DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and Lrit3

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_001274153.1	Gene:	Lrit3 / 242235	MGIID:	2685267	Length:	681	Species:	Mus musculus

Alignment Length:	482	Identity:	100/482 - (20%)
Similarity:	144/482 - (29%)	Gaps:	184/482 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 VELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANSSHSGEYTCQVRLRSG 343
            :|.....|.|.||||..    ||.::........|:.|..|||.|      |:.      |:.|.
Mouse    96 IETSSFYNLRQLHELRL----DGNSLTAFPWVSLLDMPHLRTLDL------HNN------RIASV 144

  Fly   344 GYPAVS----------ASARLQILEPP-------LFFTPMRAETFGEFGGQVQLTCDVVGEPTPQ 391
            ...||.          :|.||..|.|.       |..||.|:..|                |..:
Mouse   145 PNEAVRYLRNLTCLDLSSNRLTTLPPDFLDSWSHLAVTPSRSPDF----------------PPRR 193

  Fly   392 V-------KWFRNAESVDAHIESG-RYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWL 448
            :       .||     .|.||... ..:..||:.:|    :||  .:..|
Mouse   194 IILGLQDNPWF-----CDCHISKVIELSKVTDHAVV----LLD--PLMVC--------------- 232

  Fly   449 RVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALD 513
                                          ||.....|...:|.|......|.:.:....:|:..
Mouse   233 ------------------------------SEPERFQGILFQRVELEKCLKPSVMMSATKITSAL 267

  Fly   514 GKDATISCRAVGSPNPNITWIYNETQLVDISSRVQILES-GD------LLISNIRSVDAGLYICV 571
            |.:..:.|.|.|.|.|.:||..::...|:.:   .|.|| |:      :.:::|...|||.|.|.
Mouse   268 GSNVLLRCDAKGHPTPQLTWTRSDGSTVNYT---VIQESPGEGIRWSIISLTSISHKDAGDYRCK 329

  Fly   572 RANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVS----SDP-----------SVP 621
            ..|.||               |.:..|..||:.|:|.||....|    .:|           |.|
Mouse   330 AKNLAG---------------ISEAVVTVTVVGGVTTTLSPDSSERSPGEPPEQHPQPGLGGSTP 379

  Fly   622 YNIDWYREGQSSTPI-----------------SNSQRIGVQADGQLEIQAVRASDVGSYACVVTS 669
            .:..|...|.:|.|.                 |:...|...|.....:|              ||
Mouse   380 PSKSWLSPGLTSAPSYPTPSAALYTSTWSPPPSSLPPIFSAASATTSVQ--------------TS 430

  Fly   670 PGGNETRAARLSVIELPFPPSNVKVER 696
            ..|...|.:....:..|...||.|:|:
Mouse   431 ISGRTARTSHQPPLLHPGGKSNAKIEK 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	23/85 (27%)
		Ig	280..343	CDD:299845	17/62 (27%)
		IG_like	375..450	CDD:214653	12/82 (15%)
		Ig	378..447	CDD:143165	12/76 (16%)
		Ig	506..587	CDD:299845	23/87 (26%)
		IG_like	506..587	CDD:214653	23/87 (26%)
		I-set	592..682	CDD:254352	24/121 (20%)
		Ig	595..682	CDD:299845	23/118 (19%)
		FN3	686..789	CDD:238020	5/11 (45%)
		FN3	798..893	CDD:238020
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Lrit3	NP_001274153.1	LRR 1. /evidence=ECO:0000255	56..79
		LRR_8	61..117	CDD:290566	9/24 (38%)
		LRR 2. /evidence=ECO:0000255	80..103		1/6 (17%)
		leucine-rich repeat	83..106	CDD:275378	2/9 (22%)
		LRR 3. /evidence=ECO:0000255	104..128		8/27 (30%)
		LRR_8	105..165	CDD:290566	19/75 (25%)
		LRR_4	106..146	CDD:289563	15/55 (27%)
		leucine-rich repeat	107..130	CDD:275378	7/26 (27%)
		LRR_4	129..170	CDD:289563	14/52 (27%)
		LRR 4. /evidence=ECO:0000255	129..151		10/33 (30%)
		leucine-rich repeat	131..154	CDD:275378	9/34 (26%)
		LRR 5. /evidence=ECO:0000255	152..175		5/22 (23%)
		leucine-rich repeat	155..168	CDD:275378	3/12 (25%)
		Ig	254..335	CDD:299845	22/83 (27%)
		IG_like	263..339	CDD:214653	24/93 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..391		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..464		10/47 (21%)
		FN3	489..563	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900