DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and lad-2

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_001023496.1	Gene:	lad-2 / 177078	WormBaseID:	WBGene00002243	Length:	1187	Species:	Caenorhabditis elegans

Alignment Length:	1177	Identity:	268/1177 - (22%)
Similarity:	449/1177 - (38%)	Gaps:	237/1177 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 LQCHALGYPQPT--YRWLKDGVPV------------GDFSSSQFYRFHSTRREDAGSYQCIARND 143
            |:|.|   .:.|  |.|||||.|.            ....|..|.:.|::.:   |.|||.|.|.
Worm    51 LRCEA---DENTDRYSWLKDGEPFVIDSEDVLWEKESQSGSIVFTKPHASHQ---GYYQCFASNI 109

  Fly   144 AGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMW---QSEDGPLNYD 205
            .|:..|.|..:.:..:..|.......|.|..|.....:..|....|.|.::|   ..:|..:...
Worm   110 FGTALSNKMHLRLGSLEHFPKRDVKLLRVKEGESLTLNCTPPRGTPDPKIVWLYRSLDDSSVIET 174

  Fly   206 IK---YAFTHANQLIILSADENDRKG---YRAKAINTQL-GKEESSAFVHLNV--SGDPYIEVAP 261
            |:   ....:...|...|.:.:|.|.   |...|.:..| |:..|...:.|::  |.|....| .
Worm   175 IRSRHITVDNEGHLHFSSVELSDGKATLVYECAATSPVLRGEYRSGDRIQLDIEPSQDKSHPV-K 238

  Fly   262 EIIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLK-DGLAVETAGVRHTLND-PWNRTLALL 324
            ::.|.|.:|.|:.| |.::||||...|||..:  .|.| ||...::.....|.:: .:.|:|.:.
Worm   239 KMSVSPSEVTVRAG-GQLKLQCIFGGRPLPTI--FWSKIDGELPKSRIKDLTSHESDFGRSLIVE 300

  Fly   325 QANSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLF-FTPMR-----AETFGEFGGQVQLTCD 383
            ..:...:|.|.|:.|       .:..:..::::..|.: |.|.|     .|:.||      |.|.
Worm   301 NVHPDDAGAYECRGR-------HLVHTVNVRVMAAPFWEFDPPRDISLPEESTGE------LECL 352

  Fly   384 VVGEPTPQVKWFRNAESVDAHIE-SGRYTLNTDNTLVIKKLILD-DAAMFQCLAINEAGENSAST 446
            ..|:|||.:.|..|.:.:....| |.|..|:....|.::.|..| |..::||.|.|..|...|:.
Worm   353 AGGQPTPIITWSMNGKFLHELAEDSRRVLLDHGRILRVRNLNHDLDTGVYQCNASNPLGYVFANA 417

  Fly   447 WLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTA 511
            ::.|:                     :||..                ||..:|...::...:...
Worm   418 FVHVR---------------------AHAPF----------------FRMPAARHWKVVLHSTVV 445

  Fly   512 LDGKDATISCRAVGSPNPNITWIYNETQLVDISSR-VQILESGDLLISN-------IRSVDAGLY 568
            ||       |....:|...:.|       ||...| :|::|..:.|..|       :.|.|.|||
Worm   446 LD-------CDVDAAPEAMVRW-------VDADDRPLQVVEGKNKLFPNHTFMVYDVNSADEGLY 496

  Fly   569 ICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLL--GLTATLQCKVSSDPSVPYNIDWYREGQ 631
            .|..:|:.|..:....|.|...|..::.|....::|  |.||.:.|:..:||.:|....|...|:
Worm   497 YCNVSNKYGINRATNRLQVFKPTYFVRIPTPKRLILEAGETAEVFCEAVADPRLPIRYQWTINGK 561

  Fly   632 SSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVER 696
               .::.||...:..| :|..::||....|...|...:....:..:.:|.|.::|..|    |..
Worm   562 ---VLTESQYYEILPD-RLRFRSVRGRHSGIIDCAAITDVDVKLASMQLIVKDVPAHP----VVE 618

  Fly   697 LPEPQQRSINVSWTPGFDGNSPISKFIIQ-------------RREVS---ELGPVPDPLLNWITE 745
            .....:|...|.|....|....|.|:|::             ..||:   |...|...|..|:.
Worm   619 TAHCSERKATVKWVAASDHGDSIKKYIVEMFTDFKKNEWEVINEEVNVNKETFEVDITLTPWVN- 682

  Fly   746 LSNVSADQRWILLENLKAATVYQFRVSAVNRVG------EGSPSEPSNVVELPQEAPSGPPVGFV 804
                                 |.|||.|||..|      :|.|.|.....:.....|...|.|..
Worm   683 ---------------------YTFRVVAVNSHGRSDMKIDGQPKEDWLTCQTRPSFPYTNPTGVK 726

  Fly   805 GSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVP---WSYQNITNEAQRNF-LIQELI 865
            |.......::..|:|....:.|...:.|::||:|    :.|   |: :.:..::..|| :|::..
Worm   727 GEGTEPDNLVISWKPLDRYYWNAPNMQYLVRYKL----DEPIHGWT-EFLVEDSLANFTIIRDQP 786

  Fly   866 TWKDYIVQIAAYNNMGVG-VYTEGSKIKTKEGVPEAPPTNVKVEA-INSTAARCRWTPPNPQQIN 928
            |::.|::|:.:.|::|.. |..|.....:.|.||:..|.:..::. ||.|.....|.|.:...:|
Worm   787 TFRKYLIQVQSVNSVGPSIVEPEIHHGWSGEDVPDEAPRDFHIDTQINFTTINFTWNPVDANTVN 851

  Fly   929 GINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQT-AILGGLEKFTEYNISVLCFTDP 992
            |...||:|:.|:..      ..|.:....:|       |..| .::......|.|:..:......
Worm   852 GHFVGYEIEYWKAE------NTIRKYSIKIP-------ANSTYKVINSFHAVTNYSAHIRTRNKR 903

  Fly   993 GDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRASNGILTGYTVRYQVKDRPDTLK 1057
            .....|..|:....:..|.:|..|....|...::.:.|..|...||.:.||.:.:| .::.:|.:
Worm   904 LRSAPSDYVSFAMPEGPPGKVHNLRVYSVGSTAILLQWDAPLQPNGRIRGYFISFQ-NEKNETEE 967

  Fly  1058 SFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQSGVEPV------LPHAPTALAL 1116
            ::.:......|. .:.:..|.|...:.|.||.|.| |.|      :.||      :|.|| ...:
Worm   968 TYVIHRQKHYLH-EKSEPDTGYKVSVWAETRAGEG-PVT------LRPVRTWPARIPDAP-IFRV 1023

  Fly  1117 SNIEAFSVVLQFTPGFDGNSSITKWKVEG------QTAR-NMTWFTICEINDPDAETLTVTGLVP 1174
            .||...|.|:::.|   .|.|:  ||:.|      .||. :.|||        .:|.:    .:|
Worm  1024 KNISLDSFVVEWQP---NNHSV--WKMPGAAFFVNYTAESSKTWF--------QSEII----YLP 1071

  Fly  1175 FTQYRLR 1181
            :|:..:|
Worm  1072 YTEITIR 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	23/77 (30%)
		I-set	72..150	CDD:254352	21/70 (30%)
		Ig	172..245	CDD:299845	17/82 (21%)
		IG_like	280..356	CDD:214653	18/77 (23%)
		Ig	280..343	CDD:299845	18/64 (28%)
		IG_like	375..450	CDD:214653	22/76 (29%)
		Ig	378..447	CDD:143165	22/70 (31%)
		Ig	506..587	CDD:299845	21/88 (24%)
		IG_like	506..587	CDD:214653	21/88 (24%)
		I-set	592..682	CDD:254352	20/91 (22%)
		Ig	595..682	CDD:299845	20/88 (23%)
		FN3	686..789	CDD:238020	27/124 (22%)
		FN3	798..893	CDD:238020	22/99 (22%)
		FN3	901..1005	CDD:238020	20/105 (19%)
		fn3	1011..1094	CDD:278470	19/82 (23%)
		FN3	1108..1202	CDD:238020	22/81 (27%)
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
lad-2	NP_001023496.1	IG_like	48..116	CDD:214653	21/70 (30%)
		Ig	49..121	CDD:299845	23/75 (31%)
		Ig	124..214	CDD:299845	16/89 (18%)
		IG_like	244..325	CDD:214653	23/90 (26%)
		Ig	255..325	CDD:299845	18/78 (23%)
		I-set	335..421	CDD:254352	27/91 (30%)
		Ig4_L1-NrCAM_like	344..422	CDD:143179	25/83 (30%)
		IG_like	438..515	CDD:214653	21/90 (23%)
		Ig	443..516	CDD:299845	21/86 (24%)
		IG_like	527..608	CDD:214653	19/84 (23%)
		Ig	535..>593	CDD:299845	17/61 (28%)
		FN3	610..697	CDD:238020	24/112 (21%)
		FN3	721..804	CDD:238020	20/87 (23%)
		fn3	823..909	CDD:278470	18/98 (18%)
		FN3	921..1010	CDD:238020	24/97 (25%)
		FN3	1016..1108	CDD:238020	22/81 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910