DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and Sdk2

DIOPT Version :10

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_766388.2 Gene:Sdk2 / 237979 MGIID:2443847 Length:2176 Species:Mus musculus


Alignment Length:2286 Identity:846/2286 - (37%)
Similarity:1193/2286 - (52%) Gaps:231/2286 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 PRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDGVPVGDFSSSQFYRFHSTRREDAGSY 136
            |.|.|.|..: .:..||:..:|.|.|.|.....::||.:...:..||....|...|..|..||.|
Mouse    30 PYFKTEPVRT-QVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTRFSLEYRYMITSLDRTHAGFY 93

  Fly   137 QCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDGP 201
            :||.||..|::...:::|.|||||.||. .|.|.:|..|..|:...|.|.|.|.|.|.|..:...
Mouse    94 RCIVRNRMGALLQRQTEVQVAYMGSFEE-GEKRQSVNHGEAAVIRAPRISSFPRPQVTWFRDGRK 157

  Fly   202 LNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVS--GDPYIEVAPEII 264
            :....:.|.|..|.|:|||....|...|..:|:|.:.|..::|..:.|.|.  |.|...:||.||
Mouse   158 IPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLAVENVGGPADPIAPTII 222

  Fly   265 VRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANSS 329
            :.|::..|..||..|.::|:||||||.:|..:|.||| |..::|:     ..:||.|.:.....|
Mouse   223 IPPKNTSVVAGTSEVTMECVANARPLIKLHIVWKKDG-APLSSGI-----SDYNRRLTIANPTVS 281

  Fly   330 HSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKW 394
            .:|.|.|:..|||.....|:..|.|.:||||.|..........|....|.:.|...|.|.|.:.|
Mouse   282 DAGYYECEAMLRSSSVAPVTRGAYLSVLEPPQFVREPERHITAEMEKVVDIPCRAKGVPPPSITW 346

  Fly   395 FRNAESVDAHIESG---RYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAK 456
            :::|    |.:|.|   |:...:|..|.|..|:.||..|.||.|.|.|||...||:|.|.     
Mouse   347 YKDA----ALVEVGKLTRFKQRSDGGLQISGLLPDDTGMLQCFAHNAAGEAQTSTYLAVT----- 402

  Fly   457 NRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISC 521
                                                    :.||.:...|.:.|.:||....::|
Mouse   403 ----------------------------------------SIAPNITRGPLDSTVIDGMSVVLAC 427

  Fly   522 RAVGSPNPNITWIYNETQLVDIS---SRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEA 583
            ...|:|.|.|||...|..|...|   .|..:||||.||||.....|||.|.|:..|..|..:..|
Mouse   428 ETSGAPRPAITWQKGERILASGSVQLPRFTLLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 492

  Fly   584 YLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADG 648
            .|.|..||:|.:||.|.:|:.|..|::.|.|:.||.|.....|.::| ::..:..:.||.:..:|
Mouse   493 DLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTVRYVWEKDG-ATLAVETNPRIRLDRNG 556

  Fly   649 QLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGF 713
            .|.|....:.|:|:|.|.|.|.|||::|.|.|.|.:||..|.: .|..|...::|:||::|...|
Mouse   557 SLHISQTWSGDIGTYTCRVLSAGGNDSRNAHLRVRQLPHAPEH-PVATLSTVERRAINLTWAKPF 620

  Fly   714 DGNSPISKFIIQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVG 778
            |||||:.::::   |:|| ...|     |...|::|..:...::::.|..|..||||:.|||.||
Mouse   621 DGNSPLMRYVL---EMSE-NNAP-----WTILLASVDPEATSVMVKGLVPARSYQFRLCAVNDVG 676

  Fly   779 EGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNN 843
            :|..|:.:..|.||:|.|:.||...:.|.|:...|:.|||||.|.|:||.:.|||:||.|.|   
Mouse   677 KGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAG--- 738

  Fly   844 VPWSYQ--NITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIK--TKEGVPEAPPTN 904
            :|..||  |||:....|.|:::||.|.:|.:::||||:.|:|||:  ||:.  |.:|||..||.|
Mouse   739 LPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYS--SKVTEWTLQGVPTVPPGN 801

  Fly   905 VKVEAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQ 969
            |..||.|||..|..|..|:||.|||||||||:.||:..      ::.|..|.|..|:..|.:  .
Mouse   802 VHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPA------QEEEVTMVTARPNFQDSI--H 858

  Fly   970 TAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPR 1034
            ...:.||:|||||..||||||.||||..||...|.|.:|||..|..|.|:|:.|.|:||.|..|.
Mouse   859 VGFVSGLKKFTEYFTSVLCFTTPGDGPRSSPQLVRTHEDVPGPVGHLSFNDILDTSLKVSWQEPG 923

  Fly  1035 ASNGILTGYTVRYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATI 1099
            ..|||||||.:.::..:|.:|..:..|.....|..|..|.|.|.|..|:.|.|..|.|....:||
Mouse   924 EKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTI 988

  Fly  1100 QSGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQT---ARNMTWFTICEI-N 1160
            .|||.|.||.|||.|.:|||...||.|||.||:||.:||::|.||.|.   .....|..|.:: |
Mouse   989 SSGVPPELPGAPTNLGISNIGPRSVTLQFRPGYDGKTSISRWVVEAQVGVIGEGEEWLLIYQLGN 1053

  Fly  1161 DPDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLR 1225
            :|||.::.|..|.|||.|..|:...|:||:|.||:.::..||:||.|...|.|||:|..|...|.
Mouse  1054 EPDARSMEVPDLNPFTYYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDIAPANVTLRTASETSLW 1118

  Fly  1226 VRWIPLQQTEWYGNPR--GYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVK 1288
            :||:||.:.|:.|||.  ||.|.|.   ::.|..|.:  |..::|.....:.::.|||||.|.|:
Mouse  1119 LRWMPLPEMEYNGNPESVGYKIKYG---RSDGHGKTL--SHTVQDRVEREYTIEDLEEWTEYRVQ 1178

  Fly  1289 MNACNDVGCSKESDTAVERTREAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFY 1353
            :.|.|.:|....|...|.||||:|||.||.:|.|.||:|::::|:|.|:|...|||.:.||||.|
Mouse  1179 VQAFNAIGSGPWSQAVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEIPEADRNGLVLGYKVRY 1243

  Fly  1354 AAADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVP 1418
            ...|...|.....:..|::.:..||.|.|||:|.|||||:||:|:|:.|.|||..:|.:|.||.|
Mouse  1244 KEKDSDSQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPP 1308

  Fly  1419 SNVSFPDVSLTMARIIWDVPVDPNGKILAYQVTYTLNGSAMLNYSRE-FPPSDRTFRATELLPGK 1482
            ..:.||:|..|..|:||..|..|||.|||||:|:.||.:.....:.| ..||.|.:.||.|.|..
Mouse  1309 MGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNATTANTATVEVLAPSARQYMATGLKPES 1373

  Fly  1483 YYSFSCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRSQIQAHQITFSWTPGRDGFAPLRY 1547
            .|.|..|||||.|||:.|.|||.||..|:|||.||.|.:.:..::|..:..||.||.||.:|:||
Mouse  1374 VYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSKPVVQQEDVKARSVLLSWEPGSDGLSPVRY 1438

  Fly  1548 YTVEMRE-NEGRWQPLPERVDPSLSSFTAVGLRPYMTYQFRIQATNDLGPSAFSRESVIVRTLPA 1611
            ||::.|| ..|||......|..:.|:||...|:|:.:|:||::||||:|.|.||.||..:.||.|
Mouse  1439 YTIQTRELPSGRWALHSASVSHNASAFTVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQA 1503

  Fly  1612 APAVGVGGLKVVPITTTSVRVQWSALETALWNGDASTGGYRILYQQL------------SDFPTA 1664
            ||......|.|.|.|||||.::|........||...  |:||.|::|            .:.|.|
Mouse  1504 APDEAPTILSVTPHTTTSVLIRWQPPSEDKINGILL--GFRIRYRELLYDGLRGFTLRGINNPGA 1566

  Fly  1665 --LQSTPKTDVHGINENSVV---LSDLQQDRNYEIVVLPFNSQGPGPATPPAAVYVGEAVPTGEP 1724
              .:.|....:..:...|:.   |.:|.:.|.|||.:..:|:.|.||.:||..|:|||||||..|
Mouse  1567 KWAELTSLYSMRNLTRPSLTQYELDNLSKHRRYEIRMSIYNAVGEGPLSPPQEVFVGEAVPTAAP 1631

  Fly  1725 RAVDAAPISSTEVRLLWKPPKQSMQNGDILGYKIYYLVTYSPQALEPGRKWE-------EEIEVV 1782
            :.|.....::|::.:.|:||....|||||.|||||:              ||       |.::.:
Mouse  1632 QNVAIHSATATQLDVTWEPPPLDNQNGDIQGYKIYF--------------WEVQRRNLTERVKTL 1682

  Fly  1783 SATATSHSLVFLDKFTEYRIQLLAFNPAGDGPRSAPITVKTLPGVPSAPLHLRFSDITMQSLEVT 1847
            .....|..|..|..:|.|.:.:.|||.|||||||.|...:|....||||..::||::|..|:.|:
Mouse  1683 FLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTRGQTQQAAPSAPGSVKFSELTTTSVNVS 1747

  Fly  1848 WDPPKFLNGEILGYLVTYETTEENEKFSKQVKQKVSNTT---LRVQNLEEEVTYTFTVRAQTSVD 1909
            ||.|:|.||.:.||.:.||.....:..||.|...|...:   |:|::|.|.:||.|.::|:| ..
Mouse  1748 WDAPQFPNGPLEGYRLVYEPCTPVDGVSKIVTVDVKGNSPLWLKVKDLAEGMTYRFRIKAKT-FT 1811

  Fly  1910 YGPGISENVTTGPQDGSPVAPRDLILTKTLSSVEMHWINGPSGRGPILGYLIEAKKRDDSRWTKI 1974
            |||.|..|:||||.:|:|..|...|:.:..|::.:||.:|..|:|||..|:|||:..|:..|..:
Mouse  1812 YGPEIEANITTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDIL 1876

  Fly  1975 EQTRKGMMQDFTVSYHILMPSTAYTFRVIAYNRYGISFPVYSKDSILTPSKLHLEYGYLQHKPFY 2039
            .:.....:..:|.|..||.|..:|.|||||.|.||...|  |..|...|::        :..|||
Mouse  1877 IKDIPKEVTSYTFSMDILKPGVSYDFRVIAVNDYGFGTP--SSPSQSVPAQ--------KASPFY 1931

  Fly  2040 RQTWFMVSLAATSIVIIVMVIAVLCVKSKSYKYKQEAQK-------TLEESMAMSIDERQELALE 2097
            .:.||:|.:|...::.|::::.||.::.:|.||.::...       .|.....:|:||....|||
Mouse  1932 EEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYSKKTDSGGNTKSGALGHGEMLSLDESSFPALE 1996

  Fly  2098 LYRSRHGVGTGTLNSVGTLRSGTLGTLGRKSTSRPPPGVHLGKSPPRPSPASVAYHSDEESLKCY 2162
            |...|..|               ..:..||:      |::. :|||||||.|:.| |||:..|..
Mouse  1997 LNNRRLSV---------------KNSFCRKN------GLYT-RSPPRPSPGSLHY-SDEDVTKYN 2038

  Fly  2163 DENP-DDSSVTEKPSEVSSSEASQHSESENESVRSDPHSFVNHYANVNDSLRQSWKKTKP----V 2222
            |..| :.||:||||||:|.|:.|. ||.|.::.....|||||||.: :.:...||::.:.    .
Mouse  2039 DLIPAESSSLTEKPSEISDSQGSD-SEYEVDTNTQKAHSFVNHYIS-DPTYYNSWRRQQKGISRA 2101

  Fly  2223 RNYSSYTDS---EPEGSAVMSLNG---GQIIVNNMAR---------------------------S 2254
            :.| |||:|   ||:...|.:.|.   |.:.....:|                           |
Mouse  2102 QAY-SYTESDSGEPDHVTVPNSNSTQQGSLFRPKASRTPTPQNPPNPQSQQSTLYRPPSSLAPGS 2165

  Fly  2255 RAPLPGFSSFV 2265
            |||:.||||||
Mouse  2166 RAPIAGFSSFV 2176

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig_3 72..142 CDD:464046 22/69 (32%)
Ig 280..344 CDD:409353 24/63 (38%)
Ig strand B 280..283 CDD:409353 0/2 (0%)
Ig strand C 292..298 CDD:409353 1/5 (20%)
Ig strand E 319..323 CDD:409353 2/3 (67%)
Ig strand F 333..338 CDD:409353 2/4 (50%)
Ig 360..451 CDD:472250 31/93 (33%)
Ig strand B 378..382 CDD:409353 1/3 (33%)
Ig strand C 391..395 CDD:409353 0/3 (0%)
Ig strand E 416..420 CDD:409353 1/3 (33%)
Ig strand F 430..435 CDD:409353 3/4 (75%)
Ig strand G 443..446 CDD:409353 0/2 (0%)
Ig 502..587 CDD:472250 32/87 (37%)
Ig strand B 517..521 CDD:409353 0/3 (0%)
Ig strand C 530..534 CDD:409353 2/3 (67%)
Ig strand E 554..557 CDD:409353 1/2 (50%)
Ig strand F 567..572 CDD:409353 2/4 (50%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 31/89 (35%)
Ig strand B 608..612 CDD:409353 1/3 (33%)
Ig strand C 623..627 CDD:409353 0/3 (0%)
Ig strand E 648..652 CDD:409353 2/3 (67%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 1/2 (50%)
FN3 686..789 CDD:238020 34/102 (33%)
FN3 798..893 CDD:238020 43/98 (44%)
FN3 901..1005 CDD:238020 50/103 (49%)
FN3 <960..>1261 CDD:442628 132/306 (43%)
fn3 1317..1402 CDD:394996 37/84 (44%)
FN3 1415..1507 CDD:238020 44/92 (48%)
FN3 1513..1608 CDD:238020 41/95 (43%)
FN3 1583..>2011 CDD:442628 167/454 (37%)
Sdk2NP_766388.2 Ig_3 29..99 CDD:464046 22/69 (32%)
Ig 126..201 CDD:472250 22/74 (30%)
Ig strand B 134..138 CDD:409353 1/3 (33%)
Ig strand C 148..152 CDD:409353 1/3 (33%)
Ig strand E 170..174 CDD:409353 2/3 (67%)
Ig strand F 184..189 CDD:409353 1/4 (25%)
Ig strand G 197..200 CDD:409353 0/2 (0%)
Ig_3 226..290 CDD:464046 25/69 (36%)
Ig 312..401 CDD:472250 31/92 (34%)
Ig strand B 330..334 CDD:409353 1/3 (33%)
Ig strand C 343..347 CDD:409353 0/3 (0%)
Ig strand E 367..371 CDD:409353 1/3 (33%)
Ig strand F 381..386 CDD:409353 3/4 (75%)
Ig strand G 394..397 CDD:409353 0/2 (0%)
Ig 408..496 CDD:472250 32/87 (37%)
Ig strand B 423..427 CDD:409544 0/3 (0%)
Ig strand C 436..440 CDD:409544 2/3 (67%)
Ig strand E 462..466 CDD:409544 2/3 (67%)
Ig strand F 476..481 CDD:409544 2/4 (50%)
Ig strand G 489..492 CDD:409544 0/2 (0%)
Ig 502..590 CDD:472250 31/88 (35%)
Ig strand B 517..521 CDD:409544 1/3 (33%)
Ig strand C 530..536 CDD:409544 0/5 (0%)
Ig strand E 556..560 CDD:409544 2/3 (67%)
Ig strand F 570..575 CDD:409544 2/4 (50%)
Ig strand G 583..586 CDD:409544 1/2 (50%)
FN3 594..685 CDD:238020 34/100 (34%)
FN3 737..1220 CDD:442628 215/500 (43%)
FN3 1103..1198 CDD:238020 35/99 (35%)
fn3 1207..1292 CDD:394996 37/84 (44%)
FN3 <1276..>1526 CDD:442628 118/249 (47%)
FN3 1507..1620 CDD:238020 32/114 (28%)
FN3 1630..1723 CDD:238020 35/106 (33%)
FN3 <1698..>1929 CDD:442628 91/241 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1712..1734 11/21 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2013..2032 11/20 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2043..2070 14/27 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2102..2176 19/74 (26%)
PDZ-binding. /evidence=ECO:0000269|PubMed:20219992 2170..2176 4/5 (80%)

Return to query results.
Submit another query.