DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and Nfasc

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_006529697.2	Gene:	Nfasc / 269116	MGIID:	104753	Length:	1466	Species:	Mus musculus

Alignment Length:	1356	Identity:	302/1356 - (22%)
Similarity:	490/1356 - (36%)	Gaps:	314/1356 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AIEMPSQPKLASLLAVLVLLCYCDSCFFCYADANLQQQNSIVQQQQLQAPRFTTHPSSSGSIVSE 87
            |||:|..|.:                                 |.:|..|...|..|....||..
Mouse   126 AIEIPMDPSI---------------------------------QNELTQPPTITKQSVKDHIVDP 157

  Fly    88 GSTKILQCHALGYPQPTYRWLKD------------------GVPVGDFSSSQFYRFHSTRREDAG 134
            ....:::|.|.|.|.|::.|.::                  |..|.||.|.      ....|..|
Mouse   158 RDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSG------GRPEEYEG 216

  Fly   135 SYQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMW---- 195
            .|||.|||..|:..|.:..:.|:...::.......:.|..|.|......|...:|.|.:.|
Mouse   217 EYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSS 281

  Fly   196 -----------QSEDGPLNY--------------DIKYAFTHANQ------LIIL-------SAD 222
                       |..:|.|.:              :.::.|||..|      |.:|       |:.
Mouse   282 MEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNNPYNDSSL 346

  Fly   223 ENDRKGYRAKAINTQLGKEESSAFVHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANA 287
            .|....|.|:.:     .|.:.:|::      |....:.::::|..|:.         |:|||:.
Mouse   347 RNHPDIYSARGV-----AERTPSFMY------PQGTSSSQMVLRGMDLL---------LECIASG 391

  Fly   288 RPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANSSHSGEYTCQVRLRSGGYP---AVS 349
            .|..::  .|.|.|..:.:...:.   :.:|:.|.:...:...||||.|....:.|...   :|.
Mouse   392 VPTPDI--AWYKKGGDLPSNKAKF---ENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 451

  Fly   350 ASARLQILEPP--LFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTL 412
            ..|....|:.|  |...|      ||.|   :|.|...|.|.|.|:|..|.|.    ::|.....
Mouse   452 VKAAPYWLDEPKNLILAP------GEDG---RLVCRANGNPKPTVQWMVNGEP----LQSAPPNP 503

  Fly   413 NTD---NTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASH 474
            |.:   :|::.:...:...|::||...||.|...|:.::.|..          ..||:|..|..
Mouse   504 NREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD----------VPPRMLSARNQ- 557

  Fly   475 AGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYN-ET 538
                                      ::.:...|.|.||       |...|||.|.:.|..| :.
Mouse   558 --------------------------LIRVILYNRTRLD-------CPFFGSPIPTLRWFKNGQG 589

  Fly   539 QLVDISSRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVL 603
            ..:| .....:.|:|.|.|..||..|.|:|.||..|..|..:.:..|.|...|:|.:.|.|....
Mouse   590 SNLD-GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAK 653

  Fly   604 LGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVT 668
            .|.|..|:|:|..|||:...:.|.::.:   |:....|: .:.|..|.|..|...|.|||.|:.:
Mouse   654 RGTTVQLECRVKHDPSLKLTVSWLKDDE---PLYIGNRM-KKEDDSLTIFGVAERDQGSYTCMAS 714

  Fly   669 SPGGNETRAARLSVIELPFPPSNVKVERLPEPQ-------------QRSINVSWTPGFDGNSPIS 720
            :....:...|.|:|:.....|:| ::..||:.:             :||:.::|.||.|.||||:
Mouse   715 TELDQDLAKAYLTVLADQATPTN-RLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDDNNSPIT 778

  Fly   721 KFIIQRREVSELGP--------VPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRV 777
            .:::|..| .:..|        .|..:.:.:..||               ....|||||.|||.|
Mouse   779 DYVVQFEE-DQFQPGVWHDHSRFPGSVNSAVLHLS---------------PYVNYQFRVIAVNEV 827

  Fly   778 GEGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYN 842
            |...||.||.........|...|....|.....:.:...|.|.......|..|.||:::|   ..
Mouse   828 GSSHPSLPSERYRTSGAPPESNPSDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWR---RR 889

  Fly   843 NVPWSYQNITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKV 907
            ....::.|:|....| :::.:...:..|.:::.|.|:.|.|...:.....:.|..|.|.||.||:
Mouse   890 ETRETWNNVTVWGSR-YVVGQTPVYVPYEIRVQAENDFGKGPEPDTIIGYSGEDYPRAAPTEVKI 953

  Fly   908 EAINSTAARCRWTPPNPQQINGINQGYKIQAW-QRRLIDGEWRDIERRMKTVPPSLIDPLAEQTA 971
            ..:||||...:|.......:.|..:.|:...| :..|:...|...:|:..:.|..      ....
Mouse   954 RVLNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGD------RPRG 1012

  Fly   972 ILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRAS 1036
            ::..|..::.|.:.::.....|||..|......|.:.||...........:..::.:.|..|...
Mouse  1013 VVARLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHP 1077

  Fly  1037 NGILTGYTVRYQVKDRPDTLKSF--NLTADDTELTVNQLQATTHYWFEIVAWTRVGSG------- 1092
            ||||.||.:||...:.....|..  |.:.:.|:.:|.:....:.|.|.:.|.|:||||
Mouse  1078 NGILIGYILRYVPFNGTKLGKQMVENFSPNQTKFSVQRADPVSRYRFSLSARTQVGSGEAATEES 1142

  Fly  1093 -IPKTATIQSGVEPVLPHAPTALA----LSNIEAFSVVLQFTPGFDGNSSITKWKVEGQTARNMT 1152
             .|......:...|.||  ||.:.    :|:.:|.::.        ..|..|...:.........
Mouse  1143 PAPPNEATPTAAPPTLP--PTTVGTTGLVSSTDATALA--------ATSEATTVPIIPTVVPTTV 1197

  Fly  1153 WFTICEINDPDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVR 1217
            ..||.......|.|.|.|    .|:     |.......:|..|...|.|:|        :||||
Mouse  1198 ATTIATTTTTTAATTTTT----TTE-----SPPTTTAGTKIHETAPDEQSI--------WNVTV- 1244

  Fly  1218 AMSAQQLRVRWIPLQQTEWYGNPRGYNISYKQLVKTPGT---IKYVPRSVVIEDHT 1270
                         |..::|      .||::|...: |||   ::|:.     .:||
Mouse  1245 -------------LPNSKW------ANITWKHNFR-PGTDFVVEYID-----SNHT 1275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	26/103 (25%)
		I-set	72..150	CDD:254352	25/95 (26%)
		Ig	172..245	CDD:299845	21/114 (18%)
		IG_like	280..356	CDD:214653	18/78 (23%)
		Ig	280..343	CDD:299845	15/62 (24%)
		IG_like	375..450	CDD:214653	20/77 (26%)
		Ig	378..447	CDD:143165	19/71 (27%)
		Ig	506..587	CDD:299845	26/81 (32%)
		IG_like	506..587	CDD:214653	26/81 (32%)
		I-set	592..682	CDD:254352	25/89 (28%)
		Ig	595..682	CDD:299845	24/86 (28%)
		FN3	686..789	CDD:238020	34/123 (28%)
		FN3	798..893	CDD:238020	17/94 (18%)
		FN3	901..1005	CDD:238020	22/104 (21%)
		fn3	1011..1094	CDD:278470	22/92 (24%)
		FN3	1108..1202	CDD:238020	18/97 (19%)
		FN3	1210..1308	CDD:238020	15/64 (23%)
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Nfasc	XP_006529697.2	Ig_hNeurofascin_like	161..237	CDD:143283	21/81 (26%)
		Ig	242..334	CDD:386229	14/91 (15%)
		Ig3_L1-CAM_like	383..453	CDD:319298	17/83 (20%)
		Ig	470..545	CDD:386229	22/81 (27%)
		Ig	568..634	CDD:319273	23/73 (32%)
		Ig	647..728	CDD:386229	24/84 (29%)
		FN3	747..837	CDD:238020	29/105 (28%)
		FN3	848..929	CDD:214495	16/84 (19%)
		FN3	947..1046	CDD:238020	22/104 (21%)
		FN3	1051..1142	CDD:238020	23/90 (26%)
		FN3	1241..1320	CDD:238020	15/61 (25%)
		Bravo_FIGEY	1358..1438	CDD:372781
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910