DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and Lrit1

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_666357.2	Gene:	Lrit1 / 239037	MGIID:	2385320	Length:	624	Species:	Mus musculus

Alignment Length:	540	Identity:	111/540 - (20%)
Similarity:	189/540 - (35%)	Gaps:	154/540 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 VSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLW-----LKDGLAVETAGVR 310
            |..||.:.:.|..| .|...|:::....:........|||..||.||     |.:..|:...|:|
Mouse    44 VCSDPDLTLPPASI-PPDTCKLRLERTAIRRVPGETFRPLSRLEQLWLPYNALSELSALMLRGLR 107

  Fly   311 --HTLNDPWNRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILE---PPLFFTPMRAET 370
              ..|..|.||.:..                    .:.|:..:.:||:|:   ..|...|..|..
Mouse   108 RLRELRLPGNRLVTF--------------------PWAALRDTPQLQLLDLQANRLSTLPPEAAH 152

  Fly   371 FGEFGGQVQLT-CDVVGEPTPQVKWFRNAESVD--AHIESGRYTLNTDNTLVIKKLILD-----D 427
            |.|     .|| .|:......::.    .|.:|  ||:::|.:.......|::.  :.|     |
Mouse   153 FLE-----NLTFLDLSNNQLMRLP----EELLDVWAHLKTGPFLSGHHARLILG--LQDNPWVCD 206

  Fly   428 AAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRK 492
            ..::..:.:.:...:|...::..:.        |.|.||.|                :|.:..:.
Mouse   207 CRLYDLVHLLDGWVSSNLIFIEARL--------RCASPRSL----------------AGVAFSQL 247

  Fly   493 EFRFASAPIMELPPQNVTALD---GKDATISCRAVGSPNPNITW------IYNETQLVDISSRVQ 548
            |.|...:|  ||.| .||::.   |....:.|.|.|.|.|.::|      ..|.|...::||...
Mouse   248 ELRKCQSP--ELRP-GVTSIISPLGSTVLLRCGATGIPGPEMSWRRANGRPLNGTVHQEVSSDGS 309

  Fly   549 ILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCK 613
            .....||.:.::  .|:|.|||...|..|:  .|..:|:     |:..|..:|...|:...|..:
Mouse   310 SWTLLDLPVVSL--FDSGDYICQAKNFLGA--SETLISL-----IVTEPQTSTGYSGIPGVLWAR 365

  Fly   614 ---------------------------VSSDPSVP--------YNIDWYREGQSSTPISNSQRIG 643
                                       :::.||:|        .|......|:.|...|..|
Mouse   366 TGEGAEAAAYNNKLVARHVPHMPEHVALATKPSMPSIKEELALQNFQMDVPGEFSREPSEHQ--- 427

  Fly   644 VQADGQLEIQAVRASDV-----GSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQR 703
                   |.|.||:..|     .|.:.|..:|....|.|  .||:...|...::: ....||.:.
Mouse   428 -------EAQMVRSLKVVGDTYHSVSLVWKAPQAGNTTA--FSVLYAVFGHRDMR-RMTVEPGKT 482

  Fly   704 SINVSWTPGFDGNSPISKFI 723
            |:.:      :|.:|.:|::
Mouse   483 SVTI------EGLAPKTKYV 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	17/82 (21%)
		Ig	280..343	CDD:299845	15/69 (22%)
		IG_like	375..450	CDD:214653	12/82 (15%)
		Ig	378..447	CDD:143165	12/76 (16%)
		Ig	506..587	CDD:299845	24/89 (27%)
		IG_like	506..587	CDD:214653	24/89 (27%)
		I-set	592..682	CDD:254352	23/129 (18%)
		Ig	595..682	CDD:299845	22/126 (17%)
		FN3	686..789	CDD:238020	7/38 (18%)
		FN3	798..893	CDD:238020
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Lrit1	NP_666357.2	LRRNT	23..61	CDD:214470	6/17 (35%)
		LRR 1	60..81		1/20 (5%)
		LRR_8	63..143	CDD:290566	20/99 (20%)
		leucine-rich repeat	64..84	CDD:275378	3/19 (16%)
		LRR 2	84..105		6/20 (30%)
		leucine-rich repeat	85..132	CDD:275378	13/66 (20%)
		LRR 3	108..129		5/40 (13%)
		LRR_8	131..>176	CDD:290566	12/53 (23%)
		LRR_4	131..172	CDD:289563	11/49 (22%)
		LRR 4	132..153		6/20 (30%)
		leucine-rich repeat	133..156	CDD:275378	8/27 (30%)
		LRR 5	156..177		4/24 (17%)
		leucine-rich repeat	157..180	CDD:275378	5/26 (19%)
		leucine-rich repeat	181..205	CDD:275378	3/25 (12%)
		TPKR_C2	201..>241	CDD:301599	7/63 (11%)
		Ig	258..346	CDD:299845	25/97 (26%)
		IG_like	268..346	CDD:214653	22/86 (26%)
		FN3	432..502	CDD:214495	17/74 (23%)
		LRR 6	526..549
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900