DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and Fstl5

DIOPT Version :9

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_001240648.1 Gene:Fstl5 / 213262 MGIID:2442179 Length:847 Species:Mus musculus


Alignment Length:646 Identity:127/646 - (19%)
Similarity:207/646 - (32%) Gaps:231/646 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   502 MELPPQ---NVTALD-GKDATISCRAVGSPNPNITW-----IYNETQLVDISSRVQILESGDLLI 557
            :.||..   ::||.. |:.|.:||..||:..|.|.|     :.|...|.||:   ...:.|.|.|
Mouse   247 LSLPEDQRVSITAATVGQSAVLSCAIVGTLRPPIIWKRNNIVLNNLDLEDIN---DFGDDGSLYI 308

  Fly   558 SNIRSVDAGLYIC-------VRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVS 615
            :.:.:|..|.|.|       ||......|.....:.|...:|..:|        |:||:|:|...
Mouse   309 TKVTTVHMGNYTCYADGYENVRQTHIFQVNVPPVIRVYPESQAREP--------GVTASLRCHAE 365

  Fly   616 SDPSVPYNIDWYREGQSSTPISNSQRIGVQADG-QLEIQAVRASDVGSYACVVTSPGGNETRAAR 679
            ..|..  .:.|.:.|...|| ..|:::.:||:| ::.|..||..|.|:|.|:..:..|.:...:.
Mouse   366 GIPDP--QLGWLKNGIDITP-KLSKQLTLQANGSEVHISNVRYEDTGAYTCIARNEAGVDEDISS 427

  Fly   680 LSVIELP------------------------------FPPSNVKVERLPEPQQRSINVS------ 708
            |.|.:..                              ..|:..:.:|..:|.::.:...      
Mouse   428 LFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPTECEFQRHIKPSEKLLGYQDEVCPK 492

  Fly   709 ----------WTPGFDGNSPISKFI--------------IQRREVSE---LGPVPDPLLNWITEL 746
                      |....:..   .|||              :|.::|.:   ..|||..|      .
Mouse   493 AEEDEVQRCVWASAVNVK---DKFIYVAQPTLDRILIVDVQSQKVVQAVSTDPVPVKL------H 548

  Fly   747 SNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVE--------LPQEAPSGPPVG- 802
            .:.|.||.|:|                    ..||..:.|..::        :|.......||| 
Mouse   549 YDKSHDQVWVL--------------------SWGSMEKTSPTLQVITLASGNVPHHTIHTQPVGK 593

  Fly   803 --------FVGSARSMSEIITQWQPPLEEHRNG--------QILGYILRYRLFGYNNVPWSYQNI 851
                    |:.:.   :.|||..:.....|::.        :.:.||....|.....:|.|    
Mouse   594 QFDRVDDFFIPTP---TLIITHMRFGFILHKDESALHKIDLETMSYIKTINLKDSRCIPLS---- 651

  Fly   852 TNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVEAI------ 910
                                   .||.::| |.|.    |..|..:..|.|..:.|:::      
Mouse   652 -----------------------LAYTHLG-GYYF----ISCKADITGATPPQLVVDSVTDSIIG 688

  Fly   911 -NSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWR---DIERRMKTVPPSLIDPLAEQTA 971
             ||......:..|:...:..:|....:...|...|.||..   ||...:.      |..||.|.:
Mouse   689 FNSDVTGTPYVSPDGHYLVSVNDVKGLVRVQYITIRGEILDAFDIHTNLH------ISDLAFQPS 747

  Fly   972 ILGGLEKFTE---YNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVL 1029
                   |||   |||.         |.:|.|..|:             |.::|...||::
Mouse   748 -------FTEAHQYNIY---------GSSSQQTDVL-------------FVELSSGKVKMI 779

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig 71..157 CDD:299845
I-set 72..150 CDD:254352
Ig 172..245 CDD:299845
IG_like 280..356 CDD:214653
Ig 280..343 CDD:299845
IG_like 375..450 CDD:214653
Ig 378..447 CDD:143165
Ig 506..587 CDD:299845 25/96 (26%)
IG_like 506..587 CDD:214653 25/96 (26%)
I-set 592..682 CDD:254352 25/90 (28%)
Ig 595..682 CDD:299845 24/87 (28%)
FN3 686..789 CDD:238020 21/165 (13%)
FN3 798..893 CDD:238020 19/111 (17%)
FN3 901..1005 CDD:238020 26/116 (22%)
fn3 1011..1094 CDD:278470 4/19 (21%)
FN3 1108..1202 CDD:238020
FN3 1210..1308 CDD:238020
fn3 1317..1402 CDD:278470
FN3 1415..1507 CDD:238020
FN3 1513..1608 CDD:238020
fn3 1617..1708 CDD:278470
FN3 1722..1823 CDD:238020
FN3 1828..1920 CDD:238020
FN3 1927..2016 CDD:238020
Fstl5NP_001240648.1 KAZAL_FS 93..133 CDD:238052
EF-hand_7 182..243 CDD:372618
Ig 266..323 CDD:319273 19/59 (32%)
Ig2_Follistatin_like 358..433 CDD:143213 22/77 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7870
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.950

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