378..447 CDD:143165 17/78 (22%)
Ig 506..587 CDD:299845 20/86 (23%)
IG_like 506..587 CDD:214653 20/86 (23%)
I-set 592..682 CDD:254352 27/95 (28%)
Ig 595..682 CDD:299845 26/92 (28%)
FN3 686..789 CDD:238020
FN3 798..893 CDD:238020
FN3 901..1005 CDD:238020
fn3 1011..1094 CDD:278470
FN3 1108..1202 CDD:238020
FN3 1210..1308 CDD:238020
fn3 1317..1402 CDD:278470
FN3 1415..1507 CDD:238020
FN3 1513..1608 CDD:238020
fn3 1617..1708 CDD:278470
FN3 1722..1823 CDD:238020
FN3 1828..1920 CDD:238020
FN3 1927..2016 CDD:238020
rstNP_001284835.1 IG_like 34..130 CDD:214653 28/100 (28%)
Ig 42..114 CDD:299845 18/76 (24%)
C2-set_2 135..225 CDD:285423 18/100 (18%)
Ig_3 265..329 CDD:290638 7/63 (11%)
I-set 346..420 CDD:254352 19/82 (23%)
Ig 360..425 CDD:299845 17/73 (23%)
Ig5_KIRREL3-like 428..524 CDD:143235 28/102 (27%)
IG_like 435..524 CDD:214653 27/95 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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