DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and Lifr

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_001345522.1	Gene:	Lifr / 16880	MGIID:	96788	Length:	1092	Species:	Mus musculus

Alignment Length:	1361	Identity:	274/1361 - (20%)
Similarity:	453/1361 - (33%)	Gaps:	476/1361 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   623 NIDWYREGQS---STPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIE 684
            |:.|.....:   .|..:|..:.||| |.:.....:|..|....|.:..|||         :|.:
Mouse    24 NLPWLLSALTLLHLTMHANGLKRGVQ-DLKCTTNNMRVWDCTWPAPLGVSPG---------TVKD 78

  Fly   685 L----------PFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVSELGPVPDPL 739
            :          |...:|||:..| .|....:.:::..||.     |||.:..::||.:...|
Mouse    79 ICIKDRFHSCHPLETTNVKIPAL-SPGDHEVTINYLNGFQ-----SKFTLNEKDVSLIPETP--- 134

  Fly   740 LNWITELSNVSADQRWILLENLKAATVYQFRVSAV----NRVGEGSPSEPSNV---VELPQEAPS 797
                 |:.::|||                |..|::    |..|...| .|||.   :::.|. |.
Mouse   135 -----EILDLSAD----------------FFTSSLLLKWNDRGSALP-HPSNATWEIKVLQN-PR 176

  Fly   798 GPPVGFV--GSARSMSEIITQW----QPPLE-EHRNGQILGYILRYRLFGYNNVPWS-YQNITNE 854
            ..||..|  .:..|..:.:..|    ..||: ...:..|..:|......||..  || :..:.|
Mouse   177 TEPVALVLLNTMLSGKDTVQHWNWTSDLPLQCATHSVSIRWHIDSPHFSGYKE--WSDWSPLKN- 238

  Fly   855 AQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNV----KVEAINSTAA 915
                      |:|                       |:..|       |||    ||....|...
Mouse   239 ----------ISW-----------------------IRNTE-------TNVFPQDKVVLAGSNMT 263

  Fly   916 RCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRM-----KTVPPSLID-PLAEQTAILG 974
            .|..:|                   .:::.|:..:..|.:     :||...::: |::|.:
Mouse   264 ICCMSP-------------------TKVLSGQIGNTLRPLIHLYGQTVAIHILNIPVSENS---- 305

  Fly   975 GLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRASNGI 1039
                    ..:::..||  |.|..:.|......|||.::: ....|:  :.:...|.|.|.: |:
Mouse   306 --------GTNIIFITD--DDVYGTVVFAGYPPDVPQKLS-CETHDL--KEIICSWNPGRIT-GL 356

  Fly  1040 L----TGYTVRYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGS---GIPKTA 1097
            :    |.||:...:..:...........::|    .:|....|...||..:|..|.   |..::|
Mouse   357 VGPRNTEYTLFESISGKSAVFHRIEGLTNET----YRLGVQMHPGQEIHNFTLTGRNPLGQAQSA 417

  Fly  1098 TIQSGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQ-TARNMTWFTICEIND 1161
            .:.:..|.|.||.||:|.:.:|.  |.|:.|:           |.:.|. |..|:    :|:|
Mouse   418 VVINVTERVAPHDPTSLKVKDIN--STVVTFS-----------WYLPGNFTKINL----LCQI-- 463

  Fly  1162 PDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRV 1226
                                                   :..:|..|....|.|:|.
Mouse   464 ---------------------------------------EICKANSKKEVRNATIRG-------- 481

  Fly  1227 RWIPLQQTEWYGNPRGYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHV-LDSLEEWTLYEVKMN 1290
                                                   .||.|  .|| :|.|..:|.|..:
Mouse   482 ---------------------------------------AEDST--YHVAVDKLNPYTAYTFR-- 503

  Fly  1291 ACNDVGCSKE--------SDTAVERTREAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQID 1347
                |.||.:        ||.....|.||.||.||...:..::....::|.|..:|....||:|.
Mouse   504 ----VRCSSKTFWKWSRWSDEKRHLTTEATPSKGPDTWREWSSDGKNLIVYWKPLPINEANGKIL 564

  Fly  1348 GYKVFYAAADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFE 1412
            .|.|..:..:..|.||....|.:    ....:|.|. .|.:.|:|    .|.|.|:||.::.:.|
Mouse   565 SYNVSCSLNEETQSVLEIFDPQH----RAEIQLSKN-DYIISVVA----RNSAGSSPPSKIASME 620

  Fly  1413 DTPGVPSNVSFPDVSLTMA-----RIIWDVPVDPNGKILAYQVTYTLNGSAMLNYSREFP----- 1467
                :|::    |:::..|     ||......|||     ....|.:.   ..|.||..|
Mouse   621 ----IPND----DITVEQAVGLGNRIFLTWRHDPN-----MTCDYVIK---WCNSSRSEPCLLDW 669

  Fly  1468 ---PSDRT---FRATELLPG---KYYSFSCTAQTRLGWGKIATALVYTTNNRERPQAPSV-PQIS 1522
               ||:.|   ..:.:..||   .:|.:.||.|   |:..:.:.:.|.     ...||.| |..:
Mouse   670 RKVPSNSTETVIESDQFQPGVRYNFYLYGCTNQ---GYQLLRSIIGYV-----EELAPIVAPNFT 726

  Fly  1523 RSQIQAHQITFSW--TPGRD--GFAPLRYYTVEMRENEGRWQPL-----PERVDPSLSSFTAVG- 1577
            .....|..|...|  .|..:  ||  ||.|....::.| |..|.     |...|..|.:.|.:.
Mouse   727 VEDTSADSILVKWDDIPVEELRGF--LRGYLFYFQKGE-RDTPKTRSLEPHHSDIKLKNITDISQ 788

  Fly  1578 -------LRPYMTYQFRIQA--TNDLGP--SAF--SRES----VIVRTLPAAPAVGVGGLKVVPI 1625
                   |:...:|...::|  ...|||  |.|  ::|:    :|...:|.|.||.||
Mouse   789 KTLRIADLQGKTSYHLVLRAYTHGGLGPEKSMFVVTKENSVGLIIAILIPVAVAVIVG------- 846

  Fly  1626 TTTSV----RVQW----------------------------SALETALWN----GDASTGGYRIL 1654
            ..||:    :.:|                            :||:|...|    .:......|.:
Mouse   847 VVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSNALKTLEMNPCTPNNVEVLESRSI 911

  Fly  1655 YQQLSD----FPTALQSTPKTDVHGINENSVVLSDLQQDRNYEIVVLPFNSQGPGPATPPAAVYV 1715
            ..::.|    .|.|.:...:::|.  .||.||:|........||             |.|||..|
Mouse   912 VPKIEDTEIISPVAERPGERSEVD--PENHVVVSYCPPIIEEEI-------------TNPAADEV 961

  Fly  1716 GEAVPTGEPRAVDAAPISSTEVRLLWKPPKQSMQNGD-----ILGYKIYYLVTYSPQALEPGRKW 1775
            |           .|:.:...:|:.:::|..::.:..|     :.|||....:..|| |:|.....
Mouse   962 G-----------GASQVVYIDVQSMYQPQAKAEEEQDVDPVVVAGYKPQMRLPISP-AVEDTAAE 1014

  Fly  1776 EEEIEVV----SATATSHSLVFLD--KFTEYRIQLLAF-NPAG-------------DGPRS 1816
            :||.:..    .|...:.:||..|  :.|:...::::| :|..             |.|:|
Mouse  1015 DEEGKTAGYRPQANVNTWNLVSPDSPRSTDSNNEVVSFGSPCSINSRQFLIPPKDEDSPKS 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653
		Ig	280..343	CDD:299845
		IG_like	375..450	CDD:214653
		Ig	378..447	CDD:143165
		Ig	506..587	CDD:299845
		IG_like	506..587	CDD:214653
		I-set	592..682	CDD:254352	14/61 (23%)
		Ig	595..682	CDD:299845	14/61 (23%)
		FN3	686..789	CDD:238020	26/109 (24%)
		FN3	798..893	CDD:238020	17/102 (17%)
		FN3	901..1005	CDD:238020	19/113 (17%)
		fn3	1011..1094	CDD:278470	16/89 (18%)
		FN3	1108..1202	CDD:238020	15/94 (16%)
		FN3	1210..1308	CDD:238020	17/106 (16%)
		fn3	1317..1402	CDD:278470	20/84 (24%)
		FN3	1415..1507	CDD:238020	24/110 (22%)
		FN3	1513..1608	CDD:238020	30/122 (25%)
		fn3	1617..1708	CDD:278470	21/130 (16%)
		FN3	1722..1823	CDD:238020	23/120 (19%)
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Lifr	NP_001345522.1	LIFR_N	50..124	CDD:375634	19/88 (22%)
		LIFR_D2	126..239	CDD:375455	31/151 (21%)
		FN3	428..525	CDD:238020	34/209 (16%)
		WSXWS motif	514..518		0/3 (0%)
		FN3	547..613	CDD:389787	20/74 (27%)
		FN3	724..816	CDD:238020	20/94 (21%)
		Box 1 motif	864..872		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1009..1092		13/67 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910