DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and neo1a

DIOPT Version :10

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:XP_009301739.1 Gene:neo1a / 266983 ZFINID:ZDB-GENE-021031-1 Length:1450 Species:Danio rerio


Alignment Length:1270 Identity:306/1270 - (24%)
Similarity:480/1270 - (37%) Gaps:319/1270 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   267 PQDVKVKVGTGVVELQCIANARPLHELETLWLKDG--LAVETAGVRHTLNDPWNRTLALLQANSS 329
            |.|.....|..|: |.|..::....::|  |.|||  |::.:...|..|.|.     :||.::..
Zfish    40 PSDTLAVRGAPVL-LNCSVHSESPAKIE--WKKDGSFLSLASDERRQVLADG-----SLLISSVV 96

  Fly   330 HS-------GEYTCQVRLRSGGYPAVSASARLQILEPPLFFT-PMRAETFGEFGGQVQLTCDVVG 386
            ||       |.|.|...:.:.| ..:|.:|||.:.....|.: |..|..  ..|....|:|:|..
Zfish    97 HSKHNKPDEGVYQCVATIDNLG-TIISRTARLNVAGIARFLSQPEMASV--RVGDSQVLSCEVNP 158

  Fly   387 EPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVK 451
            :....::|.:|.|:|:  ::...::| ....|||......||.:::|: |:.||          .
Zfish   159 DLVSFIRWEQNKEAVE--LDHRVFSL-PSGALVISNATETDAGLYRCV-IDNAG----------P 209

  Fly   452 TKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKD 516
            |||::.     ||..||          :|.|.|     |..||      :.|  ||:|:.|.|:.
Zfish   210 TKTSEE-----AQLHIL----------TETGEE-----RTLEF------LQE--PQHVSKLVGES 246

  Fly   517 ATISCRAVGSPNPNITWIYNETQLVDISSRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKG 581
            ..:.|...|.|.|.|||:|.:..:.|.|.|.:||..|.|.|.|:...|||:|.|:..|..||::.
Zfish   247 VLLPCVVTGYPTPEITWMYKDQLIEDSSGRFEILGGGSLRIFNLTEEDAGVYNCLAENTNGSIEA 311

  Fly   582 EAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQA 646
            :|.|::....|.::.||:...........:|:||..||.  .|.|.:.|.:..|   |....:..
Zfish   312 QAELTLKDSPQFLKKPVNVFAHEATDVIFECEVSGSPSP--TIKWVKNGDAVIP---SDYFKIIK 371

  Fly   647 DGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIE----LPFPPSNVKVERLPEPQQRSINV 707
            :..|::..:..||.|.|.|:..:..||...:|:|.:::    ||.|        .|....|:...
Zfish   372 EQNLQVLGLVKSDEGFYQCLAENDAGNVQSSAQLVILDQDVTLPLP--------RPTSLTRATTD 428

  Fly   708 SWTPGFDGNSPISKFIIQRREVSELGPVPDP--------------LLNW----------IT---- 744
            ...||..|.:               ||.|..              .|.|          :|    
Zfish   429 RLMPGSRGGA---------------GPTPSAPRDVVASLVSTRFLKLTWRLPAEPHGDDVTYSVY 478

  Fly   745 ---------ELSNVS-ADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSGP 799
                     .:.|.| ..:..:.::||...|.|.|||.|.|:.|.|..|.|..|...|:....||
Zfish   479 YSLEGTNRERIVNTSRPGEMQVTIQNLMPDTKYAFRVVAHNKNGPGESSVPLKVETQPEVQVPGP 543

  Fly   800 PVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQNITNEAQRNFLIQEL 864
            .........|.|.:...|..||  ..||:|..|.:.|...|.:    |.|:: :....::.:..|
Zfish   544 APNLHAVVMSPSTVSLSWDVPL--IGNGEIQNYKIYYMEKGMD----SEQDL-DVNTLSYTMTGL 601

  Fly   865 ITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVEAINSTAARCRWTPPNPQQING 929
            ..:.:|..::.|||..|.||.||...::|...||.:||.|:.||.:||.:...||.||.....||
Zfish   602 KKFTEYSFRLVAYNKHGPGVSTEDISVRTYSDVPSSPPQNMTVEVLNSKSLMIRWQPPPADAQNG 666

  Fly   930 INQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQTA------ILGGLEKFTEYNISVLC 988
            ...||||:          :|...|:.:         :||.|:      ::.||::.|||.:.|..
Zfish   667 EITGYKIR----------YRKGTRKSE---------VAEITSGSQLYQLIDGLQRGTEYMLRVSA 712

  Fly   989 FTDPGDGVASSQVAVMTMDD------VPDEVTGLHFDDVSDRSVKVLWAPPRASNGILTGYTVRY 1047
            .|..|.|.|:......|.:.      |||..:.||...:.: |:.|.|.||...:.::.||::.|
Zfish   713 MTVNGTGPATDWTTAETFESDLDESRVPDVPSSLHVRSLVN-SIVVSWTPPENQDIVVRGYSISY 776

  Fly  1048 QV-KDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIP--KTATIQSGVEPVLP- 1108
            .: .....|:|   :.......|:..|...:||...:.|:..||.|||  ::|..:...:|:.| 
Zfish   777 GIGSPHAQTIK---VDYKQRYYTIENLNPNSHYVITLKAFNNVGEGIPVYESAITRPQSDPIDPD 838

  Fly  1109 -------HAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQTARNMTWFTICEINDPDAET 1166
                   |||                :||                            :.||    
Zfish   839 VDLYELFHAP----------------YTP----------------------------VPDP---- 855

  Fly  1167 LTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRWI-- 1229
                                                   .|..||..|....::...::|.|.  
Zfish   856 ---------------------------------------IPMLPPVGVQASVLNQDTIKVTWADN 881

  Fly  1230 PLQQTEWYGNPRGYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKMNACND 1294
            .|.:.:...:.|.|.:.:|  ...|...|:     .:.:.|...|.:..|:..||||..:.....
Zfish   882 SLPKNQKITDARYYTVRWK--TNIPANTKF-----KVANTTTLFHTVTGLKPNTLYEFSVMVTKG 939

  Fly  1295 VGCSKESDTAVERTREAVPSYGPLDVQANATSS--TTVVVQWGEVPRQHRNGQIDGYKVFYAA-- 1355
            ...|..|.||...|.|::||..|.||...:...  .|::|.|  .|....||:|.||.::|:.  
Zfish   940 RRTSTWSMTAHGTTFESIPSSPPKDVTVVSKEGRPKTIIVNW--QPPSEANGKITGYIIYYSTDV 1002

  Fly  1356 -ADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGALS----------------- 1402
             |:....|:...:.|.  .|..:.||.....|:.::.|....|.|.:|                 
Zfish  1003 KAEVHDWVIEPVVGNR--LTHQIQELTLDTTYYFKIQARNSKGMGPMSEAVQFRTPKAESSDKMA 1065

  Fly  1403 ---TPPIRVQTFEDTPGVPSNVSF-----PDVSLT 1429
               .|.|.|:  :..|..|.| .|     ||:|.|
Zfish  1066 NDQAPGISVK--QGRPSAPDN-GFGSPGKPDMSGT 1097

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig_3 72..142 CDD:464046
Ig 280..344 CDD:409353 18/72 (25%)
Ig strand B 280..283 CDD:409353 1/2 (50%)
Ig strand C 292..298 CDD:409353 1/5 (20%)
Ig strand E 319..323 CDD:409353 0/3 (0%)
Ig strand F 333..338 CDD:409353 2/4 (50%)
Ig 360..451 CDD:472250 21/91 (23%)
Ig strand B 378..382 CDD:409353 1/3 (33%)
Ig strand C 391..395 CDD:409353 0/3 (0%)
Ig strand E 416..420 CDD:409353 1/3 (33%)
Ig strand F 430..435 CDD:409353 1/4 (25%)
Ig strand G 443..446 CDD:409353 0/2 (0%)
Ig 502..587 CDD:472250 33/84 (39%)
Ig strand B 517..521 CDD:409353 0/3 (0%)
Ig strand C 530..534 CDD:409353 2/3 (67%)
Ig strand E 554..557 CDD:409353 1/2 (50%)
Ig strand F 567..572 CDD:409353 2/4 (50%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 23/89 (26%)
Ig strand B 608..612 CDD:409353 0/3 (0%)
Ig strand C 623..627 CDD:409353 1/3 (33%)
Ig strand E 648..652 CDD:409353 1/3 (33%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 0/2 (0%)
FN3 686..789 CDD:238020 28/140 (20%)
FN3 798..893 CDD:238020 25/94 (27%)
FN3 901..1005 CDD:238020 32/109 (29%)
FN3 <960..>1261 CDD:442628 61/325 (19%)
fn3 1317..1402 CDD:394996 23/89 (26%)
FN3 1415..1507 CDD:238020 8/20 (40%)
FN3 1513..1608 CDD:238020
FN3 1583..>2011 CDD:442628
neo1aXP_009301739.1 IgI_1_Neogenin_like 33..129 CDD:409387 27/97 (28%)
Ig strand A 33..36 CDD:409387
Ig strand A' 39..45 CDD:409387 2/4 (50%)
Ig strand B 49..59 CDD:409387 3/10 (30%)
Ig strand C 63..69 CDD:409387 2/7 (29%)
Ig strand C' 71..74 CDD:409387 1/2 (50%)
Ig strand D 81..86 CDD:409387 1/4 (25%)
Ig strand E 88..94 CDD:409387 2/10 (20%)
Ig strand F 106..113 CDD:409387 3/6 (50%)
Ig strand G 118..129 CDD:409387 5/11 (45%)
IG_like 143..220 CDD:214653 23/97 (24%)
Ig strand B 151..154 CDD:409353 1/2 (50%)
Ig strand C 163..167 CDD:409353 0/3 (0%)
Ig strand E 185..189 CDD:409353 1/3 (33%)
Ig strand F 199..204 CDD:409353 1/5 (20%)
Ig strand G 213..216 CDD:409353 0/7 (0%)
I-set 231..316 CDD:400151 34/92 (37%)
Ig strand B 247..251 CDD:409353 0/3 (0%)
Ig strand C 260..264 CDD:409353 2/3 (67%)
Ig strand E 283..287 CDD:409353 2/3 (67%)
Ig strand F 297..302 CDD:409353 2/4 (50%)
Ig strand G 310..313 CDD:409353 0/2 (0%)
IgI_4_Neogenin_like 324..407 CDD:409388 22/87 (25%)
Ig strand A 324..327 CDD:409388 0/2 (0%)
Ig strand A' 329..333 CDD:409388 0/3 (0%)
Ig strand B 336..345 CDD:409388 1/8 (13%)
Ig strand C 350..356 CDD:409388 2/7 (29%)
Ig strand C' 358..361 CDD:409388 1/2 (50%)
Ig strand D 366..370 CDD:409388 0/3 (0%)
Ig strand E 374..378 CDD:409388 1/3 (33%)
Ig strand F 386..394 CDD:409388 3/7 (43%)
Ig strand G 397..407 CDD:409388 4/9 (44%)
FN3 <436..852 CDD:442628 118/504 (23%)
FN3 712..>1061 CDD:442628 91/450 (20%)
Neogenin_C 1157..1450 CDD:461954
Blue background indicates that the domain is not in the aligned region.

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