DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and ncam1a

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_009293555.1	Gene:	ncam1a / 30447	ZFINID:	ZDB-GENE-990415-31	Length:	1010	Species:	Danio rerio

Alignment Length:	872	Identity:	182/872 - (20%)
Similarity:	303/872 - (34%)	Gaps:	273/872 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VSEGSTKILQCHALG------YPQPTYRWLKDGVPVGDFS------SSQFYRFHSTRREDAGSYQ 137
            :|.|.:|...|..:|      :..|....|..|.|  |.|      ||.....::...:.||.|:
Zfish    31 ISVGESKFFLCEVVGDAKEIDWFAPNGEKLLPGRP--DISISKTDESSSTLTIYNANVDHAGMYK 93

  Fly   138 CIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDGPL 202
            |:|::.                   |..::|.:.|     .||.....:..|.|....:.:|..:
Zfish    94 CVAKSG-------------------EKESQGTIIV-----KIFQKLTFQYAPSPQEFNEGDDADI 134

  Fly   203 NYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVSGDPYIEVAPEIIVRP 267
            ..|:                                            :|..|     |.||.|.
Zfish   135 ICDV--------------------------------------------ISSPP-----PTIIWRY 150

  Fly   268 QDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANSSHSG 332
            :.::::..|. |.|:.::|..               ::..|::.|                 ..|
Zfish   151 KKMRIQPETD-VRLKVLSNNH---------------LQIRGIKKT-----------------DEG 182

  Fly   333 EYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGG------QVQLTCDVVGEPTPQ 391
            :|||:.|:.:.|      ...|::::..:...|.....:.|...      .|.|.|...|.|.|.
Zfish   183 DYTCEGRIMARG------EIDLRVIKVIVNVLPSIRTRYTELNATADINQAVTLACHADGYPEPT 241

  Fly   392 VKWFRNAESVDAHIESG-RYTLNTDNT-LVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKT 454
            |||.|.    :..:||. :|:||.|.: |.||.:...|...::|:|.|:|||.|....|.|
Zfish   242 VKWARG----NTELESDEKYSLNEDGSELTIKDVNKLDEGDYKCIARNKAGERSEEVTLNV---- 298

  Fly   455 AKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALD-GKDAT 518
                   ..||:|..:                                    :|.||.: .:..|
Zfish   299 -------FVQPKITFL------------------------------------ENQTASELEEQIT 320

  Fly   519 ISCRAVGSPNPNITW-----IYNETQ-----------------LVDISSRVQILESGDLLISNIR 561
            ::|.|.|.|.|||.|     ::.|.:                 :|...:||     ..|.:..::
Zfish   321 LTCEATGDPTPNIIWSFGRRVFTENEQASWTRPEKHKSLDGNVVVRSDARV-----SSLTLKYVQ 380

  Fly   562 SVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDW 626
            ..|||.|:|...|..|......||.|....: ||.|.......|..|.:.|:..:.|..  ::.|
Zfish   381 FTDAGQYLCTARNSIGQDIQSMYLEVRYAPK-IQGPQAVFTWEGNPANITCEALAHPGA--SVLW 442

  Fly   627 YREGQSSTPISNSQRIGV---QADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFP 688
            :|:|| ..|.:|:..:.:   .....||:.....:|.|||.|..|:..|.|::...|...::|..
Zfish   443 FRDGQ-QLPSANTTNVKIYNTPTVSFLEVTPDSQNDFGSYNCTATNVIGTESKEFILVQADVPSA 506

  Fly   689 PSNVKVERLPEPQQRSINVSW-TPGFDGNSPISKFIIQRREVSELGPVPDPLLNWITELSNVSAD 752
            ||   :||: ||...:..:.: .|...|..|:.|:..:.|...:         :|......:...
Zfish   507 PS---IERV-EPYSSTAMIEFEEPASSGGVPVLKYKAEWRIAGQ---------DWTDREYELEDG 558

  Fly   753 QRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNV----VELP----QEAPSG-PPVGFVGSAR 808
            ...|.:..||..|.|:.::||:|..|||..|.|.:.    |.||    .|.|:. ||
Zfish   559 LNLITIVGLKPETTYEVKISAINGKGEGESSAPESFKTQPVRLPFRMSPETPTSIPP-------- 615

  Fly   809 SMSEIITQWQPPLEEHR------------------NGQILGYILRYRLFGYNNVPWSYQNITNEA 855
            :.::|..:..||..|.:                  ...|..|::|||  ..|...|..:....:|
Zfish   616 TTADIKGEPNPPKLEAKPQSTGNEMKVHFIKQDDGGSPIKHYLVRYR--AKNRQDWKPEIRMPDA 678

  Fly   856 QRNFLIQELITWK-DYIVQIAAYNNMG 881
            . ::::...:.|. :|.|.:.|.|..|
Zfish   679 S-DYIVLRGLDWNTEYEVYVIAENQRG 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	18/83 (22%)
		I-set	72..150	CDD:254352	18/76 (24%)
		Ig	172..245	CDD:299845	7/72 (10%)
		IG_like	280..356	CDD:214653	11/75 (15%)
		Ig	280..343	CDD:299845	9/62 (15%)
		IG_like	375..450	CDD:214653	28/82 (34%)
		Ig	378..447	CDD:143165	27/70 (39%)
		Ig	506..587	CDD:299845	26/103 (25%)
		IG_like	506..587	CDD:214653	26/103 (25%)
		I-set	592..682	CDD:254352	24/92 (26%)
		Ig	595..682	CDD:299845	23/89 (26%)
		FN3	686..789	CDD:238020	26/107 (24%)
		FN3	798..893	CDD:238020	20/104 (19%)
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
ncam1a	XP_009293555.1	Ig	20..112	CDD:299845	21/106 (20%)
		I-set	21..111	CDD:254352	21/105 (20%)
		IG_like	121..200	CDD:214653	23/166 (14%)
		IGc2	128..189	CDD:197706	18/142 (13%)
		Ig	208..301	CDD:299845	31/107 (29%)
		IG_like	219..298	CDD:214653	28/82 (34%)
		Ig	300..406	CDD:299845	29/146 (20%)
		IG_like	308..406	CDD:214653	26/102 (25%)
		ig	413..498	CDD:278476	22/87 (25%)
		IG_like	415..498	CDD:214653	21/85 (25%)
		fn3	505..589	CDD:278470	23/96 (24%)
		FN3	624..715	CDD:238020	17/84 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900