DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdk and Dcc

DIOPT Version :10

Sequence 1:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster
Sequence 2:NP_031857.2 Gene:Dcc / 13176 MGIID:94869 Length:1447 Species:Mus musculus


Alignment Length:1758 Identity:413/1758 - (23%)
Similarity:640/1758 - (36%) Gaps:483/1758 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   248 HLNVSGDPYIEVAP----EIIVRPQDVKVKVGTGVVELQCIANA-RPLHELETLWLKDGLAVETA 307
            ||.|:|   .::.|    ..:..|.|. |.:..|.|.|.|.|.: |.:..::  |.|||| :...
Mouse    26 HLQVTG---FQIKPFTSLHFVSEPSDA-VTMRGGNVLLNCSAESDRGVPVIK--WKKDGL-ILAL 83

  Fly   308 GVRHTLNDPWNRTL---ALLQANSSHS-------GEYTCQVRLRSGGYPAVSASARLQILEPPLF 362
            |:     |...:.|   :||..|..||       |.|.|:..|...| ..:|.:|::.:..|..|
Mouse    84 GM-----DDRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLADSG-SIISRTAKVTVAGPLRF 142

  Fly   363 FTPMRAETFGEF-GGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILD 426
            .:  :.|:...| |..|.|.|:|:|||.|.:.|.:|.:.::......|..:.....|.|.:|...
Mouse   143 LS--QTESITAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLNPLPGDSRVVVLPSGALQISRLQPG 205

  Fly   427 DAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRR 491
            |:.:::|.|.|.|...:.:.                |:.|||    |..||             .
Mouse   206 DSGVYRCSARNPASIRTGNE----------------AEVRIL----SDPGL-------------H 237

  Fly   492 KEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQILESGDLL 556
            ::..|...      |.||.|::||||.:.|...|.|.|:.||:..|..:...|.:..:|...:||
Mouse   238 RQLYFLQR------PSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLL 296

  Fly   557 ISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVP 621
            |||:...|:|.|.||...:..::...|.|:|||....:..|.:......:....:|.||..| ||
Mouse   297 ISNVTDDDSGTYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKP-VP 360

  Fly   622 YNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELP 686
             .::|.:.|....|....|.:|   ...|.|..|..||.|.|.||..:..||...:|:|.|.:..
Mouse   361 -TVNWMKNGDVVIPSDYFQIVG---GSNLRILGVVKSDEGFYQCVAENEAGNAQSSAQLIVPKPA 421

  Fly   687 FPPSNVKVERLPEP---------QQRSINVSWTPGFDGNSPISKFIIQRREVSELGPVPDPLLNW 742
            .|.|::    ||..         ..|.:.:||.|..:....|..|.:   ..|..|...:..|| 
Mouse   422 IPSSSI----LPSAPRDVLPVLVSSRFVRLSWRPPAEAKGNIQTFTV---FFSREGDNRERALN- 478

  Fly   743 ITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSGPPVGFVGSA 807
            .|:..::.     :.:.|||...:|.|||.|.|..|.|..|:|..|...|:....||.......:
Mouse   479 TTQPGSLQ-----LTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLHAVS 538

  Fly   808 RSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQNITNEAQRNFLIQELITWKDYIV 872
            .|.:.|:..|:||  .:.||.:.|    ||||.........|||..:. .::.::.|..:.:|.:
Mouse   539 TSPTSILITWEPP--AYANGPVQG----YRLFCTEVSTGKEQNIEVDG-LSYKLEGLKKFTEYTL 596

  Fly   873 QIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVEAINSTAARCRWTPPNPQQINGINQGYKIQ 937
            :..|||..|.||.|:...:.|...||.|||.|:.:|.:||.:.:..|.||.....||...||||:
Mouse   597 RFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNISLEVVNSRSIKVSWLPPPSGTQNGFITGYKIR 661

  Fly   938 AWQRRLIDGEWRDIERR--MKTVPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQ 1000
                      .|...||  |:|:.|:.:      ..:..||||.::|:..|...|..|.|..|:.
Mouse   662 ----------HRKTTRRGEMETLEPNNL------WYLFTGLEKGSQYSFQVSAMTVNGTGPPSNW 710

  Fly  1001 VAVMTMDD------VPDEVTGLHFDDVSDRSVKVLWAPPRASNGILTGYTVRYQVKD------RP 1053
            ....|.::      |||:.:.||....:: .:.:.|.||...|.::.||.:.|.|..      |.
Mouse   711 YTAETPENDLDESQVPDQPSSLHVRPQTN-CIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRV 774

  Fly  1054 DTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIP--KTATIQSGVEPVLPHAPTALAL 1116
            |:.:.:        .::.:|::::||...:.|:...|.|:|  ::||.:|..:|..|        
Mouse   775 DSKQRY--------YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDP-------- 823

  Fly  1117 SNIEAFSVVLQF-TPGFDGNSSITKWKVEGQTARNMTWFTICEINDPDAETLTVTGLVPFTQYRL 1180
              ::.:.::..| |.|                              ||..|              
Mouse   824 --VDYYPLLDDFPTSG------------------------------PDVST-------------- 842

  Fly  1181 RLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRW----IPLQQTEWYGNPR 1241
                                      |..||..|...|::.:.:||.|    :|..|..  .:.|
Mouse   843 --------------------------PMLPPVGVQAVALTHEAVRVSWADNSVPKNQKT--SDVR 879

  Fly  1242 GYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKMNACNDVGCSKESDTAVE 1306
            .|.:.::  .....:.||..     ||.|:.|:....|:..|:||..:....:...|..|.||..
Mouse   880 LYTVRWR--TSFSASAKYKS-----EDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHA 937

  Fly  1307 RTREAVPSYGPLD--VQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIP- 1368
            .|.||.|:..|.|  |.........|:|.|  .|....||:|..|.:||        .|.|.|| 
Mouse   938 TTYEAAPTSAPKDLTVITREGKPRAVIVSW--QPPLEANGKITAYILFY--------TLDKNIPI 992

  Fly  1369 --------NNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVPSNVSFPD 1425
                    :....|..:.:|....:|:.::.|....|.|.|| .||..:|.:        |..||
Mouse   993 DDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNVKGVGPLS-DPILFRTLK--------VEHPD 1048

  Fly  1426 VSLTMARI--------IWDVPVDPNGKILAYQVTYTLNGSAMLN---YSREFPPSDRTFRATELL 1479
               .||..        .|  |||.|           |...:.||   ..:..||..      .:.
Mouse  1049 ---KMANDQGRHGDGGYW--PVDTN-----------LIDRSTLNEPPIGQMHPPHG------SVT 1091

  Fly  1480 PGKYYSFSCTAQTRLGWGKIATALVY-----------TTNNRERPQAPSVPQISRSQIQAHQITF 1533
            |.|..:........:|   :.|.||.           :...|::....||.:...||        
Mouse  1092 PQKNSNLLVITVVTVG---VLTVLVVVIVAVICTRRSSAQQRKKRATHSVSKRKGSQ-------- 1145

  Fly  1534 SWTPGRDGFAP---LRYYTVEMRENE--------GRWQPLPERVD----PSLSSFTAVGLRPYMT 1583
                 :|...|   :.:..:||:..|        ||..|:....|    ....|.|.:|.:   :
Mouse  1146 -----KDLRPPDLWIHHEEMEMKNIEKPTGTDPAGRDSPIQSCQDLTPVSHSQSETQMGSK---S 1202

  Fly  1584 YQFRIQATNDLGPSAFSRESVIVRTLPAA-----------------PAVGVGGLKVVPITTTSVR 1631
            .....|.|.|.|.|.    |.:.|:|.|.                 |||    :..:|:.|    
Mouse  1203 ASHSGQDTEDAGSSM----STLERSLAARRATRAKLMIPMEAQSSNPAV----VSAIPVPT---- 1255

  Fly  1632 VQWSALETALWNG--DASTGGYRILYQQLS----DFPTALQSTPKTDVHGINENSVVLSDLQQDR 1690
                 ||:|.:.|  .:.|.||.  :.|.:    .|||                      |..||
Mouse  1256 -----LESAQYPGILPSPTCGYP--HPQFTLRPVPFPT----------------------LSVDR 1291

  Fly  1691 NYEIVVLPFNSQGP----GPATPPAAVYVGEAVPTGE---PRAVDAA------PISSTEVRLLWK 1742
            .:........|:||    .|..|||.    ...|:.|   .|.:..|      |:.|....||  
Mouse  1292 GFGAGRTQSVSEGPTTQQQPMLPPAQ----PEHPSSEEAPSRTIPTACVRPTHPLRSFANPLL-- 1350

  Fly  1743 PPKQSMQNGDILGYKIYYLVTYSPQALEPGRKWEEEIEVVSATATSHSLVFLDKFTEYRIQLLAF 1807
            ||..|         .|...|.|:|...:||                      ....:..::..:.
Mouse  1351 PPPMS---------AIEPKVPYTPLLSQPG----------------------PTLPKTHVKTASL 1384

  Fly  1808 NPAGDGPRSAPITVKTLPGVPSAPLHLRFSDITMQSLEVTWDPPKFLNGEILGYLVTYETTEENE 1872
            ..||.. ||..:.|    .||:||      :::.:|.:.|.||..           .||..:.:|
Mouse  1385 GLAGKA-RSPLLPV----SVPTAP------EVSEESHKPTEDPAS-----------VYEQDDLSE 1427

  Fly  1873 KFS 1875
            :.:
Mouse  1428 QMA 1430

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdkNP_001284756.1 Ig_3 72..142 CDD:464046
Ig 280..344 CDD:409353 21/74 (28%)
Ig strand B 280..283 CDD:409353 1/2 (50%)
Ig strand C 292..298 CDD:409353 0/5 (0%)
Ig strand E 319..323 CDD:409353 1/6 (17%)
Ig strand F 333..338 CDD:409353 2/4 (50%)
Ig 360..451 CDD:472250 23/91 (25%)
Ig strand B 378..382 CDD:409353 2/3 (67%)
Ig strand C 391..395 CDD:409353 0/3 (0%)
Ig strand E 416..420 CDD:409353 1/3 (33%)
Ig strand F 430..435 CDD:409353 1/4 (25%)
Ig strand G 443..446 CDD:409353 0/2 (0%)
Ig 502..587 CDD:472250 29/84 (35%)
Ig strand B 517..521 CDD:409353 1/3 (33%)
Ig strand C 530..534 CDD:409353 1/3 (33%)
Ig strand E 554..557 CDD:409353 1/2 (50%)
Ig strand F 567..572 CDD:409353 2/4 (50%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 25/89 (28%)
Ig strand B 608..612 CDD:409353 0/3 (0%)
Ig strand C 623..627 CDD:409353 0/3 (0%)
Ig strand E 648..652 CDD:409353 1/3 (33%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 0/2 (0%)
FN3 686..789 CDD:238020 28/111 (25%)
FN3 798..893 CDD:238020 26/94 (28%)
FN3 901..1005 CDD:238020 31/105 (30%)
FN3 <960..>1261 CDD:442628 59/319 (18%)
fn3 1317..1402 CDD:394996 23/95 (24%)
FN3 1415..1507 CDD:238020 21/113 (19%)
FN3 1513..1608 CDD:238020 22/109 (20%)
FN3 1583..>2011 CDD:442628 68/329 (21%)
DccNP_031857.2 IgI_1_Neogenin_like 39..136 CDD:409387 29/106 (27%)
Ig strand A 39..42 CDD:409387 0/2 (0%)
Ig strand A' 45..51 CDD:409387 2/6 (33%)
Ig strand B 55..65 CDD:409387 5/9 (56%)
Ig strand C 70..76 CDD:409387 1/7 (14%)
Ig strand C' 78..81 CDD:409387 2/3 (67%)
Ig strand D 88..93 CDD:409387 0/4 (0%)
Ig strand E 95..101 CDD:409387 2/5 (40%)
Ig strand F 113..120 CDD:409387 3/6 (50%)
Ig strand G 125..136 CDD:409387 3/11 (27%)
Ig_3 139..216 CDD:464046 22/78 (28%)
I-set 241..327 CDD:400151 30/91 (33%)
Ig strand B 257..261 CDD:409353 1/3 (33%)
Ig strand C 270..274 CDD:409353 1/3 (33%)
Ig strand E 293..297 CDD:409353 1/3 (33%)
Ig strand F 307..312 CDD:409353 2/4 (50%)
Ig strand G 322..325 CDD:409353 1/2 (50%)
IgI_4_Neogenin_like 334..417 CDD:409388 25/87 (29%)
Ig strand A 334..337 CDD:409388 0/2 (0%)
Ig strand A' 339..343 CDD:409388 0/3 (0%)
Ig strand B 346..355 CDD:409388 1/8 (13%)
Ig strand C 360..366 CDD:409388 2/6 (33%)
Ig strand C' 368..371 CDD:409388 1/2 (50%)
Ig strand D 376..380 CDD:409388 1/3 (33%)
Ig strand E 384..388 CDD:409388 1/3 (33%)
Ig strand F 396..404 CDD:409388 4/7 (57%)
Ig strand G 407..417 CDD:409388 4/9 (44%)
FN3 429..521 CDD:238020 26/100 (26%)
FN3 <478..901 CDD:442628 128/549 (23%)
FN3 946..1041 CDD:238020 27/105 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1153 7/39 (18%)
Neogenin_C 1148..1445 CDD:461954 79/386 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1166..1220 14/60 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1291..1329 10/41 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1419 9/45 (20%)
Blue background indicates that the domain is not in the aligned region.

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