DRSC/TRiP Functional Genomics Resources

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Protein Alignment sdk and Robo1

DIOPT Version :10

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:XP_017172382.1 Gene:Robo1 / 19876 MGIID:1274781 Length:1687 Species:Mus musculus


Alignment Length:1806 Identity:374/1806 - (20%)
Similarity:592/1806 - (32%) Gaps:590/1806 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 DANLQQQNSIVQQQQLQAPRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDG------- 111
            |.:|....|.::|:.. .||...|||.  .|||:|....|.|.|.|.|.||..|.|.|       
Mouse    84 DNSLGYTGSRLRQEDF-PPRIVEHPSD--LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDK 145

  Fly   112 ---------VPVGDFSSSQFYRF-HSTR-REDAGSYQCIARNDAGSIFSEKSDVVVAYMGIFENT 165
                     :|.|   |..|.|. |..: |.|.|.|.|:|||..|...|..:.:.||.:......
Mouse   146 DDPRSHRMLLPSG---SLFFLRIVHGRKSRPDEGVYICVARNYLGEAVSHNASLEVAILRDDFRQ 207

  Fly   166 TEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDGPLNYDIKYAFTHANQLIILSADENDRKGYR 230
            ....:.|..|.||:.:..|....|.|::.|:.:..||:                  |:::|...|
Mouse   208 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD------------------DKDERITIR 254

  Fly   231 -AKAINTQLGKEESSAFVHL--NVSGDPYIEVAP-EIIVRPQDVKVKVGTGVVELQCIANARPLH 291
             .|.:.|...|.::..:|.:  |:.|:...|||. .::.||..||                ||  
Mouse   255 GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK----------------RP-- 301

  Fly   292 ELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQI 356
                    ..|||       |::|               |.|:.|:.|                 
Mouse   302 --------SNLAV-------TVDD---------------SAEFKCEAR----------------- 319

  Fly   357 LEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIK 421
                                         |:|.|.|:|.::    |..:...||.:..|:||.|:
Mouse   320 -----------------------------GDPVPTVRWRKD----DGELPKSRYEIRDDHTLKIR 351

  Fly   422 KLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESG 486
            |:...|...:.|:|.|..|:..||..|.|:                         :|||      
Mouse   352 KVTAGDMGSYTCVAENMVGKAEASATLTVQ-------------------------VGSE------ 385

  Fly   487 SSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYNETQLV-------DIS 544
                        .|...:.|::.....|:..|..|.|.|:|.|.|.|....:|.:       ..|
Mouse   386 ------------PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSS 438

  Fly   545 SRVQILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQII---------QPPVDT 600
            ||..:.::|||.|:|::..|.|.|||...|.|||:..:|||.|   |.:|         |.||:.
Mouse   439 SRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV---TDVIADRPPPVIRQGPVNQ 500

  Fly   601 TVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYAC 665
            ||.:..|..|.|..:..|:.  .|.|.::|...:  :...||.....|.|:|:..:..|.|.|.|
Mouse   501 TVAVDGTLILSCVATGSPAP--TILWRKDGVLVS--TQDSRIKQLESGVLQIRYAKLGDTGRYTC 561

  Fly   666 VVTSPGGNETRAARLSVIELPFP------------PSNVKVERLPEPQQRSINVSWTPGFDGNSP 718
            ..::|.|..|.:|.:.|.|...|            ||......:.:..:.::.:||.|..:..:.
Mouse   562 TASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSKNTVTLSWQPNLNSGAT 626

  Fly   719 ISKFIIQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPS 783
            .:.:||:....:...       :|.|...||..:.  ..::.||...:|.|.|.|.|..|...||
Mouse   627 PTSYIIEAFSHASGS-------SWQTAAENVKTET--FAIKGLKPNAIYLFLVRAANAYGISDPS 682

  Fly   784 EPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPP-------LEEH-----RNGQILGYILRY 836
            :.|:.|:.....|:...|......|.:..::.....|       :|.|     ::..|.||.:.|
Mouse   683 QISDPVKTQDVPPTSQGVDHKQVQRELGNVVLHLHNPTILSSSSVEVHWTVDQQSQYIQGYKILY 747

  Fly   837 RLFG--YNNVPWSYQNITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPE 899
            |..|  :....|....:....:.:.:|.:|....:|.::...:.|...|..:|....||.|..|.
Mouse   748 RPSGASHGESEWLVFEVRTPTKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPS 812

  Fly   900 APPTNVKVEAI--NSTAARCRWTPPNPQQINGINQGYKIQAW---------QRRLIDGEWRDIER 953
            |||.:|.|...  |.||....|.||.....||:.|.||:  |         ..:.:||.      
Mouse   813 APPRSVTVSKNDGNGTAILVTWQPPPEDTQNGMVQEYKV--WCLGNETKYHINKTVDGS------ 869

  Fly   954 RMKTVPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDD-----VPDEV 1013
            ....|.|||:..:              .|::.|...|..|.|| .|:...:.:|.     .|::.
Mouse   870 TFSVVIPSLVPGI--------------RYSVEVAASTGAGPGV-KSEPQFIQLDSHGNPVSPEDQ 919

  Fly  1014 TGL--HFDDVSDRSVKV-----------------LWAPPRASNGILTGY-------------TVR 1046
            ..|  ...||..:...:                 |:...:..||:.:.|             ||.
Mouse   920 VSLAQQISDVVRQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVT 984

  Fly  1047 YQ---------------------------------------------------------VKDRP- 1053
            ||                                                         ...|| 
Mouse   985 YQRGGEAVSSGGRPGLLNISEPATQPWLADTWPNTGNNHNDCSINCCTAGNGNSDSNLTTYSRPA 1049

  Fly  1054 DTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQSG-------VEP---VLP 1108
            |.:.::|...|:.:..:...::|.:...::      .:.|.:..|..|.       |.|   ..|
Mouse  1050 DCIANYNNQLDNKQTNLMLPESTVYGDVDL------SNKINEMKTFNSPNLKDGRFVNPSGQPTP 1108

  Fly  1109 HAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQTARNMT--WFTICE---INDPDAETLT 1168
            :|.|.|..:|:..     ....| .|:||...||..||....:.  .:.|.|   :|.......|
Mouse  1109 YATTQLIQANLSN-----NMNNG-AGDSSEKHWKPPGQQKPEVAPIQYNIMEQNKLNKDYRANDT 1167

  Fly  1169 VTGLVPFTQ---------YRLRLSASNVVGS------SKPSEATKD-----FQTIQARPKHPP-- 1211
            :...:|:.|         |......|:..||      ::..:|.|.     ...:...|.|||  
Mouse  1168 IPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKAPKQGGMNWADLLPPPPAHPPPH 1232

  Fly  1212 -----FNVTVRAMSAQQLRVRWIP----LQQTEW--YGNPRGYNISYKQLVKTPGTIKYVPRSVV 1265
                 :|::|.....|::.....|    |||.|.  ..:.||.....:....:|..:.|      
Mouse  1233 SNSEEYNMSVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSY------ 1291

  Fly  1266 IEDHTANSHVLDSLEEWTLYEVKMNACNDVGC--------------------------------- 1297
              .|.:.:.:..|.:| .|..:..:...|:|.                                 
Mouse  1292 --SHQSTATLTPSPQE-ELQPMLQDCPEDLGHMPHPPDRRRQPVSPPPPPRPISPPHTYGYISGP 1353

  Fly  1298 -------------SKESDTAVER--TR-------EAVPSYGPLDVQANATSSTTVVVQWGEVPRQ 1340
                         ..|:|..|.:  ||       |..|:....|::::.|.|  ::..||....:
Mouse  1354 LVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGS--MINGWGSASEE 1416

  Fly  1341 H-----RNGQIDGYKVFYAAADRGQQV------------------------LHKT-IPNNATFTT 1375
            .     |:........|:..||..|.|                        .|.: .|...:..:
Mouse  1417 DNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVS 1481

  Fly  1376 TLTELKKYVVY-------------HVQVLAYTRLGNGALSTPPIRVQTFEDTPGVPSN------- 1420
            |.:.:...|:.             |::..||.    ..|..||:.....: :|.|.|.       
Mouse  1482 TDSNMSAVVIQKARPAKKQKHQPGHLRREAYA----DDLPPPPVPPPAIK-SPTVQSKAQLEVRP 1541

  Fly  1421 VSFPDVSLTMARIIWDVPVDPNGKILAYQVTYTLNGSAMLNYSREFP---------PSDRTFRAT 1476
            |..|.::...||.  |...|..|.  :|:....|:|..:.:. |..|         |:|...|.|
Mouse  1542 VMVPKLASIEART--DRSSDRKGG--SYKGREALDGRQVTDL-RTNPSDPREAQEQPNDGKGRGT 1601

  Fly  1477 EL----LPGKYYSFSCTAQTRLGWGKIATALVY------TTNNRERPQAPS 1517
            :.    ||        .|:|.||...|   |.|      |:||...|.:.|
Mouse  1602 KAAKRDLP--------PAKTHLGQEDI---LPYCRPTFPTSNNPRDPSSSS 1641

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig_3 72..142 CDD:464046 31/87 (36%)
Ig 280..344 CDD:409353 11/63 (17%)
Ig strand B 280..283 CDD:409353 0/2 (0%)
Ig strand C 292..298 CDD:409353 0/5 (0%)
Ig strand E 319..323 CDD:409353 0/3 (0%)
Ig strand F 333..338 CDD:409353 2/4 (50%)
Ig 360..451 CDD:472250 21/90 (23%)
Ig strand B 378..382 CDD:409353 0/3 (0%)
Ig strand C 391..395 CDD:409353 1/3 (33%)
Ig strand E 416..420 CDD:409353 2/3 (67%)
Ig strand F 430..435 CDD:409353 1/4 (25%)
Ig strand G 443..446 CDD:409353 1/2 (50%)
Ig 502..587 CDD:472250 31/91 (34%)
Ig strand B 517..521 CDD:409353 1/3 (33%)
Ig strand C 530..534 CDD:409353 1/3 (33%)
Ig strand E 554..557 CDD:409353 2/2 (100%)
Ig strand F 567..572 CDD:409353 3/4 (75%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 26/98 (27%)
Ig strand B 608..612 CDD:409353 1/3 (33%)
Ig strand C 623..627 CDD:409353 1/3 (33%)
Ig strand E 648..652 CDD:409353 2/3 (67%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 1/2 (50%)
FN3 686..789 CDD:238020 23/114 (20%)
FN3 798..893 CDD:238020 18/108 (17%)
FN3 901..1005 CDD:238020 29/114 (25%)
FN3 <960..>1261 CDD:442628 75/443 (17%)
fn3 1317..1402 CDD:394996 18/127 (14%)
FN3 1415..1507 CDD:238020 28/117 (24%)
FN3 1513..1608 CDD:238020 2/5 (40%)
FN3 1583..>2011 CDD:442628
Robo1XP_017172382.1 IgC_1_Robo 101..199 CDD:409490 35/102 (34%)
Ig strand A 101..105 CDD:409490 2/3 (67%)
Ig strand A' 108..113 CDD:409490 2/6 (33%)
Ig strand B 117..125 CDD:409490 2/7 (29%)
Ig strand C 131..136 CDD:409490 2/4 (50%)
Ig strand C' 139..141 CDD:409490 0/1 (0%)
Ig strand D 152..155 CDD:409490 0/2 (0%)
Ig strand E 158..164 CDD:409490 3/8 (38%)
Ig strand F 176..184 CDD:409490 4/7 (57%)
Ig strand G 187..199 CDD:409490 2/11 (18%)
IgI_2_Robo 206..291 CDD:409389 22/102 (22%)
Ig strand A 206..209 CDD:409389 0/2 (0%)
Ig strand A' 211..215 CDD:409389 0/3 (0%)
Ig strand B 219..226 CDD:409389 2/6 (33%)
Ig strand C 234..239 CDD:409389 1/4 (25%)
Ig strand C' 241..244 CDD:409389 0/2 (0%)
Ig strand D 250..254 CDD:409389 1/3 (33%)
Ig strand E 256..262 CDD:409389 1/5 (20%)
Ig strand F 269..277 CDD:409389 1/7 (14%)
Ig strand G 280..291 CDD:409389 4/10 (40%)
IgI_3_Robo 298..380 CDD:409390 34/179 (19%)
Ig strand A 298..301 CDD:409390 2/18 (11%)
Ig strand A' 303..307 CDD:409390 3/10 (30%)
Ig strand B 310..319 CDD:409390 4/23 (17%)
Ig strand C 325..330 CDD:409390 2/4 (50%)
Ig strand C' 333..336 CDD:409390 0/2 (0%)
Ig strand D 339..344 CDD:409390 2/4 (50%)
Ig strand E 345..352 CDD:409390 4/6 (67%)
Ig strand F 359..367 CDD:409390 2/7 (29%)
Ig strand G 370..380 CDD:409390 4/9 (44%)
IgI_4_Robo 388..485 CDD:409391 33/99 (33%)
Ig strand A 388..392 CDD:409391 0/3 (0%)
Ig strand A' 394..398 CDD:409391 0/3 (0%)
Ig strand B 404..412 CDD:409391 3/7 (43%)
Ig strand C 415..422 CDD:409391 3/6 (50%)
Ig strand C' 424..427 CDD:409391 0/2 (0%)
Ig strand D 440..445 CDD:409391 1/4 (25%)
Ig strand E 447..454 CDD:409391 4/6 (67%)
Ig strand F 460..469 CDD:409391 4/8 (50%)
FN3 461..897 CDD:442628 114/473 (24%)
Ig strand G 471..482 CDD:409391 6/13 (46%)
IgI_5_Robo 492..578 CDD:409544 25/89 (28%)
Ig strand A 492..495 CDD:409544 0/2 (0%)
Ig strand A' 499..502 CDD:409544 0/2 (0%)
Ig strand B 508..515 CDD:409544 2/6 (33%)
Ig strand C 521..526 CDD:409544 2/4 (50%)
Ig strand C' 528..530 CDD:409544 1/1 (100%)
Ig strand D 537..541 CDD:409544 2/3 (67%)
Ig strand E 544..549 CDD:409544 2/4 (50%)
Ig strand F 557..565 CDD:409544 3/7 (43%)
Ig strand G 568..578 CDD:409544 3/9 (33%)
FN3 597..683 CDD:238020 20/94 (21%)
Blue background indicates that the domain is not in the aligned region.

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