DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and IL31RA

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_620586.3	Gene:	IL31RA / 133396	HGNCID:	18969	Length:	764	Species:	Homo sapiens

Alignment Length:	752	Identity:	152/752 - (20%)
Similarity:	249/752 - (33%)	Gaps:	269/752 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   732 LGPVPDPL---LNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQ 793
            |.|.|..:   :.|...|        |:|      .::.:|.::|:       |::|.|
Human    22 LSPQPSCVNLGMMWTWAL--------WML------PSLCKFSLAAL-------PAKPEN------ 59

  Fly   794 EAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGY----ILRYRLFG--YNNVPWSYQNIT 852
                   :..|...|  ..:...|.|       |:...|    :.|...||  ::|...:.....
Human    60 -------ISCVYYYR--KNLTCTWSP-------GKETSYTQYTVKRTYAFGEKHDNCTTNSSTSE 108

  Fly   853 NEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTK------EGVPEA-PPTNVKVEAI 910
            |.|..:|.:..:....:|.:::.|.|..||        ||:.      |.:.:. ||...:|:.:
Human   109 NRASCSFFLPRITIPDNYTIEVEAENGDGV--------IKSHMTYWRLENIAKTEPPKIFRVKPV 165

  Fly   911 --NSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDI----ERRMKTVPPSLIDPLAEQ 969
              .....:..|..|   ::..::...|.....|.:....|.::    .|:.|           .|
Human   166 LGIKRMIQIEWIKP---ELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDK-----------NQ 216

  Fly   970 TAILGGLEKFTEYNISVLC-------FTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDV------ 1021
            |..|.||:.||||.|::.|       ::|     .|.:...||.::.|   .||....|
Human   217 TYNLTGLQPFTEYVIALRCAVKESKFWSD-----WSQEKMGMTEEEAP---CGLELWRVLKPAEA 273

  Fly  1022 -SDRSVKVLWAPPRASNGI--LTGYTVRYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEI 1083
             ..|.|::||...|.:..:  ..||.:.|..:...:..::.|.|....||.:    ....:|..:
Human   274 DGRRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHL----GGESFWVSM 334

  Fly  1084 VAWTRVGSGIPKTATIQSGVEPVLPHAPTALALSNIEAFS--------VVLQFTPGFDGNSSITK 1140
            :::..:|.....|..|.:..|.         :...||...        ||...:...|.|:
Human   335 ISYNSLGKSPVATLRIPAIQEK---------SFQCIEVMQACVAEDQLVVKWQSSALDVNT---- 386

  Fly  1141 WKVEGQTARNMTWFTICEINDPDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQA 1205
            |.:|        ||.     |.|:|..|             ||..:|      |:||.  .|||
Human   387 WMIE--------WFP-----DVDSEPTT-------------LSWESV------SQATN--WTIQ- 416

  Fly  1206 RPKHPPFNVTVRAMSAQQLRVRWIPLQQTEWYGNPRGYNIS-YKQLVKTPGTIKYVPRSVVIEDH 1269
            :.|..||               |.             |||| |..|....|           |.:
Human   417 QDKLKPF---------------WC-------------YNISVYPMLHDKVG-----------EPY 442

  Fly  1270 TANSHVLDSLEEWTLYEVKMNACNDVGCSKESDTAVERTREAVPSYGPLDVQANATSSTTVVVQW 1334
            :..::                                 .:|.|||.|| :.:.......||.:.|
Human   443 SIQAY---------------------------------AKEGVPSEGP-ETKVENIGVKTVTITW 473

  Fly  1335 GEVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLG-- 1397
            .|:|:..|.|.|..|.:||.|  .|.:...||: |::.....|..||:...|.|||:|.|..|
Human   474 KEIPKSERKGIICNYTIFYQA--EGGKGFSKTV-NSSILQYGLESLKRKTSYIVQVMASTSAGGT 535

  Fly  1398 NGALSTPPIRVQTFEDTPGVPSNVSFPDVSLTMARII 1434
            ||                   ::::|..:|.::..||
Human   536 NG-------------------TSINFKTLSFSVFEII 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653
		Ig	280..343	CDD:299845
		IG_like	375..450	CDD:214653
		Ig	378..447	CDD:143165
		Ig	506..587	CDD:299845
		IG_like	506..587	CDD:214653
		I-set	592..682	CDD:254352
		Ig	595..682	CDD:299845
		FN3	686..789	CDD:238020	12/59 (20%)
		FN3	798..893	CDD:238020	19/100 (19%)
		FN3	901..1005	CDD:238020	23/116 (20%)
		fn3	1011..1094	CDD:278470	17/91 (19%)
		FN3	1108..1202	CDD:238020	20/101 (20%)
		FN3	1210..1308	CDD:238020	11/98 (11%)
		fn3	1317..1402	CDD:278470	29/86 (34%)
		FN3	1415..1507	CDD:238020	4/20 (20%)
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
IL31RA	NP_620586.3	FN3	57..151	CDD:304408	23/123 (19%)
		FN3	155..254	CDD:238020	23/117 (20%)
		FN3	453..533	CDD:214495	29/83 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910