DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and NFASC

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_024310051.1	Gene:	NFASC / 23114	HGNCID:	29866	Length:	1513	Species:	Homo sapiens

Alignment Length:	1351	Identity:	299/1351 - (22%)
Similarity:	487/1351 - (36%)	Gaps:	324/1351 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AIEMPSQPKLASLLAVLVLLCYCDSCFFCYADANLQQQNSIVQQQQLQAPRFTTHPSSSGSIVSE 87
            |||:|..|.:                                 |.:|..|...|..|:...||..
Human   173 AIEIPMDPSI---------------------------------QNELTQPPTITKQSAKDHIVDP 204

  Fly    88 GSTKILQCHALGYPQPTYRWLKD------------------GVPVGDFSSSQFYRFHSTRREDAG 134
            ....:::|.|.|.|.|::.|.::                  |..|.||.|.      ....|..|
Human   205 RDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSG------GRPEEYEG 263

  Fly   135 SYQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMW---- 195
            .|||.|||..|:..|.:..:.|:...::.......:.|..|.|......|...:|.|.:.|
Human   264 EYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSS 328

  Fly   196 -----------QSEDGPLNY--------------DIKYAFTHANQ------LIIL-------SAD 222
                       |..:|.|.:              :.::.|||..|      |.:|       |:.
Human   329 MEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSL 393

  Fly   223 ENDRKGYRAKAINTQLGKEESSAFVHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANA 287
            .|....|.|:.:     .|.:.:|::      |....:.::::|..|:.         |:|||:.
Human   394 RNHPDMYSARGV-----AERTPSFMY------PQGTASSQMVLRGMDLL---------LECIASG 438

  Fly   288 RPLHELETLWLKDG--LAVETAGVRHTLNDPWNRTLALLQANSSHSGEYTCQVRLRSGGYP---A 347
            .|..::  .|.|.|  |..:.|...:     :|:.|.:...:...||||.|....:.|...   :
Human   439 VPTPDI--AWYKKGGDLPSDKAKFEN-----FNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 496

  Fly   348 VSASARLQILEPP--LFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRY 410
            |...|....|:.|  |...|      ||.|   :|.|...|.|.|.|:|..|.|.    ::|...
Human   497 VRVKAAPYWLDEPKNLILAP------GEDG---RLVCRANGNPKPTVQWMVNGEP----LQSAPP 548

  Fly   411 TLNTD---NTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRA 472
            ..|.:   :|::.:...:...|::||...||.|...|:.::.|..          ..||:|..|.
Human   549 NPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD----------VPPRMLSPRN 603

  Fly   473 SHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYN- 536
            .                           ::.:...|.|.||       |...|||.|.:.|..|
Human   604 Q---------------------------LIRVILYNRTRLD-------CPFFGSPIPTLRWFKNG 634

  Fly   537 ETQLVDISSRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTT 601
            :...:| .....:.|:|.|.|..||..|.|:|.||..|..|..:.:..|.|...|:|.:.|.|..
Human   635 QGSNLD-GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV 698

  Fly   602 VLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACV 666
            ...|.|..|:|:|..|||:...:.|.::.:   |:....|: .:.|..|.|..|...|.|||.||
Human   699 ARRGTTVQLECRVKHDPSLKLTVSWLKDDE---PLYIGNRM-KKEDDSLTIFGVAERDQGSYTCV 759

  Fly   667 VTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQ-------------QRSINVSWTPGFDGNSP 718
            .::....:...|.|:|:.....|:| ::..||:.:             :||:.::|.||...|||
Human   760 ASTELDQDLAKAYLTVLADQATPTN-RLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSP 823

  Fly   719 ISKFIIQRREVSELGP--------VPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVN 775
            |:.:::|..| .:..|        .|..:.:.:..||               ....|||||.|:|
Human   824 ITDYVVQFEE-DQFQPGVWHDHSKYPGSVNSAVLRLS---------------PYVNYQFRVIAIN 872

  Fly   776 RVGEGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFG 840
            .||...||.||.........|...|....|.....:.:...|.|.......|..|.||:::|
Human   873 EVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWR--- 934

  Fly   841 YNNVPWSYQNITNEAQRN-------FLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVP 898
                    :..|.||..|       :::.:...:..|.:::.|.|:.|.|...|.....:.|..|
Human   935 --------RRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYP 991

  Fly   899 EAPPTNVKVEAINSTAARCRWTPPNPQQINGINQGYKIQAW-QRRLIDGEWRDIERRMKTVPPSL 962
            .|.||.|||..:||||...:|.......:.|..:.|:...| :..|:...|...:|:..:.|...
Human   992 RAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDR 1056

  Fly   963 IDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVK 1027
            :      ..::..|..::.|.:.::.....|||..|......|.:.||...........:..::.
Human  1057 L------RGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETIN 1115

  Fly  1028 VLWAPPRASNGILTGYTVRYQVKDRPDTLKSF--NLTADDTELTVNQLQATTHYWFEIVAWTRVG 1090
            :.|..|...|||:.|||::|...:.....|..  |.:.:.|:.||.:....:.|.|.:.|.|:||
Human  1116 LEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVG 1180

  Fly  1091 SG----------------------IPKT-----------------ATIQSGVEPVLPH-APTALA 1115
            ||                      :|.|                 ||.::...|::|. |||.:|
Human  1181 SGEAVTEESPAPPNEATPTAAPPTLPPTTVGATGAVSSTDATAIAATTEATTVPIIPTVAPTTIA 1245

  Fly  1116 --------LSNIEAFSVVLQFTPGFDGNSSITKWKVEGQTARNMTWFTICEINDPDAETLTVT-- 1170
                    .:...|.:...:..|.....:.|.:...:.|:..|:|..       |:::...:|
Human  1246 TTTTVATTTTTTAAATTTTESPPTTTSGTKIHESAPDEQSIWNVTVL-------PNSKWANITWK 1303

  Fly  1171 -GLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMS 1220
             ...|.|.:.:....||....:.|.:|  ..|.||....:|....|:|..|
Human  1304 HNFGPGTDFVVEYIDSNHTKKTVPVKA--QAQPIQLTDLYPGMTYTLRVYS 1352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	26/103 (25%)
		I-set	72..150	CDD:254352	25/95 (26%)
		Ig	172..245	CDD:299845	21/114 (18%)
		IG_like	280..356	CDD:214653	20/80 (25%)
		Ig	280..343	CDD:299845	17/64 (27%)
		IG_like	375..450	CDD:214653	20/77 (26%)
		Ig	378..447	CDD:143165	19/71 (27%)
		Ig	506..587	CDD:299845	26/81 (32%)
		IG_like	506..587	CDD:214653	26/81 (32%)
		I-set	592..682	CDD:254352	26/89 (29%)
		Ig	595..682	CDD:299845	25/86 (29%)
		FN3	686..789	CDD:238020	32/123 (26%)
		FN3	798..893	CDD:238020	19/101 (19%)
		FN3	901..1005	CDD:238020	23/104 (22%)
		fn3	1011..1094	CDD:278470	22/106 (21%)
		FN3	1108..1202	CDD:238020	19/105 (18%)
		FN3	1210..1308	CDD:238020	4/11 (36%)
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
NFASC	XP_024310051.1	Ig_hNeurofascin_like	208..284	CDD:143283	21/81 (26%)
		Ig	289..381	CDD:325142	14/91 (15%)
		Ig3_L1-CAM_like	430..500	CDD:319298	19/85 (22%)
		Ig	517..592	CDD:325142	22/81 (27%)
		Ig	615..681	CDD:319273	23/73 (32%)
		I-set	694..775	CDD:254352	25/84 (30%)
		FN3	794..884	CDD:238020	27/105 (26%)
		FN3	895..985	CDD:238020	19/100 (19%)
		FN3	994..1093	CDD:238020	23/104 (22%)
		FN3	1098..1189	CDD:238020	23/90 (26%)
		fn3	1287..1359	CDD:306538	17/75 (23%)
		Bravo_FIGEY	1405..1489	CDD:316405
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910