DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and Lrit1

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_647547.2	Gene:	Lrit1 / 246214	RGDID:	628607	Length:	623	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	106/556 - (19%)
Similarity:	182/556 - (32%)	Gaps:	187/556 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 VSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETA-----GVR 310
            |..||.:.:.|..| .|...|:::....:........|||..||.|||......|.:     |:|
  Rat    44 VCSDPDLTLPPASI-PPDTCKLRLERTAIRRVPGETFRPLSRLEQLWLPYNALSELSTLMLRGLR 107

  Fly   311 ----------HTLNDPWNRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTP 365
                      |.:..||                            .|:..:.:||:|:
  Rat   108 RLRELRLPGNHLVTFPW----------------------------AALKDTPQLQLLD------- 137

  Fly   366 MRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVD-----------------AHIESGRYTLN 413
            ::|......             |...|.:..|...:|                 ||:::|.|..:
  Rat   138 LQANRLSTL-------------PPEAVHFLENLTFLDLSNNQLMRLPEELLDTWAHLKTGPYLSS 189

  Fly   414 TDNTLVIKKLILDDAAMFQCLAIN--EAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAG 476
            ....||:.  :.|:..:..|...:  ...:..||..:.::.:.      |...||.|
  Rat   190 RRTRLVLG--LQDNPWVCDCRLYDLVHLLDGWASNLIFIEARL------RCGSPRSL-------- 238

  Fly   477 LGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALD---GKDATISCRAVGSPNPNITW----- 533
                    :|.:..:.|.|...:|  ||.| .||::.   |....:.|.|.|.|.|.::|
  Rat   239 --------AGVAFSQLELRKCQSP--ELRP-GVTSIISPLGSTVLLRCGATGIPGPEMSWRRANG 292

  Fly   534 -IYNETQLVDISSRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPP 597
             ..|.|...::||........||.:.::  .|:|.|||...|..|:  .|..:|:     |:..|
  Rat   293 RPLNGTVHQEVSSDGSSWTLLDLPVVSL--FDSGDYICQAKNFLGA--SETLISL-----IVTEP 348

  Fly   598 VDTTVLLGLTATLQCK---------------------------VSSDPSVPYNIDWYREGQSSTP 635
            ..:|...|:...|..:                           :::.||||       ..:...|
  Rat   349 QTSTEYTGIPGALWARTGEGAEAAAYNNKLVARHVPHVPEPVALATKPSVP-------SIKEELP 406

  Fly   636 ISNSQRIGVQADGQL--------EIQAVRASDV-----GSYACVVTSPGGNETRAARLSVIELPF 687
            :.|.|   :...|:.        |.|.||:..|     .|.:.|..:|....|.|  .||:...|
  Rat   407 LQNFQ---MDVPGEFSREPSEHQETQMVRSLKVVGDTYHSVSLVWKAPQAGNTTA--FSVLYAVF 466

  Fly   688 PPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFI 723
            ...::: ....|..:.|:.:      :|.:|.:|::
  Rat   467 GQRDMR-RMTVEAGKTSVTI------EGLAPKTKYV 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	16/90 (18%)
		Ig	280..343	CDD:299845	14/77 (18%)
		IG_like	375..450	CDD:214653	14/93 (15%)
		Ig	378..447	CDD:143165	14/87 (16%)
		Ig	506..587	CDD:299845	24/89 (27%)
		IG_like	506..587	CDD:214653	24/89 (27%)
		I-set	592..682	CDD:254352	23/129 (18%)
		Ig	595..682	CDD:299845	22/126 (17%)
		FN3	686..789	CDD:238020	6/38 (16%)
		FN3	798..893	CDD:238020
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Lrit1	NP_647547.2	LRRNT	23..61	CDD:214470	6/17 (35%)
		LRR 1	60..81		1/20 (5%)
		LRR_8	63..143	CDD:290566	20/114 (18%)
		leucine-rich repeat	64..84	CDD:275378	3/19 (16%)
		LRR 2	84..105		6/20 (30%)
		leucine-rich repeat	85..132	CDD:275378	12/74 (16%)
		LRR 3	108..128		4/47 (9%)
		LRR_8	131..>176	CDD:290566	8/64 (13%)
		LRR_4	131..172	CDD:289563	8/60 (13%)
		LRR 4	132..153		6/40 (15%)
		leucine-rich repeat	133..156	CDD:275378	6/42 (14%)
		LRR 5	156..177		2/20 (10%)
		leucine-rich repeat	157..180	CDD:275378	1/22 (5%)
		leucine-rich repeat	181..205	CDD:275378	5/25 (20%)
		TPKR_C2	201..>240	CDD:301599	7/60 (12%)
		Ig	257..345	CDD:299845	25/97 (26%)
		IG_like	267..345	CDD:214653	22/86 (26%)
		FN3	431..501	CDD:214495	16/74 (22%)
		LRR 6	525..548
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900