DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and Ncam1

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_006510118.1	Gene:	Ncam1 / 17967	MGIID:	97281	Length:	1162	Species:	Mus musculus

Alignment Length:	1424	Identity:	275/1424 - (19%)
Similarity:	466/1424 - (32%)	Gaps:	424/1424 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SSGSIVSEGSTKILQCHALG-YPQPTYRWLKDGVPVGDFSS--------------SQFYRFHSTR 129
            |.|.| |.|.:|...|...| .......|..   |.|:..|              |.....::..
Mouse    27 SQGEI-SVGESKFFLCQVAGDAKDKDISWFS---PNGEKLSPNQQRISVVWNDDDSSTLTIYNAN 87

  Fly   130 REDAGSYQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVM 194
            .:|||.|:|:...:.|:......:|.:....:|:|....: ....|..|:.....:.|:| |:::
Mouse    88 IDDAGIYKCVVTAEDGTQSEATVNVKIFQKLMFKNAPTPQ-EFKEGEDAVIVCDVVSSLP-PTII 150

  Fly   195 W--QSEDGPLNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVSGDPYI 257
            |  :..|..|..|:::.....|.|.|....:.|...||.:.
Mouse   151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEG------------------------ 191

  Fly   258 EVAPEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLA 322
                .|:.| .::..|      ::|.|.|..|
Mouse   192 ----RILAR-GEINFK------DIQVIVNVPP--------------------------------- 212

  Fly   323 LLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGE 387
            .:||..|                 .|:|:|.|                    |..|.|.||..|.
Mouse   213 TVQARQS-----------------IVNATANL--------------------GQSVTLVCDADGF 240

  Fly   388 PTPQVKWFRNAESVDAHIESGRYTLNTDNT--LVIKKLILDDAAMFQCLAINEAGENSASTWLRV 450
            |.|.:.|.::.|.::...|.....:.:|::  |.|:.:..:|.|.:.|:|.|:|||..||..|:|
Mouse   241 PEPTMSWTKDGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASIHLKV 305

  Fly   451 KTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALD-G 514
                       .|:|:|..|                                    :|.||:: .
Mouse   306 -----------FAKPKITYV------------------------------------ENQTAMELE 323

  Fly   515 KDATISCRAVGSPNPNITWIYNETQLVDISS-------RVQILESGD-------------LLISN 559
            :..|::|.|.|.|.|:|||   .|...:|||       |.:..|:.|             |.:.:
Mouse   324 EQVTLTCEASGDPIPSITW---RTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKS 385

  Fly   560 IRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNI 624
            |:..|||.|||..:|..|......||.|....: :|.||......|....:.|:|.:.||.  .|
Mouse   386 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSA--TI 447

  Fly   625 DWYREGQ--SSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPF 687
            .|:|:||  .|:..||.:.....:...||:.....:|.|:|.|...:..|.|:....|...:.|.
Mouse   448 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 512

  Fly   688 PPSNVKVERLPEPQQRSINVSW-TPGFDGNSPISKFIIQRREVSELGPVPDPLLNWITELSNVSA 751
            .||   ::|: ||...:..|.: .|...|..||.|:   :.|...||
Mouse   513 SPS---IDRV-EPYSSTAQVQFDEPEATGGVPILKY---KAEWKSLG------------------ 552

  Fly   752 DQRW---------------ILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSGPPV 801
            ::.|               :.:..||..|.|..|::|:|..|.|..|..:.....|..:|  ||:
Mouse   553 EESWHFKWYDAKEANMEGIVTIMGLKPETRYSVRLAALNGKGLGEISAATEFKTQPVHSP--PPL 615

  Fly   802 GFVGSAR--SMSEIITQWQPPL---------------------------------EEHRNGQILG 831
            ....|:.  .:|...|.|..|:                                 ::.....|..
Mouse   616 APANSSTLVPLSPRATTWPLPVLPTTDLSKGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRH 680

  Fly   832 YILRYRLFGYNNVPWSYQNITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEG 896
            |:::||....:.  |..:........:.:::.|....:|.|.:.|.|..|        |.|....
Mouse   681 YLVKYRAKLASE--WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG--------KSKAAHF 735

  Fly   897 V--PEAPPTNVKVEAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVP 959
            |  ..|.||.:               |.|.....|::.|
Mouse   736 VFRTSAQPTAI---------------PANGSPTAGLSTG-------------------------- 759

  Fly   960 PSLIDPLAEQTAILGGLEKFTEYNIS----VLCFT-----DPGDGVASSQV----AVMTMDDVPD 1011
             :::..|.....:|..:...|.|.::    ::|..     ..|.|.....:    |..:.|:..:
Mouse   760 -AIVGILIVIFVLLLVVMDITCYFLNKCGLLMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKE 823

  Fly  1012 EVTGLHFDDVSDRSVKVLWAPPRASNGILTGYTVRYQVKDRPDTLKSFNLTADDTELTVNQLQAT 1076
            .:..:..::  :|:       |....|       ::...:....|....|.||.|....:.|.:.
Mouse   824 PIVEVRTEE--ERT-------PNHDGG-------KHTEPNETTPLTEPELPADTTATVEDMLPSV 872

  Fly  1077 THYW------FEIVAWTRVGSGIPKTATIQSGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGN 1135
            |...      .|..| |...|...:|.|:.|.:.|.....|.:   :::.|.    |.||    :
Mouse   873 TTVTTNSDTITETFA-TAQNSPTSETTTLTSSIAPPATTVPDS---NSVPAG----QATP----S 925

  Fly  1136 SSITKWKVEGQTARNMTWFTICEIND-----PDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSE 1195
            ..:|.......:|..:.  .:.:::|     |.|..|:.|.|.         :...|:..|.|:.
Mouse   926 KGVTASSSSPASAPKVA--PLVDLSDTPTSAPSASNLSSTVLA---------NQGAVLSPSTPAS 979

  Fly  1196 ATKDFQTIQARP--KHPPFNVTVRAMSAQQLRVRWIPL----QQTEWYGNPRGYNISYKQLVKTP 1254
            |.   :|.:|.|  |..|......|.:|..|.....|.    |..:...:.:|.:....|    |
Mouse   980 AG---ETSKAPPASKASPAPTPTPAGAASPLAAVAAPATDAPQAKQEAPSTKGPDPEPTQ----P 1037

  Fly  1255 GTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKMNACN----DVGCSKESDTAVERTREAVPSY 1315
            ||:|..|.:........:.....:..:..  ::||:..|    |:..:|:...|:.....|..:.
Mouse  1038 GTVKNPPEAATAPASPKSKAATTNPSQGE--DLKMDEGNFKTPDIDLAKDVFAALGSPAPATGAS 1100

  Fly  1316 GPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIPNNATFT 1374
            |.....|.:|:.:.|    ...|.:...|.::.......:..:......||:||:||.|
Mouse  1101 GQASELAPSTADSAV----PPAPAKTEKGPVETKSEPPESEAKPAPTEVKTVPNDATQT 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	20/91 (22%)
		I-set	72..150	CDD:254352	19/84 (23%)
		Ig	172..245	CDD:299845	15/74 (20%)
		IG_like	280..356	CDD:214653	11/75 (15%)
		Ig	280..343	CDD:299845	7/62 (11%)
		IG_like	375..450	CDD:214653	25/76 (33%)
		Ig	378..447	CDD:143165	23/70 (33%)
		Ig	506..587	CDD:299845	31/101 (31%)
		IG_like	506..587	CDD:214653	31/101 (31%)
		I-set	592..682	CDD:254352	25/91 (27%)
		Ig	595..682	CDD:299845	25/88 (28%)
		FN3	686..789	CDD:238020	26/118 (22%)
		FN3	798..893	CDD:238020	19/129 (15%)
		FN3	901..1005	CDD:238020	14/116 (12%)
		fn3	1011..1094	CDD:278470	14/88 (16%)
		FN3	1108..1202	CDD:238020	17/98 (17%)
		FN3	1210..1308	CDD:238020	19/105 (18%)
		fn3	1317..1402	CDD:278470	12/58 (21%)
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Ncam1	XP_006510118.1	Ig1_NCAM-1	20..115	CDD:143273	20/91 (22%)
		IG	124..190	CDD:214652	15/67 (22%)
		Ig3_NCAM-1_like	211..308	CDD:143207	34/177 (19%)
		Ig_NCAM-1	307..413	CDD:143277	35/144 (24%)
		Ig_3	417..494	CDD:372822	22/79 (28%)
		FN3	509..606	CDD:238020	26/121 (21%)
		fn3	649..731	CDD:365830	12/91 (13%)
		PHA03247	<905..1140	CDD:223021	48/269 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900