DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and Ncam1

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_038936733.1	Gene:	Ncam1 / 24586	RGDID:	67378	Length:	1136	Species:	Rattus norvegicus

Alignment Length:	1405	Identity:	279/1405 - (19%)
Similarity:	458/1405 - (32%)	Gaps:	412/1405 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SSGSIVSEGSTKILQCHALG-YPQPTYRWLKDGVPVGDFSS--------------SQFYRFHSTR 129
            |.|.| |.|.:|...|...| .......|..   |.|:..|              |.....::..
  Rat    27 SQGEI-SVGESKFFLCQVAGDAKDKDISWFS---PNGEKLSPNQQRISVVWNDDDSSTLTIYNAN 87

  Fly   130 REDAGSYQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVM 194
            .:|||.|:|:...:.|:......:|.:....:|:|....: ....|..|:.....:.|:| |:::
  Rat    88 IDDAGIYKCVVTAEDGTQSEATVNVKIFQKLMFKNAPTPQ-EFKEGEDAVIVCDVVSSLP-PTII 150

  Fly   195 W--QSEDGPLNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVSGDPYI 257
            |  :..|..|..|:::.....|.|.|....:.|...||.:.
  Rat   151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEG------------------------ 191

  Fly   258 EVAPEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLA 322
                .|:.| .::..|      ::|.|.|..|
  Rat   192 ----RILAR-GEINFK------DIQVIVNVPP--------------------------------- 212

  Fly   323 LLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGE 387
            .:||..|                 .|:|:|.|                    |..|.|.||..|.
  Rat   213 TVQARQS-----------------IVNATANL--------------------GQSVTLVCDADGF 240

  Fly   388 PTPQVKWFRNAESVDAHIESGRYTLNTDNT--LVIKKLILDDAAMFQCLAINEAGENSASTWLRV 450
            |.|.:.|.::.|.::...|.....:.:|::  |.|:.:..:|.|.:.|:|.|:|||..||..|:|
  Rat   241 PEPTMSWTKDGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASIHLKV 305

  Fly   451 KTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALD-G 514
                       .|:|:|..|                                    :|.||:: .
  Rat   306 -----------FAKPKITYV------------------------------------ENQTAMELE 323

  Fly   515 KDATISCRAVGSPNPNITWIYNETQLVDISS-------RVQILESGD-------------LLISN 559
            :..|::|.|.|.|.|:|||   .|...:|||       |.:..|:.|             |.:.:
  Rat   324 EQVTLTCEASGDPIPSITW---RTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKS 385

  Fly   560 IRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNI 624
            |:..|||.|||..:|..|......||.|....: :|.||......|....:.|:|.:.||.  .|
  Rat   386 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSA--TI 447

  Fly   625 DWYREGQ--SSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPF 687
            .|:|:||  .|:..||.:.....:...||:.....:|.|:|.|...:..|.|:....|...:.|.
  Rat   448 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 512

  Fly   688 PPSNVKVERLPEPQQRSINVSW-TPGFDGNSPISKFIIQRREVSELGPVPDPLLNWITELSNVSA 751
            .||   ::|: ||...:..|.: .|...|..||.|:..:.:.:.|..        |
  Rat   513 SPS---IDRV-EPYSSTAQVQFDEPEATGGVPILKYKAEWKSLGEEA--------W--------- 556

  Fly   752 DQRW-----------ILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSGPPVGFVG 805
            ..:|           :.:..||..|.|..|::|:|..|.|..|..:.....|..:|  ||.|...
  Rat   557 HSKWYDAKEANMEGIVTIMGLKPETRYAVRLAALNGKGLGEISAATEFKTQPVHSP--PPQGEPS 619

  Fly   806 SAR---SMSEIITQWQPPLEEHRNG--QILGYILRYRLFGYNNVPWSYQNITNEAQRNFLIQELI 865
            :.:   .|.|.....:..|.:..:|  .|..|:::||....:.  |..:........:.:::.|.
  Rat   620 APKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVKYRAKLASE--WKPEIRLPSGSDHVMLKSLD 682

  Fly   866 TWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGV--PEAPPTNVKVEAINSTAARCRWTPPNPQQIN 928
            ...:|.|.:.|.|..|        |.|....|  ..|.||.:               |.|.....
  Rat   683 WNAEYEVYVVAENQQG--------KSKAAHFVFRTSAQPTAI---------------PANGSPTA 724

  Fly   929 GINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQTAILGGLEKFTEYNIS----VLCF 989
            |::.|                           :::..|.....:|..:...|.|.::    ::|.
  Rat   725 GLSTG---------------------------AIVGILIVIFVLLLVVMDITCYFLNKCGLLMCI 762

  Fly   990 T-----DPGDGVASSQV----AVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRASNGILTGYTV 1045
            .     ..|.|.....:    |..:.|:..:.:..:..::  :|:       |....|
  Rat   763 AVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEE--ERT-------PNHDGG------- 811

  Fly  1046 RYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYW------FEIVAWTRVGSGIPKTATIQSGVE 1104
            ::...:....|....|.||.|....:.|.:.|...      .|..| |...|...:|.|:.|.:.
  Rat   812 KHTEPNETTPLTEPELPADTTATVEDMLPSVTTVTTNSDTITETFA-TAQNSPTSETTTLTSSIA 875

  Fly  1105 PVLPHAPTALALSNIEAFSVVL-QFTPGFDGNSSITKWKVEGQTARNMTWFTICEINDPDAETLT 1168
            |.....|        |:.||.. |.||.            :|.||.:         :.|.|....
  Rat   876 PPATTVP--------ESNSVPAGQATPS------------KGVTASS---------SSPPASVPK 911

  Fly  1169 VTGLVPFTQYRLRLSASN------------VVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSA 1221
            |..||..:.......::|            |:..|.|:.| .:...:.|..|..|......|.:|
  Rat   912 VAPLVDLSDTPTSAPSANNLSSTVLANQGAVLSPSTPASA-GETSKVPATSKPSPTPTPTPAGAA 975

  Fly  1222 QQLRVRWIPL----QQTEWYGNPRGYNISYKQLVKTPGTIK---------YVPRSVVIEDHTANS 1273
            ..|.....|.    |..:...:.:|.:....|    |||:|         ..|:|......|.|.
  Rat   976 SPLAAVAAPATEAPQAKQEAPSTKGLDPEPTQ----PGTVKNPTEAATAPASPKSKAPSVSTTNP 1036

  Fly  1274 HVLDSLEEWTLYEVKMNACN----DVGCSKESDTAVERTREAVPSYGPLDVQANATSSTTVVVQW 1334
            ...:.|        ||:..|    |:..:|:...|:.....|..:.|.....|.:|:.:.|
  Rat  1037 SQGEDL--------KMDEGNFKTPDIDLAKDVFAALGSPAPATGASGQASELAPSTADSAV---- 1089

  Fly  1335 GEVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIPNNATFT 1374
            ...|.:...|.::.......:..:......||:||.||.|
  Rat  1090 PPAPAKTEKGPVETKSEPQESEAKPAPTEVKTVPNEATQT 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	20/91 (22%)
		I-set	72..150	CDD:254352	19/84 (23%)
		Ig	172..245	CDD:299845	15/74 (20%)
		IG_like	280..356	CDD:214653	11/75 (15%)
		Ig	280..343	CDD:299845	7/62 (11%)
		IG_like	375..450	CDD:214653	25/76 (33%)
		Ig	378..447	CDD:143165	23/70 (33%)
		Ig	506..587	CDD:299845	31/101 (31%)
		IG_like	506..587	CDD:214653	31/101 (31%)
		I-set	592..682	CDD:254352	25/91 (27%)
		Ig	595..682	CDD:299845	25/88 (28%)
		FN3	686..789	CDD:238020	25/114 (22%)
		FN3	798..893	CDD:238020	19/99 (19%)
		FN3	901..1005	CDD:238020	14/116 (12%)
		fn3	1011..1094	CDD:278470	14/88 (16%)
		FN3	1108..1202	CDD:238020	20/106 (19%)
		FN3	1210..1308	CDD:238020	23/114 (20%)
		fn3	1317..1402	CDD:278470	12/58 (21%)
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Ncam1	XP_038936733.1	IgI_1_NCAM-1	20..116	CDD:409451	20/92 (22%)
		Ig strand B	37..41	CDD:409451	1/3 (33%)
		Ig strand C	51..55	CDD:409451	0/3 (0%)
		Ig strand E	79..83	CDD:409451	0/3 (0%)
		Ig strand F	93..98	CDD:409451	2/4 (50%)
		Ig strand G	107..110	CDD:409451	0/2 (0%)
		IG_like	124..190	CDD:214653	15/67 (22%)
		Ig strand B	135..139	CDD:409353	1/3 (33%)
		Ig strand C	148..152	CDD:409353	0/3 (0%)
		Ig strand E	172..176	CDD:409353	2/3 (67%)
		Ig strand F	186..191	CDD:409353	2/4 (50%)
		IgI_3_NCAM-1	211..308	CDD:143207	34/177 (19%)
		Ig strand B	231..235	CDD:143207	2/3 (67%)
		Ig strand C	244..248	CDD:143207	0/3 (0%)
		Ig strand E	271..275	CDD:143207	1/3 (33%)
		Ig strand F	285..290	CDD:143207	1/4 (25%)
		Ig strand G	298..301	CDD:143207	1/2 (50%)
		IgI_NCAM-1	307..413	CDD:143277	35/144 (24%)
		Ig strand B	326..330	CDD:143277	1/3 (33%)
		Ig strand C	339..343	CDD:143277	3/6 (50%)
		Ig strand E	379..383	CDD:143277	1/3 (33%)
		Ig strand F	393..398	CDD:143277	3/4 (75%)
		Ig strand G	406..409	CDD:143277	0/2 (0%)
		Ig_3	422..494	CDD:404760	21/73 (29%)
		Ig strand B	433..437	CDD:409353	0/3 (0%)
		Ig strand C	446..450	CDD:409353	1/3 (33%)
		Ig strand E	473..477	CDD:409353	1/3 (33%)
		Ig strand F	487..492	CDD:409353	2/4 (50%)
		FN3	509..606	CDD:238020	25/117 (21%)
		fn3	619..701	CDD:394996	16/91 (18%)
		Herpes_BLLF1	<842..1133	CDD:282904	68/335 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900