DRSC/TRiP Functional Genomics Resources

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Protein Alignment sdk and let-805

DIOPT Version :9

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_001022641.1 Gene:let-805 / 175384 WormBaseID:WBGene00002915 Length:4450 Species:Caenorhabditis elegans


Alignment Length:2407 Identity:507/2407 - (21%)
Similarity:822/2407 - (34%) Gaps:646/2407 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 LKSAASSLRRRRPKTTITATLA----------IEMPSQPKLASLLAV---LVLLCY--------C 45
            |..|::.|.|.|...:..||:|          .::||.|:...|..|   ||...:        |
 Worm   743 LNVASTYLVRVRALDSSRATVATSPSASFSVLCQVPSAPENVRLERVSEQLVRAAWDSSQESGDC 807

  Fly    46 DSCFFCYADANLQQQNSIVQQQQLQAPRFTTHPSSSGSIVSEGST------KILQCHALGYPQP- 103
            .|.||.....|.|..|..|             |.|..|:...||:      ::...:..|...| 
 Worm   808 QSYFFITGQQNGQAINQRV-------------PGSDRSVDIAGSSQGDWRVQVRGVNTAGSGTPS 859

  Fly   104 -----------------------TYRWLKDGVPVGDFSSSQFYRFHSTRREDAGSYQCIARNDAG 145
                                   |..|.|     |:||:|..      |..|:|...|    ...
 Worm   860 RDAIFASSAQQSRRSKRSVCDPRTDFWCK-----GEFSNSPL------REPDSGEALC----STP 909

  Fly   146 SIFSEKSDVVVAY------MGIF--------ENT---TEGRLT-----------VISG------- 175
            .:.::::|::|.:      .|::        ||:   |.|:|.           .::|       
 Worm   910 RVLAQENDLIVKWKSEGDGRGVYGYHVQFRNENSGWKTYGQLVPYVRDNMEYTQTLTGLERGHAY 974

  Fly   176 --HPAIFD------------------MPPIE-------------------SIPVPSVMWQSEDGP 201
              |..:.|                  .||..                   ::| |...|...|  
 Worm   975 FIHVQVLDRNSYVMYTSAQSSAKSSCSPPTHTPSHLQVAAPDASHVRVQWALP-PQSTWGCSD-- 1036

  Fly   202 LNYDIKYAFTHANQLIILSADE---------NDRKGYRAKAINTQLGKEESSAFVHLNVSGDPYI 257
            :.::|:.........::|.:.:         |.....:.:|||:    ...||:.....:..|  
 Worm  1037 IQFEIQPEEPRGQPAVVLGSHQTSHIFNSAPNQMWSVKIRAINS----AGHSAWTPAAQTKTP-- 1095

  Fly   258 EVAPEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLA 322
             ...|:|:.| ||..:.|..::..:...|...|  :|:..|:.....|::..:|....|:|   .
 Worm  1096 -PGGELIIGP-DVSYRQGKPIISWRSKENTNDL--IESFVLEWKSTTESSWRQHRNPIPYN---G 1153

  Fly   323 LLQANSSHSGE----YTCQVRL------RSGGY--PAVSASARLQILEPPLFFTPMRAETFGEFG 375
            ..:..|...||    :|.|||:      |...|  |.|....:.|...|......::....|...
 Worm  1154 WQRPYSVDLGELPQGHTYQVRIVAKDPNRGNAYTSPVVQVQTQSQCKAPRRAPADVQVSPLGPTQ 1218

  Fly   376 GQVQ--------LTCD----VVGEPTPQVKWFRNAESVDAHI--ESGRYTLNTDNTLVIKKLILD 426
            .:||        ..||    :|...|||.:.|:|..:.:..:  :|..||               
 Worm  1219 IRVQWAPLHESEWNCDRLWYIVKHSTPQNQGFKNLTNGENFVVFDSDPYT--------------- 1268

  Fly   427 DAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGS-------- 483
             ...|:..|.|.|||   |.|.|.::.    :.:.:|...:..:|....|..|.:.|        
 Worm  1269 -QWNFEVQAANPAGE---SQWSRAQSA----QTQGVAPGAVANLRVQPIGPDSLQCSWQPPVNPN 1325

  Fly   484 -------------ESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIY 535
                         ..|:.|..:|           .|:.:|             |..|:..||.::
 Worm  1326 GRITQYEVTYQLISRGNCDNNQE-----------APRTIT-------------VNGPHFTITGLH 1366

  Fly   536 NETQL---VDISSRVQILESGDLLISNIRSVDAG--LYI------------------CVRANEAG 577
            ..::.   |...|.|...|...|.|...::..:|  ||:                  |::.|  |
 Worm  1367 PHSKYRVGVAAKSNVGAGERVSLEIQTDQAAPSGAPLYLRTEDIRPTDVSISWQAPPCLQTN--G 1429

  Fly   578 SVKGEAY-LSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNI-----------DWYREG 630
            .:....| ::...|.|.:|...:.  :.|..|.::   :..|...||:           .|..| 
 Worm  1430 EITEYEYEVTAGDRRQTVQKTTEN--IRGTRAKIE---NLQPQTRYNVKVRAYTARGAGPWSTE- 1488

  Fly   631 QSSTPISNSQ-RIGVQADGQLEIQAVRASD--------------VGSYACVVTSPGGNETRAARL 680
               .|...|. :..|||.|.:::....|.:              |..|.|.....|..:.:..:.
 Worm  1489 ---VPFQTSAGQQNVQAPGFVKVLHTGADNAQLVWQSPYPNPGYVDKYKCRYAPSGTQQYQERQF 1550

  Fly   681 SVI-----------ELP-FPPSN----VKVERLPEPQQRSINVS-------WTPGFDGNSP---- 718
            ..:           .|| .||.:    .::|.|...|.....||       |.|    .||    
 Worm  1551 PAVSPCQQRQIERQNLPQSPPGSRLHCGRIENLRPEQTYDFQVSAHVKDSGWGP----YSPPERT 1611

  Fly   719 -ISKFIIQRREVSELGPVPDPL-LNW--------------IT----------ELSNVSADQRWIL 757
             :::..:|...|.::|...:.| :||              ||          :..||........
 Worm  1612 KVTESAVQVLFVKKIGGSENSLHINWDVRPDDKNRVTAFRITVVPQDGSQRSQTFNVDRATYQYR 1676

  Fly   758 LENLKAATVYQFRVSAV--NRVGEGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPP 820
            ::||:..|.|...|||.  ..:..|:.:..:..........:.|.|    .|...:.|..:|   
 Worm  1677 IDNLRPRTTYNVTVSAATHKEMCGGTAAVMTTDAAALTALSTAPRV----IAEEPTSITIEW--- 1734

  Fly   821 LEEHRNGQILGYILRYRLFG------YNNVPWSYQNITNEAQRNFLIQELITWKDYIVQIAAYNN 879
              |.||.:..|:|:.|||.|      ...:|......|..|..:.|....:.  |..|::.:..|
 Worm  1735 --ESRNREAGGFIVEYRLEGGAWQQYARRIPAHPSQTTYTATVDGLPTNAVV--DLRVRVVSQQN 1795

  Fly   880 MGVGVYTEGSKIKTKEGVPEAPPTNVKVEAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLI 944
            .......| .:.:||...|.:||..|:|:|.::...|..|..|..            ..|   :.
 Worm  1796 EQSNPSPE-VRARTKCSPPTSPPQGVRVDAPSTNEVRVSWARPAK------------NTW---MC 1844

  Fly   945 DGEWRDIERRMKTVPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDV 1009
            |....:|..|:...|..::....:||......|....:.:.:......|....|.:.::.|....
 Worm  1845 DQMNVEISYRVGNQPEKVLTVPGDQTEYTFPAEPNQRWVVKLRATNQVGSSQWSPEQSITTRQGA 1909

  Fly  1010 PDEVTGLHFDDVSDRSVKVLWAPPRASNGILTGYTVRYQVKDR--------PDTLKSFNLTAD-- 1064
            |..|..|....:|...|.|.|..|....|.:.||.:.|::|.|        .|..:.|....:  
 Worm  1910 PGSVRDLRVKALSPNEVHVQWLAPLVQRGTIVGYDISYRLKHRLACPEEEPRDVSRDFVTVYNHK 1974

  Fly  1065 DTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQSGVEPVLPHAPTALALSNIEAF--SVVLQ 1127
            |.:.|:..|...:.|...:.|.| ...|..:|..:.:..:|  |.:| .|.|.:..|.  |:..|
 Worm  1975 DLDYTITGLLPYSLYEVRVRART-TELGPEETKEVSTEQQP--PSSP-PLNLESTYALERSLSFQ 2035

  Fly  1128 FTP------------------GFDGNSSITKW-KVEGQTARNMTWFTICEINDPDAETLTVTGLV 1173
            :.|                  |.|      .| |:|.|.|           |..|.. :|:.||.
 Worm  2036 WEPVDCSQRHGHVVNYEYEILGQD------DWAKLERQIA-----------NTSDLR-VTIDGLT 2082

  Fly  1174 PFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRWIPLQQTEWYG 1238
            |:|:|.:|:.|.|.:|.. |:.......|.:|:...||.::.|.........|.|:|....  ||
 Worm  2083 PYTKYVMRVKAYNSIGGG-PNTENLVVMTAKAQAPLPPQDLVVAQEGTSFFMVSWLPPYPP--YG 2144

  Fly  1239 NPRGYNISYKQ----------------LVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEV 1287
            ....|.|.|:|                |::.||.   .||      ...|:..|||.:::.:...
 Worm  2145 PHDAYKIRYQQIPSDDWKEVEKGIKDPLLQCPGE---SPR------FCYNATGLDSGQQFKIQVA 2200

  Fly  1288 KMNACNDVGCSKESDTAVERTREAVPSYGP---------LDVQANATSSTTVV--------VQWG 1335
                                ||....||||         |.|..:|..:..::        ::| 
 Worm  2201 --------------------TRIEGGSYGPWSSLVIANTLQVLPDAPRAIHLIEKTDHSLHIRW- 2244

  Fly  1336 EVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNG- 1399
             ||.....|.:..|:|...:.|.........|.|:.|.|....||.....|::.:.|.|:.|.| 
 Worm  2245 -VPPIDPKGYVTQYRVSIVSLDDVNDKKRTHIVNHPTLTYLFEELNPETSYNISISAGTKQGFGR 2308

  Fly  1400 ----ALSTPPIRVQTFEDTPGV-PSNVSFPDVSLTMARIIWDVPVDPNGKILAYQVTYTLNGSAM 1459
                ..:|.|..:......|.| |...:..||.       |:..:||..::..|.:...      
 Worm  2309 EIWTRYTTDPFNIPVVGTMPTVTPDGANALDVQ-------WNAVLDPKNRVKGYIIEIR------ 2360

  Fly  1460 LNYSREFPPSDRTFRATELLPGKYYSFSCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRS 1524
               :.:.|........|....||...|.  ..|.|....:....:...:.|:|...||....:|:
 Worm  2361 ---NSDTPVWQEIGGVTNHDAGKSTYFK--KLTGLDSDTLYFIRIKVVDQRQRVGVPSPEAQART 2420

  Fly  1525 QIQAH---------------QITFSW-TPGRDGF--APLRYYTVEMRENEGRWQPLPERVD-PSL 1570
            ...|.               |:..|| .|.::.:  :.:||....:...|||     :::| ||.
 Worm  2421 GCAAPLSPPTNLNLASPSNVQVRVSWQAPNQNSWKCSAIRYKLEYINGTEGR-----KQIDLPSS 2480

  Fly  1571 SSFTAVGLRPYMTYQFRIQATNDLGPSAFSRESVIVRTLPAAPAVGVGGLKVVPITTTSVRVQWS 1635
            |.......:....:..||:..||.|.|.:|:| :.:.|...||. .|.||...|...||:..:|.
 Worm  2481 SIEHLFDSKSNTKWTVRIRTENDAGSSEWSKE-LSITTSEGAPG-PVEGLTAKPTGPTSIVARWK 2543

  Fly  1636 ALETALWNGDASTGGYRILYQQLSDFPTALQSTPKTDVHGINENSVVLSDLQQDRNYEIVVLPFN 1700
            .....  ||..:  ||.:.||..|......:|:...:.|..||.. .|..|..|..|||.|:...
 Worm  2544 PPRDP--NGVIT--GYTLTYQLKSIGECGPRSSTPIEKHVKNEEE-TLEGLLPDSTYEIHVVAHT 2603

  Fly  1701 SQGPGPATPPAAVYVGEAVPTGEPRAVDAAPISSTEVRLLWKPPKQSMQNGDILGYKIYYLVTYS 1765
            |.. ||.:....|...||.|||.|:.|.|..::|:...:.|..|:...:||.|..|: |.|    
 Worm  2604 SHA-GPQSSVVTVTTEEAAPTGPPQNVRAGSVTSSRADITWTQPECEQRNGKITDYE-YEL---- 2662

  Fly  1766 PQALEPGRKWEEEIEVVSATATSH------SLVFLDKFTEYRIQLLAFNPAGDGPRSAPITVKTL 1824
                     |  .::..:..:|.|      :|..|..:|:|:|::.|.|..||||.|..:...|.
 Worm  2663 ---------W--SMDTWADNSTGHNPTERLNLDQLIPYTQYQIRVRAINKEGDGPFSEWVPFTTS 2716

  Fly  1825 PGVPSAPLHLRFSDITMQSLEVTWDPPKFLNGEILGYLVTY---------ETTEENEKFSKQVKQ 1880
            ...|.||..|:.......::|::|.||...:|.|..|.|.|         |...|.::.......
 Worm  2717 ATNPPAPSDLQEEATFPHAIEISWLPPTPPHGNIDFYKVRYTPSGEANYREIRVETDRLECSDSN 2781

  Fly  1881 KVSNTTLRVQNLEEEVTYTFTVRAQTSVDYGPGISE---NVTTGPQDGS-PVAPRDLILT-KTLS 1940
            |......|:.:|:.|..|...|.|.|.   |.|.||   .:|:..|..: ||..|:|.:| ||.:
 Worm  2782 KKDRLCYRLSDLDPEQEYDIQVSAHTE---GGGWSEWSDELTSRTQQQNIPVLERELEVTDKTSN 2843

  Fly  1941 SVEMHWINGPSGRGP-ILGYLIEAKKRDD-SRWTK---IEQTRKGMMQDFTVSYHILMPSTAYTF 2000
            |:.:.|...|..:.. ::||::|.|..|| :.|.:   :.:.|| ...|:.::...|..:|.|.|
 Worm  2844 SISLKWEGLPQDQATHVVGYVLEFKSEDDNAEWQEYNGVVKHRK-TSSDYKITVKQLETATLYFF 2907

  Fly  2001 RV 2002
            |:
 Worm  2908 RL 2909

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig 71..157 CDD:299845 19/115 (17%)
I-set 72..150 CDD:254352 18/107 (17%)
Ig 172..245 CDD:299845 15/127 (12%)
IG_like 280..356 CDD:214653 19/87 (22%)
Ig 280..343 CDD:299845 16/72 (22%)
IG_like 375..450 CDD:214653 21/88 (24%)
Ig 378..447 CDD:143165 20/82 (24%)
Ig 506..587 CDD:299845 19/104 (18%)
IG_like 506..587 CDD:214653 19/104 (18%)
I-set 592..682 CDD:254352 20/115 (17%)
Ig 595..682 CDD:299845 19/112 (17%)
FN3 686..789 CDD:238020 30/146 (21%)
FN3 798..893 CDD:238020 22/100 (22%)
FN3 901..1005 CDD:238020 18/103 (17%)
fn3 1011..1094 CDD:278470 22/92 (24%)
FN3 1108..1202 CDD:238020 28/114 (25%)
FN3 1210..1308 CDD:238020 21/113 (19%)
fn3 1317..1402 CDD:278470 22/106 (21%)
FN3 1415..1507 CDD:238020 16/92 (17%)
FN3 1513..1608 CDD:238020 25/113 (22%)
fn3 1617..1708 CDD:278470 28/90 (31%)
FN3 1722..1823 CDD:238020 28/106 (26%)
FN3 1828..1920 CDD:238020 27/103 (26%)
FN3 1927..2016 CDD:238020 25/82 (30%)
let-805NP_001022641.1 fn3 30..110 CDD:278470
fn3 143..212 CDD:278470
fn3 241..310 CDD:278470
FN3 438..530 CDD:238020
FN3 1007..1094 CDD:238020 12/93 (13%)
FN3 1115..1195 CDD:238020 19/84 (23%)
FN3 1205..1293 CDD:238020 23/110 (21%)
fn3 1299..1386 CDD:278470 16/110 (15%)
FN3 1400..1493 CDD:238020 18/103 (17%)
FN3 1502..1613 CDD:238020 20/114 (18%)
fn3 1629..1696 CDD:278470 14/66 (21%)
FN3 1720..1808 CDD:238020 22/99 (22%)
FN3 1815..1905 CDD:238020 18/104 (17%)
FN3 1910..1997 CDD:238020 21/86 (24%)
FN3 2017..2100 CDD:214495 26/101 (26%)
FN3 2116..2219 CDD:238020 27/133 (20%)
FN3 2224..2307 CDD:214495 18/84 (21%)
FN3 2322..2420 CDD:238020 20/115 (17%)
fn3 2427..2510 CDD:278470 19/87 (22%)
FN3 2522..2617 CDD:238020 30/101 (30%)
FN3 2624..2715 CDD:238020 28/106 (26%)
FN3 2720..2823 CDD:238020 28/105 (27%)
FN3 2833..2929 CDD:238020 23/78 (29%)
FN3 2937..3011 CDD:214495
FN3 3040..3129 CDD:238020
FN3 3145..3237 CDD:238020
FN3 3243..3350 CDD:238020
fn3 3368..3436 CDD:278470
fn3 3460..3550 CDD:278470
fn3 3567..3639 CDD:278470
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 46 1.000 Domainoid score I8189
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_104033
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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