DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and Il6st

DIOPT Version :9

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_034690.3 Gene:Il6st / 16195 MGIID:96560 Length:917 Species:Mus musculus


Alignment Length:873 Identity:186/873 - (21%)
Similarity:307/873 - (35%) Gaps:263/873 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   782 PSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPW 846
            |.:|:|:..:..|.               ..::.||.|..|.:..   ..|.|:..        |
Mouse   126 PDKPTNLTCIVNEG---------------KNMLCQWDPGRETYLE---TNYTLKSE--------W 164

  Fly   847 S---YQNITNEAQRNFLIQELITWKDYI---VQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNV 905
            :   :.:..::...:.::..:.|:  |:   |.:.|.|.:| .|.:|.......:.|...||.|:
Mouse   165 ATEKFPDCQSKHGTSCMVSYMPTY--YVNIEVWVEAENALG-KVSSESINFDPVDKVKPTPPYNL 226

  Fly   906 KVEAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMK------TVPPSLID 964
            .|              .|.::::.|.:...:.:....|:|.: .||:.|.|      .||  |.|
Mouse   227 SV--------------TNSEELSSILKLSWVSSGLGGLLDLK-SDIQYRTKDASTWIQVP--LED 274

  Fly   965 PLAEQTAI-LGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSD----- 1023
            .::.:|:. :..|:.||||...:....|.|.|..|         |..:|.:|..::|...     
Mouse   275 TMSPRTSFTVQDLKPFTEYVFRIRSIKDSGKGYWS---------DWSEEASGTTYEDRPSRPPSF 330

  Fly  1024 ------------RSVKVLW--APPRASNGILTGY-TVRYQVKDRPDTLKSFNLTADDTELTVNQL 1073
                        |||:::|  .|...:||.:..| .:..|.|....|     .|...||||||  
Mouse   331 WYKTNPSHGQEYRSVRLIWKALPLSEANGKILDYEVILTQSKSVSQT-----YTVTGTELTVN-- 388

  Fly  1074 QATTHYWFEIVAWTRVGSGIPKTATIQSGVEPVLPHAPTALALSNIEAFS----VVLQFTPGFDG 1134
            .....|...:.|..:||.......||.|      ||...|.::.|::||.    :.:::||   .
Mouse   389 LTNDRYVASLAARNKVGKSAAAVLTIPS------PHVTAAYSVVNLKAFPKDNLLWVEWTP---P 444

  Fly  1135 NSSITKWKVEGQTARNMTWFTICE----INDPDAETLTVTGLVPFTQYRLRLSASNV-------V 1188
            ...::|:.:|        |..:.|    :.|...|..||..    |..|.||..|..       |
Mouse   445 PKPVSKYILE--------WCVLSENAPCVEDWQQEDATVNR----THLRGRLLESKCYQITVTPV 497

  Fly  1189 GSSKP--SEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRWIPLQQTEWYGNPRGYNISYKQLV 1251
            .::.|  ||:.|.:.. ||.|...| .|..:.:...:..:.|..:...:..|..|.|:|||:..|
Mouse   498 FATGPGGSESLKAYLK-QAAPARGP-TVRTKKVGKNEAVLAWDQIPVDDQNGFIRNYSISYRTSV 560

  Fly  1252 KTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKMNACNDVGCSKESDTAVERTREAVPSYG 1316
            .        ...||..|.:...:.|.||...|||.|:|.|..|.| .|:               |
Mouse   561 G--------KEMVVHVDSSHTEYTLSSLSSDTLYMVRMAAYTDEG-GKD---------------G 601

  Fly  1317 PLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIPNNATF--TTTLTE 1379
            |     ..|.:|....|          |:|:..                .:|....|  ||.|..
Mouse   602 P-----EFTFTTPKFAQ----------GEIEAI----------------VVPVCLAFLLTTLLGV 635

  Fly  1380 L---------KKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVPSNVSFPDVSLTMARIIW 1435
            |         ||::..:|...:.:.:...:..|||  ...|.....:.|:.:|.|||:       
Mouse   636 LFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPP--RHNFNSKDQMYSDGNFTDVSV------- 691

  Fly  1436 DVPVDPNGK-----------ILAYQVTYT------LNGSAMLNYSREFPPSDRTFRATELLPGKY 1483
             |.::.|.|           :...:...|      :.||:.::.||   ||..:....|      
Mouse   692 -VEIEANNKKPCPDDLKSVDLFKKEKVSTEGHSSGIGGSSCMSSSR---PSISSNEENE------ 746

  Fly  1484 YSFSCTAQTRLGWGKIATALVYTT--NNRERPQAPSVPQISRSQIQAHQITFSWTP--------- 1537
                 :||:      .|:.:.|:|  ::..|.|.|||...|||:.....:.....|         
Mouse   747 -----SAQS------TASTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDSV 800

  Fly  1538 -GRDGFAPLRYYTVEMRENEGRWQPLPE 1564
             |.|...|.:.|   .::|..:.:..||
Mouse   801 DGGDEILPRQPY---FKQNCSQPEACPE 825

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig 71..157 CDD:299845
I-set 72..150 CDD:254352
Ig 172..245 CDD:299845
IG_like 280..356 CDD:214653
Ig 280..343 CDD:299845
IG_like 375..450 CDD:214653
Ig 378..447 CDD:143165
Ig 506..587 CDD:299845
IG_like 506..587 CDD:214653
I-set 592..682 CDD:254352
Ig 595..682 CDD:299845
FN3 686..789 CDD:238020 3/6 (50%)
FN3 798..893 CDD:238020 15/100 (15%)
FN3 901..1005 CDD:238020 26/110 (24%)
fn3 1011..1094 CDD:278470 25/102 (25%)
FN3 1108..1202 CDD:238020 26/110 (24%)
FN3 1210..1308 CDD:238020 25/97 (26%)
fn3 1317..1402 CDD:278470 15/95 (16%)
FN3 1415..1507 CDD:238020 20/108 (19%)
FN3 1513..1608 CDD:238020 15/62 (24%)
fn3 1617..1708 CDD:278470
FN3 1722..1823 CDD:238020
FN3 1828..1920 CDD:238020
FN3 1927..2016 CDD:238020
Il6stNP_034690.3 Lep_receptor_Ig 26..112 CDD:399379
FN3 125..213 CDD:419708 19/115 (17%)
FN3 220..319 CDD:238020 29/124 (23%)
WSXWS motif 308..312 2/12 (17%)
FN3 521..597 CDD:214495 23/84 (27%)
Box 1 motif 649..657 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..678 4/21 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 719..754 11/54 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 898..917
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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