back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and Prtg

DIOPT Version :10

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_780694.3	Gene:	Prtg / 235472	MGIID:	2444710	Length:	1191	Species:	Mus musculus

Alignment Length:	1245	Identity:	263/1245 - (21%)
Similarity:	435/1245 - (34%)	Gaps:	334/1245 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 GGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIES 407
            |..|.|.:.:.|..::.|...|..|.:       .|.|.|...||...:|.|.:|...:.   |:
Mouse    22 GSVPGVWSFSELFFMKEPQDATVTRKD-------PVVLDCQAHGEGPIKVTWLKNGAKLS---EN 76

  Fly   408 GRYTLNTDNTLVIKKL-----ILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRI 467
            .|..:.::.:|.|.::     ...|...:||||:|:.|                         .|
Mouse    77 KRIQVLSNGSLYISEVEGRRGEQSDEGFYQCLAVNKYG-------------------------AI 116

  Fly   468 LRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNIT 532
            |..:| |..|                   ::....|:.|.:....:|..|..||:...:|...||
Mouse   117 LSQKA-HLTL-------------------STISAFEVHPVSTEVHEGGVARFSCKISSTPPAVIT 161

  Fly   533 WIYNETQLVDISSRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKG-EAYLSVLVRTQ---- 592
            |.:|.|.|.....||..|.||.|.|.::...|||.|.||.|..|...|. ||.|:::...:
Mouse   162 WEFNRTALPTTMDRVTALPSGVLQIYDVGPEDAGNYRCVAATIAHKRKSMEASLTIVAANETRSF 226

  Fly   593 ----IIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQ 653
                ||..|.:.|..|..|..|:|..:..|. |. |.|.|....|..:.|::.:|   :|.|.|.
Mouse   227 YMPTIIASPQNVTASLHQTVVLECMATGYPR-PI-ISWSRLDHKSIDVFNTRVLG---NGNLIIS 286

  Fly   654 AVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVK-VERLPEPQQRSINVSWTPGFDGNS 717
            .|:....|.|.|..|:||......| ::.:.:..|||.|: .|.|..|:               :
Mouse   287 DVKLQHAGVYVCRATTPGTRNFTVA-MATLTVLAPPSFVEWPESLTRPR---------------A 335

  Fly   718 PISKFIIQRREVSELGPVPDPLLNWITELSNVSADQR---------------------WILLENL 761
            ..::|:.|..      .:|.|.::|:.....:.::.|                     ..:.||.
Mouse   336 GTARFVCQAE------GIPSPKMSWLKNGRRIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENS 394

  Fly   762 KAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRN 826
            :.:.:.:.|::.|  :.|..||.|.||               .....|.|.|:..|:.||  :.:
Mouse   395 QGSVLSRARLTVV--MSEDRPSAPYNV---------------HAETMSSSAILLAWERPL--YNS 440

  Fly   827 GQILGYILRY-RLFGYNNVPWSYQNITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSK 890
            .:::.|.:.| :..|.||.  .||.:......:::|.:|....:|...|.||..:|....::...
Mouse   441 DKVIAYSVHYMKAEGLNNE--EYQVVLGNDTTHYIIDDLEPDSNYTFYIVAYMPLGASQMSDHVT 503

  Fly   891 IKTKEGVPEAPPTNVKVEAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGE---WRDIE 952
            ..|.|.||..|| .:.:.:.:.|.....|.|              |.|..||   |:   :| :.
Mouse   504 QNTLEDVPLRPP-EISLTSRSPTDILVSWLP--------------IPAKYRR---GQVVLYR-LS 549

  Fly   953 RRMKT--------VPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDV 1009
            .|:.|        :|.::.:.|.|      ||:..:.|.:.:...|..|.|.:|    |.|....
Mouse   550 FRLSTENAIQVVELPGTVHEYLLE------GLKPDSVYLVRITAATRVGLGESS----VWTSHRT 604

  Fly  1010 PDEVT-------GLHFDDVSDRSVKVLWAPPRASNGILTGYTVRYQVKDRPDTLKSFNLTADDTE 1067
            |...:       .||.:.::..::.|.|.........:.||.:.|:.:.:.:....| |...|..
Mouse   605 PKATSVKAPKSPELHLEPLNCTTISVRWLQDTEDPAAIRGYKLFYKEEGQQEHGPIF-LDTGDLL 668

  Fly  1068 LTVNQLQATTHYWFEIVAWTRVGSG--------IPKTATIQSGVEPVLPHAPTALALSNIEAFSV 1124
            .|::.|.....|...::|:..:..|        .|...:::..:.|..|......|.:|..: |:
Mouse   669 YTLSGLDPRRKYHVRLLAYNNMEEGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSS-SI 732

  Fly  1125 VLQF-TPGFDG----NSSITKWKVEGQTARNMTWFTICEINDPDAETLTVTGLVPFTQYR--LRL 1182
            .|.: .|.|..    |.:|....|..|.|..:.:....|.:      :.|.||.|.|:|.  :||
Mouse   733 FLHWRRPAFTTAQVINYTIRCNPVGLQNASLVLYLQTSETH------MLVQGLEPNTKYEFAVRL 791

  Fly  1183 SASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRWIPLQQTEWYGNPRGYNISY 1247
            ....:   |.|........|:...|..||..|.|..:......|.|.|         |.|
Mouse   792 HVDQL---SSPWSPVVYHSTLPEAPTGPPVGVKVTLIEDDTALVSWKP---------PDG----- 839

  Fly  1248 KQLVKTPGTIKYVPRSVVIEDHTANSH--------VLDSLEEWTLYEVKMNACNDVG-------- 1296
            .:.|.|..||.|..|...|.......|        :|::|....:|.||::|.|:||
Mouse   840 PETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSV 904

  Fly  1297 ----CSKESDTAVERTR-------EAVPSYGPLDVQANAT------------------------- 1325
                ..|::..:.:|.:       :....|..|| |.:.|
Mouse   905 ELAVLPKDASESNQRPKRLDSSNAKVYSGYYHLD-QKSMTGIAVGVGIALTCILICVLILIYRSK 968

  Fly  1326 ---SSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQQVLHKT---------IPNNATFTTTLT 1378
               ||.:...|.|..|....:..:      .|.:|.|:.:...|         :|::.......|
Mouse   969 ARKSSASKTAQSGTQPLSQASASV------AAGSDMGKNLERATETAESLVPMMPSSFIDAKGGT 1027

  Fly  1379 EL--------------KKYVVYH--------------VQVLAYTRLGNGALSTPPIRVQTFEDTP 1415
            :|              ||::.:.              .|.:.:.:.|...|.:.       ||:|
Mouse  1028 DLIINSYGPIIKNNTKKKWLFFQDTKKIKVEQTQRRFTQAVCFYQPGTTVLISD-------EDSP 1085

  Fly  1416 GVP-SNVSFP 1424
            |.| ...|||
Mouse  1086 GSPGQTASFP 1095

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.