DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and LRIT1

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_056428.1	Gene:	LRIT1 / 26103	HGNCID:	23404	Length:	623	Species:	Homo sapiens

Alignment Length:	627	Identity:	121/627 - (19%)
Similarity:	198/627 - (31%)	Gaps:	232/627 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 VSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIA-------NARPLHELETLWLKDGLAVETAG 308
            |..||.:.:.|..|  |.|      |..:.|:..|       ..|||..||.|||
Human    44 VCNDPDMTLPPASI--PPD------TSRLRLERTAIRRVPGEAFRPLGRLEQLWL---------- 90

  Fly   309 VRHTLNDPWNRTLALLQANSSHSGEYTCQVRL---RSGGYP--AVSASARLQILE---PPLFFTP 365
                   |:| .|:.|.|..........::||   |...:|  |:..:.:|::|:   ..|...|
Human    91 -------PYN-ALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVP 147

  Fly   366 MRAETFGEFGGQVQLTCDVVGEPTPQ---VKWFRNAESVDAHIESG--------RYTLN-TDNTL 418
            ..|..|.|....:.|:.:.:.. .||   |.|        ||:|:|        |..|. .||..
Human   148 AEAARFLENLTFLDLSSNQLMR-LPQELIVSW--------AHLETGIFPPGHHPRRVLGLQDNPW 203

  Fly   419 VIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGS 483
            .....:.|...:....|.|.|         .::|:.      |.|.||.|
Human   204 ACDCRLYDLVHLLDGWAPNLA---------FIETEL------RCASPRSL--------------- 238

  Fly   484 ESGSSDRRKEFRFASAPIMELPP--QNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSR 546
             :|.:..:.|.|....|  ||.|  .::.:|.|..|.:.|.|.|.|.|.::|.....:.::.:..
Human   239 -AGVAFSQLELRKCQGP--ELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVH 300

  Fly   547 VQILESGD----LLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLT 607
            .::...|.    |.:..:..:|:|.|||...|..|:  .|..:|::|    .:||..|
Human   301 QEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGA--SETVISLIV----TEPPTST------- 352

  Fly   608 ATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGG 672
                 :.|..|...    |.|.|                                        ||
Human   353 -----EHSGSPGAL----WARTG----------------------------------------GG 368

  Fly   673 NETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVSELGPVPD 737
            .|..|....::....|       ::|:|                           .|...||
Human   369 GEAAAYNNKLVARHVP-------QIPKP---------------------------AVLATGP--- 396

  Fly   738 PLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSGPPVG 802
                      :|.:.:..:.||:        |::.|:..:.:|...        |.||.....|.
Human   397 ----------SVPSTKEELTLEH--------FQMDALGELSDGRAG--------PSEARMVRSVK 435

  Fly   803 FVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNV 844
            .||.......::  |:.|..::..    .:.:.|.:||.:::
Human   436 VVGDTYHSVSLV--WKAPQAKNTT----AFSVLYAVFGQHSM 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	21/87 (24%)
		Ig	280..343	CDD:299845	18/72 (25%)
		IG_like	375..450	CDD:214653	17/86 (20%)
		Ig	378..447	CDD:143165	17/80 (21%)
		Ig	506..587	CDD:299845	20/86 (23%)
		IG_like	506..587	CDD:214653	20/86 (23%)
		I-set	592..682	CDD:254352	12/89 (13%)
		Ig	595..682	CDD:299845	12/86 (14%)
		FN3	686..789	CDD:238020	12/102 (12%)
		FN3	798..893	CDD:238020	8/47 (17%)
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
LRIT1	NP_056428.1	LRR 1	60..81		4/26 (15%)
		leucine-rich repeat	61..84	CDD:275378	6/22 (27%)
		LRR_8	63..143	CDD:290566	22/97 (23%)
		LRR 2	84..105		10/38 (26%)
		leucine-rich repeat	85..132	CDD:275378	15/64 (23%)
		LRR 3	108..129		5/20 (25%)
		LRR_8	131..202	CDD:290566	19/79 (24%)
		LRR_4	131..171	CDD:289563	8/40 (20%)
		LRR 4	132..153		5/20 (25%)
		leucine-rich repeat	133..156	CDD:275378	6/22 (27%)
		LRR 5	156..177		3/21 (14%)
		leucine-rich repeat	157..180	CDD:275378	5/31 (16%)
		leucine-rich repeat	181..205	CDD:275378	6/23 (26%)
		TPKR_C2	201..>240	CDD:301599	11/69 (16%)
		Ig	267..345	CDD:299845	19/79 (24%)
		IG_like	267..345	CDD:214653	19/79 (24%)
		FN3	431..498	CDD:214495	8/47 (17%)
		LRR 6. /evidence=ECO:0000305	571..594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900